|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The gap-free genome of mulberry elucidates the architecture and evolution of polycentric chromosomes显示文摘Mulberry is a fundamental component of the global sericulture industry,and its positive impact on our health and the environment cannot be overstated.However,the mulberry reference genomes reported previously remained unassembled or unplaced sequences.Here,we report the assembly and analysis of the telomere-to-telomere gap-free reference genome of the mulberry species,Morus notabilis,which has emerged as an important reference in mulberry gene function research and genetic improvement.The mulberry gap-free reference genome produced here provides an unprecedented opportunity for us to study the structure and function of centromeres.Our results revealed that all mulberry centromeric regions share conserved centromeric satellite repeats with different copies.Strikingly,we found that M.notabilis is a species with polycentric chromosomes and the only reported polycentric chromosome species up to now.We propose a compelling model that explains the formation mechanism of new centromeres and addresses the unsolved scientific question of the chromosome fusion-fission cycle in mulberry species.Our study sheds light on the functional genomics,chromosome evolution,and genetic improvement of mulberry species. | Bi Ma Honghong Wang Jingchun Liu Lin Chen Xiaoyu Xia Wuqi Wei Zhen Yang Jianglian Yuan Yiwei Luo Ningjia He | 2023 | Horticulture Research2023，10，7： | 1 |
| 2 | Detection of Serum Gastric Cancer-Associated MG7-Ag from Gastric Cancer Patients Using a Sensitive and Convenient ELISA Method显示文摘 | Bin Jin Xin Wang Yan Jin Wensen Xia Bei Chen Lin Liu Zheng Chen Liu Hong Wenqi Du Kun Yan Honghong Wang Donghong Yuan Xiaoli Hui Li He Faming Zhang Yunping Zhao Kaichun Wu Daiming Fan | 2009 | Cancer Investigation2009，，2： | 1 |
| 3 | Production and in vitro antioxidant activity of exopolysaccharide by a mutant, Cordyceps militaris SU5-08显示文摘 | Rongshan Lin Honghong Liu Suqian Wu Lifei Pang Mengshi Jia Keming Fan Shouhua Jia Le Jia | 2012 | International Journal of Biological Macromolecules (-)2012，，1： | 1 |
| 4 | Cell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells显示文摘Multicellular organisms such as plants contain various cell types with specialized functions.Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level.Guard cells(GCs)are specialized epidermal cells that regulate the movement of the stomata and gaseous exchange,and provide a model genetic system for analyzing cell fate,signaling,and function.Several proteomics analyses of GC are available,but these are limited in depth.Here we used enzymatic isolation and flow cytometry to enrich GC and mesophyll cell protoplasts and perform in-depth proteomics in these two major cell types in Arabidopsis leaves.We identified approximately 3,000 proteins not previously found in the GC proteome and more than600 proteins that may be specific to GC.The depth of our proteomics enabled us to uncover a guard cell-specific kinase cascade whereby Raf15and Snf1-related kinase2.6(SnRK2.6)/OST1(open stomata 1)mediate abscisic acid(ABA)-induced stomatal closure.RAF15 directly phosphorylated SnRK2.6/OST1 at the conserved Ser175 residue in its activation loop and was sufficient to reactivate the inactive form of SnRK2.6/OST1.ABAtriggered SnRK2.6/OST1 activation and stomatal closure was impaired in raf15 mutants.We also showed enrichment of enzymes and flavone metabolism in GC,and consistent,dramatic accumulation of flavone metabolites.Our study answers the long-standing question of how ABA activates SnRK2.6/OST1 in GCs and represents a resource potentially providing further insights into the molecular basis of GC and mesophyll cell development,metabolism,structure,and function. | Hongliang Wang Yubei Wang Tian Sang Zhen Lin Rongxia Li Weiwei Ren Xin Shen Bing Zhao Xiao Wang Xuebin Zhang Shaoqun Zhou Shaojun Dai Honghong Hu Chun-Peng Song Pengcheng Wang | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 5 | An insight to calculate soil conservation service显示文摘Quantifying soil conservation service is critical for sustainable land management. However, the traditional algo-rithm includes a gap between barren land and real soil erosion (BSERef), and its paradox is that a mass of barrenland rarely exists in ecologically adaptable areas with fertile soils, which might overestimate soil conservationservice. This study suggests a practical algorithm to effectively evaluate soil conservation service of differentecosystems. We propose a new algorithm based on the difference between cropland without control practicesand real soil erosion (CSERef), which is compared with the BSERef algorithm. Our results show that: (1) a nearlyfive times smaller mean soil conservation amount of cropland occurred in the CSERef algorithm (3.76×106 t·yr–1)than in the BSERef algorithm (20.04×106 t·yr–1);(2) land use has higher explanatory power for the spatial dif-ferentiation of soil conservation rate in the CSERef algorithm (15.93% – 46.34%) than in the BSERef algorithm(5.95% – 44.49%). Our results demonstrate that the BSERef algorithm overestimates the soil conservation serviceof cropland in ecologically adaptable areas, whereas the CSERef algorithm can effectively assess the influence ofland use change induced by anthropogenic activities on soil conservation service. Furthermore, we develop anassessment framework in terms of land use classification system following the Chinese Academy of Sciences. Theframework considers that for water bodies, there is no soil conservation service;for non-ecologically adaptable ar-eas (unused land) with vast barren lands and vegetation cover below 5%, the BSERef algorithm is recommended;the CSERef algorithm is suggested to use in ecologically adaptable areas (including woodland, grassland, crop-land and construction land). This assessment framework can provide scientific assistance for decision-makers toformulate strategies for sustainable land management. | Shaojuan Lu Xingwu Duan Shengzhao Wei Honghong Lin | 2022 | Geography and Sustainability2022，3，3： | 0 |
