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| 1 | TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation显示文摘Transforming growth factor-beta(TGF-β)/bone morphogenetic protein(BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases. Perturbations of TGF-β/BMP activity are almost invariably linked to a wide variety of clinical outcomes, i.e., skeletal, extra skeletal anomalies, autoimmune, cancer, and cardiovascular diseases. Phosphorylation of TGF-β(I/II) or BMP receptors activates intracellular downstream Smads, the transducer of TGF-β/BMP signals. This signaling is modulated by various factors and pathways, including transcription factor Runx2. The signaling network in skeletal development and bone formation is overwhelmingly complex and highly time and space specific.Additive, positive, negative, or synergistic effects are observed when TGF-β/BMP interacts with the pathways of MAPK, Wnt, Hedgehog(Hh), Notch, Akt/m TOR, and mi RNA to regulate the effects of BMP-induced signaling in bone dynamics. Accumulating evidence indicates that Runx2 is the key integrator, whereas Hh is a possible modulator, mi RNAs are regulators, and b-catenin is a mediator/regulator within the extensive intracellular network. This review focuses on the activation of BMP signaling and interaction with other regulatory components and pathways highlighting the molecular mechanisms regarding TGF-β/BMP function and regulation that could allow understanding the complexity of bone tissue dynamics. | Md Shaifur Rahman Naznin Akhtar Hossen Mohammad Jamil Rajat Suvra Banik Sikder M Asaduzzaman | 2015 | Bone Research2015，3，1： | 53 |
| 2 | Young Yum pill inhibits inflammatory mediators and nuclear factor-kappa B signaling in lipopolysaccharide-stimulated RAW 264.7 macrophages显示文摘OBJECTIVE: To investigate the effect of Young Yum pill (YYP) on inflammatory mediators in cultured RAW 264.7 cells and elucidate the nuclear factor- kappa B (NF-κB)-related mechanism behind the action. METHODS: YYP was extracted with 95% ethanol Lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages were used to evaluate the effect of YYP on inflammatory mediators. Production of nitric oxide (NO) and prostaglandin E2 (PGE2) were measured by Griess test and enzyme-linked immunosorbent assay, respectively. The levels of genes and proteins involved in the generation of inflammatory mediators were examined using real-time polymerase chain reaction and Western blotting, respectively. RESULTS: YYP dose-dependently suppressed LPS-induced production of NO, PGE2 and tumor necrosis factor-α(TNF-α), and elevation of mRNA and protein levels of inducible NO synthase and cyclooxygenase- 2 in RAW 264.7 macrophages. These observations were associated with decreased NF-κB p65 phosphorylation and nuclear localization, enhanced Akt (protein kinase B) phosphorylation, as well as reduced inhibitor of κB (IκB)α degradation and IκB kinase α/β phosphorylation. CONCLUSION: The present study demonstrated an inhibitory effect of YYP on the NF-κB-regulated inflammatory mediators NO, PGE2 and TNF-α in LPS-stimulated RAW 264.7 macrophages, providing a pharmacological basis for the use of YYP in treating inflammatory disorders. | Yin Chengle Muhammad Jahangir Hossen Anfernee Kai-Wing Tse Su Tao Fu Xiuqiong Li Ting Guo Hui Zhu Peili Li Junkui Chou Jiyao Wang Yaping Yu Zhiling | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 3 | Adaptive particle swarm optimization ( APSO ) for multimodal function optimization 显示文摘 | Hossen M S Rabbi F Rahman M M | 2009 | International Journal of Engineering and Technology2009，1，3： | 1 |
| 4 | Effect of milling on the content of deoxynivalenol, nivalenol, and zearalenone in Japanese wheat 显示文摘 | Yazhi Zheng Sharif Md Hossen Ynki Sago | 2014 | Food Control2014，40，2： | 1 |
| 5 | In vitro-antimicrobial and in vivo cytotoxic activity of some ferrocene derivative bioactive metal complexes of first transition series显示文摘 | Haque M E Rahman M Z Hossen M | 2006 | Pak J App Sciences2006，6，5： | 1 |
| 6 | Light emitting diodes increase phenolics of buck- wheat ( Fagopyrum esculentum ) sprouts 显示文摘 | Hossen MZ | 2007 | Journal of Plant Interactions2007，2，1： | 1 |
| 7 | Effect of Lo Han Kuo (Siraitia grosvenori Swingle ) on Nasal Rubbing and Scratching Behavior in ICR Mice显示文摘 | HOSSEN M A SHINMEI Y JIANG S | 2005 | Biological and Pharmaceutical Bulletin2005，28，2： | 1 |
| 8 | Role of substance P on histamine Ha antagonist-induced scratching behavior in mice 显示文摘 | HOSSEN M A INOUE T SHINMEI Y | 2006 | J Pharmacol Sci2006，100，： | 1 |
| 9 | Nanostruetured macro-mesoporous zirconia impregnated by noble metal for catalytic total oxidation of toluene显示文摘 | TIDAHY H L HOSSEN M SIFFERT S COUSIN R LAMONIER J F ABOUKIS A Su B L GIRAUDON J M LECLERCQ G | 2008 | Catal Today2008，137，24： | 1 |
