|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | high-entropy silicide:(Mo_(0.2)Nb_(0.2)Ta_(0.2)Ti_(0.2)W_(0.2))Si_(2)显示文摘A high-entropy metal disilicide,(Mo_(0.2)Nb_(0.2)Ta_(0.2)Ti_(0.2)W_(0.2))Si_(2),has been successfully synthesized.X-ray diffraction(XRD),energy dispersive X-ray spectroscopy(EDX),and electron backscatter diffraction(EBSD)collectively show the formation of a single high-entropy silicide phase.This high-entropy(Mo_(0.2)Nb_(0.2)Ta_(0.2)Ti_(0.2)W_(0.2))Si_(2) possesses a hexagonal C40 crystal structure with ABC stacking sequence and a space group of P6222.This discovery expands the known families of high-entropy materials from metals,oxides,borides,carbides,and nitrides to a silicide,for the first time to our knowledge,as well as demonstrating that a new,non-cubic,crystal structure(with lower symmetry)can be made into highentropy phase.This(Mo_(0.2)Nb_(0.2)Ta_(0.2)Ti_(0.2)W_(0.2))Si_(2) exhibits high nanohardness of 16.7±1.9 GPa and Vickers hardness of 11.6±0.5 GPa.Moreover,it has a low thermal conductivity of 6.9±1.1Wm^(-1) K^(-1),which is approximately one order of magnitude lower than that of the widely-used tetragonal MoSi_(2) and ~1/3 of those reported values for the hexagonal NbSi_(2) and TaSi_(2) with the same crystal structure. | Joshua Gild Jeffrey Braun Kevin Kaufmann Eduardo Marin Tyler Harrington Patrick Hopkins Kenneth Vecchio Jian Luo | 2019 | Journal of Materiomics2019，5，3： | 27 |
| 2 | 卒中相关性肺炎的诊断卒中肺炎共识小组的推荐意见显示文摘背景和目的下呼吸道感染常并发于卒中并对转归造成不利影响。对于并发于卒中的下呼吸道感染性疾病,目前尚无公认的专业术语或诊断金标准,这导致临床诊疗和研究受到影响。本共识旨在提出急性卒中并发下呼吸道感染的标准化术语和可操作性诊断标准。方法对多个文献数据库进行系统检索,经过证据回顾和2轮讨论,最后于2014年9月在英国曼彻斯特召开共识会议,经75%以上共识小组成员达成一致意见后形成共识。结果达成的共识如下:(1)推荐使用卒中相关性肺炎(stroke-associated pneumonia, SAP )作为卒中发病后7 d内发生的下呼吸道感染性疾病的专业术语。(2)提议对 SAP 使用经过改良的美国疾病控制预防中心(Centers for Disease Control and Prevention, CDC)诊断标准:①很可能的 SAP:符合 CDC 诊断标准,但复查或动态监测胸部 X 片仍缺乏典型改变;②确诊的 SAP:符合 CDC 诊断标准,且胸部 X 片有典型改变。(3)关于白细胞计数或 C反应蛋白在 SAP 诊断中的作用证据有限。(4)其他生物学标记物(如降钙素原)的证据不足。结论提议根据 CDC 诊断标准对 SAP 的术语和诊断制定可操作性的共识标准,需要在卒中患者中进行前瞻性研究来确定其信度、效度以及对医生行为(包括抗生素选择)和临床转归的影响。 | Craig J. Smith Amit K Kishore Andy Vail Angel Chamorro Javier Garau Stephen J. Hopkins Mario Di Napoli Lalit Kalra Peter Langhorne Joan Montaner Christine Roffe Anthony G. Rudd Pippa J. TyrreU Diederik van de Peek Mark Woodhead Andreas Meisel 范琳琳 宿英英 | 2016 | 国际脑血管病杂志2016，24，2： | 17 |
| 3 | 800kV气体绝缘金属封闭输电线路及竖井安装显示文摘气体绝缘金属封闭输电线路(GIL)因其传输容量大、可靠性高、电磁兼容性好等优点,正在广泛地应用于核电站、城市输电和大型水电站等场合。对于500kV及以上电压等级,1回GIL的输送容量相当于同电压等级的交链聚乙烯(XLPE)电缆两三回的输送容量。对拉西瓦水电站800kV GIL的结构、设计、制造及安装调试等特殊问题进行了介绍。特别对高海拔(2450m)、高落差(207m)场合(例如竖井中)安装GIL,给出了一些建议。对比发现,GIL与传统的电缆及全封闭组合电器(GIS)母线相比,在可靠性及经济性上有一定的优越性。 | 马仲鸣 李六零 Gary Bowman Mel Hopkins | 2008 | 中国电力2008，41，8： | 15 |
| 4 | 颅外段颈动脉疾病筛查指南——美国神经影像学学会多学科实践指南委员会向医疗卫生专业人员的声明:血管和介入神经病学学会共同倡议显示文摘这份新声明旨在普通人群和经过选择的患者亚群中针对无症状颈动脉狭窄的筛查提供全面和及时的循证推荐。这些推荐针对下列群体:普通人群中的高危者;接受心脏直视手术(包括冠状动脉旁路术)的患者;外周血管病、腹主动脉瘤和。肾动脉狭窄患者;头颈部恶性肿瘤放射治疗后患者;颈动脉内膜切除术或支架置入术后患者;视网膜缺血综合征患者;晕厥、头昏、眩晕或耳鸣患者;有血管病家族史和高同型半胱氨酸血症的患者。这些推荐是在患病率、预期益处和在经过选择的人群中来自其他专业组织的当前指南基础上做出的。 | Adnan Ⅰ. Qureshi Andrei V. Alexandrov Charles H. Tegeler Robert W. Hobson Ⅱ J. Dennis Baker L. Nelson Hopkins 陈红兵(译) 刘新峰(译) | 2007 | 国际脑血管病杂志2007，15，4： | 8 |
