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| 1 | Thymic epithelial cell development and differentiation: cellular and molecular regulation显示文摘Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of signals including intracellular signaling networks and cell-cell interaction are required for TEC development and differentiation. Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful regulators promoting TEC development and differentiation. Crosstalks with thymocytes and other stromal cells for extrinsic signals like RANKL, CD40L, lymphotoxin, fibroblast growth factor (FGF) and Wnt are also definitely required to establish a functional thymic microenvironment. In this review, we will summarize our current understanding about TEC development and differentiation, and its underlying multiple signal pathways. | Lina Sun Haiying Luo Hongran Li Yong Zhao | 2013 | Protein & Cell2013，4，5： | 4 |
| 2 | Photo-controlled release of paclitaxel and model drugs from RNA pyramids显示文摘Stimuli-resp on sive release of drugs from a nano carrier in spatial-,temporal-,and dosage-controlled fashi ons is of great interest in the pharmaceutical industry.Paclitaxel is one of the most effective and popular chemotherapeutic drugs against a number of cancers such as metastatic or non metastatic breast can cer,non-small cell lung can cer,refractory ovaria n cancer,AIDS-related Kaposi's sarcoma,and head and neck can cers.Here,by taki ng the adva ntage of RNA nanotechno logy in biomedical and material scie nee,we developed a three-dime nsional pyramid-shaped RNA nanocage for a photocontrolled release of cargo,using paclitaxel as a model drug.The light-triggered release of paclitaxel or fluorophore Cy5 was achieved by incorporation of photocleavable spacers into the RNA nanoparticles.Upon irradiation with ultraviolet light,cargos were rapidly released(within 5 min).In vitro treatment of breast can cer cells with the RNA nano particles harbori ng photocleavable paclitaxel showed higher cytotoxicity as compared to RNA nanoparticles without the photocleavable spacer.The methodology provides proof of con cept for the applicati on of the light-triggered con trolled release of drugs from RNA nano cages. | Congcong Xu Hui Li Kaiming Zhang Daniel W.Binzel Hongran Yin Wah Chiu Peixuan Guo | 2019 | Nano Research2019，12，1： | 3 |
| 3 | Flexible Piezoresistive Sensors based on Conducting Polymer-coated Fabric Applied to Human Physiological Signals Monitoring显示文摘This paper describes a flexible pressure sensor based on polypyrrole(PPy)-Cotton composites,in which PPy is grown on cellulose fibers of cotton pads via an in situ vapor growth method,which is beneficial to the homogeneity of the composites.The resulting devices exhibits rapid response and recovery speed,the response and recovery times are 220 ms and 240 ms,respectively.The optimal PPy-Cotton Pads(PCPs)sensor shows low detection limit,which is about 50 Pa.At the same time,it exhibits excellent durability in the measurement of repeated loading-unloading pressure over 1000 cycles.The resultant sensor can be attached on different positions of body and applied to recording physiological signals,such as wrist pulse,vocal cord vibration,respiration and eyes blinking.Finally,a 4×4 pressure sensor array shows that the PCPs sensor has capability in pressure distribution detection and represents great potential in the fields of wearable electronics and biomedical devices. | Xiuzhu Lin Tong Zhang Junhou Cao Han Wen Teng Fei Sen Liu Rui Wang Hui Ren Hongran Zhao | 2020 | Journal of Bionic Engineering2020，17，1： | 1 |
| 4 | Video Super Resolution Based on Non-local Regularization and Reliable Motion Estimation显示文摘 | Lu Jian Zhang Hongran Sun Yi | 2014 | Signal Processing:Image Communication2014，29，29： | 1 |
| 5 | Biocompatible Multifunctional E-Skins with Excellent Self-Healing Ability Enabled by Clean and Scalable Fabrication显示文摘Electronic skins(e-skins) with an excellent sensing performance have been widely developed over the last few decades.However,wearability,biocompatibility,environmental friendliness and scalability have become new limitations. Self-healing ability can improve the long-term robustness and reliability of e-skins. However,self-healing ability and integration are hardly balanced in classical structures of self-healable devices. Here,cellulose nanofiber/poly(vinyl alcohol)(CNF/PVA),a biocompatible moisture-inspired self-healable composite,was applied both as the binder in functional layers and the substrate. Various functional layers comprising particular carbon materials and CNF/PVA were patterned on the substrate. A planar structure was beneficial for integration,and the active self-healing ability of the functional layers endowed self-healed e-skins with a higher toughness. Water served as both the only solvent throughout the fabrication process and the trigger of the self-healing process,which avoids the pollution and bioincompatibility caused by the application of noxious additives. Our e-skins could achieve real-time monitoring of whole-body physiological signals and environmental temperature and humidity. Cross-interference between di erent external stimuli was suppressed through reasonable material selection and structural design. Combined with conventional electronics,data could be transmitted to a nearby smartphone for post-processing. This work provides a previously unexplored strategy for multifunctional e-skins with an excellent practicality. | Xiuzhu Lin Fan Li Yu Bing Teng Fei Sen Liu Hongran Zhao Tong Zhang | 2021 | Nano-Micro Letters2021，13，12： | 1 |