| 10 | Functional constipation in Bangladeshi school aged children:A hidden misty at community显示文摘BACKGROUND Constipation is a common problem in children and a frequent cause of hospital visit in both primary&specialized care,which needs proper evaluation&management.Presentation of constipation is variable among children.In Bangladesh there has been no published data regarding constipation in community among school aged children.AIM To determine the magnitude of functional constipation and its risk factors in community among Bangladeshi school children.METHODS This descriptive cross sectional study was conducted in different schools of Dhaka division,Bangladesh.All school aged children between 5-16 years of age who attended school were included in this study.Samples were collected randomly.Proper clinical history&physical examinations(without digital rectal examination)&available investigations(if done previously)were recorded.Diagnosis of functional constipation was done by Rome IV criteria and was compared with children without constipation.Children with any red flag sign,known chronic disease or any findings suggestive of organic disease and on treatment of constipation were excluded.Statistical analysis of the results was done by using Windows based software device with Statistical Packages for Social Science 20.For all statistical tests,P value of less than 0.05 was considered as statistically significant.RESULTS Total study populations were 707 and male was 443 and female 264.Among them,134(19%)children had constipation.In constipated children,78 children fulfilled the Rome IV criteria for functional constipation and it was 11%of total population.Mean age of children having functional constipation was 11.24±3.54 years and Male female ratio was 1:1.78.Anorexia,nausea,abdominal pain,hard stool,blood with hard stool,alternate hard and loose stool and fecal mass in left iliac fossa were analyzed between two group and all were significantly higher in children with functional constipation group.Children of school,where toilet numbers were inadequate had 2.5 times more constipation risk in comparison to children of school with adequate toilet number(OR=2.493,95%CI:1.214-5.120).Children who feel embarrassed to use toilet at school,had 3.6 times higher risk of constipation(OR=3.552,95%CI:1.435-8.794).Here children with H/O affected sibs and parents/grandparents had 4 and 2.6 times more chance of constipation respectively in comparison to children without H/O affected sibs(OR=3.977,95%CI:1.884–8.397)and parents/grandparents(OR=2.569,95%CI:1.172-5.629).Children with inadequate fluid intake had 2 times more risk of constipation in comparison to children with adequate fluid intake(OR=1.972,95%CI:1.135-3.426).Children who passed electronic screen time of>2 h/d had 2 times more chance of constipation in comparison to children who passed electronic screen time<2 h(OR=2.138,95%CI:1.063-4.301).CONCLUSION Constipation is not uncommon in Bangladeshi school aged children.Inadequate toilet number,family history of constipation,inadequate fluid intake,feeling embarrassed to use toilet at school,and electronic screen time for>2 h/d were found as risk factors in the present study for functional constipation. | Md Benzamin ASM Bazlul Karim Md Rukunuzzaman Md Wahiduzzaman Mazumder Masud Rana Rubaiyat Alam Mohammad Majharul Islam Md Shafiul Alam Kamal Hossen Afsana Yasmin Kaniz Fathema Mukesh Khadga Aisharza Sultana Aishy | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 1 |
| 11 | Two-Dimensional Sub-Band DFT Algorithm显示文摘 | Heutc U | 1994 | Proceedings IEEE/NOPRSIG Alesund1994，，： | 1 |
| 12 | Phospholipase Dcatalyzed synthesis of novel phospholipidphytosterol conjugates显示文摘 | Hossen M Hernandez E | 2004 | Lipids2004，39，8： | 1 |
| 13 | Efficiency of plant growth-promoting rhizobacteria (PGPR) for the enhancement of rice growth显示文摘 | Ashrafuzzaman M Hossen F A Ismail M R | 2009 | African Journal of biotechnology2009，8，7： | 1 |
| 14 | In vitro-anti-micro-bial and in vivo cytotoxic activity of some ferrocene derivativebioactive metal complexes of first transition se-ries 显示文摘 | Haque M E Rahman M Z Hossen M | 2006 | PakJApp Sciences2006，6，5： | 1 |
| 15 | Increasing effect by simulta- neous use of levocabastine and pemirolast on experimental aller- gic conjunctivitis in rats 显示文摘 | Minami K Hossen MA Kamei C | 2005 | Biol Pharm Bull2005，28，3： | 1 |
| 16 | Subband decomposition soft-decision algorithm for heart rate variability analysis in patients with obstructive sleep apnea and normal controls显示文摘 | HOSSEN A GHUNAIMI B A HASSAN M O | 2005 | Signal Processing2005，85，： | 1 |
| 17 | Carbon sequestration in ecosystems : The role of stoicliometry显示文摘 | Hossen Dag O Agren G L Thomas R | 2004 | Ecology2004，85，： | 1 |
| 18 | Involvement of histamine H3 receptors in scratching hehaviour in mast cell-deficient mice 显示文摘 | Hossen M A Sugimoto Y Kayasuga R | 2003 | Br J Dermatol2003，149，1： | 1 |
| 19 | Light emitting diodes increase phenolics of buck- wheat (Fagopyrum esculentum ) sprouts 显示文摘 | Hossen MZ | 2007 | J Plant Int2007，2，： | 1 |
| 20 | Effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in mice显示文摘 | Shinmei Y Hossen MA Okihara K | 2004 | Int Immunopharmacol2004，4，1011： | 1 |
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