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| 1 | Effects of co-administration of methanol leaf extract of Catharanthus roseus on the hypoglycemic activity of metformin and glibenclamide in rats显示文摘Objective:To investigate the interacting effects of co-administration of methanol leaf extract of Catharanthus roseus(C.roseus) on the hypoglycemic activity of metformin as well as glibenclamide using experimental rats.Methods:Phytochemical analysis as well as acute toxicity and lethality(LD50) test were carried out on its methanol leaf extract.The alloxan model for experimental induction of diabetes in rats was employed.Six groups comprising five rats each were used.GroupsⅡ,ⅢandⅣreceived 250 mg/kg of extract,100 mg/kg of metformin and 1 mg/kg of glibenclamide respectively,while V and VI were administered metformin-extract and glibenclamide-extract combinations respectively at doses as above.Group I served as negative control and received only distilled water.All administration was done once daily for seven days. Fasting blood glucose was determined at 2,12,24,72 and 168 h using a glucometer.One-way ANOVA with post-hoc tests was used to assess for significant difference due to administration of drug alone and with co-administration of drug and extract.Results:The LD50 was 2 121.32 mg/kg. The phytochemical studies indicated the presence of saponins,tannins,alkaloids,phlotatannins, flavonoids,triterpenoids,reducing sugars,anthraquinones and glycosides.All medicaments significantly reduced blood glucose levels when compared with control alone(P<0.05) with the highest percentage reduction in blood glucose(64.86%) exhibited by metformin-extract combination.Conclusions:The leaf extract of C.roseus significandy increases the hypoglycemic effect of metformin. | Ohadoma SC Michael HU | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 2 |
| 2 | Face recognition using Laplacianfaces 显示文摘 | He X F Yan SC Hu Y | 2005 | IEEE Transactions on Pattern Analysis and Machine Intelligence(S0162-8828)2005，27，3： | 1 |
| 3 | Cellular proteins specifically bind to the 5'-noncoding of hepatitis C virus RNA显示文摘 | Yen JH Chang SC Hu CR | 1995 | Virology1995，208，2： | 1 |
| 4 | The TVBF dual blade plate and its application显示文摘 | Rao SC Moo ZS Hu YZ | 1991 | Spine1991，16，3： | 1 |
| 5 | Leptin-a growth factor in normaland malignant breast cells and for normal mammary gland development显示文摘 | Hu X Juneja SC Maihle NJ | 2002 | Natl Cancer Inst2002，94，22： | 1 |
| 6 | Rates of cutaneous metastases from different internal malignancies : experience from a Taiwanese medical center 显示文摘 | Hu SC Chen GS Wu CS | 2009 | J Am Acad Dermatol2009，60，3： | 1 |
| 7 | Differentiation of spinal motor neurons from pluripotent human stem cells显示文摘 | Hu BY Zhang SC | 2009 | Nat Protoc2009，4，9： | 1 |
| 8 | Dendrite development regulated by CREST, a calcium-regulated transcriptional activator显示文摘 | Aizawa H Hu SC Bobb K | 2004 | Science2004，303，： | 1 |
| 9 | Differentiation of spinal motor neurons from pluripotent human stem cells显示文摘 | Hu BY Zhang SC | 2009 | Nat Protoc2009，4，9： | 1 |
| 10 | Curcumin enhances the im- munosuppressive activity of cyclosporine in rat cardiac allografts and in mixed lymphocyte reactions显示文摘 | Chueh SC Lai MK Hu IS | 2003 | Ransplant Proc2003，35，4： | 1 |
| 11 | Xanthones from Hypericum ascyron 显示文摘 | Hu LH Yip SC Sim KY | 1999 | 52:13711999，52，： | 1 |
| 12 | Autotaxin-lysophosphatidic acidsignaling axis mediates tumorigenesis and development of ac-quired resistance to sunitinib in renal cell carcinoma 显示文摘 | Su SC Hu X Kenney PA | 2013 | ClinCancer Res2013，19，23： | 1 |
| 13 | Complex Caged Polyisoprenylated Benzophenone Derivatives, Sampsoniones A and B, from Hypericum sampsonii 显示文摘 | Hu LH Yip SC | 1998 | Tetrahedron Letters1998，39，： | 1 |
| 14 | Unresectable malignant biliary obstruction:treatment by selfexpandable biliary endoprostheses显示文摘 | Glattli A Stain SC Baer HU | 1993 | HPB Surg1993，6，： | 1 |
| 15 | Differentiation of spinal motor neurons from pluri-potent human stem cells显示文摘 | Hu BY Zhang SC | 2009 | Nat Protoc2009，4，9： | 1 |
| 16 | The applicability of the theory of planned behav-ior to the intention to quit smoking across workplaces in southern Tai-wan 显示文摘 | Hu SC Lanese RR | 1998 | Addictive Behaviors1998，23，2： | 1 |
| 17 | Leptin-a growth factor in normal and malignant breast cells and for normal mammary gland derelopment显示文摘 | Juneja SC Machle NJ | 2002 | J Natl Cancer Inst2002，94，22： | 1 |
| 18 | Unresectable malignant biliary obstruction: treatmentby self- expandable biliary endoprostheses 显示文摘 | Stain Sc Baer Hu | 1993 | HPB-Surg1993，6，3： | 1 |
| 19 | Rates of cutaneous metastases from different internal malignancies:Experience from a Taiwanese medical center显示文摘 | Hu SC Chen GS Wu CS | 2009 | J Am Acad Dermatol2009，60，： | 1 |
| 20 | Total--factor energy efficiency of regions in China显示文摘 | Hu JL Wang SC | 2006 | Energy Economics2006，，54： | 1 |
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