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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control显示文摘The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. | WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin | 2014 | Science China Earth Sciences2014，57，1： | 106 |
| 3 | Incidence and mortality of stomach cancer in China,2014显示文摘Objective: In this study,we aimed to estimate the updated incidence and mortality rate of stomach cancer based on the cancer registration data in 2014,collected by the National Central Cancer Registry of China(NCCRC).Methods: In 2017,339 registries' data were qualified based on the criteria of data quality control of the NCCRC.Cases of stomach cancer were retrieved from the national database.We estimated numbers of stomach cancer cases and deaths in China using age-specific rates and corresponding national population stratified by area,sex,agegroup(0,1–4,5–9,10–14,…,85+).Chinese standard population in 2000 and Segi's world population were applied for age-standardized incidence and mortality rates.Results: In 2014,410,400 new stomach cancer cases and 293,800 cancer-associated deaths were estimated to have occurred in China.The crude incidence rate of stomach cancer was 30.00/100,000,age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 19.62/100,000 and19.51/100,000,respectively.The crude mortality rate of stomach cancer was 21.48/100,000,age-standardized mortality rates by Chinese(ASMRC) and by world standard population(ASMRW) were 13.44/100,000 and13.30/100,000,respectively.Incidence and mortality rates in rural areas were both higher than that in urban areas.Stomach cancer has a strong relationship with gender and age.The disease has occurred more frequently among men than women with a male to female ratio of 2.4 for ASIRC.After age group of 40-44 years,incidence rates are substantially higher in men than in women,same pattern was seen for age-specific mortality rates.Conclusions: There is still a heavy burden of stomach cancer in China.The incidence and mortality patterns of stomach cancer show substantial gender and regional disparities.Great effort is needed to provide more accessible health services,sufficient financial resources,and adequate cancer-care infrastructure for the Chinese population,especially for people living in rural areas. | Lei Yang Rongshou Zheng Ning Wang Yannan Yuan Shuo Liu Huichao Li Siwei Zhang Hongmei Zeng Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，3： | 114 |
| 4 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 5 | Mechanisms simultaneously regulate smooth muscle proliferation and differentiation显示文摘Vascular smooth muscle cell(VSMC) differentiation and proliferation are two important physiological processes during vascular development.The phenotypic alteration from differentiated to proliferative VSMC contributes to the development of several major cardiovascular diseases including atherosclerosis,hypertension,restenosis after angioplasty or bypass,diabetic vascular complications,and transplantation arteriopathy.Since the VSMC phenotype in these pathological conditions resembles that of developing VSMC during embryonic development,understanding of the molecular mechanisms that control VSMC differentiation will provide fundamental insights into the pathological processes of these cardiovascular diseases.Although VSMC differentiation is usually accompanied by an irreversible cell cycle exit,VSMC proliferation and differentiation occur concurrently during embryonic development.The molecular mechanisms simultaneously regulating these two processes,however,remain largely unknown.Our