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| 1 | Highly efficient pure white polymer light-emitting devices based on poly(N-vinylcarbazole) doped with blue and red phosphorescent dyes显示文摘Efficient white-polymer-light-emitting devices (WPLEDs) have been fabricated with a single emitting layer containing a hole-transporting host polymer,poly(N-vinylcarbzole),and an electron-transporting auxiliary,1,3-bis[(4-tert-butylphenyl)-1,3,4-oxadiazolyl]-phenylene,codoped with two phosphorescent dyes:Iridium(III)bis (2-(4,6-difluorophenyl)-pyridinato-N,C2') picolinate (FIrpic) and home-made Ir-G2 for blue and red emission,respectively.With the structure of ITO/PEDOT:PSS 4083(40 nm)/emission layer(80 nm)/Ba(4 nm)/Al(120 nm),the device showed a maximal luminous efficiency (LE) of 13.5 cd A-1(corresponding to an external quantum efficiency (EQE) of 6.8%),and a peak power efficiency (PE) of 6.5 lm W-1 at 6.0 V.Meanwhile,the device exhibited pure white emission with Commission Internationale de l'Eclairage (CIE) coordinates of (0.34,0.35) at a current density of 12 mA cm-2,which is very close to the equi-energy white point with CIE coordinates of (0.33,0.33).The device performance can be further optimized when more balanced hole/electron injection is achieved by incorporating a lower conducting type anode buffer layer (PEDOT:PSS) and incorporating poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorenene)-alt-2,7-(9,9-dioctyfluorene)] (PFN) as an electron injection layer at the cathode.The optimized device showed an LE of 24.6 cd A-1 (with an EQE of 14.1%),while the peak power efficiency reached 12.66 lm W-1.Moreover,the WPLEDs showed good electroluminescence (EL) stability over a wide range of operating current density and luminance. | HU SuJun ZOU JianHua ZHOU GuiJiang LI DongYun WU HongBin SU ShiJian WONG Wai-Yeung YANG Wei PENG JunBiao CAO Yong | 2011 | Science China Chemistry2011，54，4： | 4 |
| 2 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 3 | Electroluminescence performances of 1,1-bis(4-(N,N-dimethylamino)phenyl)-2,3,4,5-tetraphenylsilole based polymers in three cathode architectures显示文摘A new silole monomer with two 4-(N,N-dimethylamino)phenyl substitutions on silicon atom as designed and synthesized.Three copolymers PF-N-HPS1,PF-N-HPS10 and PF-N-HPS20 were then obtained by copolymerizations of 2,7-fluorene derivatives with the silole monomer at feed ratios of 1%,10%,and 20%.Their UV-vis absorption,electrochemical,photoluminescent,and electroluminescent (EL) properties were investigated.PF-N-HPS possessed HOMO levels of 5.25-5.58 eV,and showed green emissions.Using PF-N-HPS as the emissive layer,three different polymer light-emitting diodes were fabricated as device A with ITO/PEDOT/PF-N-HPS/Al,device B with ITO/PEDOT/PF-N-HPS/Ba/Al,and device C with ITO/PEDOT/PF-N-HPS/TPBI/Ba/Al.For the device A,PF-N-HPS only showed very low EL efficiency of 0.06-0.33 cd/A,indicating that the Al cathode could not inject electron efficiently to the emissive polymers containing the 4-(N,N-dimethylamino)phenyl groups.For the device B,low work function Ba supplied better electron injections,and the EL efficiency could be improved to 0.85-1.44 cd/A.TPBI with a deep HOMO level of 6.2 eV could enhance electron transport and hole blocking.Thus modified recombinations and largely elevated EL efficiency of 4.56-7.96 cd/A were achieved for the device C.The separation of the emissive layer and metal cathode with the TPBI layer may also suppress exciton quenching at the cathode interface. | LIU ZhiTian HU SuJun ZHANG LinHua CHEN JunWu PENG JunBiao CAO Yong | 2013 | Science China Chemistry2013，56，8： | 2 |
| 4 | Quantitative analysis of secretome from adipocytes regulated by insulin显示文摘Adipocyte 是经由肽和蛋白质的分泌物在另外的机关涉及精力的存储和版本,而且在精力新陈代谢的规定的不仅一个中央播放器。在胰岛素抵抗和类型的致病期间 2 糖尿病, adipocytes 受到胰岛素的增加的层次,它可以在 adipokines 的分泌物上有主要影响。我们承担了劈得开的编码同位素的亲密关系标签(cICAT ) ,没有标签的 quantitation 来临鉴别是差别的能分泌的因素由 3T3-L1 adipocytes 藏匿了与或没有胰岛素处理并且确定。cICAT 和没有标签的结果的联合,有 317 蛋白质,预言或注解同样能分泌的蛋白质。在这些能分泌的蛋白质之中, 179 蛋白质和 53 蛋白质分别地显著地起来调整、下面调整。77 的一个总数报导 adipokines 在我们的学习被确定,例如 adiponectin,组织蛋白酶 D, cystatin C, resistin,和 transferrin。这些 adipokines 的西方的污点分析从集体 spectrometry 证实了量的结果,并且由增加胰岛素剂量揭示了这些蛋白质的个性化的 secreting 模式。另外, 240 蛋白质是在我们的学习,其大多数在胰岛素处理之上起来调整从 3T3-L1 adipocytes 分泌了蛋白质最新被识别并且确定。进一步全面的生物信息学分析表明在细胞外的矩阵受体相互作用小径和 glycan 结构降级小径的能分泌的蛋白质由胰岛素刺激是显著地起来调整的。 | Hu Zhou Yuanyuan Xiao Rongxia Li Shangyu Hong Sujun Li Lianshui Wang Rong Zeng Kan Liao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，11： | 2 |
| 5 | Role of Neu-p11/luzindole in the regulation of nsulin signaling pathways and insulin resistance显示文摘 | Xiuping Li Shichang Cai Weidong Yin Xiaobo Hu Sujun Zhang Zhengming Li Xing Li Moshe Laudon | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 1 |
