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| 1 | Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide显示文摘AIM:To examine the relevance of hypoxia inducible factor(HIF-1)and nitric oxide(NO)on the preservation of fatty liver against cold ischemia-reperfusion injury(IRI). METHODS:We used an isolated perfused rat liver model and we evaluated HIF-1αin steatotic and non-steatotic livers preserved for 24 h at 4℃in University of Wisconsin and IGL-1 solutions,and then subjected to 2 h of normothermic reperfusion.After normoxic reperfusion,liver enzymes,bile production,bromosulfophthalein clearance,as well as HIF-1αand NO[endothelial NO synthase(eNOS)activity and nitrites/nitrates]were also measured.Other factors associated with the higher susceptibility of steatotic livers to IRI,such as mitochondrial damage and vascular resistance were evaluated. RESULTS:A significant increase in HIF-1αwas found in steatotic and non-steatotic livers preserved in IGL-1 after cold storage.Livers preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function parameters.These benefits were enhanced by the addition of trimetazidine(an antiischemic drug),which induces NO and eNOS activation, to IGL-1 solution.In normoxic reperfusion,the presence of NO favors HIF-1αaccumulation,promoting also the activation of other cytoprotective genes,such as hemeoxygenase-1. CONCLUSION:We found evidence for the role of the HIF-1α/NO system in fatty liver preservation,especially when IGL-1 solution is used. | Mohamed Amine Zaouali Ismail Ben Mosbah Eleonora Boncompagni Hassen Ben Abdennebi Maria Teresa Mitjavila Ramon Bartrons Isabel Freitas Antoni Rimola Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，28： | 11 |
| 2 | Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution显示文摘AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1 solution supplemented with or without IGF-1 and then perfused 'ex vivo ' for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.RESULTS: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.CONCLUSION: IGL-1 enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion. | Mohamed Amine Zaouali Susagna Padrissa-Altés Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 3 | The Influence of the Color Model on the Performance of a CBIR System Based on Color Moments显示文摘 | Mawloud Mosbah Bachir Boucheham | 2014 | 通讯和计算机(中英文版)2014，11，3： | 4 |
| 4 | Miniplate removal in trauma and orthognathic surgery—a retrospective study显示文摘 | M.R Mosbah D Oloyede D.A Koppel K.F Moos D Stenhouse | 2003 | International Journal of Oral & Maxillofacial Surgery2003，，2： | 2 |
| 5 | Differentiation of renal cell carcinoma subtypes by multislice computerized tomography 显示文摘 | Sheir KZ E1-Azab M Mosbah A | 2005 | J Urol2005，174，： | 1 |
| 6 | Influence of deposition temperature on structural, optical and electrical properties of sputtered A1 doped ZnO thin films 显示文摘 | Mosbah A Aida M S | 2012 | J Alloy Compd2012，515，： | 1 |
| 7 | Economical Evaluation of a Low-Enthalpy Geothermal Resource Located in an Arid-Zone Area显示文摘 | Salah Masheitil Brian Agnew Sara Walker Mosbah Talbi | 2012 | Journal of Energy and Power Engineering2012，6，7： | 1 |
| 8 | Treamen of complete staghorn stones:a prospective randomized comparison of open surgery versus percutaneous nephrolithotomy显示文摘 | Shokeir A Mosbah A | 2005 | J Urol2005，173，2： | 1 |
| 9 | Does the ex-tent of lymphadeneetomy influence disease-free survival? A pro- spective single-center study显示文摘 | ABOL-ENEIN H TILKI D MOSBAH A | 2011 | Eru Urol2011，60，3： | 1 |
| 10 | The ure-thral kock pouch:long-term functional and oncological results in men显示文摘 | Shaaban AA Mosbah A El-Bahnasawy MS | 2003 | BJU Int2003，92，4： | 1 |
| 11 | Chemosensory protein from the moth Mamestra brassicae expression and secondary structure from t H and is N NMR 显示文摘 | Campanacci V Mosbah A Bornet O | 2001 | European Journal of Biochemistry2001，268，17： | 1 |
| 12 | Treatment of com- plete staghorn stones: a prospective randomized comparison of open surgery versus percutaneous nephrolithotomy显示文摘 | A1-Kohlany KM Shokeir AA Mosbah A | 2005 | J Uro12005，173，2： | 1 |
| 13 | Correlation of glucosinolate content to myrosinase activity in horseradish(Armoracia rusticana)显示文摘 | Li X Mosbah M K | 2004 | Journal of Agricultural and Food Chemistry2004，52，23： | 1 |
| 14 | Treatment of complete staghorn stones:A prospective randomized comparison of open surgery versus percutaneous nephrolithotomy 显示文摘 | AL-Kohlany KM Shokeir AA Mosbah A | 2005 | J Urol2005，173，： | 1 |
| 15 | Differentia tion of renal cell carcinoma subtypes by muhislice corn puterized tomography显示文摘 | Sheir K Z E1-Azab M Mosbah A | 2005 | J Urol2005，174，： | 1 |
| 16 | Treatment of complete staghorn stones:a prospective randomized comparison of open surgery versus percutaneous nephrolithotomy显示文摘 | AI-Kohlany KM Shokeir AA Mosbah A | 2005 | JUrol2005，173，2： | 1 |
| 17 | New insights into fatty liver preservation using Institute Georges Lopez preservation solution显示文摘 | Zaouali M Mosbah I Abdennebi H | | 0，，： | 1 |
| 18 | Developmental and nutritional aspects of chayote ( Sechium edule , Cucurbitaceae)显示文摘 | Louis H. Aung Amelia Ball Mosbah Kushad | 1990 | Economic Botany1990，，2： | 1 |
| 19 | Treatment of complete staghorn stones: a prospective randomized comparison of open surgery versus percutaneous nephrolithotomy显示文摘 | Al-Kohlany KM Shokeir AA Mosbah A | 2005 | J Urol2005，173，2： | 1 |
| 20 | Abrasive Wear of WC-FeAl Composites显示文摘 | Mosbah AY Wexler D Calka A | 2005 | Wear2005，258，9： | 1 |
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