| 5 | Structural immunology of costimualtory and coinhibitory molecules显示文摘The T cell costimulatory pathways are central to regulating immune responses,and targeting these pathways represents one of the most promising approaches for achieving immunotherapy.The molecular structures of costimulation revealed invaluable mechanistic insights underlying costimulatory receptor/ligand specificity,affinity,oligomeric state,and valency,which provided the bases for better manipulation of these signaling pathways.The incredible growth of this field led to identification of new members and unexpected interactions,revealing a complicated regulatory network of immune responses.The advances in structural biology of costimulation will promise unprecedented opportunities for furthering our understanding and therapeutic application of T cell costimulatory pathways. | WANG ShengDian1 & CHEN LiePing1,2 1Center for Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2Department of Oncology,Johns Hopkins University School of Medicine,Baltimore,Maryland,USA | 2010 | Science China(Life Sciences)2010，53，2： | 8 |
| 6 | Teracluster LSSC-II--Its designing principles and applications in large scale numerical simulations显示文摘The teracluster LSSC-II installed at the State Key Laboratory of Scientific and Engineering Computing, Chinese Academy of Sciences is one of the most powerful PC clusters in China. It has a peek performance of 2Tflops. With a Linpack performance of 1.04Tflops, it is ranked at the 43rd place in the 20th TOP500 List (November 2002), 51st place in the 21st TOP500 List (June 2003), and the 82nd place in the 22nd TOP500 List (November 2003) with a new Linpack performance of 1.3Tflops. In this paper, we present some design principles of this cluster, as well as its applications in some large-scale numerical simulations. | ZHANG Linbo, CHEN Shiyi, LI Xinliang, CAO Jianwen, ZHANG Wensheng & GONG XingaoState Key Laboratory of Scientific and Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Department of Mechanical Engineering, The Johns Hopkins University and Center for Computational Science and Engineering, Peking University, Beijing 100875, China Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China Parallel Computing Laboratory, Institute of Software, Chinese Academy of Sciences, Beijing 100080, China Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Surface Physics Laboratory (National Key Laboratory), Fudan University, Shanghai 200433 Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China | 2004 | Science China Mathematics2004，47，z1： | 8 |
| 7 | 电子处方至少可以节约290亿美元显示文摘一个名为“启动电子医疗”的非盈利组织在一份报告中说,如果医生给药房传送电子处方,那么美国医疗卫生系统一年可以节省290亿美元(合162亿英镑,242亿欧元)。该组织总部位于华盛顿,其宗旨在于通过信息技术提高医疗的安全性和有效性。 | Janice Hopkins Tanne 侯充 | 2004 | 英国医学杂志中文版2004，7，5： | 6 |
| 8 | Microarray,SAGE and their applications to cardiovascular diseases显示文摘The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area. | SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA | 2002 | Cell Research2002，12，2： | 5 |
| 9 | Ranibizumab for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen David M. Brown Dennis M. Marcus David S. Boyer Sunil Patel Leonard Feiner Andrea Gibson Judy Sy Amy Chen Rundle J. Jill Hopkins Roman G. Rubio Jason S. Ehrlich | 2012 | Ophthalmology2012，，4： | 4 |
| 10 | 癌治疗中不同化疗加放疗策略的理论基础显示文摘治疗癌症的两个策略一是化疗与放疗同时应用,一是在完成一种治疗后再开始第二种治疗。临床研究表明,两种治疗同时进行时,毒性是癌治疗效果明显改善的主要限制因素。而完成一种方式治疗后再给另一种治疗方案,由于需要较长时间,以致在序贯治疗期间可能发生肿瘤再增殖而降低疗效。现已提出化疗加放疗治疗癌症的第三种策略,即先给化疗并保持化疗方案不变,在两个疗程之间尽可能早地加入放疗以最大限度地减少交叉耐药性的发生。这种化疗与放疗交替治疗的目的主要是减少毒性,同时又不显著降低疗效而提高治疗指数。 | Looney WB Hopkins HA 丁永为 | 1992 | 国外医学(肿瘤学分册)1992，19，6： | 3 |
