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| 1 | CONDUCTIVITY METHOD APPLIED TO THE STUDY OFINTERACTION BETWEEN ADSORBENT AND ADSORBATE Ⅰ. ADSORPTION OF LOW CONCENTRATION OF FREE ACID BY REGENERABLE CHITIN显示文摘The adsorption of low concentration of free acid by regenerable chitin is followed by electric conductance determination. The effect of acid concentration, content of functional amino groups, and ionic strength on adsorption was discussed. Experimental results indicate that the active centre of regenerable chitin is the free amino groups on its surface, and that the rate of adsorption of free acid was found to be affected by two factors: the interaction between the adsorbent and the adsorbate in solution and that between the adsorbate molecules or ions in solution. | Chen Bingren He Guangping Ling Moyu Wang Ruixiang Chen Wensen (Department of Chemistry, South China Normal University, Guangzhou, 510631) | 1997 | Chinese Journal of Reactive Polymers1997，6，1： | 7 |
| 2 | Effects of drought stress on photosynthesis and chlorophyll fluorescence images of soybean(Glycine max)seedlings显示文摘The main purpose of this research is to provide a theoretical foundation for the screening of drought-resistant soybean varieties and to establish an efficient method to detect the PSII actual photochemical quantum yields efficiently.Three soybean varieties were compared in this experiment after 15 d when they were planted in a greenhouse.These varieties were then exposed to light drought stress(LD)and serious drought stress(SD)conditions.With five times’measurement,chlorophyll fluorescence and soil-plant analysis development considered as the main basis for this study.Several parameters in SD conditions significantly reduced,such as net photosynthetic rates(Pn),stomatal conductance(Gs),PSII primary light energy conversion efficiency(Fv/FM),PSII actual photochemical quantum yields[Y(II)],photochemical quenching coefficient(qP)and non-photochemical quenching coefficient(qN).The soybeans in the seedling stage adapted to the inhibitory effect of drought stress on photosynthesis through stomatal limitation.Under serious drought stress,non-stomatal limitation damaged the plant photosynthetic system.The amplitudes of Pn and Y(II)of drought-resistant Qihuang 35 were lower than those of the two other varieties.Based on the data of this study,a new method had been developed to detect Y(II)which reflected the photosynthetic capacity of plant,R=0.85989,u=0.048803 when using multiple linear regression,and R=0.84285,u=0.054739 when using partial least square regression. | Wensen Wang Cheng Wang Dayu Pan Yakun Zhang Bin Luo Jianwei Ji | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 7 |
| 3 | 固溶原子、析出相和变形对Al-Sc-Zr合金组织和性能的定量影响(英文)显示文摘为了研究固溶原子、析出相粒子和冷变形对Al-Sc-Zr合金组织和性能的影响,对连续流变挤压制备的Al-Sc-Zr合金进行形变热处理,采用电导率、强度、显微硬度测试以及光学显微镜、TEM、STEM对合金在不同处理状态下的显微组织和性能进行研究。建立固溶原子、析出相粒子和冷变形对合金导电率定量贡献的数学模型。结果表明:固溶、时效和冷变形都能使合金的强度得到显著的提升,而固溶原子、沉淀粒子和冷变形对Al合金导电率影响值分别是10.5%(IACS)、2.3%(IACS)和0.5%(IACS)。时效和冷变形处理是获得高强高导铝合金导线的关键。 | 管仁国 金红梅 Wensen JIANG 王祥 王宇翔 李征 张俭 Huinan LIU | 2019 | Transactions of Nonferrous Metals Society of China2019，29，5： | 7 |
| 4 | Nanomaterials for treating cardiovascular diseases:A review显示文摘Nanomaterials such as nanostructured surfaces,nanoparticles,and nanocomposites represent new viable sources for future therapeutics for cardiovascular diseases.The special properties of nanomaterials such as their intrinsic physiochemical properties,surface energy and surface topographies could actively enhance desirable cellular responses within the cardiovascular system,projecting a growing potential for clinical translation.Recent progress on nanomaterials opened up new opportunities for treating cardiovascular diseases.Successful translation of nanomaterials into cardiovascular applications requires a comprehensive understanding of both nanomaterials and biomedicine,and,thus,it is critical to stress current advancements on both sides.In this review,the authors introduced crucial fabrication techniques for promising nanomaterials for cardiovascular applications.This review highlighted the key elements to consider for their fabrication,properties and applications.The important concerns relevant to cardiovascular nanomaterials,such as cellular responses to nanomaterials and the toxicity of nanomaterials,are also discussed.This review provided an overview of necessary knowledge and key concerns on nanomaterials specific for treating cardiovascular diseases,from the perspectives of both material science and biomedicine. | Wensen Jiang Dana Rutherford Tiffany Vuong Huinan Liu | 2017 | Bioactive Materials2017，2，4： | 6 |
