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488篇 您的检索式:作者名="Hodi"
    题名 作者 年代 出处 被引量
1Unique cytologic features of thyroiditis caused by immune checkpoint inhibitor therapy for malignant melanoma显示文摘Blockade of immune checkpoint molecules to reverse cancer-induced immune suppression can improve anti-tumor immune responses in cancer patients.Monoclonal antibodies targeting two such molecules,Programmed cell death protein 1(PD-1)and cytotoxic T-lymphocyte associated protein 4(CTLA-4)have shown clinical benefit in the treatment of advanced malignancies,including metastatic melanoma.Adverse effects of these immune checkpoint inhibitors include immune-related adverse events(irAE),of which one of the most common is autoimmune thyroiditis.Though thyroiditis is increasingly recognized,there are no reports of the pathological findings that occur in immunotherapy-induced thyroiditis.We present a case of immunotherapy-induced thyroiditis demonstrating its unique cytopathologic features.A 51-year-old woman with metastatic melanoma was found to have a suppressed TSH and elevated free thyroxine concentration 14 days after starting treatment with nivolumab(PD-1 antagonist)plus ipilimumab(CTLA-4 antagonist)therapy.A thyroid biopsy was performed based on ultrasound findings and cytopathology revealed unique features including abundant clusters of necrotic cells,lymphocytes and CD163-positive histiocytes.This case reports cytopathologic features found in immune checkpoint inhibitor related thyroiditis.These appear to be unique findings and may help inform future research regarding the pathophysiology and mechanisms of this condition.Trevor E.Angell Le Min Tad J.Wieczorek F.Stephen Hodi 2018Genes & Diseases2018,5,1:13
2Developing a Common Language for Tumor Response to Immunotherapy: Immune-Related Response Criteria Using Unidimensional Measurements显示文摘Mizuki Nishino Anita Giobbie-Hurder Maria Gargano Margaret Suda Nikhil H. Ramaiya F. Stephen Hodi 2013Clinical Cancer Research2013,,14:2
3Enhancing the clinical activity of granulocyte- macrophage colonystimulating factor-secreting tumor cell vaccines显示文摘Jinushi M Stephen Hodi F Dranoff G 2008Immunol Rev2008,222,:1
4Brachial artery vasoreactivity is associated with cross-sectional and longitudinal anatomical measures of atherosclerosis in postmenopausal women with coronary artery disease 显示文摘Gatto NM Hodis HN Liu CR 2008Atherosclerosis2008,196,:1
5The role of carotid arterial intima-medla thickness in predicting clinical coronary events显示文摘Hodis H N Mack W J LaBree L 1998Ann Intern Med1998,128,4:1
6Brachial artery vasoreactivity is associated with cross-sectional an6 lon- gitudinal anatomical measures of atherosclerosis in post- menopausal women with coronary artery disease显示文摘Gatto N M Hodis H N Liu C R 2008Atherosclerosis2008,196,2:1
7Improved survival with ipilimumab in patients with metastatic melanoma显示文摘HODI F S O'DAY S J MCDERMOTT D F 0,,08:1
8Safety, activity, and immune correlates of anti-PD-1 antibody in cancer显示文摘Topalian SL Hodi FS Brahmer JR 2012N Engl J Med2012,366,26:1
9Highly recurrent TERTpromoter mutations in human melanoma显示文摘Huang FW Hodis E Xu MJ 2013Science2013,339,6122:1
10Association Between Human Immunodeficiency Virus Infection and Stiffness of the Common Carotid Artery显示文摘Eric C. Seaberg Lorie Benning A. Richey Sharrett Jason M. Lazar Howard N. Hodis Wendy J. Mack Mark J. Siedner John P. Phair Lawrence A. Kingsley Robert C. Kaplan 2010Stroke2010,,10:1
11The role of carotid arterial intima-medical thickness in predicing clinical coronary events 显示文摘Hodis HN Mack WJ LaBree L 1998Ann Intern Med1998,128,4:1
12Synergistic inhibition of LDL oxidation by phytoestrogens and ascorbic acid 显示文摘Hwang J Sevanian A Hodis H N 2000Free Radical Biology & Medicine2000,29,1:1
13Improved survival with ipilimumab in patients with metastatic melanoma 显示文摘Hodi FS O'Day SJ McDermott DF 2010N Engl J Med2010,363,8:1
14A landscape of driver mutations in melanoma显示文摘Hodis E Watson I R Kryukov G V 2012Cell2012,150,2:1
15Improved sur- vival with ipilimumab in patients with metastatic melanoma显示文摘HODI F S O'DAY S J MCDERMOTY D F 2010N Engl J Med2010,363,8:1
16Hypertensive posterior reversible encephalopathy syndrome causing posterior fossa edema and hydrocephalus显示文摘Grossbach AJ Abel TJ Hodis B 2014J Clin Neurosci2014,21,2:1
17Improved survival with ipilimumab in patients with metastatic melanoma 显示文摘HODI F S O' DAY S J MCDERMO33' D F 2010N Engl J Med2010,363,8:1
18Triglyceride and cholesterol - rich lipoproteins have a differential effect on mild/moderate and severe lesion progression as assessed by quantitative coronary angiography in a controlled trial of lovastatin 显示文摘Hodis HN Mack WJ Azen SP 1994Circulation1994,90,:1
19Safety, activity, and immune correlates of anti-PD-1 antibody in cancer显示文摘Topalian SL Hodi FS Brahmer JR 2012N Engl J Med2012,366,26:1
20Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterialsites显示文摘Karim R Hodis HN Detrano R 0,,07:1
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