| 6 | Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia显示文摘Accumulating evidence has shown that the apoptosis of trophoblast cells plays an important role in the pathogenesis of preeclampsia,and an intricate interplay between DNA methylation and polycomb group(PcG)proteinmediated gene silencing has been highlighted recently.Here,we provide evidence that the expression of nervous system polycomb 1(NSPc1),a BMI1 homologous polycomb protein,is significantly elevated in trophoblast cells during preeclampsia,which accelerates trophoblast cell apoptosis.Since NSPc1 acts predominantly as a transcriptional inactivator that specifically represses HOXA11 expression in trophoblast cells during preeclampsia,we further show that NSPc1 is required for DNMT3a recruitment and maintenance of the DNA methylation in the HOXA11 promoter in trophoblast cells during preeclampsia.In addition,we find that the interplay of DNMT3a and NSPc1 represses the expression of HOXA11 and promotes trophoblast cell apoptosis.Taken together,these results indicate that the cooperation between NSPc1 and DNMT3a reduces HOXA11 expression in preeclampsia pathophysiology,which provides novel therapeutic approaches for targeted inhibition of trophoblast cell apoptosis during preeclampsia pathogenesis. | Lin Xie Ning Ding Siqi Sheng Honghong Zhang He Yin Lina Gao Hui Zhang Shengchao Ma Anning Yang Guizhong Li Yun Jiao Qing Shi Yideng Jiang Huiping Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，2： | 0 |
| 7 | Adaptive Chirality of an Achiral Cage:Chirality Transfer,Induction,and Circularly Polarized Luminescence through Aqueous Host-Guest Complexation显示文摘Chirality transfer,induction,and circularly polarized luminescence(CPL)using supramolecular hosts,such as macrocycles and cages,have been explored for wide-ranging applicationsin chiral recognition,sensing,catalysis,and chiroptical functional materials.Herein,we report the adaptive chirality of an achiral tetraphenylethene(TPE)-basedoctacationic cage(1)inducedby bindingwith enantiopure deoxynucleotides(A,T,C,and G)throughhost-guest(H-G)complexationinwater.The hydrophobic cavity of the cage efficiently stabilizes the hydrogen-bonded dimerization of deoxynucleotides(A_(2),T_(2),C_(2),and G_(2))to form H-G complexes in 1∶2 ratios.Given the photophysical properties and dynamic rotational conformation of the TPE units of the cage,cage⊃deoxynucleotide complexes exhibited excellent chiroptical propertiesbased on chirality transfer andinduction from the chiral guest to the achiral host.For this supramolecular system,the cage showed a unique adaptive chirality of the double clockwise-typed(PP)rotational conformation of the two TPE units,which was induced by chiral guests(e.g.,A_(2),T_(2),C_(2),and G_(2))through H-G complexation in water.Furthermore,the adaptive chirality of the cage⊃deoxynucleotide complexes successfully induced CPL signals in homogeneous aqueous solutions.This study provides insights for the construction of adaptive chirality from an achiral TPE-based octacationic cage with dynamic conformational nature,and might facilitate further design of chiral functional materials for several applications,such as chiral recognition,sensing,displays,catalysis,and other chiral fluorescent supramolecular systems based on aqueous H-G complexation. | Lin Cheng Kai Liu Yanjuan Duan Honghong Duan Yawen Li Meng Gao Liping Cao | 2021 | CCS Chemistry2021，3，11： | 0 |
| 8 | Transfer learning aided high-throughput computational design of oxygen evolution reaction catalysts in acid conditions显示文摘Sluggish oxygen evolution reaction(OER)in acid conditions is one of the bottlenecks that prevent the wide adoption of proton exchange membrane water electrolyzer for green hydrogen production.Despite recent advancements in developing high-performance catalysts for acid OER,the current electrocatalysts still rely on iridium-and ruthenium-based materials,urging continuous efforts to discover better performance catalysts as well as reduce the usage of noble metals.Pyrochlore structured oxide is a family of potential high-performance acid OER catalysts with a flexible compositional space to tune the electrochemical capabilities.However,exploring the large composition space of pyrochlore compounds demands an imperative approach to enable efficient screening.Here we present a highthroughput screening pipeline that integrates density functional theory calculations and a transfer learning approach to predict the critical properties of pyrochlore compounds.The high-throughput screening recommends three sets of candidates for potential acid OER applications,totaling 61 candidates from 6912 pyrochlore compounds.In addition to 3d-transition metals,p-block metals are identified as promising dopants to improve the catalytic activity of pyrochlore oxides.This work demonstrates not only an efficient approach for finding suitable pyrochlores towards acid OER but also suggests the great compositional flexibility of pyrochlore compounds to be considered as a new materials platform for a variety of applications. | Siwen Wang Honghong Lin Yui Wakabayashi Li Qin Zhou Charles A.Roberts Debasish Banerjee Hongfei Jia Chen Ling | 2023 | Journal of Energy Chemistry2023，，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员