| 6 | Immunization via hair follicles by topical application of naked DNA to normal skin 显示文摘 | Hongran F Qun L Georgiann RM | 1999 | Nature Biotechnology1999，17，9： | 1 |
| 7 | Preparation, Characterization and in vitro Release of Chitosan-stavudine Conjugate Nano-prodrug显示文摘Chitosan-stavudine (d4T) conjugate with a succinic spacer was synthesized via carbodiimide coupling reaction and structurally characterized. In order to nanosize it for improving its therapeutic properties, the chitosan-5'-O-succinyl-d4T conjugate was crosslinked with sodium tripolyphosphate (TPP) to obtain the chitosan-d4T conjugate nano-prodrug. The morphologies of chitosan-d4T conjugate nanoparticles were observed by transmission electron microscopy (TEM), and their zeta potential, particle size, and polydispersity (size distribution) were measured by the dynamic light scattering (DLS) techniques. In vitro drug release studies at pH 1.1 and pH 7.4 indicate that the crosslinked chitosan-d4T conjugate nano-prodrug can prevent the coupled d4T from leaking out before entering the target viral reservoirs and provide a mild sustained release without the burst release. The results reveal that constructing conjugated chitosan nano-prodrugs may be a promising approach for improving the therapy efficacy of drugs in antiviral treatment. | 曾戎 WANG Zehu WANG Hongran CHEN Liqiang 乔仁忠 HU Liming LI Zelin | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，3： | 1 |
| 8 | Removal of Cu, Zn, and Cd from aqueous solutions by the dairy manure-derived biochar显示文摘 | Xiaoyun Xu Xinde Cao Ling Zhao Hailong Wang Hongran Yu Bin Gao | 2013 | Environmental Science and Pollution Research2013，，1： | 1 |
| 9 | Universal precursor seismicity pattern before locked-segment rupture and evolutionary rule for landmark earthquakes显示文摘Despite extensive investigations,no precursor patterns for reliably predicting major earthquakes have thus far been identified.Seismogenic locked segments that can accumulate adequate strain energy to cause major earthquakes are highly heterogeneous and low brittle.The progressive cracking of the locked segments with these properties can produce an interesting seismic phenomenon:a landmark earthquake and a sequence of smaller subsequent earthquakes(pre-shocks)always arise prior to another landmark earthquake within a well-defined seismic zone and its current seismic period.Applying a mechanical model,magnitude constraint conditions,and case study data of 62 worldwide seismic zones,we show that two adjacent landmark earthquakes reliably occur at the volume-expansion point and peak-stress point(rupture)of a locked segment;thus,the former is an identified precursor for the latter.Such a precursor seismicity pattern before the locked-segment rupture has definite physical meanings,and it is universal regardless of the focal depth.Because the evolution of landmark earthquakes follows a deterministic rule described by the model,they are predictable.The results of this study lay a firm physical foundation for reliably predicting the occurrence of future landmark earthquakes in a seismic zone and can greatly improve our understanding of earthquake generation mechanism. | Hongran Chen Siqing Qin Lei Xue Baicun Yang Ke Zhang | 2022 | Geoscience Frontiers2022，13，3： | 1 |
| 10 | Removal of Cu, Zn, and Cd from aqueous solutions by the dairy manure-derived biochar显示文摘 | Xiaoyun Xu Xinde Cao Ling Zhao Hailong Wang Hongran Yu Bin Gao | 2013 | Environmental Science and Pollution Research2013，，1： | 1 |
| 11 | 3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution显示文摘Ribonucleic acid(RNA)nanotechnology platforms have the potential of harboring therapeutics for in vivo delivery in disease treatment.However,the nonspecific interaction between the harbored hydrophobic drugs and cells or other components before reaching the diseased site has been an obstacle in drug delivery.Here we report an encapsulation strategy to prevent such nonspecific hydrophobic interactions in vitro and in vivo based on a self-assembled three-dimensional(3D)RNA nanocage.By placing an RNA three-way junction(3WJ)in the cavity of the nanocage,the conjugated hydrophobic molecules were specifically positioned within the nanocage,preventing their exposure to the biological environment.The assembly of the nanocages was characterized by native polyacrylamide gel electrophoresis(PAGE),atomic force microscopy(AFM),and cryogenic electron microscopy(cryo-EM)imaging.The stealth effect of the nanocage for hydrophobic molecules in vitro was evaluated by gel electrophoresis,flow cytometry,and confocal microscopy.The in vivo sheathing effect of the nanocage for hydrophobic molecules was assessed by biodistribution profiling in mice.The RNA nanocages with hydrophobic biomolecules underwent faster clearance in liver and spleen in comparison to their counterparts.Therefore,this encapsulation strategy holds promise for in vivo delivery of hydrophobic drugs for disease treatment. | Congcong Xu Kaiming Zhang Hongran Yin Zhefeng Li Alexey Krasnoslobodtsev Zhen Zheng Zhouxiang Ji Sijin Guo Shanshan Li Wah Chiu Peixuan Guo | 2020 | Nano Research2020，13，12： | 0 |
