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| 1 | High prevalence of epilepsy in onchocerciasis endemic health areas in Democratic Republic of the Congo显示文摘Background:A high prevalence of epilepsy has been observed in many onchocerciasis endemic regions.This study is to estimate the prevalence of active epilepsy and exposure to Onchocerca volvulus infection in a rural population in Ituri province,Democratic Republic of Congo.Methods:In August 2016,a community-based cross-sectional study was conducted in an onchocerciasis endemic area in the rural health zone of Logo,Ituri Province.Households within two neighbouring health areas were randomly sampled.To identify persons with epilepsy,a three-stage approach was used.In the first stage,all individuals of the selected households were screened for epilepsy by non-medical field workers using a validated 5-item questionnaire.In the second and third stage,suspected cases of epilepsy were examined by non-specialist medical doctors,and by a neurologist,respectively.A case of epilepsy was defined according to the 2014 International League Against Epilepsy(ILAE)guidelines.Exposure to O.volvulus was assessed by testing for IgG4 antibodies to an O.volvulus antigen(OV16 Rapid Test,)in individuals aged 3 years and older.Results:Out of 1389 participants included in the survey,64 were considered to have active epilepsy(prevalence 4.6%)(95%confidence interval[CI]:3.6-5.8).The highest age-specific epilepsy prevalence estimate was observed in those aged 20 to 29 years(8.2%).Median age of epilepsy onset was 10 years,with a peak incidence of epilepsy in the 10 to 15 year-old age group.OV16 test results were available for 912 participants,of whom 30.5%(95%CI,27.6-33.6)tested positive.The prevalence of OV16 positivity in a village ranged from 8.6 to 68.0%.After adjusting for age,gender and ivermectin use,a significant association between exposure to onchocerciasis and epilepsy was observed(adjusted odds ratio=3.19,95%CI:1.63-5.64)(P<0.001).Conclusions:A high prevalence of epilepsy and a significant association between epilepsy and exposure to O.volvulus were observed in the population in Ituri province,Democratic Republic of Congo.There is an urgent need to implement a CDTI programme and to scale up an epilepsy treatment and care programme. | Evy Lenaerts Michel Mandro Deby Mukendi Patrick Suykerbuyk Housseini Dolo Deogratias Wonya’Rossi Françoise Ngave Chellafe Ensoy-Musoro Anne Laudisoit An Hotterbeekx Robert Colebunders | 2018 | Infectious Diseases of Poverty2018，7，1： | 5 |
| 2 | Accuracy and outcome of rapid ultrasound in shock and hypotension (RUSH) in Egyptian polytrauma patients显示文摘 | Adel Hamed Elbaih Ahmed Mohamed Housseini Mohamed E.M. Khalifa | 2018 | Chinese Journal of Traumatology2018，21，3： | 4 |
| 3 | parison of three-dimensional rotational angiography and digital subtraction angiography for the evaluation of the liver transplants显示文摘 | Housseini AM Bozlar U Schmitt TM | | 0，，： | 1 |
| 4 | Neutrophil gelati- nase-associated lipocalin as a new diagnostic tool for acute kidney injury显示文摘 | E1 Housseini Y Sehmidtko J Meier P | 2013 | Rev Med Suisse2013，9，406： | 1 |
| 5 | Pneumonia in Solid Organ Recipients: Spectrum of Pathogens in 217 Episodes显示文摘 | H. Bonatti T.L. Pruett G. Brandacher K.D. Hagspiel A.M. Housseini C.D. Sifri R.G. Sawyer | 2009 | Transplantation Proceedings2009，，1： | 1 |
| 6 | Comparison of three-dimensional rotational angiography and digital subtraction angiography for the evaluation of the liver transplants显示文摘 | Housseini AM Bozlar U Schmmit TM | 2009 | Clin Image2009，33，2： | 1 |