recent study demonstrates that cell division cycle 7,a key regulator of cell cycle,promotes both VSMC differentiation and proliferation through different mechanisms during the initial phase of VSMC differentiation.Conversely,Krüppel-like factor 4 appears to be a repressor for both VSMC differentiation and proliferation.This review attempts to highlight the novel role of cell division cycle 7 in TGF-β-induced VSMC differentiation and proliferation.The role of Krüppel-like factor 4 in suppressing these two processes will also be discussed. | Ning Shi Shi-You Chen | 2014 | The Journal of Biomedical Research2014，28，1： | 45 |
| 6 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 7 | Fuzzy interface treatment in Eulerian method显示文摘In this paper, we incorporate fuzzy mathematics approach into the Eulerian method to simulate three dimensional multi-material interfaces. In particular, we propose a fuzzy interface treatment for describing interfaces, designing transport plans, and computing transport quantities. Using a set of three-dimensional inviscid isothermal elastic-plastic hydrodynamic equations, we simulate shaped charge jet in different filled dynamite structures. Strain and stress have been under consideration in simulations. Numerical results demonstrate that the fuzzy interface treatment is correct and efficient for three-dimensional multi-material problems. | NING Jianguo1 & CHEN Longwei1,2 1. National Key Laboratory of Protection and Control of Explosive Disaster, Beijing Institute of Technology, Beijing 100081, China 2. The Faculty of Land Resource Engineering, Kunming University of Science and Technology, Kunming 650093, China Correspondence should be addressed to Ning Jianguo | 2004 | Science China(Technological Sciences)2004，47，5： | 40 |
| 8 | Effect of drug treatment on hyperplastic gastric polyps infected with Helicobacter pylorh A randomized, controlled trial显示文摘瞄准:为了学习,增生的胃的息肉上的药物疗法的效果与 Helicobacter 感染了 pylori (H pylori ) 。方法:有感染 H pylori 的增生的胃的息肉(在直径的 3-10 公里)的 48 个病人随机被分到一个治疗组( n = 24 )它收到了质子泵禁止者( omeprazole 或 lansoprazole ), clarithromycin ,枸橼酸铋和 tinidazole ,并且控制组织( n = 24 )它收到了胃粘膜( tepretone )的保护的代理人。病人们在注册和 1-12 瞬间术后疗法前定期经历了内视镜检查法和 H pylori 检查。结果:在治疗的 22 个病人组织, 21 在控制组织完成了全部测试协议。在治疗组,息肉消失了 1-12 瞬间(平均, 6.5+/-1.1 瞬间) 在在 22 中的 15 个的治疗以后,病人(68.2%) 和 H pylori 感染在 22 个病人(86.4%) 中的 19 个被根除。然而,在学习,在息肉的没有变化或 H pylori 地位以后的 12 个月在任何控制((b) P<0.01 ) 被看见。结论:最增生的胃的息肉消失在 H pylori 的根除以后。 | Feng Ji Zi-Wei Wang Jian-Wen Ning Qun-Yan Wang Jian-Yong Chen You-Ming Li | 2006 | World Journal of Gastroenterology2006，12，11： | 38 |
| 9 | Fundus artery occlusion caused by cosmetic facial injections显示文摘 | Chen Yanyun Wang Wenying Li Jipeng Yu Yajie Li Lin Lu Ning | 2014 | Chinese Medical Journal2014，，8： | 35 |
| 10 | Widespread Whole Genome Duplications Contribute to Genome Complexity and Species Diversity in Angiosperms显示文摘基因复制为产生新奇功能提供进化潜力,当 polyploidization 或整个染色体复制(WGD ) 开始加倍染色体并且导致百~千个保留的副本时。WGD 被通常在优核质的许多充满种类的系发现的证据强烈支持,并且因此在种类多样化被看作一个主要驱动力。我们执行了 59 公共 genomes/transcriptomes 和盖住被子植物的主要的系的 46 最新定序的 transcriptomes 的比较 genomic 和 phylogenomic 分析 ? 由调查几万个基因家谱检测大规模基因复制事件。这些分析证实了大多数以前报导的 WGD 并且在许多系为新奇的提供了充分证据。检测 WGD 与约 2160 万年的估计的半衰期在进化期间支持了指数的基因损失的一个模型,并且与两个被相关有多样化的高度和全球气候的时期的系的出现变化。新数据集和分析 ? 检测了广泛地在支持被子植物放射并且提高他们的改编到环境变化为 WGD 的角色在被子植物进化,在必要细胞的新陈代谢的基因功能的揭开的优先的保留,和提供的线索期间散布的许多新奇 WGD。 | Ren Ren Haifeng Wang Chunce Guo Ning Zhang Liping Zeng Yamao Chen Hong Ma Ji Qi | 2018 | Molecular Plant2018，11，3： | 35 |
