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| 1 | Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing显示文摘Gastric cancer(GC) is a highly heterogeneous disease with multiple cellular types and poor prognosis.However, the cellular evolution and molecular basis of GC at the individual intra-tumor level has not been well demonstrated. We performed single-cell whole exome sequencing to detect somatic singlenucleotide variants(SNVs) and significantly mutated genes(SMGs) among 34 tumor cells and 9 normal cells from a patient with GC. The Complete Prediction for Protein Conformation(CPPC) approach directly predicting the folding conformation of the protein 3D structure with Protein Folding Shape Code, combined with functional experiments were used to confirm the characterization of mutated SMGs in GC cells. We identified 201 somatic SNVs, including 117 non-synonymous mutations in GC cells. Further analysis identified 24 significant mutated genes(SMGs) in single cells, for which a single amino acid change might affect protein conformation. Among them, two genes(CDC27 and FLG) that were mutated only in single cells but not in the corresponding tumor tissue, were recurrently present in another GC tissue cohort, and may play a potential role to promote carcinogenesis, as confirmed by functional characterization. Our findings showed a mutational landscape of GC at intra-tumor level for the first time and provided opportunities for understanding the heterogeneity and individualized target therapy for this disease. | Lihua Peng Rui Xing Dongbing Liu Li Bao Wenxiang Cheng Hongyi Wang Yuan Yu Xiaofeng Liu Lu Jiang Yan Wu Zhongxue An Qiaoyi Liang Ryong Nam Kim Young Kee Shin Huanming Yang Jian Wang Jun Yu Xiuqing Zhang Xun Xu Jiaan Yang Kui Wu Shida Zhu Youyong Lu | 2019 | Science Bulletin2019，64，4： | 3 |
| 2 | Exp2 polymorphisms associated with variation for fiber quality properties in cotton(Gossypium spp.)显示文摘Plant expansins are a group of extracellular proteins thought to affect the quality of cotton fibers. Previous expression profile analysis revealed that six Expansin A genes are present in cotton, of which two(GhExp1 and GhExp2) produce transcripts that are specific to the developing cotton fiber. To identify the phenotypic function of Exp2, and to determine whether nucleotide variation among alleles of Exp2 affects fiber quality, candidate gene association mapping was conducted. Gene-specific primers were designed to amplify the Exp2 gene. By amplicon sequencing, the nucleotide diversity of Exp2 was investigated across92 accessions(including 7 Gossypium arboreum, 74 Gossypium hirsutum, and 11 Gossypium barbadense accessions) with different fiber qualities. Twenty-six SNPs and seven InDels including 14 from the coding region of Exp2 were detected, forming twelve distinct haplotypes in the cotton collection. Among the 14 SNPs in the coding region, five were missense mutations and nine were synonymous nucleotide changes. The average SNP/InDel per nucleotide ratio was 2.61%(one SNP per 39 bp), with 1.81 and 3.87% occurring in coding and non-coding regions, respectively. Nucleotide and haplotype diversity across the entire Exp2 region was 0.00603(π) and 0.844, respectively, and diversity in non-coding regions was higher than that in coding regions. For linkage disequilibrium(LD), the mean r2 value for all polymorphism loci pairs was 0.48, and LD did not decay over 748 bp. Based on132 simple sequence repeat(SSR) loci evenly covering 26 chromosomes, the population structure was estimated, and the accessions were divided into seven groups that agreed well with their genomic origin and evolutionary history. A general linear model was used to calculate the Exp2-wide diversity–trait associations of 5 fiber quality traits, considering population structure(Q). Four SNPs in Exp2 were associated with at least one of the fiber quality traits, but not with fiber elongation. The highest positive effect on UHML and STR was observed for haplotype Hap_6 of Exp2. There was a significant association of Exp2 with fiber quality traits. There were many haplotypes in the Exp2 region, of which the most favorable was Hap_6. The association between nucleotide diversity and these fiber traitssheds light on the gene's potential contribution to the improvement of fiber quality, and should be useful to facilitate MAS programs in cotton. | Daohua He Zhongping Lei Hongyi Xing Baoshan Tang Junxing Zhao Bixia Lu | 2014 | The Crop Journal2014，2，5： | 1 |