| 5 | Role of VEGF in the growth and metastasis of a murine bladder carcinoma显示文摘Bladder transitional cell carcinoma is the most common form of carcinoma in the urinary system. Although overexpression of VEGF has been identified in tissue, serum, and urine of patients with bladder cancer, the role of VEGF in transitional cell carcinoma of the bladder has not beenclearly elucidated. Here, we dissected the effect of VEGFduring bladder tumor growth and progression by modifying a BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine) induced mouse bladder transitional cell carcinoma cell lineBTT-T739 by stable transfection of antisense VEGF121 cDNA. The transfection resulted in more than 80% reduction inVEGF production. The growth of the transduced tumor cells in vitro was not affected, however, these cells formed small or no tumors in vivo. Even in the tumors formed, there were mini- mal vascularization, extensive necrosis and longerlatency compared to those formed by parental cells. Thepermeability of tumor vasculature and metastatic tumor growth were also significantly suppressed in antisense VEGFcDNA trans- fected cells. In addition, the transfer ofanti-angiogenic gene in a combination of sFlk-1 and ExTekwith electroporation can suppress the tumor growthefficiently. Taken together, these results demonstrated thatVEGF plays an important role in bladder tumorangiogenesis and angiogenesis plays an important role in bladder tumor growth and metastasis. | WANG Feng WU Jihong TIAN Yuhua CHEN Xiafang HU Honghui WU Wensen LI Chuanyuan | 2003 | Chinese Science Bulletin2003，48，22： | 4 |
| 6 | One-dimensional microstructure-assisted intradermal and intracellular delivery显示文摘The advancement in the materials manufacturing at micrometer and nanometer scales has already enabled numerous applications in electronics, optics, chemistry, biology and medicine. Biomedical devices carrying micro-/nanostructures are currently being widely used in drug delivery, drug release, biosensing and therapy. New clinical methods for disease diagnosis and treatments are being developed enabled by nanotech no logy. One-dimensional (ID) structures are playi ng an importa nt role in the direct drug delivery both in vivo and ex vivo among various micro-/nanostructures. Here, in this paper, we reviewed recent progresses made on next-generation intradermal and intracellular delivery strategies and applications with focus on ID microstructure-based approaches. | Wensen Jiang Liang Ma Xiaobin Xu | 2019 | Bio-Design and Manufacturing2019，2，1： | 3 |
| 7 | Curcumin’s prevention of inflammation-driven early gastric cancer and its molecular mechanism显示文摘Worldwide,gastric cancer is the second leading cause of cancer deaths and the fifth most common malignant tumor.Gastric cancer is believed to be caused by a variety of factors,such as genetics,epigenetics,and environmental influences.Among the pathogenic factors,inflammation has been considered as one of the main risk factors for gastric cancer.There are currently limited ways to prevent gastric cancer.Although the combined application of aspirin and non-steroidal anti-inflammatory drugs can reduce the risk,it has great side effects and can easily cause gastric perforation or gastric bleeding.Therefore,an alternative plan is urgently needed.Curcumin is the yellow pigment in the rhizome of the plant turmeric.Current studies have found that curcumin has a protective effect on gastric mucosal damage caused by non-steroidal anti-inflammatory drugs,gastric mucosal damage in rats,and gastric mucosal damage caused by stress bleeding and Helicobacter pylori infection.Curcumin shows significant antiinflammatory and anti-cancer activities by regulating DNA methylation,histone modification,nuclear factor erythrocyte 2 related factor 2 and other related signal pathways.In this article,the latest evidence of curcumin for epigenetic changes in gastric cancer and its potential contribution to gastric cancer were discussed. | Wensen Zhang Na Cui Jin Ye Bingyou Yang Yanping Sun Haixue Kuang | 2022 | Chinese Herbal Medicines2022，14，2： | 3 |
| 8 | 3D-printed models improve surgical planning for correction of severe postburn ankle contracture with an external fixator显示文摘Gradual distraction with an external fixator is a widely used treatment for severe postburn ankle contracture(SPAC).However,application of external fixators is complex,and conventional two-dimensional(2D)imaging-based surgical planning is not particularly helpful due to a lack of spatial geometry.The purpose of this study was to evaluate the surgical planning process for this procedure with patient-specific three-dimension-printed models(3DPMs).In this study,patients coming from two centers were divided into two cohorts(3DPM group vs.control group)depending on whether a 3DPM was used for preoperative surgical planning.Operation duration,improvement in metatarsal-tibial angle(MTA),range of motion(ROM),the American Orthopedic Foot and Ankle Society(AOFAS)scores,complications,and patient-reported satisfaction were compared between two groups.The 3DPM group had significantly shorter operation duration than the control group((2.0±0.3)h vs.(3.2±0.3)h,P<0.01).MTA,ROM,and AOFAS scores between the two groups showed no significant differences pre-operation,after the removal of the external fixator,or at follow-up.Plantigrade feet were achieved and gait was substantially improved in all patients at the final follow-up.Pin-tract infections occurred in two patients(one in each group)during distraction and were treated with wound care and oral antibiotics.Patients in the 3DPM group reported higher satisfaction than those in the control group,owing to better patient-surgeon communication.Surgical planning using patient-specific 3DPMs significantly reduced operation duration and increased patient satisfaction,while providing similar improvements in ankle movement and function compared to traditional surgical planning for the correction of SPAC with external fixators. | Youbai CHEN Zehao NIU Weiqian JIANG Ran TAO Yonghong LEI Lingli GUO Kexue ZHANG Wensen XIA Baoqiang SONG Luyu HUANG Qixu ZHANG Yan HAN | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，10： | 3 |
