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| 1 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 2 | Physiological functions and clinical implications of fibrinogen-like 2:A review显示文摘Fibrinogen-like 2(FGL2) encompasses a transmembrane(m FGL2) and a soluble(s FGL2) form with differential tertiary structure and biological activities. Typically, m FGL2 functions as prothrombinase that is capable of initiating coagulation in tissue without activation of the blood clotting cascade, whereas s FGL2 largely acts as an immunosuppressor that can repress proliferation of alloreactive T lymphocytes and maturation of bone marrow dendritic cells. Protein sequences of FGL2 exhibit evolutionary conservation across wide variety of species, especially at the carboxyl terminus that contains fibrinogen related domain(FRED). The FRED of FGL2 confers specificity and complexity in the action of FGL2, including receptor recognition, calcium affiliation, and substrate binding. Constitutive expression of FGL2 during embryogenesis and in mature tissues suggests FGL2 might be physiologically important. However, excessive induction of FGL2 under certain medical conditions(e.g. pathogen invasion) could trigger complement activation, inflammatory response,cellular apoptosis, and immune dysfunctions. On the other hand, complete absence of FGL2 is also detrimental as lack of FGL2 can cause autoimmune glomerulonephritis and acute cellular rejection of xenografts. All these roles involve m FGL2, s FGL2, or their combination. Although it is not clear how m FGL2 is cleaved off its host cells and secreted into the blood, circulating s FGL2 has been found correlated with disease severity and viral loading among patients with human hepatitis B virus or hepatitis C virus infection. Further studies are warranted to understand how FGL2 expression is regulated under physiological and pathological conditions. Even more interesting is to determine whether m FGL2 can fulfill an immunoregulatory role through its FRED at carboxyl end of the molecule and, and vice versa, whether s FGL2 is procoagulant upon binding to a target cell. Knowledge in this area should shed light on development of s FGL2 as an alternative immunosuppressive agent for organ transplantation or as a biomarker for predicting disease progression, monitoring therapeutic effects, and targeting FGL2 for repression in ameliorating fulminant viral hepatitis. | Genyan Yang W Craig Hooper | 2013 | World Journal of Clinical Infectious Diseases2013，3，3： | 2 |
| 3 | Mutations in the genes regulating methylene tetra- hydrofolate reductase ( MTHR C -T677 ) and cystathione ( 3-synthase ( CBS G-A919, CBS T-C833 ) are not associated with myocardial infarction in African Americans 显示文摘 | ANNE DILLERY W CRAIG HOOPER MUHYDINE EI- JAMIL | 2001 | Thrum Res2001，103，： | 1 |
| 4 | Strategy-related characteristics of discrete-event languages and models 显示文摘 | Hooper J W | 1986 | Simulation (S0037-5497)1986，46，4： | 1 |
| 5 | Molecular anal ysis of commensal host microbial relationships in the intestine显示文摘 | Hooper L V Melissa H W Anders T | 2001 | Science2001，291，5505： | 1 |
| 6 | Mechanisms of indentation creep显示文摘 | LI W B HENSHALL J L HOOPER R M | 1991 | Acta Metallurgicaet Materialia1991，39，12： | 1 |
| 7 | α-and β-ruthenium trichloride显示文摘 | Hyde K R Hooper E W Waters J | 1965 | J Less-Common Met1965，，8： | 1 |
| 8 | Human parvovirus B19 in young male patients with hemophicia A:associations with treatment product exposure and joint rangeof-motion limitation显示文摘 | SOUCIE J M SIWAK E B HOOPER W C | 2004 | Transfusion2004，44，8： | 1 |
| 9 | Venous thromboembolism:a public health concern显示文摘 | Beckman M G Hooper W C Critchley S E | 2010 | Am J Prev Med2010，38，4： | 1 |
| 10 | Comparison of slot and holes in the screening of mechanical pulp 显示文摘 | Hooper A W | 1987 | Pulp & Paper Canada1987，，10： | 1 |
| 11 | Catabolic plasmids of environmental and ecological significance显示文摘 | Sayler G S Hooper S W Layton A C | 1990 | Micro Ecol1990，19，： | 1 |
| 12 | Catabolic plasmids of environmental and ecological significance:A review显示文摘 | SAYLER G S HOOPER S W LAYTON A C | 1990 | Microbial Ecology1990，19，： | 1 |
| 13 | Swelling equilibria for positively ionized polyacrylamide hydrogels显示文摘 | Hooper H H Baker J P Blanch H W | 1990 | Macromolecules1990，23，： | 1 |
| 14 | Mechanisms of indentation creep 显示文摘 | Li W B Henshall J L Hooper R M | 1991 | Acta Matall Mater1991，39，： | 1 |
| 15 | Lessons from the polybrominated diphenyl ethers (PBDEs):precautionary principle,primary prevention,and the value of community-based body-burden monitoring using breast milk显示文摘 | HOOPER K SHE J W | 2003 | Environmental Health Perspectives2003，111，1： | 1 |
| 16 | Ecological fate,effects and prospects for the elimination of environmental polychlorinated hiphenyls ( PCBs ) 显示文摘 | HOOPER S W PETTIGREW C A SAYLER G S | 1990 | Environmental and Toxicology Chemistry1990，9，： | 1 |
| 17 | Making tunnel barriers (including metals) transparent 显示文摘 | I R Hooper T W Preist J R Sambles | 2006 | Phys Rev Lett2006，97，05： | 1 |
| 18 | Fluoroquinolone antimic- robial agents显示文摘 | David C Hooper D C John S W | 1991 | New Eng J Med1991，324，6： | 1 |
| 19 | Regulation of proinflammatory cytokines in human lung epithelial cells infected with mycoplasma pneumoniae 显示文摘 | YANG J HOOPER W C PHILLIPS D J | 2002 | Infect Immun2002，70，7： | 1 |
| 20 | Cytokines in Mycoplasma pneumoniae infections显示文摘 | Yang J Hooper W C Phillips D J | 2004 | Cytokine Growth Factor Rev2004，15，2： | 1 |
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