| 3 | 3D printed triboelectric nanogenerator as self-powered human–machine interactive sensor for breathing-based language expression显示文摘Human–machine interfaces(HMIs)are important windows for a human to communicate with the outside world.The current HMI devices such as cellphones,tablets,and computers can be used to help people with aphasia for language expression.However,these conventional HMI devices are not friendly to some particular groups who also lose their abilities of physical movements like in the intensive care unit(ICU)or vegetative patients to realize language expression.Herein,we report a breath-driven triboelectric nanogenerator(TENG)acting as a HMI sensor for language expression through human breathing without voice controls or manual operations.The TENG is integrated within a mask and fabricated via a three-dimensional(3D)printing method.When wearing the mask,the TENG can produce responsive electric signals corresponding to the airflow from breathing,which is capable of recognizing human breathing types with different intensities,lengths,and frequencies.On the basis of the breathing recognition ability,a breathing-based language expressing system is further developed through introducing the Morse code as a communication protocol.Compared with conventional language expressing devices,this system can extract subjective information of a person from breathing behaviors and output corresponding language text,which is not relying on voices or physical movements.This research for the first time introduces the self-powered breathing-based language expressing method to the field of HMI technology by using a 3D printed TENG,and could make HMI interactions become more friendly and fascinating. | Pengcheng Zhu Baosen Zhang Hongyi Wang Yiheng Wu Hengjun Cao Liubing He Chaoyue Li Xuepeng Luo Xing Li Yanchao Mao | 2022 | Nano Research2022，15，8： | 1 |
| 4 | 6 - 18 Operation Status of On-line Ion Sources in 2012显示文摘 | FengYucheng Lu Wang Li Jinyu Zhang Wenhui Ma Hongyi Ma Baohua Wang Hui Li Jiaqing Lin Shuhao Cao Yun Sha Shan W u Qi Guo Junwei Fang Xing Yang Yao Li Xixia Zhang Hengjuan Zhao Huanyu Zhang Xuezhen Sun Liangting Zhao Hongwei | 2012 | IMP & HIRFL Annual Report2012，，1： | 1 |
| 5 | 6-15 Status Report of On-line Ion Sources in 2015显示文摘In 2015, the service time of the two on-line ion sources of HIRFL-CSR accelerator facility, SECRAL and LECR3, is 3 335.5 and 3 168.5 h, respectively, amouting to 6 504 h. Except 26Mg7+, which was required by the accelerator but failed to be produced due the oxidation of the material, 20 kinds of ion beams have been delivered successfull.The failure time is 49 h this year, mainly attributed to the breakdown of the cryostat system. | Feng Yucheng Lu Wang Zhang Wenhui Ma Hongyi Yang Yao Fang Xing Guo Junwei Ma Baohua Wang Hui Qian Cheng Zhang Junjie Li Jibo Jin Qianyu sheng Sifan Liu Pengyan Li Xixia Zhao Huanyu Zhang Xuezhen Sun Liangting | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 6 | 6-42 Status Report of On-line Ion Sources in 2014显示文摘In 2014, the service time of the two on-line ion sources of HIRFL-CSR accelerator facility, SECRAL and LECR3is 3 594 and 3 457.2 h, respectively, amouting to 7051.2 h. 17 kinds of ion beams have been delivered successfull.The failure time is shrinked down to 8 h in this year, which is the lowest among these years. Table 1 summarizesthe main information about the ion beams delievered by the two ion