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| 1 | APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES显示文摘Objective To assess the efficacy and safety of lornoxicam, one non-steroidal anti-inflammatory drug (NSAID) in patient-controlled analgesia (PCA) in patients undergoing abdominal surgeries. Methods Thirty-nine patients scheduled for abdominal surgeries were randomly assigned to different PCA treatment groups using either lornoxicam or fentanyl postoperatively. Pain intensity difference (PID) and sum of pain intensity difference (SPID) were used to assess the analgesic efficacy of both drugs during a 24-hour period. Results The analgesic efficacy of lornoxicam is 1/66 of fentanyl, which was shown by SPID value of 3.250 and 3.058, respectively (P > 0.05). Lornoxicam caused fewer adverse events than fentanyl (33% vs. 68%, P < 0.05). Conclusion In clinic, we can use lornoxicam to treat postoperative pain effectively and with less adverse reactions com-pared with fentanyl. | HongZhao Tie-huYe Zhi-yiGong YangXue Zhang-gangXue Wen-qiHuang | 2005 | Chinese Medical Sciences Journal2005，20，1： | 26 |
| 2 | THE DYNAMIC BEHAVIORS OF VISCOELASTIC PIPE CONVEYING FLUID WITH THE KELVIN MODEL显示文摘Based on the differential constitutive relationship of linear viscoelastic material,a solid-liquidcoupling vibration equation for viscoelastic pipe conveying fluid is derived by the D’Alembert’s principle.Thecritical flow velocities and natural frequencies of the cantilever pipe conveying fluid with the Kelvin model(flutter instability)are calculated with the modified finite difference method in the form of the recurrence for-mula.The curves between the complex frequencies of the first,second and third mode and flow velocity ofthe pipe are plotted.On the basis of the numerical calculation results,the dynamic behaviors and stability ofthe pipe are discussed.It should be pointed out that the delay time of viscoelastic material with the Kelvinmodel has a remarkable effect on the dynamic characteristics and stability behaviors of the cantilevered pipeconveying fluid,which is a gyroscopic non-conservative system. | Wang Zhongmin Zhao Fengqun Feng Zhenyu Liu Hongzhao | 2000 | Acta Mechanica Solida Sinica2000，13，3： | 12 |
| 3 | The temporal and spatial distribution of ancient rice in China and its implications显示文摘The relics of ancient rice have been regarded as the most important objective evidence of the origina- tion and spread of rice cultivation.Based on the records of 280 rice relics sites and the rice cropping regionalization as well as the distribution map of paddy soils,the current study compiled the temporal and spatial distribution map of ancient rice distribution in China.The map shows that the distribution of ancient rice is spatially extensive and meantime comparatively concentrated,temporarily covering a long and relatively continuous time-span.The rice relics in the Central China double and single rice cropping regions are among the earliest and the most abundant ones,possessing continuity in time sequence.Combined with the discovery of ancient rice and paddy filed relics,soil micromorphology, pollen combination and element geochemistry,it is suggested that Central China was the origin center of rice cultivation in China.Rice had been spread to the rest part of China in three major waves,also to the East Asian part like Korea and Japan.The temporal and spatial distribution of ancient rice reflects the past environmental change,which is also meaningful to the current rice regionalization and plan- ning as well as food security in China. | GONG ZiTong CHEN HongZhao YUAN DaGang ZHAO YuGuo WU YunJin ZHANG GanLin | 2007 | Chinese Science Bulletin2007，52，8： | 11 |
| 4 | Optimum Design for Shrink-fit Multi-layer Vessels under Ultrahigh Pressure Using Different Materials显示文摘Multi-layer pressure vessels are widely used in every field of high pressure technology.For the purpose of enhancing a vessels' load bearing capacity,a beneficial process like shrink-fit is usually employed.However,few documents on optimum design for multi-layer shrink-fit vessels made of different strength materials can be found,available data are mainly on two-layer vessels.In this paper,an optimum design approach is developed for shrink-fit multi-layer vessels under ultrahigh pressure by using different materials.Maximum shear stress theory is applied as design criteria.The inner and outer radii of a multi-layer vessel,as well as the material of each layer,are assumed to be known.The optimization mathematical model is,thereby,built.Lagrange multipliers method is required to obtain the optimal design formula of wall ratio(ratio of outer to inner radii) of each layer,from which the optimum formulas of shrinkage pressure and radial interference are derived with