| 11 | Safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in hepatitis C virus/human immunodeficiency virus co-infected patients显示文摘AIM To evaluate the safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in patients with hepatitis C virus(HCV)/human immunodeficiency virus(HIV) co-infection in an urban HIV clinic.METHODS A retrospective cohort study of 40 subjects co-infected with HIV-1 and HCV treated with the fixed-dose combination of ledipasvir and sofosbuvir for 12 wk from 2014 to 2016.All patients included were receiving antiretroviral therapy(ART) with HIV RNA values of 100 copies/m L or fewer regardless of baseline HCV RNA level.The primary end point was a sustained virologic response of HCV at 12 wk(SVR12) after the end of therapy.RESULTS Of the 40 patients enrolled,55% were black,22.5% had been previously treated for HCV,and 25% hadcirrhosis.The patients were on a wide range of ART.Overall,39 patients(97.5%) had a SVR 12 after the end of therapy,including rates of 97.1% in patients with HCV genotype 1 a and 100% in those with HCV genotype 1 b.One patient with HCV genotype 3 a was included and achieved SVR12.Rates of SVR12 were similar regardless of previous treatment or the presence of compensated cirrhosis.Only 1 patient experienced relapse at week 12 following treatment and deep sequencing didn't reveal any resistance associated mutation in the NS5A or NS5B region.Interestingly,7(17.5%) patients who were adherent to ART experienced HIV viral breakthrough which resolved after continuing the same ART regimen.Two(5%) patients experienced HIV-1 virologic rebound due to noncompliance with HIV therapy,which resolved after resuming the same ART regimen.No severe adverse events were observed and no patient discontinued treatment because of adverse events.The most common adverse events included headache(12.5%),fatigue(10%),and diarrhea(2.5%).CONCLUSION This retrospective study demonstrated the high rates of SVR12 of ledipasvir/sofosbuvir on HCV eradication in patients co-infected with HCV and HIV,regardless of HCV baseline levels,HCV treatment history or cirrhosis condition.The oral combination of ledipasvir/sofosbuvir represents a safe and well tolerated HCV treatment option that does not require modification for many of the common HIV ART.Occasional HIV virologic rebound occurred but later resolved without the need to change ART. | Xiaoping He Lynne Hopkins George Everett Willie M Carter Cynthia SchroppDyce Khalid Abusaada Vincent Hsu | 2017 | World Journal of Hepatology2017，9，30： | 2 |
| 12 | Update on novel endoscopic therapies to treat gastroesophageal reflux disease: A review显示文摘Endoscopic treatments for gastroesophageal reflux disease(GERD) have become increasingly popular in recent years. While surgical intervention with the Laparoscopic Nissen Fundoplication remains the gold standard, two endoscopic interventions, specifically, are gaining traction in clinical use(Esophy X and Stretta). The Esophy X(Endo Gastric Solutions, Inc., Redmond, WA, United States) was developed as a method of restoring the valve at the GE junction through an endoluminal fundoplication(ELF) technique. Long-term data suggests that transoral incisional fundoplication(TIF) with Esophy X may be effective for symptom control and proton pump inhibitor reduction or cessation for up to 2-6 years. There is no evidence that Esophy