| 12 | The Booming Economy of Taikang County 显示文摘TheBoomingEconomyofTaikangCountyByLIZHONGZHE&HANHONGRANTAIKANGCOUNTY,locatedinnorthernZhoukouPrefecZhengzhou,thecapitalofHena... | LI ZHONGZHE & HAN HONGRAN | 1996 | China Today1996，45，8： | 0 |
| 13 | Heterogeneous distribution of Cardinium in whitefly populations is associated with host nuclear genetic background显示文摘Inherited bacterial symbionts are very common in arthropods, but infection frequency can vary widely among populations. Experiments and interpopulation comparisons suggest that host genetic background might be important in explaining this variation. Our extensive field investigation showed that the infection pattern of the facultative symbiont Cardinium was heterogeneous across geographical populations of the invasive whitefly Bemisia tabaci Mediterranean (MED) in China, with genetic nuclear differences evident in 2 of the populations: 1 with a low infection rate (SD line) and 1 with a high infection rate (HaN line). However, whether the heterogeneous frequency of Cardinium is associated with the host genetic background remains poorly understood. Here, we compared the fitness of the Cardinium-infected and uninfected sublines with similar nuclear genetic backgrounds from SD and HaN lines, respectively, and further determine whether host extranuclear or nuclear genotype influenced the Cardinium–host phenotype by performing 2 new introgression series of 6 generations between SD and HaN lines (i.e., Cardinium-infected females of SD were backcrossed with uninfected males of HaN, and vice versa). The results showed that Cardinium provides marginal fitness benefits in the SD line, whereas Cardinium provides strong fitness benefits in the HaN line. Further, both Cardinium and the Cardinium–host nuclear interaction influence the fecundity and pre-adult survival rate of B. tabaci, whereas the extranuclear genotype does not. In conclusion, our results provide evidence that Cardinium-mediated fitness effects were closely associated with the host genetic background, which provides a fundamental basis for understanding the mechanism underlying the heterogeneous distribution of Cardinium in B. tabaci MED populations across China. | Hongran Li Ying Liu Xiaoying Wei Huipeng Pan Youjun Zhang Xuguo Zhou Dong Chu | 2023 | Insect Science2023，30，6： | 0 |
| 14 | Bromine and oxygen redox species mediated highly selective electro-epoxidation of styrene显示文摘Olefin epoxidation is an essential transformation and arouses great interest among the scientific community for the key role of epoxide in the chemical industry.Traditional methods suffer from harmful oxidants and require harsh operating conditions and complex separation processes.Electro-epoxidation through bromine redox reactions is an eco-friendly strategy.However,the lack of efficient electrodes always limits the selectivity of epoxidation and results in massive energy consumption.Herein,we found that GF-CoS_(2)/CoS heterostructures anchored on graphite felt(GF-CoS_(2)/CoS)can efficiently facilitate the generation of bromine redox species on the anode.The synergistic cooperation between the bromine redox species and oxygen redox species(generated on a graphite rod cathode)can establish a benign electro-epoxidation system for olefin substrates in an ambient environment.Under the optimized reaction conditions,the epoxidation of styrene can achieve a yield of 97% at 30 mA cm^(-2).Importantly,the applied voltage(4-5 V)is roughly half of the Pt-based electrode system(7.8-9.3 V),hence,saving half of the energy.We demonstrated that our proposed strategy could also be applied to other olefins.Because of the simple,sustainable,and economic advantages of the epoxidation process,we believe this strategy is highly desirable for technical applications. | Yuchi Zhang Asma Iqbal Jiantao Zai Shu-Yu Zhang Hongran Guo Xuejiao Liu Ibrahim ul Islam Hira Fazal Xuefeng Qian | 2022 | Organic Chemistry Frontiers2022，9，2： | 0 |
| 15 | Primary Osteosarcoma of the Breast in Young Women: One Case Report and Literature Review显示文摘Case ReportA 21-year-old female with a breast tumor for over a month came toour hospital.The physical examinations on her breast showed a mam-mary neoplasm of about 4 cm,with a good range of motion and noabnormality seen in the skin.The patient remained single,and had nofamily history of breast cancer or ovarian carcinoma.CT and | Xuefeng Bai Hongran Cao | 2009 | Clinical oncology and cancer resexreh2009，6，4： | 0 |
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