the superposition principle employed.These formulas are applicable for the optimization design of all multi-layer vessels made of different materials,or same materials.The formulas of the limit working pressure and the contact pressure show that the optimum wall ratio of each layer and limit working pressure are only related to all selected material strength and unrelated to the position of the layer placement in the vessel.However,shrinkage pressure is related to the position of the layer placement in the vessel.Optimization design of an open ended shrink-fit three-layer vessel using different materials and comparisons proved that the optimized multi-layer vessels have outstanding characteristics of small radial interference and are easier for assembly.When the stress of each layer is distributed more evenly and appropriately,the load bearing capability and safety of vessels are enhanced.Therefore,this design is material-saving and cost-effective,and has prospect of engineering application. | YUAN Gexia LIU Hongzhao WANG Zhongrnin | 2010 | Chinese Journal of Mechanical Engineering2010，23，5： | 6 |
| 5 | Inhibitory effects of docetaxel on expression of VEGF, bFGF and MMPs of LS174T cell显示文摘AIM: To study the effects of non-cytotoxJc concentrations of docetaxel on some important angiogenic factors of LS174T Cells.METHODS: The non-cytotoxic concentration of docetaxel and the activity of gelatinase were determined with MTT and gelatin zymography respectively, the expression of VEGF (vascular endothelial growth factor), bFGF (basic fibroblast growth factor), MMP (matrix metalloproteinase) 2 and MMP 9 was investigated with RT-PCR and Western blot.RESULTS: The maximum non-cytotoxic concentration of docetaxel on LS174T Cells was 1.0 ng/ml. Compared with the solvent control group, 0.1, 0.5, 1.0 ng/ml of docetaxel could downregulate the expression of VEGF, bFGF, MMP 2and MMP 9 and suppress the activity of gelatinase.CONCLUSION: Our study suggests that the non-cytotoxic concentrations of docetaxel have strong antiangiogenic activity on LS174T Cells, which suggests docetaxel may be a promising antiangiogenic agent. | Xue-LiangGuo Geng-JinLin HongZhao YangGao U-PingQian San-RongXu Li-NaFu Qingxu Jie-JunWang | 2003 | World Journal of Gastroenterology2003，9，9： | 6 |
| 6 | Expression of 1A6 gene and its correlation with intestinal gastric carcinoma显示文摘AIM: To investigate the expression of 1A6 gene in the lesionsduring the development of intestinal gastric carcinoma.METHODS: One hundred and thirty-six cases of intestinalmetaplasia (IM) from surgical resections and biopsy wereclassified by mucous staining. Expression of 1A6 in all caseswas detected using immunohistochemical S-P method.RESULTS: The positive rates of 1A6in normal and superficialgastritis (SG), severe atrophic gastritis (SAG), type Ⅰ, Ⅱ, ⅢIM, dysplasia (Dys) and intestinal gastric carcinoma (IGC)were 12.2 %, 16.7 %, 7.1%, 22.6 %, 47.8 %, 46.9 % and60.8 %, respectively. A significant difference among typeⅢ IM and SG, SAG, type I and Ⅱ IM was found (P<0.01),the difference between type Ⅲ and Dys, IGC being notsignificant.CONCLUSION: As a new tumor-related gene, expression of1A6 may be an effective parameter to predict the malignanttransformation of precancerous lesion to gastric carcinoma. | Yi-QiangLiu HongZhao TaoNing YangKe Ji-YouLi | 2003 | World Journal of Gastroenterology2003，9，2： | 5 |
| 7 | Role of multiphase scans by multirow-detector helical CT in detecting small hepatocellular carcinoma显示文摘AIM: To evaluate the role of multiphasic scanning by multirow-detector helical CT (MDCT) in detecing small hypervascular hepatocellular carcinoma (SHCC).METHODS: Multiphasic scanning was carried out in 75patients with SHCC with Marconi MX8000 CT scanner. The early arterial phase (EAP), late arterial phase (LAP) and the portal venous phase (PVP) scans were started at 21 s, 34 s and 85 s respectively. The mean difference of CT values between tumor and liver parenchyma for each scanning phase was measured, and the sensitivity of detection of SHCC in each of these phases and in the combined phase was calculated and statistically analyzed.RESULTS: The mean difference of CT values between tumor and liver parenchyma was significant in 71 lesions≥1 cm in three phases (P<0.05). In 91 tumor foci, the detectability of SHCC was 45.1%, 83.5% and 92.3% in EAP, LAP and double arterial phases (DAP), respectively. The early arterial phase plus the portal venous phase and the double arterial phase plus the portal venous phase were 94.5%, 97.8%,respectively. Whereas the detectability in LAP plus PVP and in DAP plus PVP had no statistical difference.CONCLUSION: The utility of faster speed and thinner slice MDCT and multiphase scanning protocol can improve the detectability of hypervascular small hepatocellular