| 11 | Insomnia is associated with increased mortality in patients with first-ever stroke:a 6-year follow-up in a Chinese cohort study显示文摘Objective Insomnia is a highly prevalent disorder among patients suffering from stroke.The association between insomnia and stroke mortality is less studied,particularly using the latest diagnostic criteria.The current study examined the relationship between insomnia and mortality among patients with first-evonal hazard models were used to calculate HRs for stroke er stroke in China.Methods Patients with acute cerebrovascular diseases(stroke)were recruited from 56 hospitals in China's Mainland.Insomnia was defined as difficulty falling asleep,or difficulty staying asleep or waking up early,for at least two consecutive visits.Demographic data,medical history and clinical data were collected.Four follow-up visits occurred within the first year after stroke,and the last follow-up call was conducted 6 years later.Cox proportional hazard models were used to calculate HRs for stroke mortality.results Insomnia was reported by 38.4%(489/1273)of patients at baseline.During the 6 years of follow-up,after adjusting for all confounders,insomnia was found to be associated with increased mortality(HR=1.66,95%CI 1.10 to 2.48).Old age(HR=1.08,95%CI 1.06 to 1.10),stroke recurrence in the first year of follow-up(HR=2.53,95%CI 1.48 to 4.31)and stroke survivors with hypertension(HR=1.62,95%CI 1.04 to 2.53)had substantially higher risk of mortality.Conclusions Besides old age,stroke recurrence in the first year of follow-up and hypertension,insomnia is associated with increased risk of mortality in patients with first-ever stroke in China.More studies about prompt and efficient interventions for insomnia are expected in the future.Trial registration number rctn62169508. | Li-Jun Li Yang Yang Bo-Yuan Guan Qi Chen An-Xin Wang Yong-Jun Wang Ning Zhang Chun-Xue Wang | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 12 | Toll-like receptor 7 and 9 expression in peripheral blood mononuclear cells from patients with chronic hepatitis B and related hepatocellular carcinoma显示文摘现在的学习的目的是调查像使用费的受体( TLR )的表示 7 和 9 在外部血有长期的肝炎 B ( HBV )感染和相关肝细胞 carcinoma.Methods 的病人的单音的原子房间( PBMC ):学习组与长期的肝炎由 52 patients:41 组成 B 和 11 健康控制。 TLR7 和 TLR9 的蛋白质和 mRNA 层次用即时 PCR 被评估,西方的污点分析,并且流动 cytometry.We 也检测了浆液在病人的 HBV 的病毒的负担并且分析了在 HBV-DNA 拷贝和 TLR expression.Results 之间的关联:我们的结果与控制相比在所有 HBV 感染组表明了更低的 TLR7 表情。我们发现 HBV 感染与健康的组相比导致了 TLR9 mRNA,而是 TLR9 蛋白质的增加的表情的减少的表情。TLR 蛋白质层次与浆液 HBV-DNA 有关(P < 0.01 ).Conclusion : 在蛋白质水平在感染 HBV 的病人,而是增加的 TLR9 表情的 PBMC 有在 TLR7 表示和 TLR9 mRNA 的规定下面的。 | Ning XU Hang-ping YAO Zhen SUN Zhi CHEN | 2008 | Acta Pharmacologica Sinica2008，29，2： | 31 |
| 13 | Contemporary crustal movement of continental China obtained by global positioning system(GPS) measurements显示文摘We obtain a unified horizontal velocity field of continental China and vicinity through measurements at 81 GPS stations provided by the National Key Infrastructure Project, Crustal Movement Observation Network of China. The velocity field delineates patterns of movements and deformation of active crustal blocks in continental China under the Eurasia-fixed reference frame. The space-based geodesy also clearly shows for the first time the horizontal movementand deformation of continental China induced by indentation of the Indian plate. The data provide kinematic constraints for simulating dynamic process of continental litho-spheric deformation. | MA Zongjin, CHEN Xinlian, YE Shuhua, LAI Xian, WEI Ziqing, CHEN Junrong, NING Jinsheng, XU Huoze & DING Guoyu1. Insitute of Geology, China Seismological Bureau, Beijing 100029, China (e-mail: disgroup@publi.bta.net.cn)2. Center for Analysis and Prediction, China Seismological Bureau, Beijing 100036, China 3. Shanghai Astronomic Observatory, Chinese Academy of Sciences, Shanghai 200030, China 4. Institute of Seismology, China Seismological Bureau, Wuhan 430077, China 5. Institute of Survey and Mapping, Xi’an 710054, China 6. National Bureau of Survey and Mapping, Beijing 100830, China 7. Wuhan University, Wuhan 430077, China 8. Institute of Geodesy and Geophysics, Wuhan 430077, China 9. China Seismological Bureau, Beijing 100036, China | 2001 | Chinese Science Bulletin2001，46，18： | 34 |