| 7 | Community perceptions of epilepsy and its treatment in an onchocerciasis endemic region in Ituri,Democratic Republic of Congo显示文摘Background:A recent study in the Logo and Rethy health zones in the Ituri Province in the Democratic Republic of Congo(DRC)reported that the majority of the persons with epilepsy(PWE)had not been treated with anti-epileptic medication(AEM)or had stopped treatment.Prior to the implementation of an epilepsy treatment programme in these health zones,this study investigated the perceptions and experiences regarding epilepsy and its treatment amongst community leaders,PWE and/or their families,traditional healers and health professionals.Methods:A total of 14 focus group discussions(FGD)and 39 semi-structured interviews(SSI)were conducted with PWE and/or their family members,community leaders,traditional healers,and health professionals in the Logo and Rethy health zones during February 2-19,2017.Results:In the two health zones,the clinical signs of convulsive epilepsy were recognized by community members.However,a variety of misconceptions about epilepsy were identified including the beliefs that epilepsy is a family-related condition,a contagious disease,is transmitted by insects,saliva or by touching a person of the same sex during seizures,or is caused by evil spirits and witchcraft.The role of traditional healers in spreading these beliefs was revealed.The study also reported sexual abuse on PWE,stigmatisation of PWE and loss of productivity of PWE and their families.Some PWE had been using AEM and traditional treatment but were not convinced about the efficacy of these treatment options.The lack of training of health providers about epilepsy care,financial barriers in obtaining AEM,and the shortage of AEM at primary health facilities were revealed.As remedies,the community requested access to a decentralized center for epilepsy treatment.They also proposed using churches and community health workers as communication channels for information about epilepsy.Conclusions:Clinical signs of convulsive epilepsy were recognized by the community in the Logo and Rethy health zones but many misconceptions about epilepsy were identified.A comprehensive community-based epilepsy treatment programme with an affordable uninterrupted AEM supply needs to be established.Such a programme should address stigma,misconceptions,sexual abuse and foster the rehabilitation of PWE to alleviate poverty. | Housseini Dolo Michel Mandro Deogratias Wonya’Rossi Francoise Ngave Jessica Fraeyman Joseph NSiewe Patrick Suykerbuyk Robert Colebunders | 2018 | Infectious Diseases of Poverty2018，7，1： | 1 |
| 8 | Effect of intradialytic resistance band exercise on physical function in patients on maintenance hemodialysis:a pilot study显示文摘 | BULLANI R EL HOUSSEINI Y GIORDANO F | 2011 | J Ren Nutr2011，21，1： | 1 |
| 9 | Reversible chorea in association with Grave's disease and moyamoya syndrome 显示文摘 | Garcin B Louissaint T Housseini H | 2008 | Mov Disord2008，23，4： | 1 |
| 10 | Bladder tumour staging: comparison of diffusion- and T2-weighted MR imaging显示文摘 | Ahmed El-Assmy Mohamed E. Abou-El-Ghar Ahmed Mosbah Ahmed R. El-Nahas Huda F. Refaie Ihab A. Hekal Tarek El-Diasty El Housseiny Ibrahiem | 2009 | European Radiology2009，，7： | 1 |
| 11 | Preoperative embolization of Castleman’s disease using microspheres显示文摘 | Swee W Housseini AM Angle JF | 2009 | Ann Thorac Surg2009，88，： | 1 |
| 12 | CT angiography of renal arteriovenous fistulae:a report of two cases显示文摘 | Abdel-Gawad EA Housseini AM Cherry KJ | 2009 | Vasc Endovascular Surg2009，43，7： | 1 |
| 13 | Production of an endoinulinase from Aspergillus niger AUMC 9375, by sofid state fermentation of agricultural wastes, with purificationand characterization of the free and immobilized enzyme显示文摘 | MANAL M HOUSSEINY | 2014 | Journal of Microbiology2014，52，2： | 1 |
| 14 | A scenario-based multi-objective model for multi-stage transmission expansion planning显示文摘 | Maghouli P Housseini S H Buygi M O | 2011 | IEEE Transactions on Power Systems2011，26，1： | 1 |
