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| 1 | Natural Variations at TIG1 Encoding a TCP Tran scription Factor Contribute to Plant Architecture Domestication in Rice显示文摘The modification of plant architecture is a crucial target in rice domestication and modern genetic improvement.Although several genes regulating rice plant architecture have been characterized,the molecular mechanisms underlying rice plant architecture domestication remain largely unclear.Here we show that the inclined tiller growth in wild rice is controlled by a single dominant gene,TILLER INCLINED GROWTH 1 (T/Gf),which is located on chromosome 8 and encodes a TCP transcriptional activator.TIG1 is primarily expressed in the adaxial side of the tiller base,promotes cell elongation,and enlarges the tiller angle in wild rice.Variations in the TIG1 promoter of indica cultivars {tig1 allele) resulted in decreased expression of TIG1 in the adaxial side of tiller base and reduced cell length and tiller angle,leading to the transition from inclined tiller growth in wild rice to erect tiller growth during rice domestication.TIG1 positively regulates the expression of EXP A3,EXPB5,and SAUR39 to promote cell elongation and increase the tiller angle.Selective sweep analysis revealed that the tig1 allele was selected in indica cultivars by human beings.The cloning and characterization of TIG1 supports a new scenario of plant architecture evolution in rice. | Weifeng Zhang Lubin Tan Hongying Sun Xinhui Zhao Fengxia Liu Hongwei Cai Yongcai Fu Xianyou Sun Ping Gu Zuofeng Zhu Chuanqing Sun | 2019 | Molecular Plant2019，12，8： | 13 |
| 2 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 3 | Effect of Variable Blank Holder Force on Rectangular Box Drawing Process of Hot-galvanized Sheet Steel显示文摘At first, a series of finite element method (FEM) simulation tests were used to find the critical forming conditions of hot-galvanized sheet steel during the rectangular box drawing processing when constant blank holder forces were applied. According the test results, the reasonable alteration scope of initial variable blank holder force (VBHF) wasas 1.9~2.3 T. Then, based on the test productions of blank holder force, 12 typical VBHF curves were applied to perform the simulation tests by the simulation software of DYNAFORM. The simulation test results showed that VBHF had great effects on drawing formability of hot-galvanized sheet steel during the rectangular box drawing.However, the different VBHF curves were applied to control the whole drawing and it would get great different effects. At the same tine, the VBHF had great effects on the maximum thick thinning ratio, but had little effect on the maximum thick incrassation ratio. So, reasonable application of the VBHF would greatly decrease the fractures.When the VBHF profile is taken as curve L, the best effect of drawing formability could be obtained. When curve I is used, contrary effect could be gotten. The other types of curves would cause effects between above two types of VBHF curves. Finally, the actual tests were applied to check the validity of the FEM simulation tests. The results show that the FEM simulation tests are good ways for predicting and optimizing the VBHF. | Qunqiang FU Wei ZHU Zhiliang ZHANG Hongying GONG | 2005 | Journal of Materials Science & Technology2005，21，6： | 4 |
| 4 | Selective oxidation of propane to acrylic acid over mixed metal oxide catalysts显示文摘MoVTeNbO 的催化表演上的原子比率,水内容,氧内容,和锻烧温度混合了的金属的效果为到丙烯酸的酸的丙烷的选择氧化的氧化物催化剂系统被调查了并且讨论。在学习的催化剂之中,在 600 ° C 的温度锻烧的 MoVTeNbO 催化剂在氮的气氛下面为丙烯酸的酸以丙烷变换和选择显示出最好的表演,这被发现。为丙烷的有效 MoVTeNbO 氧化物催化剂到丙烯酸的酸的选择氧化与比较喜欢的金属的联合被获得原子比率(瞬间 1 V 0.31 Te 0.23 Nb 0.12) 。为丙烷的选择氧化的最佳反应条件是 C 3 H 8:O2 :H 2 O:N 2= 4.4:12.8:15.3:36.9。在如此的条件下面,丙烷的变换和丙烯酸的酸的最大的收益分别地到达了大约 50% 和 21% 。 | Wei Zheng Zhenxing Yu Ping Zhang Yuhang Zhang Hongying Fu Xiaoli Zhang Qiquan Sun Xinguo Hu | 2008 | Journal of Natural Gas Chemistry2008，17，2： | 3 |