| 14 | Variation of Cd concentration in various rice cultivars and derivation of cadmium toxicity thresholds for paddy soil by species-sensitivity distribution显示文摘It is imperative to derive an appropriate cadmium(Cd) health risk toxicity threshold for paddy soils to ensure the Cd concentration of rice grains meet the food safety standard. In this study, 20 rice cultivars from the main rice producing areas in China were selected, and a pot-experiment was conducted to investigate transformation of Cd in paddy soil-rice system with 0(CK), 0.3 mg kg–1(T1) and 0.6 mg kg–1(T2) Cd treatments in greenhouse. The results showed that Cd concentrations of rice grains existed significant difference(P<0.05) in 20 rice cultivars under the same Cd level in soil. The Cd concentrations of rice grains of the CK, T1 and T2 treatments were in the range of 0.143–0.202, 0.128–0.458 and 0.332–0.806 mg kg–1, respectively. Marked differences of the ratios of Cd concentration for soil to rice grain(BCFs) and transfer factors(TFs, root to grain and straw to grain) among the tested cultivars were observed in this study. The bioconcentration factors(BCFgrain) and TFs of the 20 rice cultivars were 0.300–1.112 and 0.342–0.817, respectively. The TFs of Cd from straw to grain ranged from 0.366 to 1.71, with significant differences among these 20 rice cultivars. The bioconcentration factors(BCFgrain) and TFs among the 20 rice cultivars ranged from 0.300–1.112 and 0.342–0.817, respectively. The species-sensitivity distribution(SSD) of Cd sensitivity of the rice species could be fitted well with Burr-III(R2=0.987) based on the data of BCFs. The toxicity threshold of Cd derived from SSD for the paddy soil was 0.507 mg kg–1 in the present study. | SONG Wen-en CHEN Shi-bao LIU Ji-fang CHEN Li SONG Ning-ning LI Ning LIU Bin | 2015 | Journal of Integrative Agriculture2015，14，9： | 33 |
| 15 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 16 | Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis显示文摘AIM: To evaluate whether Helicobacter pylori(H. pylori) eradication therapy benefits patients with functional dyspepsia(FD).METHODS: Randomized controlled trials(RCTs) investigating the efficacy and safety of H. pylori eradication therapy for patients with functional dyspepsia published in English(up to May 2015) were identified by searching Pub Med, EMBASE, and The Cochrane Library. Pooled estimates were measured using the fixed or random effect model. Overall effect was expressed as a pooled risk ratio(RR) or a standard mean difference(SMD). All data were analyzed with Review Manager 5.3 and Stata 12.0.RESULTS: This systematic review included 25 RCTs with a total of 5555 patients with FD. Twenty-three of these studies were used to evaluate the benefits of H. pylori eradication therapy for symptom improvement; the pooled RR was 1.23(95%CI: 1.12-1.36, P < 0.0001). H. pylori eradication therapy demonstrated symptom improvement during long-term follow-up at ≥ 1 year(RR = 1.24; 95%CI: 1.12-1.37, P < 0.0001) but not during short-term follow-up at < 1 year(RR = 1.26; 95%CI: 0.83-1.92, P = 0.27). Seven studies showed no benefit of H. pylori eradication therapy on