| 6 | A series of energy-transfer copolymers derived from fluorene and 4,7-dithienylbenzotriazole for high efficiency yellow,orange,and white light-emitting diodes显示文摘 | Zhang Lianjie Hu Sujun Chen Junwu | 2011 | Advanced Functional Materials2011，21，19： | 1 |
| 7 | Experimental investigation on boiling heat transfer characteristics of Al_2O_3-water nanofluids in swirl microchannels subjected to an acceleration force显示文摘Experiments were carried out to investigate the boiling heat transfer characteristics of Al_2O_3-water nanofluids in swirl microchannels under terrestrial gravity and acceleration fields. A centrifuge with a two-meter long rotational arm was used to simulate the acceleration magnitude up to 9 g and three various acceleration directions. Three test sections with different geometric parameters were applied. The volume concentration of Al_2O_3 nanoparticles with an average diameter of 13 nm was varied from 0.07% to 0.1%. The mass flow rate and vapor quality were in ranges of 3–6 kg/h and 0.4–1.0%, respectively. The effects of the mass flow rate, microchannel aspect ratio,vapor quality, nanoparticle volume concentration, and acceleration direction and magnitude were analyzed in a systematic manner. Experimental results showed that the acceleration direction and magnitude had significant influences on the boiling heat transfer. The heat transfer under configuration C was found to be superior to that under configurations A and B. Moreover, the heat transfer coefficient increased with increases of the mass flow rate and the volume concentration and decreased with the aspect ratio. | Sujun DONG Hongsheng JIANG Yongqi XIE Xiaoming WANG Zhongliang HU Jun WANG | 2019 | Chinese Journal of Aeronautics2019，32，5： | 1 |
| 8 | Microstructure evolution of an ultra-high strength metal alloy with tempering temperature显示文摘Optical microscopy (OM) and transmission electron microscopy (TEM) were used to investigate the effect of tempering temperature on the experimental extra-high carbon steels. It is found that tempering reaction can reduce austenite content and influence the stability of the austenite. As-normalized microstructure is a mixture of twinned martensite and retained austenite. Tempered at 250 °C for 2 h, lath martensite can occasionally be found nearby the diffusionally decomposed austenite area. It also is found that tempering at 650 °C for 2 h, nanoparticles of carbides precipitate in the martensite and decomposed austenite. | WU Sujun HU Bin HAN Bo | 2012 | Rare Metals2012，31，5： | 0 |
| 9 | Glioblastoma cell-derived exosomes functionalized with peptides as efficient nanocarriers for synergistic chemotherapy of glioblastoma with improved biosafety显示文摘Glioblastoma(GBM)has been regarded as one of the most deadly and challenging cancers to treat with extremely poor prognosis.The limited efficacy of current chemotherapies might be attributed to the presence of glioma stem cells(GSCs)as well as the difficulties in passing through the blood–brain barrier(BBB)and targeting tumor cells.Tumor-derived exosomes are emerging as novel and promising drug delivery systems.However,great concerns regarding the biosafety and BBB penetrability remain to be addressed.Herein,we have developed a simple and feasible strategy to engineer GBM cell-derived exosomes with improved biosafety termed“Exo@TDPs”to deliver the cargos of chemotherapeutic agents temozolomide(TMZ)and doxorubicin(DOX)into GBM tissues.Exo@TDPs decorated with angiopep-2(Ang-2)and CD133-targeted peptides improve the capacity to penetrate the BBB and target tumor cells.Both in vitro and in vivo studies demonstrate that Exo@TDPs can cross the BBB,target GBM cells,penetrate into deep tumor parenchyma,and release the therapeutic cargos effectively.Synergistic delivery of TMZ and DOX by Exo@TDPs exerts therapeutic effects to suppress the tumor growth and prolong the survival time of orthotopic syngeneic mouse GBM models.These findings suggest that our developed Exo@TDPs loaded with chemotherapeutic drugs may bring new possibilities for the application of tumor cell-derived exosomes for brain tumor treatment. | Ying Zhou Long Wang Lufei Chen Wei Wu Zhimin Yang Yuanzhuo Wang Anqi Wang Sujun Jiang Xuzhen Qin Zucheng Ye Zhiyuan Hu Zihua Wang | 2023 | Nano Research2023，16，12： | 0 |
| 10 | Investigation of Proton Resonant Properties in laNe via 17F+p and Its Astrophysical Implications for 14O(α,p)17F Stellar Reaction显示文摘 | Hu Jun He Jianjun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Yuan Xiaohua Lu Wan Zhang Xueheng SuJun Li Ertao Hu Zhengguo Guo Zhongya n Xu Xing Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
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