| 5 | Ectopic expression of antifreeze protein gene from Ammopiptanthus nanus confers chilling tolerance in maize显示文摘Improved chilling tolerance is important for maize production. Previous efforts in transgenics and marker-assisted breeding have not achieved practical results. In this study, the antifreeze protein(AnAFP) from the super-xerophyte Ammopiptanthus nanus was aligned to KnS-type dehydrins.Phosphorylation in vitro and subcellular localization showed that AnAFP was phosphorylated by maize casein kinase II and translocated from nucleus to cytoplasm under chilling stress. AnAFP also increased lactate dehydrogenase activity. A parent line of commercial maize hybrids was transformed with the AnAFP gene. Based on thermal asymmetric interlaced PCR, one hemizygous and two homozygous integration sites were identified in one T_(1) line. Ectopic expression of AnAFP in transgenic lines was confirmed by quantitative real-time PCR, RNA-seq, and Western blotting. After chilling treatment, the transgenic lines showed significantly improved phenotype, higher kernel production, survival rate and biomass, and lower relative electrolyte leakage and superoxide dismutation than the untransformed line. Thus, ectopic expression of AnAFP gene improved chilling tolerance in the transgenic lines, which could be used to apply for further safety assessment for commercial breeding. | Yuanyuan Zhang Yang Cao Hongying Zheng Wenqi Feng Jingtao Qu Fengling Fu Wanchen Li Haoqiang Yu | 2021 | The Crop Journal2021，9，4： | 2 |
| 6 | Soliton and bound-state soliton mode-locked fiber laser based on a MoS_2/fluorine mica Langmuir–Blodgett film saturable absorber显示文摘In this article, we report on an experimentally generated soliton and bound-state soliton passively mode-locked erbium-doped fiber laser by incorporating a saturable absorber(SA) made of MoS2∕fluorine mica(FM) that was fabricated with the Langmuir–Blodgett(LB) method. The FM substrate is 20 μm thick and easy to bend or cut,like a polymer. However, it has a higher damage threshold and a better thermal dissipation than polymers.In addition, the LB method can be used to fabricate a thin film with good uniformity. In this study, the modulation depth, saturable intensity, and unsaturated loss of the SA are measured as 5.9%, 57.69 MW∕cm2, and13.4%, respectively. Based on the SA, a soliton mode-locked laser is achieved. The pulse duration, repetition rate, and signal-to-noise ratio are 581 fs, 15.67 MHz, and 65 dB, respectively. By adjusting the polarization controller and pump power, we obtain a bound-state soliton mode-locked pulse. The temporal interval between the two solitons forming the bound-state pulse is 2.7 ps. The repetition rate of the bound-state pulses is proportional to the pump power. The maximum repetition rate is 517 MHz, corresponding to the 33 rd harmonic of the fundamental repetition rate. The results indicate that the MoS2∕FM LB film absorber is a promising photonic device in ultrafast fiber lasers. | RUIDONG Lü YONGGANG WANG JIANG WANG WEI REN LU LI SICONG LIU ZHENDONG CHEN YONGFANG LI HONGYING WANG FUXING FU | 2019 | Photonics Research2019，7，4： | 2 |
| 7 | A New Wavelet-based image denoising using undecimated discrete wavelet transform and least squares support vector machine 显示文摘 | Wang Xiangyang Yang Hongying Fu Zhongkai | 2010 | Pergamon Press2010，37，10： | 1 |
| 8 | The genetic control of glabrous glume during African rice domestication显示文摘African cultivated rice,Oryza glaberrima,is characterized by its glabrous glumes.During domestication,the pubescent glumes of its wild ancestor,Oryza barthii,lost their trichomes,and in this study,we show that glabrous glume 5(GLAG5),a WUSCHEL-like homeobox transcription factor gene on chromosome 5,is required for trichome development.DNA methylation associated with an hATtransposable element inserted in the promoter region of GLAG5 is found to reduce its expression,leading to the formation of glabrous glumes and leaves in African cultivated rice.Among 82 African cultivated rice varieties investigated in this study,59(approximately 71%)lines exhibit glabrous glumes and harbor the hAT transposon;however,the other 23 varieties(approximately 29%),which exhibit pubescent glumes,lack the hAT transposon,indicating that glag5 had undergone strong artificial selection.Theπ;/π;ratios also show the hAT transposon insertions influence the genetic diversity of an approximately 150-kb interval encompassing the GLAG5 locus.The identification of the GLAG5 gene provides new insights into the domestication of cultivated rice in Africa.We speculate that the selection of varieties with mutations in their promoter regions is an important aspect of crop domestication. | Leqin Chang Min Hu Jing Ning Wei He Jiayu Gao Marie-Noelle Ndjiondjop Yongcai Fu Fengxia Liu Hongying Sun Ping Gu Chuanqing Sun Zuofeng Zhu | 2022 | Journal of Genetics and Genomics2022，49，5： | 1 |
