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| 1 | Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species显示文摘Magnolia grandiflora is an important medicinal,ornamental and horticultural plant species.The chloroplast(cp) genome of M.grandiflora was sequenced using a 454 sequencing platform and the genome structure was compared with other related species.The complete cp genome of M.grandiflora was 159623 bp in length and contained a pair of inverted repeats(IR) of 26563 bp separated by large and small single copy(LSC,SSC) regions of 87757 and 18740 bp,respectively.A total of 129 genes were successfully annotated,18 of which included introns.The identity,number and GC content of M.grandiflora cp genes were similar to those of other Magnoliaceae species genomes.Analysis revealed 218 simple sequence repeat(SSR) loci,most composed of A or T,contributing to a bias in base composition.The types and abundances of repeat units in Magnoliaceae species were relatively conserved and these loci will be useful for developing M.grandiflora cp genome vectors.In addition,results indicated that the cp genome size in Magnoliaceae species and the position of the IR border were closely related to the length of the ycf1 gene.Phylogenetic analyses based on 66 shared genes from 30 species using maximum parsimony(MP) and maximum likelihood(ML) methods provided strong support for the phylogenetic position of Magnolia.The availability of the complete cp genome sequence of M.grandiflora provides valuable information for breeding of desirable varieties,cp genetic engineering,developing useful molecular markers and phylogenetic analyses in Magnoliaceae. | LI XiWen GAO HuanHuan WANG YiTao SONG JingYuan HENRY Robert WU HeZhen HU ZhiGang YAO Hui LUO HongMei LUO Kun PAN HongLin CHEN ShiLin | 2013 | Science China(Life Sciences)2013，56，2： | 17 |
| 2 | Characterization and analysis of coded excitation ultrasound parameters for rock properties显示文摘Coded excitation technology(CET) can effectively enhance the penetration and resolution of ultrasonic testing.To analyze the influence of rock properties on pulse compression performance(PCP) of coded excitation signals(CES),a numerical simulation,and an ultrasonic experiment on different rock samples are performed;and the detection ability of several CESs are also investigated and compared.The results of experiments showed that the loss of the signal-to-noise ratio(SNR) of Barker coded signal with tapered linear frequency modulated carrier(BTLFM) is always less than Barker coded signal with sine carrier(BS),while the resolution loss of BTLFM is lower than tapered linear frequency modulated signal(TLFM).In sum,the results not only verifiy the effectiveness of CET,but also provide a basis for the parameter settings of coded signals used in rock ultrasonic testing. | ZHU Wei WU Hezhen | 2017 | Chinese Journal of Acoustics2017，36，1： | 2 |
| 3 | Compound Gaoziban tablet(复方高滋斑片) alleviates depression via toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway显示文摘OBJECTIVE: To evaluate the effect of compound Gaoziban tablet(复方高滋斑片, CGZBT) on depression, and to investigate the underlying mechanism. METHODS: The components of CGZBT were analysed by high-performance liquid chromatography. Then, we assessed the effects of varying doses of CGZBT on an established chronic unpredictable mild stress(CUMS) model in rats. Whether animals were depressed was evaluated by sucrose preference test, open field test and forced swimming test. Neurotransmitters of hippocampus were detected by liquid chromatography-mass spectrometry. Serum levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-6, IL-4, and IL-10 were measured by enzyme-linked immunosorbent assay. Expressions of toll-like receptor 4(TLR4), myeloid differentiation factor 88(My D88), phospho-nuclear factorkappa B(p-NF-κB), cyclooxygenase-2(COX-2), ionized calcium binding adapter molecule-1(IBA-1) were assessed by immunohistochemical staining and western blotting. RESULTS: Eight compounds were identified from CGZBT, moreover, our results showed that CGZBT effectively reversed the CUMS-induced decrease in sucrose preference, shortened the movement distance and prolonged immobility time. CGZBT significantly increased levels of 5-hydroxytryptamine, dopamine, norepinephrine, 5-hydroxyindoleacetic acid levels, and reduced the expression of TNF-α, IL-1β, IL-6, yet increased IL-4 and IL-10. Furthermore, the expressions of TLR4, My D88, COX-2, p-NF-κB and IBA-1 in hippocampus were effectively reversed after treatment with CGZBT. CONCLUSIONS: These results indicated that CGZBT could, at least in part, alleviate depression induced by CUMS via the TLR4/My D88/NF-κB pathway, suggesting its potential as an antidepressant drug. | ZOU Xinshuang SHI Lei YIN Hailong LI Haiping WANG Mengheng SONG Wanci LUO Laichun WU Hezhen YANG Yanfang ZAN Junfeng LIU Yanwen DAN Hanxiong YIN Qiang YOU Pengtao | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