| 15 | Preoperative embolization of Castleman's disease using microspheres 显示文摘 | Swee W Housseini AM Angle JF | 2009 | Ann Thorac Surg2009，88，6： | 1 |
| 16 | Improvement of alkaline protease production by Penicillium chrysogenum NRRL 792 through physical and chemical mutation, optimization, characterization and genetic variation between mutant and wild-type strains 显示文摘 | Ahmed F Afifi Heba I Abo-Elmagd Manal M Housseiny | 2014 | Annals of Microbiology2014，64，： | 1 |
| 17 | Comparison of three- dimensional rotational angiography and digital subtraction angiography for the evaluation of the liver transplants 显示文摘 | Housseini AM Bozlar U Schmitt TM | 2009 | Clin Imaging2009，33，2： | 1 |
| 18 | CT angiography of renal arteriovenous fistulae:a report of two cases 显示文摘 | Abdel-Gawad EA Housseini AM Cherry K J | 2009 | Vascular and endovascular surgery2009，43，4： | 1 |
| 19 | Stigma and epilepsy in onchocerciasisendemic regions in Africa:a review and recommendations from the onchocerciasisassociated epilepsy working group显示文摘Background:In onchocerciasis-endemic areas,particularly in those with a sub-optimal onchocerciasis control programme,a high prevalence of epilepsy is observed.Both onchocerciasis and epilepsy are stigmatizing conditions.The first international workshop on onchocerciasis-associated epilepsy(OAE)was held in Antwerp,Belgium(12-14 October 2017)and during this meeting,an OAE alliance was established.In this paper,we review what is known about epilepsy-associated stigma in onchocerciasis-endemic regions,and present the recommendations of the OAE alliance working group on stigma.Main body:For this scoping review,literature searches were performed on the electronic databases PubMed,Scopus and Science Direct using the search terms'epilepsy AND onchocerciasis AND stigma'.Hand searches were also undertaken using Google Scholar,and in total seven papers were identified that addressed epilepsy-related stigma in an onchocercisasis-endemic area.Due to the limited number of published research papers on epilepsyassociated stigma in onchocerciasis-endemic areas,other relevant literature that describes important aspects related to stigma is discussed.The thematic presentation of this scoping review follows key insights on the barriers to alleviating the social consequences of stigma in highly affected onchocerciasis-endemic areas,which were established by experts during the working group on stigma and discrimination at the first international workshop on OAE.These themes are:knowledge gaps,perceived disease aetiology,access to education,marriage restrictions,psycho-social well-being,burden on the care-giver and treatment seeking behaviour.Based on the literature and expert discussions during the OAE working group on stigma,this paper describes important issues regarding epilepsy-related stigma in onchocerciasis-endemic regions and recommends interventions that are needed to reduce stigma and discrimination for the improvement of the psycho-social well-being of persons with epilepsy.Conclusions:Educating healthcare workers and communities about OAE,strengthening onchocerciasis elimination programs,decreasing the anti-epileptic treatment gap,improving the care of epilepsy-related injuries,and prioritising epilepsy research is the way forward to decreasing the stigma associated with epilepsy in onchocerciasis-endemic regions. | Sarah O'Neill Julia Irani Joseph Nelson Siewe Fodjo Denis Nono Catherine Abbo Yasuaki Sato Augustine Mugarura Housseini Dolo Maya Ronse Alfred K.Njamnshi Robert Colebunders | 2019 | Infectious Diseases of Poverty2019，8，3： | 1 |
| 20 | Effect of intradia- lytic resistance band exercise on physical function in patients on maintenance hemodialysis: a pilot study显示文摘 | Bullani R E1 Housseini Y Giordano F | 2011 | J Ren Nutr2011，21，1： | 1 |
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