| 9 | A new wavelet-based image denoising using undecimated discrete wavelet transform and least squares support vector machine 显示文摘 | WANG Xiangyang YANG Hongying FU Zhongkai | 2010 | Expert Systems with Applications2010，37，10： | 1 |
| 10 | Postharvcst biological control of gray mold rot of pear with Cryptococcus laurentii 显示文摘 | ZHANG Hongying ZHENG Xiaodong FU Chcngxin ct al | 2005 | Postharvcst Biology and Technology2005，35，： | 1 |
| 11 | The Influence of Meridional Variation in North Pacific Sea Surface Temperature Anomalies on the Arctic Stratospheric Polar Vortex显示文摘This study examines the dependence of Arctic stratospheric polar vortex(SPV)variations on the meridional positions of the sea surface temperature(SST)anomalies associated with the first leading mode of North Pacific SST.The principal component 1(PC1)of the first leading mode is obtained by empirical orthogonal function decomposition.Reanalysis data,numerical experiments,and CMIP5 model outputs all suggest that the PC1 events(positive-minus-negative PC1 events),located relatively northward(i.e.,North PC1 events),more easily weaken the Arctic SPV compared to the PC1 events located relatively southward(i.e.,South PC1 events).The analysis indicates that the North PC1-related Aleutian low anomaly is located over the northern North Pacific and thus enhances the climatological trough,which strengthens the planetary-scale wave 1 at mid-to-high latitudes and thereby weakens the SPV.The weakened stratospheric circulation further extends into the troposphere and favors negative surface temperature anomalies over Eurasia.By contrast,the South PC1-related Aleutian low anomaly is located relatively southward,and its constructive interference with the climatological trough is less efficient at high latitudes.Thus,the South PC1 events could not induce an evident enhancement of the planetary-scale waves at high latitudes and thereby a weakening of the SPV on average.The Eurasian cooling associated with South PC1 events(positive-minus-negative PC1 events)is also not prominent.The results of this study suggest that the meridional positions of the PC1 events may be useful for predicting the Arctic SPV and Eurasian surface temperature variations. | Tao WANG Qiang FU Wenshou TIAN Hongwen LIU Yifeng PENG Fei XIE Hongying TIAN Jiali LUO | 2023 | Advances in Atmospheric Sciences2023，40，12： | 1 |
| 12 | Cost-Effective Fiber Multiplexing System Based on Low Coherence Interferometers and Application to Temperature Measurement显示文摘基于低连贯的 interferometric 原则,一个划算的所有纤维 Mach-Zehnder multiplexing 系统被建议并且示威。系统由二干涉仪组成:察觉到干涉仪和解调干涉仪。由以稳定的速度常常来回扫描一根光悦耳的延期线,察觉到有不同光路径的纤维能是时间的讯问了。系统试验性地被证明与好稳定性和低系统噪音有高效。系统的 multiplexing 能力也被调查。测量包围温度的一个实验被执行。12 m/ 的敏感?? | Meng JIANG Zhongze ZHAO Kun LI Zeming WANG Yage ZHAN Hongying ZHOU Fu YANG | 2016 | Photonic Sensors2016，6，4： | 0 |
| 13 | Themis suppresses the effector function of CD8^(+)T cells in acute viral infection显示文摘CD8^(+)T cells play a central role in antiviral immune responses.Upon infection,naive CD8^(+)T cells differentiate into effector cells to eliminate virus-infected cells,and some of these effector cells further differentiate into memory cells to provide long-term protection after infection is resolved.Although extensively investigated,the underlying mechanisms of CD+T-cell differentiation remain incompletely understood.Themis is a T-cell-specific protein that plays critical roles in T-cell development.Recent studies using Themis T-cell conditional knockout mice also demonstrated that Themis is required to promote mature CD8^(+)T-cell homeostasis,cytokine responsiveness,and antibacterial responses.In this study,we used LCMV Armstrong infection as a probe to explore the role of Themis in viral infection.We found that preexisting CD8^(+)T-cell homeostasis defects and cytokine hyporesponsiveness do not impair viral clearance in Themis T-cell conditional knockout mice.Further analyses showed that in the primary immune response,Themis