| 4 | Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells显示文摘Dear Editor,The interventions that slow aging or promote healthy aging may provide preventative measures for age-related diseases(Zhang et al.,2015).Therefore,it is crucial to identify drugs that target aging-related pathologies and improve health-span in geroscience research.Using model organisms such as C.elegans and rodents,several small molecules capable of alleviating the onset or progression of aging,including rapamycin,nicotinamide mononucleotide,and metformin,have been discovered(Partridge et al.,2020).However,the safety and efficacy of these chemicals still need in-depth evaluation before clinical applications(Partridge et al.,2020).As a result,it is necessary to identify additional compounds with geroprotective effects for human cells to counteract the general trend of populational aging.However,transforming a promising compound into an approved drug requires enormous resources.Alternatively,repurposing previously approved drugs for new clinical applications offers a more efficient and less costly path toward drug develop-ment.Therefore,testing U.S.Food and Drug Administration(FDA)-approved drugs for geroprotective effects may dis-covernew therapeutics that have already been stringently tested in humans for safety. | Hezhen Shan Lingling Geng Xiaoyu Jiang Moshi Song Jianxun Wang Zunpeng Liu Xiao Zhuo Zeming Wu Jianli Hu Zhejun Ji Si Wang Piu Chan Jing Qu Weiqi Zhang Guang-Hui Liu | 2022 | Protein & Cell2022，13，7： | 1 |
| 5 | The Impact of Urban Expansion on Plant Diversity Change in Karst Regions of Southwest China显示文摘Biodiversity is vital for the integrity and stability of ecosystems and sustainable development.Karst regions of Southwest China is featured for undulating and broken karst terrain as well as high plant diversity.Land use changes induced by the growing population and expanding human settlement have threatened biodiversity preservation in this region.However,the impact of urban expansion on plant diversity remains unclear here.This study focuses on how expanding countryside landscapes affect the recovery rate of plant diversity and demonstrate how urban expansion affects plant diversity conservation in karst regions of Southwest China.In situ biodiversity investigations and multisource remote sensing images were combined to analyze the role of human settlement evolution in the conservation of plant diversity using descriptive statistics and regression analysis.Unmanned vehicle images,historical aerial photographs,and long-term remote sensing images were used to observe the human settlement pattern changes over 40 yr and found that plant diversity is restored faster in countryside ecosystems than in island ecosystems restricted by water.Forests,however,contribute the most to plant diversity conservation in both ecosystems.While the forest area is stable during urban expansion,massive forest patches play an essential role in plant diversity conservation.Arable lands and grasslands shrank but with a fragmenting trend,which was conducive to preserving plant diversity,whereas increased and regularized large patches of built-up areas were not beneficial to plant diversity.Accordingly,forest protection should be prioritized to coordinate future socioeconomic development and plant diversity conservation in karst and broader regions.Furthermore,large built-up patches should be limited,and the irregularity should be improved during urban expansion.Irregular shaped cultivated land and grassland were suggested to promote biological information exchanges as landscape corridors. | YANG Shengtian LI Chaojun LOU Hezhen LUO Ya WANG Pengfei ZHANG Jun LI Xi WU Xijin | 2022 | Chinese Geographical Science2022，32，3： | 0 |
| 6 | Effect of compound Sophorae decoction in the treatment of ulcerative colitis by tissue extract metabolomics approach显示文摘OBJECTIVE: To investigate how compound Sophorae decoction(CSD) works on rats' models of ulcerative colitis(UC) induced by 2,4,6-trinitrobenzenesulfonic acid solution(TNBS) by metabolomics studies of colon, liver, and kidney tissue extracts.METHODS: Rats with UC induced by TNBS enema were used as models in this study. Metabolic profiles of the three tissues were analyzed and pathway analysis of biomarkers was performed after CSD administration and further integration of metabolic networks.RESULTS: Thirteen biomarkers were screened from colon, liver, and kidney tissue extracts, and the levels of these substances were up-or down-regulated in the model group, but their levels were reversed after CSD administration. These biomarkers were mainly related to Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Nicotinate and nicotinamide metabolism,Alanine, aspartate and glutamate metabolism.CONCLUSION: CSD could significantly ameliorate the symptoms of UC by regulating multiple metabolic pathways. | HONG Zongchao CAI Quan DUAN Xueyun YANG Yanfang WU Hezhen JIANG Nan FAN Heng | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 0 |
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