X is more effective than surgical intervention. TIF may be most effective for patients with HH < 2 cm and Hill Grade I/II valves. Stretta(Mederi Therapeutics, Greenwich, CT, United States) was approved by the Food and Drug Administration in 2000. It delivers radiofrequency energy to the lower esophageal sphincter and gastric cardia. Published reviews of the literature are conflicted in their recommendations of Stretta in the management of GERD. The literature suggests that the Stretta procedure has an acceptable safety profile and may be effective in reducing symptom burden and quality of life scores up to 8 years post-intervention. However, there does not appear to be any sustained improvement in objective outcomes and there is no evidence that Stretta results in improved outcomes as compared to surgical intervention. Treatment modalities for GERD, as a field, suffer from a lack of standardization in primary and secondary outcomes. Although many studies have looked at health related quality of life, the tools used to do so are markedly heterogeneous. Future directions for the endoscopic treatment of GERD include novel techniques like endoscopic submucosal dissection. | Jessica Hopkins Noah J Switzer Shahzeer Karmali | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，11： | 2 |
| 13 | Effects of UV- B on the development and ultrastructure of the primary leaf of wheat (Triticum aestivum)显示文摘 | Hopkins L Bond M A Tobin A K | 1996 | J Exp Bot1996，，： | 2 |
| 14 | 中国骨科生物力学的未来显示文摘在阐述生物力学和生物工程定义和范畴、回顾生物力学的近代发展史基础上,对中国骨科生物力学今后的研究方向、发展目标及其前景作了预测。作者认为,要在医疗卫生事业上取得重要突破,需要生命科学家和工程师的精诚合作。因此,随着医疗卫生事业的进步,生物医学工程的发展前景将比以往更为灿烂。 | Edmund Y. S. Chao, Ph. D.(Orthopaedic Research, Johns Hopkins University, Baltimore, Maryland, USA) | 1995 | 医用生物力学1995，10，1： | 2 |
| 15 | 研究表明步行能使老年人免患痴呆症显示文摘两项美国研究表明,平时经常步行能预防老年痴呆症及认知能力下降。 | Janice Hopkins Tanne 杨斌 | 2005 | 英国医学杂志中文版2005，8，1： | 2 |
| 16 | 指南儿童及青少年抑郁的诊断和管理:NICE指南更新概要显示文摘本文是英国医学杂志(TheBMJ)最新指南系列文章之一,新指南基于现有的最佳证据编写;着重解读对临床实践重要的建议,特别是存在不确定和争议的部分。 | Kathryn Hopkins technical analyst Paul Crosland health economist Nicole Elliott associate director Susan Bewley committee chair and professor in complex obstetrics 崔轶 | 2015 | 英国医学杂志中文版2015，0，8： | 2 |
| 17 | Reciprocal connections between the amygdala and parabrachial nuclei:ultrastructural demonstration by degeneration and axonal transport of horseradish peroxidase in the cat 显示文摘 | Takeuchi Y McLean J H Hopkins D A | 1982 | Brain Res1982，239，： | 2 |
| 18 | Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke: A Statement for Health Care Professionals From the CRP Pooling Project Members显示文摘 | Mario Di Napoli Markus Schwaninger Roberto Cappelli Elena Ceccarelli Giacinto Di Gianfilippo Cristina Donati Hedley C.A. Emsley Sandro Forconi Stephen J. Hopkins Luca Masotti Keith W. Muir Anna Paciucci Francesca Papa Sabina Roncacci Dirk Sander Kerstin S | 2005 | Stroke2005，，6： | 2 |
| 19 | Growth and characterization of large CdSiP 2 single crystals显示文摘 | Kevin T. Zawilski Peter G. Schunemann Thomas C. Pollak David E. Zelmon Nils C. Fernelius F. Kenneth Hopkins | 2009 | Journal of Crystal Growth2009，，： | 2 |
| 20 | 远见显示文摘在研究视觉发育的早期事件中,Carla Shatz学习了睁大眼睛看数据的重要性——还有开放的思想。CarlaShatz是获取哈佛医学院神经生物系学位的第一位女博士。但她差一点不被录取。“招生委员会成员间的争论很激烈,”她说:“这是黑暗的中世纪——1971年。”学院里之前仅有的另一个女学生在读了第一年之后就辍学了。 | Karen Hopkin 张哲 | 2011 | 生物技术世界2011，，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员