deficiency promoted the differentiation of CD8^(+)effector cells and increased their TNF and IFNy production.Moreover,Themis deficiency impaired memory precursor cell(MPEC)differentiation but promoted short-lived effector cell(SLEC)differentiation.Themis deficiency also enhanced effector cytokine production in memory CD8^(+)T cells while impairing central memory CD8^(+)T-cell formation.Mechanistically,we found that Themis mediates PD-1 expression and its signaling in effector CD8^(+)T cells,which explains the elevated cytokine production in these cells when Themis is disrupted. | Jian Tang Xian Jia Jian Li Junchen Dong Jiayu Wang Wanyun Li Yuzhen Zhu Yanyan Hu Bowen Hou Chunjie Lin Yu Cong Tong Ren Changsheng Yan Hongying Yang Qian Lai Haiping Zheng Yuzhou Bao Namrata Gautam Hong-Rui Wang Bing Xu Xiao Lei Chen Qing Li Nicholas R.J.Gascoigne Guo Fu | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
| 14 | Impact of hydrogen microalloying on the mechanical behavior of Zr-bearing metallic glasses: A molecular dynamics study显示文摘Comparative studies on Zr35Cu65and Zr65Cu35amorphous systems were performed using molecular dynamic simulations to explore whether their hydrogenated mechanical behavior depends on the content of hydride-forming elements.Although both of them present an increased strength and ductility after hydrogen microalloying,we observe the improved mechanical behavior for Zr35Cu65is more pronounced than that for Zr65Cu35.In these two samples,the distribution of configurational potential energy and flexibility volume respectively follows a similar H-induced variation tendency;all of the hydrogenated alloys not just have more stable atoms with smaller flexibility volume,but possess a larger fraction of readily activated atoms.However,the atomic-scale details,based on the local'gradient atomic packing structure'model,indicate minor additions of hydrogen can promote more'soft spots'along with more strengthened'backbones'in the low-Zr alloy than that in the high-Zr sample,which endows the former with much higher strength and deformability after hydrogen microalloying.We regard this finding as a further step forward to distilling the tell-tale metrics of the H-dependent mechanical behavior observed in Zr-based metallic glasses. | Binbin Wang Liangshun Luo Fuyu Dong Liang Wang Hongying Wang Fuxin Wang Lei Luo Baoxian Su Yanqing Su Jingjie Guo Hengzhi Fu | 2020 | Journal of Materials Science & Technology2020，42，10： | 0 |
| 15 | Fine-tuning the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies via branched aliphatic functionalization显示文摘Small-molecule prodrug nanoassemblies have emerged as efficient antitumor drug delivery systems.However,in the case of camptothecins-based prodrug nanoassemblies,linear aliphatic side chain modification often results in rod-shaped or irregularly shaped nanoassemblies,which are highly unfavorable for sterilization through filtration,and may cause capillary blockage upon intravenous injection.The rational design of camptothecins-based prodrug nanoassemblies remains a challenge.Herein,we propose that branched aliphatic alcohol(BAA)functionalization could fine-tune the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies.Correspondingly,four SN38-BAA prodrugs were synthesized by conjugating 7-ethyl-10-hydroxycamptothecin(SN38)with BAAs of varying lengths via a tumor redox-responsive disulfide bond,which self-assemble into uniform spherical nanoparticles.The length of BAA was found to significant impact the multiple drug delivery process,including colloidal stability,drug release profiles and pharmacokinetics.Overall,SN38-C21 NPs(SN38-11-heneicosanol nanoparticles),featuring the longest BAA,showcased multiple therapeutic advantages,ultimately culminating the optimal antitumor efficacy and tolerance.The findings underscore the potential of BAA functionalization in strengthening the therapeutic outcomes of prodrug nanoassemblies,and provide valuable insights for developing translational camptothecins-based nanomedicines. | Guanting Li Fengli Xia Hongying Xiao Shunzhe Zheng Shuwen Fu Han Qiao Qianhui Jin Xuanbo Zhang Dun Zhou Chutong Tian Jin Sun Zhonggui He Bingjun Sun | 2024 | Nano Research2024，17，4： | 0 |
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