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| 1 | Nasopharyngeal carcinoma:Advances in genomics and molecular genetics显示文摘Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution,being of high prevalence in southern China but rare in other parts of the world [2]. | ZENG ZhaoYang HUANG HongBin ZHANG WenLing XIANC Bo ZHOU Ming ZHOU YanHong MA Jian YI Mei LI XiaYu LI XiaoLing XIONG Wei LI GuiYuan | 2011 | Science China(Life Sciences)2011，54，10： | 13 |
| 2 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 3 | Production of gasoline range hydrocarbons from methanol on hierarchical ZSM-5 and Zn/ZSM-5 catalyst prepared with soft second template显示文摘Nano hierarchical mesoporous ZSM-5 catalysts were prepared with cationic dimethyldiallyl ammonium chloride acrylamide copolymer(PDDA) as a soft second template. Using ZSM-5 catalyst as a matrix,Zn/ZSM-5 catalysts were also obtained by the wet impregnation method. The effect of the PDDA amount and Zn loadings on the properties of the catalysts,including crystallinity,morphology,textural properties,acid nature and catalytic activity in MTG reaction,was investigated by XRD,FESEM,TEM,Nitrogen adsorption–desorption isotherms and NH3-TPD method,respectively. The MTG reaction was performed in a fixed bed reactor,and the result revealed that the nano hierarchical ZSM-5 catalyst prepared with a PDDA/Si molar ratio of 0.070 possesses longer stable phase of 70 h with a liquid hydrocarbon selectivity of 29.8%.Zn/ZSM-5 catalyst with a Zn/ZSM-5 ratio of 0.07 wt.% shows the highest liquid hydrocarbon selectivity,reaching 62.5%. | Xiaodong Wang Xiaoxia Gao Mei Dong Hongbin Zhao Wei Huang | 2015 | Journal of Energy Chemistry2015，24，4： | 4 |
| 4 | Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population显示文摘The purpose of this study was to assess the relationship between arterial stiffness,as measured by brachial-ankle pulse wave velocity(baPWV),and the presence of the metabolic syndrome(MS)in a Chinese population.A total of 4,445 subjects were enrolled.The prevalence of MS in our study population was 21.7%,17.2%and 25.6%for the general population,males and females,respectively.With adjustments for age,gender,cigarette smoking,heart rate,total cholesterol,low-density lipoprotein(LDL)cholesterol,and the use of anti-hypertensive drug,the stepwise regression analysis showed that baPWV had a significant relationship with components of MS,including systolic blood pressure(P<0.001),diastolic blood pressure(P<0.001),glucose(P<0.001),highdensity lipoprotein(HDL)cholesterol(P=0.04),and triglycerides(P<0.001),but no relationship with waist circumference(P=0.25).With an increase in the number of the MS components,baPWV increased significantly both in women and men.This study indicated that the MS is indeed a risk factor for arterial stiffness.Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease. | Fang Zhou Haifeng Zhang Wenming Yao Hongbin Mei Dongjie Xu Yanhui Sheng Rong Yang Xiangqing Kong Liansheng Wang Jiangang Zou Zhijian Yang Xinli Li | 2014 | The Journal of Biomedical Research2014，28，4： | 1 |
| 5 | Influence of sea-land breeze on the formation and dissipation of severe dense fog and its burst reinforcement in the Yellow Sea coastal area,China显示文摘Based on the global reanalysis data of the National Centers for Environmental Prediction(NCEP)/National Center for Atmospheric Research,the surface meteorological observation data,sounding data and satellite observation data,this paper comprehensively analyzes the evolution process and formation mechanism of a persistent severe dense fog process occurred on February 15–17,2015 in Yancheng,eastern China.Through the numerical simulation experiment of Weather Research and Forecast(WRF)model,we further analyze the impact of sea-land breeze on the formation and burst reinforcement of fog.Results show that the precipitation caused by the southwesterly airflow in front of the upper-level trough and the low-pressure inverted trough are conducive to the formation of early rain fog,while the nighttime clear radiance under the control of surface cold high and the infiltration of weak cold advection are conducive to the formation and development of later radiation-advection fog.The WRF model simulates the fog evolution process,which is basically consistent with the actual fog area,and the simulation results are credible to a certain extent.The simulation results show that the establishment of sea breeze has an advection cooling effect on the near surface layer,which is conducive to the formation and development of the inversion layer on the near surface,providing stable stratification conditions for the formation and burst reinforcement of fog.On one hand,the strengthening of sea breeze circulation can continuously transport water vapor to the study area.On the other,the occurrence of ultra-low level jet is favorable for the accumulation of low-level water vapor.At the same time,the inversion intensity further strengthens,which is in favor of the burst reinforcement and long-term maintenance of fog. | Ya GAO Duanyang LIU Shuqi YAN Wenjun ZHOU Hongbin WANG Fan ZU Qin MEI Chuanxiang YI Ye SHENG | 2024 | Science China Earth Sciences2024，67，2： | 0 |
| 6 | POE enhanced stabilities of CsPbX_(3)(X=Br,Ⅰ)perovskite and their white LED application显示文摘Perovskite has received extensive attention due to its excellent properties, just like photoelectric, while the instability has always troubled us to the wide application of perovskite materials. Herein, we proposed to use SiO_(2)and POE to encapsulate perovskite nanocrystals(PNCs). In this work, we have successfully prepared a series of perovskite composite materials and films with different concentration ratios.Due to the protection of POE, the luminous intensity of CsPbBr_(3)@POE composite film remained above 90% after stayed in the water for 42 days. The lead concentration of CsPbBr_(3)@POE composite film was 0.8 μg/m L after 48 h of immersing in deionized water. Namely, packaging PNCs in POE could effectively prevent Pb from overflowing reduce Pb pollution. Besides, the composite films showed a wide colour gamut with 117% of NTSC colour gamut, which shows that this composite material has a development prospect in the WLED field. | Enrou Mei Jiaming Li Qingyun He Yao Tong Ruowang Liu Hongbin Fan Xiaojuan Liang Weidong Xiang | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
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