sources. Fig. 1 shows the comparison of theion beam delivering time for HIRFL-CSR accelerator facitily from the three ion sources, LECR3, SECRAL andLAPECR1 since 2007. | Feng Yucheng Lu Wang Zhang Wenhui Ma Hongyi Yang Yao Fang Xing Guo Junwei Ma Baohua Wang Hui Qian Cheng Zhang Junjie Lin Shuhao Li Jibo Li Xixia Zhang Hengjuan Zhang Xuezhen Sun Liangting | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 7 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 8 | 2018年在线离子源运行报告显示文摘HIRFL accelerator facility has been operated with two ion sources as its pre-injectors,which are LECR3 and SECRAL-II.In 2018,there were 19 kinds of ion beams delivered successfully,and the service time of the two sources are 4594.5 and 2231 h respectively,amounting to 6825.5 h in total,in which SECRAL and LECR3 provided 4 and 1 kinds of metallic ion beams respectively,and the total service time for the metallic ones is 2322 h,accounting for 34%of the total service time.Table 1 summarizes the main information about the ion beams delivered by the two ion sources. | Feng Yucheng Zhang Wenhui Ma Hongyi Fang Xing Guo Junwei Huang Wei Jia Zehua Jin Qianyu Li Jiaqing Li Jibo Li Libin Li Lixuan Lu Yuting Qian Cheng Shen Zhen Wang Guicai Wang Hui Yang Yao Zhai Yuhan Zhang Junjie Zhang Sheng Zhang Xuezhen Sun Liangting | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 9 | Cobalt-embedded few-layered carbon nanosheets toward enhanced hydrogen evolution:Rational design and insight into structure-performance correlation显示文摘Over the past decades, the energy and concomitant environment issues, such as energy shortage, air pollution and global warming, have been becoming increasingly striking world-wide challenges [1,2]. Such a dilemma in turn appeals to the development and employment of clean and renewable energy. | Liwen Xing Hongyi Gao Dandan Jia Xiao Chen Mengyi Han Junjun Lv Ang Li Ge Wang Xingtian Shu | 2021 | Journal of Energy Chemistry2021，30，7： | 0 |
| 10 | Operational Report of On-line Ion Sources in 2019显示文摘In 2019,the service time of the two on-line ion sources,LECR3 and SECRAL,is 3642.5 and 3617 h respectively,amounting to 7259.5 h.There are 19 kinds of ion beams delivered to the accelerator successfully. | Feng Yucheng Zhang Wenhui Ma Hongyi Ma Jindou Fang Xing Guo Junwei Jia Zehua Jin Qianyu Li Jiaqing Li Jibo Li Libin Li Lixuan Lu Yuting Qian Cheng Shen Zhen Wang Guicai Wang Hui Yang Yao Zhai Yuhan Zhang Junjie Zhang Xuezhen Sun Liangting | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 11 | Beam Commissioning and Operation of LEAF in 2019显示文摘Beam commissioning with several ion species,such as H2^(+),He^(+),N^(2+).Kr^(13+).Xe^(20+) and so on,was implemented in 2019.The layout of LEAF is shown in Fig.1.The transmission efficiency of the RFQ is higher than 97%with beam intensity at the level of one-hundred microampere. | Yang Yao Zhai Yuhan Guo Yuhui Jing Long Lu Wang Ma Hongyi Zhang Wenhui Sun Liepeng Xu Xianbo Shi Longbo Xing Chaochao Yang Lei He Tao Fang Xing Gao Zheng Chang Jianjun Liu Xiaojun Jin Xiaofeng Sun Liangting He Yuan Zhao Hongwei | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 12 | Development of Room Temperature ECR Ion Sources:LECR4 and LECR5显示文摘The medium charge state ECR ion sources(LECR1,LECR2,and LECR3)have been successively built in the Institute of Modern Physics(IMP),the operating microwave frequencies of which are 10~14 GHz.To get better performance,LECR4 and LECR5 were designed to operate at 14~18 GHz. | Qian Cheng Sun Liangting Lu Wang Jia Zehua Li Libin Fang Xing Guo Junwei Yang Yao Feng Yucheng Ma Hongyi Li Xixia Wang Hui Zhang Xuezheng Zhao Hongwei | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 13 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform constructing at IMP.It is a 5-year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in material sciences,astrophysics,atomic physics and highly charged ion physics,LEAF has been designed and constructed with the