quality of life with an SMD of-0.01(95%CI:-0.11 to 0.08, P = 0.80). Six studies demonstrated that H. pylori eradication therapy reduced the development of peptic ulcer disease compared to no eradication therapy(RR = 0.35; 95%CI: 0.18-0.68, P = 0.002). Eight studies showed that H. pylori eradication therapy increased the likelihood of treatment-related side effects compared to no eradication therapy(RR = 2.02; 95%CI: 1.12-3.65, P = 0.02). Ten studies demonstrated that patients who received H. pylori eradication therapy were more likely to obtain histologic resolution of chronic gastritis compared to those who did not receive eradication therapy(RR = 7.13; 95%CI: 3.68-13.81, P < 0.00001).CONCLUSION: The decision to eradicate H. pylori in patients with functional dyspepsia requires individual assessment. | Li-Jun Du Bin-Rui Chen John J Kim Sarah Kim Jin-Hua Shen Ning Dai | 2016 | World Journal of Gastroenterology2016，22，12： | 30 |
| 17 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 18 | Overexpression of brain-derived neurotrophic factor in the hippocampus protects against post-stroke depression显示文摘Post-stroke depression is associated with reduced expression of brain-derived neurotrophic factor(BDNF). In this study, we evaluated whether BDNF overexpression affects depression-like behavior in a rat model of post-stroke depression. The middle cerebral artery was occluded to produce a model of focal cerebral ischemia. These rats were then subjected to isolation-housing combined with chronic unpredictable mild stress to generate a model of post-stroke depression. A BDNF gene lentiviral vector was injected into the hippocampus. At 7 days after injection, western blot assay and real-time quantitative PCR revealed that BDNF expression in the hippocampus was increased in depressive rats injected with BDNF lentivirus compared with depressive rats injected with control vector. Furthermore, sucrose solution consumption was higher, and horizontal and vertical movement scores were increased in the open field test in these rats as well. These findings suggest that BDNF overexpression in the hippocampus of post-stroke depressive rats alleviates depression-like behaviors. | Hao-hao Chen Ning Zhang Wei-yun Li Ma-rong Fang Hui Zhang Yuan-shu Fang Ming-xing Ding Xiao-yan Fu | 2015 | Neural Regeneration Research2015，10，9： | 28 |
| 19 | Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction显示文摘In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction(AMTI), we enrolled 27 patients with AMTI and 12 matched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography(PSG) were performed on days 14 and 90 post-stroke. Compared to healthy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3;more sleep-related breathing disorders occurred; and cognitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance,sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients. | Wei Wu Linyang Cui Ying Fu Qianqian Tian Lei Liu Xuan Zhang Ning Du Ying Chen Zhijun Qiu Yijun Song Fu-Dong Shi Rong Xue | 2016 | Neuroscience Bulletin2016，32，4： | 28 |
| 20 | Gaseous elemental mercury concentration in atmosphere at urban and remote sites in China显示文摘在在北京和广州的空气 wasconducted 的气体的元素的水银集中的调查城市, Yangtze 三角洲地区性的地点和中国在 China.High temporalresolved 数据的遥远的大陆人区域的 Mt.Waliguan 的全球 AtmosphereWatch 基线天文台( CGAWBO )用显示出的自动化水银分析器 RA-915+.Results 被获得在 Mt.Waliguan 的 overallhourly 吝啬的 Hg ° 集中是在夏天和 0.6+0.08 ng/m3 inwinter.The 的 1.7+-1.1 ng/m3 在 Yangtze Delt | WANG Zhang-wei CHEN Zuo-shuai DUAN Ning ZHANG Xiao-shan | 2007 | Journal of Environmental Sciences2007，19，2： | 26 |
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