| 9 | Regulation of the radiosensitivity of tumor cells through HIF-1α dependent intracellular redox status after fractionated radiation显示文摘Tumor cells often develop resistance to radiotherapy by fractionated radiation possibly due to the heterogeneity and hypoxia in tumor tissue.However,the mechanism of refractory effect remains unclear.In the present study,a radioresistant variant HepG2/R60 cell line was isolated from human HepG2 cells by repeated exposure to radiation.The results showed that,after irradiation,the higher survival rate was in HepG2/R60 cells compared to parental cells.Hypoxia treatment could further increase the radioresistance of HepG2/R60 cells concomitant with high level of intracellular GSH and overexpression of HIF-1α.When hypoxic HepG2/R60 cells were pretreated with BSO,a GSH depleter,the refractory response was significantly reduced showing a decrease in intracellular GSH level,followed by the suppression of HIF-1α in hypoxic cells.Subsequent study found that the level of BCL-2 was down-regulated,targeted by HIF-1 prompting transcription in hypoxic cells.The effect of HIF-1α on the radiosensitivity of hypoxic cells was confirmed using YC-1,a specific inhibitor of HIF-1α.Consequently,our results suggest that the radiosensitivity of tumor cells might be regulated by fractionated radiation,and the radioresistance of cells induced by repeated exposure,under hypoxic condition,could be correlated with overexpression of HIF-1α dependent on the alteration of intracellular GSH contents. | JIN Wensen KONG Zhaolu SHEN Zhifen JIN Yizun ZHANG Wukui | 2010 | Nuclear Science and Techniques2010，21，5： | 2 |
| 10 | Effect of intracranial pressure monitoring and targeted intensive care on functional outcome after severe head injury显示文摘 | Cremer OL van Dijk GW van Wensen E | | 0，，： | 1 |
| 11 | Hereditary neuropathy with liability to pressure palsies: a clinical, electroneurophysiological and morphological study显示文摘 | Gabreels-Festen AA van Wensen PJ | 1993 | J Neurol Sci1993，116，： | 1 |
| 12 | Unified calibration technique and its applications in optical triangular profilometry显示文摘 | Anand Asundi Zhou Wensen | 1999 | Applied Optics1999，38，16： | 1 |
| 13 | Lung nodule enhancement at CY: multicenter study显示文摘 | Wensen SJ Viggiano RW Midthum DE | 2000 | Radiology2000，214，1： | 1 |
| 14 | Automated phase-measuring profilometry using defocused projection of the Rochi grating显示文摘 | Su Xianyu Zhou Wensen Bally G yon | 1992 | Opt Commun1992，94，6： | 1 |
| 15 | A direct mapping algorithm for phase-measuring profilometry显示文摘 | ZHOU Wensen SU Xianyu | 1994 | Journal of Modern Optics1994，41，1： | 1 |
| 16 | Delirium after afractured hip in more than one-third of the patients 显示文摘 | van Wensen R J Dautzenberg PL Koek HK | 2007 | Ned Tijdschr Geneeskd2007，151，10： | 1 |
| 17 | Fast phase-unwrapping algorithm based on gray-scale mask and flood fill 显示文摘 | Asundi A Wensen Z | 1998 | Applied Optics1998，37，23： | 1 |
| 18 | Minimization of thrust fluctuation in moving-magnet permanent-magnet brushless linear DC motors显示文摘 | LUO Honghao WU Jun CHANG Wensen | 2007 | IEEE Transactions on Magnetics2007，43，5： | 1 |
| 19 | Minimization of thrust fluctuation in moving magnet permanent magnet brushless linear DC motors 显示文摘 | Luo Honghao Wu Jun Chang Wensen | 2007 | IEEE Transactions on Magnetics2007，43，5： | 1 |
| 20 | Recent progress on the design and fabrication of micromotors and their biomedical applications显示文摘The advancement in the micro-/nanofabrication techniques has greatly facilitated the development of micromotors.A variety of micromotors have been invented with powerful functions,which have attracted a broad range of interests from chemistry, physics,mechanics,biology and medicine.In this paper,we reviewed recent progress in micromotors and highlighted representative works.The mechanisms of micromotors by internal and external energy sources were described.We described general fabrication strategies of the popular micromotors (wire,tubular,helical and Janus)including bottom-up and top-down approaches.In the application section,we primarily focused on the biological applications,such as biological cargo delivery, biosensing and surgery.At last,we discussed the current challenges and provided future prospects. | Wensen Jiangl Liang Ma Xiaobin Xul | 2018 | Bio-Design and Manufacturing2018，1，4： | 1 |
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