state-of-the-art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals.The layout of LEAF is given in Fig.1. | Sun Liangting Lu Liang Jia Huan Yang Yao Zhang Bin Guo Yuhui Gao Zheng Ma Hongyi Jin Xiaofeng Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jing Long Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Liu Xiaojun Li Jiaqing Lu Wang Guo Junwei Yang Long Li Libin Sun Liepeng Shi Longbo Li Chenxing Ma Wei Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 14 | 2017年在线离子源的运行报告显示文摘Considering that all the ion species provided by LAPECR1 can also be supplied by LECR3,the LAPECR1 was removed during the summer maintenance period in 2017.Therefore,HIRFL-CSR has two online ion sources presently,which are LECR3 and SECRAL.In 2017,16 kinds of ion beams have been delivered successfully,and the total service time of the two on-line ion sources is 6622.5 h,3938.5 h and 2684 h for LECR3 and SECRAL,respectively.In this year,the service time of the two ion sources contributed to metal ion beams amounts to 2028 h,corresponding to 30.6%of the total service time. | Feng Yucheng Zhang Wenhui Ma Hongyi Guo Junwei Fang Xing Yang Yao Li libin Li Jibo Qian Cheng Zhang Junjie Jin Qianyu Wang Hui Ma Baohua Shen zhen Shen dingding Wang guicai Zhang Xuezhen Sun Liangting | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 15 | 超导ECR离子源SECRAL-II最新调试结果显示文摘SECRAL-II is a third generation fully superconducting ECRIS(electron cyclotron resonance ion source)and nearly a duplicated one of SECRAL(superconducting electron cyclotron resonance ion source with advanced design in Lanzhou).They have the same magnet structure locating the axial solenoid coils inside the radial sextupole magnet.Compared with SECRAL,SECRAL-II has a slightly higher radial field and a larger plasma chamber,which makes it suitable for operation at 28 GHz.Meanwhile,the cryogenic system of SECRAL-II was built with integrated LHe recondensation cryogenic system and operated with 5 GM cryocoolers that are capable of providing a dynamic cooling capacity of more than 5 W to the 4.2 K reservoir.The main parameters of SECRAL-II are shown in Table 1. | Lu Wang Li Lixuan Li Libin Li Jibo Guo Junwei Zhang Wenhui Feng Yucheng Ma Hongyi Fang xing Yang Yao Zhang Xuezhen Sun Liangting Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 16 | 6-18 Status Report of On-line Ion Sources in 2016显示文摘HIRFL-CSR accelerator facility has been operating with 3 ion sources,which are LAPECR1,LECR3 and SECRAL.These ion sources can provide different kinds of ions with different energy.For example,LAPECR1 mainly provides H+and He+with eextraction voltage above 25 keV,LECR3 can provide the ion beams with low to medium charge states,including the metallic ions with low mass,such as C^4+,Ar^11+,B^3+,Mg^7+,etc.,while SECRAL aims to produce intense and highly charged ion beams,especially metallic ones,such like Kr^19+,Xe^31+,Ni^19+,Bi^31+,U^33+,and so on. | Feng Yucheng Zhang Wenhui Ma Hongyi Guo Junwei Fang Xing Yang Yao Ma Baohua Qian Cheng Zhang Junjie Li Jibo Wang Hui Zhang Xuezhen Sun Liangting | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 17 | 6-20 Development of SECRAL II Ion Source at IMP in 2016显示文摘SECRAL II is the second fully superconducting ECR ion source developed at IMP.It’s almost the duplicate of SECRAL,except for the cryogenic system[1].SECRAL II has integrated LHe recondensation system,which has the dynamic cooling capacity of more than 5 W.The main parameters of SECRAL I&II are shown in Table 1.The magnets of SECRAL II has been successfully fabricated and tested in 2015.In 2016,SECRAL II has been commissioned at 18 and 28 GHz with O and Xe ion beams,which has given very promising results. | Guo Junwei Sun Liangting Zhang Wenhui Shen Zhen Feng Yucheng Fang Xing Zhang Xuezhen Ma Hongyi Yang Yao Li Libing Chang Jianjun Wang Pengpeng Zhao Huanyu Zhao Hongwei | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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