carcinoma.Among which LAP is superior to EAP in depicting the lesions. | HongZhao Kang-RongZhou Fu-HuaYan | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 8 | New Re-Os Dating of Auriferous Pyrite from the Suoluogou Large Gold Deposit in Muli County, West Sichuan Province显示文摘The Suoluogou gold depositin Muli County of SichuanProvince is located in the southern section of the Ganzi-Litang suture zone (Fig.la), which is the largest golddeposit discovered in this suture zone in recent years. Atpresent, the exploration of the Suoluogou gold deposit isstill in progress, and the amount of resource is increasing. | NIE Fei LIU Shusheng SHI Meifeng SHI Hongzhao FAN Wenyu | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 4 |
| 9 | Single-cell RNA-seq analysis of testicular somatic cell development in pigs显示文摘Spermatogenesis is the process by which diploid male germ cells propagate and differentiate into haploid flagellated spermatozoa.This highly complicated process is dependent on testicular somatic cells maturation.While the role of these somatic cells in spermatogenesis is relatively well established,knowledge about their development and maturation,particularly at the molecular level,is limited.In this study,we profiled the testicular single-cell transcriptomes of Guanzhong black pigs at the age of 7,30,60,90,and 150 days.Five types of Sertoli cells,five types of Leydig cells,and four types of peritubular myoid cells were identified.Histological analysis revealed the changes in proliferation levels and marker gene expressions,and the prion-like protein gene(PRND)was identified as a novel marker for Sertoli cells.Additionally,integrated analyses of porcine and human datasets revealed similarities between human and pig testicular somatic cells.Overall,the data obtained in this study contribute to the understanding of testicular development in pigs as a model species. | Lingkai Zhang Ming Guo Zidong Liu Ruifang Liu Yi Zheng Taiyong Yu Yinghua Lv Hongzhao Lu Wenxian Zeng Tao Zhang Chuanying Pan | 2022 | Journal of Genetics and Genomics2022，49，11： | 4 |
| 10 | Research on TDM approach of sharing BRT-lane supported by vehicle-infrastructure integration显示文摘In order to increase the availability of the part-time idle bus rapid transit lane(BRT-lane),a time division multiplexing(TDM) method to share BRT-lane with the vehicles besides BRT buses is proposed based on vehicle-road collaboration. The TDM control strategy is established under the circumstance of vehicle-infrastructure integration(VII). The algorithm is given to forecast the segmented BRT travel time. According to the real time traffic information,a comprehensive model is given to estimate the vehicles' lane-changing time from/to the BRTlane to/from its neighbor lane and determine the timing sequence for vehicles collaboration. Finally,the experiment demonstrates that the predicted value of the travel time and lane-changing time is much close to the true value. The control strategy of the vehicles collaboration could promise the non-BRT vehicles to share BRT-lane without disturbing BRT's priority. | Dong Hongzhao Ling Yue Liu Dongxu Guo Mingfei | 2013 | Engineering Sciences2013，11，5： | 2 |
| 11 | Magmatic Hydrothermal Origin of the Wenyu Copper Polymetallic Deposit, Southern Lancangjiang Zone, SW China显示文摘The Wenyu copper polymetallic deposit,with proven reserves of about 0.23 Mt Cu,394 t Ag and0.04 Mt Pb,is located in the central part of the Lancangjiang volcanic rock belt(Fig.1a),which is one of the most potential copper polymetallic exploration areas in SW China.The Wenyu deposit is hosted in the Xiaodingxi Formation | YANG Yongfei FAN Wenyu LUO Maojin SHI Hongzhao | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 2 |
| 12 | Heck Arylation of Acrylonitrile with Aryl Iodides Catalyzed by a Silica-bound Arsine Palladium(0) Complex显示文摘Acrylonitrile reacts with aryl iodides in the presence of tri-n-butylamine and a catalytic amount of a silica-bound arsine palladium(0) complex to afford stereoselectively (E)-cinnamo- nitriles in high yields. | MingZhongCAI HongZHAO RongLiZHANG | 2005 | Chinese Chemical Letters2005，16，4： | 2 |
| 13 | Sirt2 induces C2C12 myoblasts proliferation by activation of the ERK1/2 pathway显示文摘 | Guofang Wu Chengchuang Song Hongzhao Lu Long Jia Gongshe Yang Xin'e Shi Shiduo Sun | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 2 |
| 14 | Paclitaxel formulation with stable sustained-release behavior and its biological safety evaluation显示文摘Biological safety and stable sustained-release of the drug are two crucial issues involved in the formulation of paclitaxel.Focusing on these issues, by using the FDA approved polylactide as carrier material, soybean lecithin as surfactant and maltodextrin as thickener, paclitaxel loaded PLA microspheres were simply prepared by solvent evaporation, thus guaranteeing the biological safety. The introduction of maltodextrin as a thickener aided to a stable sustained-release of paclitaxel. Surface morphology, particle size, drug loading rate, encapsulation efficiency and in vitro drug release behavior were investigated.Biological safety evaluations such as acute toxicity, allergies, hemolysis, skin stimulation and genotoxicity test were also carried out. Results showed that the obtained microspheres were biocompatible and could release paclitaxel at a desirable constant rate.Therefore, the simply prepared paclitaxel formulation with good biological safety and desirable release behavior exhibited great potential of local injection of paclitaxel for the clinical use in the future. | LI XuePing ZHAN Qi QI HongZhao HAN DongLin QIN YaoYao CHEN Ning LONG LiXia ZHAO Jin HOU Xin YUAN XuBo YANG XianJin | 2019 | Science China(Technological Sciences)2019，62，7： | 2 |
| 15 | Anatomic Retroperitoneoscopic Adrenalectomy for Selected Adrenal Tumors >5 cm: Our Technique and Experience显示文摘 | Baojun Wang Xin Ma Hongzhao Li Taoping Shi Dongliang Hu Bin Fu Bin Lang Guangfu Chen Xu Zhang | 2011 | Urology2011，，2： | 2 |
| 16 | NON-LINEAR DYNAMIC BEHAVIOR OF THERMOELASTIC CIRCULAR PLATE WITH VARYING THICKNESS SUBJECTED TO NONCONSERVATIVE LOADING显示文摘The non-linear dynamic behaviors of thermoelastic circular plate with varying thickness subjected to radially uniformly distributed follower forces are considered.Two coupled non-linear differential equations of motion for this problem are derived in terms of the transverse deflection and radial displacement component of the mid-plane of the plate.Using the Kantorovich averaging method,the differential equation of mode shape of the plate is derived;and the eigenvalue problem is solved by using shooting method.The eigencurves for frequencies and critical loads of the circular plate with unmovable simply supported edge and clamped edge are obtained.The effects of the variation of thickness and temperature on the frequencies and critical loads of the thermoelastic circular plate subjected to radially uniformly distributed follower forces are then discussed. | WANG Zhongmin GAO Jingbo LIHuixia LIU Hongzhao | 2008 | Chinese Journal of Mechanical Engineering2008，21，5： | 2 |
| 17 | Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis显示文摘Background:Spermatogenesis is the process by which male gametes are formed from spermatogonial stem cells and it is essential for the reliable transmission of genetic information between generations.To date,the dynamic transcriptional changes of defined populations of male germ cells in pigs have not been reported.Results:To characterize the atlas of porcine spermatogenesis,we profiled the transcriptomes of~16,966 testicular cells from a 150-day-old pig testis through single-cell RNA-sequencing(scRNA-seq).The scRNA-seq analysis identified spermatogonia,spermatocytes,spermatids and three somatic cell types in porcine testes.The functional enrichment analysis demonstrated that these cell types played diverse roles in porcine spermatogenesis.The accuracy of the defined porcine germ cell types was further validated by comparing the data from scRNA-seq with those from bulk RNA-seq.Since we delineated four distinct spermatogonial subsets,we further identified CD99 and PODXL2 as novel cell surface markers for undifferentiated and differentiating spermatogonia,respectively.Conclusions:The present study has for the first time analyzed the transcriptome of male germ cells and somatic cells in porcine testes through scRNA-seq.Four subsets of spermatogonia were identified and two novel cell surface markers were discovered,which would be helpful for studies on spermatogonial differentiation in pigs.The datasets offer valuable information on porcine spermatogenesis,and pave the way for identification of key molecular markers involved in development of male germ cells. | Lingkai Zhang Fuyuan Li Peipei Lei Ming Guo Ruifang Liu Ling Wang Taiyong Yu Yinghua Lv Tao Zhang Wenxian Zeng Hongzhao Lu Yi Zheng | 2022 | Journal of Animal Science and Biotechnology2022，13，2： | 2 |
| 18 | Hepatitis B screening, prophylaxis and re‐activation in the era of rituximab‐based chemotherapy显示文摘 | JorgeMéndez‐Navarro Kathleen E.Corey HuiZheng Lydia L.Barlow Jae YoungJang WenyuLin HongZhao Run‐XuanShao Steven L.McAfee Raymond T.Chung | 2011 | Liver International2011，，3： | 2 |
| 19 | 显示文摘 | Zhang Zhongming Guo Xuefeng Liu Hongzhao | 2003 | Transactions of Materials and Heat Treatment2003，24，2： | 1 |
| 20 | Changes inbacterial CO2 fixation with depth in agricultural soils显示文摘 | WU Xiaohong GE Tida YUAN Hongzhao | 2014 | Appl Microbiol Biotechnol2014，98，： | 1 |
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