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| 1 | 云南农村地区50~74岁人群10年缺血性心血管病发病风险预测显示文摘目的了解云南农村地区50~74岁人群缺血性心血管病(ICVD)危险因素的暴露情况及对未来10年的患病风险进行评估,为云南农村地区ICVD的防治提供科学依据。方法采用随机分层整群抽样的方法,抽取云南省4个县区11个村中50~74岁的研究对象611人进行流行病学调查,计算危险因素暴露率,应用“国人ICVD10年发病危险度评估方法”简易模型并进行改良,对其10年ICVD的发病危险度进行评估。结果在该人群中,高血压、超重(或)肥胖、高血脂症、吸烟和糖尿病等危险因素的暴露率分别为30.0%、13.9%、1.6%、48.4%、1.5%。ICVD10年发病绝对危险度极低危、低危、中危、高危及极高危的检出率分别为73.8%、15.2%、6.2%、3.3%和1.5%。绝对危险度〈10%(包括极低危和低危)有544人,占89.03%;≥10%(包括中危、高危及极高危)有67人,占10.97%。男性50~54岁组和女性60~64岁组平均危险度水平低于评估方法提出的平均危险度参考标准,其余组均高于评估方法参考标准。结论云南农村地区50~74岁总体人群心血管疾病危险因素水平较高,10年ICVD发病风险较大,应积极加强对心血管疾病危险因素的干预。 | 马里兰 吴新华 陈章荣 曹慧丽 Detrano RC 杨瑛 董榆 匡时权 李利华 | 2015 | 中华高血压杂志2015，23，2： | 13 |
| 2 | Subclinical atherosclerosis in northern and southern China: the Chinese paradox显示文摘背景冠的心疾病(CHD ) 的发生是更高的在北比在南部的中国,然而,在传统的 CHD 的差别冒险的,解释这。没有学习在可以帮助在发生解释差别的无临床症状的动脉粥样硬化检验了差别。这研究为在北、南部的中国之间的石灰化用冠的计算断层摄影术(CT ) 在无临床症状的动脉粥样硬化检验了这些差别。我们在一个大多中心选择了参加者的一件随机的样品的方法为冠的钙在一个北城市(诺思) 里扫描的进行中的流行病的学习(北京, n = 49 ) 并且在二个南部的城市(南方) 里(上海, n = 50,并且广州, n = 50 ) 。从三个领域中心的参加者(意味着年龄 67 年) 经历了用动脉粥样硬化扫描的多种族的学习为冠的钙测量扫描的冠的风险因素评估和心脏的 CT 协议。结果调整了在诺思中国(北京) 的转变木头的冠的动脉钙 20 是 3.1 +/-0.4 并且在华南(上海和广州) 是 2.2 +/- 0.3 (P = 0.04 ) 。为北京的北城市的吝啬的钙分数比广州的南部的城市的高三倍(P = 0.01 ) 并且比为上海的南部的城市高 2.5 倍(P = 0.03 ) 。结论无临床症状的动脉粥样硬化的程度在广州和上海的二个南部的城市里比那在北京的北城市里是显著地更高的,甚至在为标准心脏的风险因素调整以后。这发现建议标准风险因素充分不在临床的 CHD 发生解释北方南方差别。 | Jie Huang Yang-Feng Wu Xiao-Qing Liu Ding Ding Lian-Cheng Zhao Bin Lu Xian Li Nathan D Wong Laurie D Dustin Stanley P Azen Robert C Detrano | 2011 | Journal of Geriatric Cardiology2011，8，2： | 7 |
| 3 | Effect of age on aortic atherosclerosis显示文摘Objective To examine the association of atherosclerosis burden in the survivors of an asymptomatic elderly cohort study and its relationship to other coronary risk factors (specifically, age) by evaluating aortic atherosclerotic wall burden by magnetic resonance imaging (MRI). Methods A total of 312 participants in an ongoing observational cohort study underwent cardiac and descending thoracic aorta imaging by MRI. Maximum wall thickness was measured and the mean wall thickness calculated.Wall/outer wall ratio was used as a normalized wall index (NWI) adjusted for artery size difference among participants. Percent wall volume (PWV) was calculated as NWI ×100.Results In this asymptomatic cohort (mean age: 76 years), the mean (SD) aortic wall area andwall thicknesswere 222 ±45 mm2 and 2.7 ±0.4 mm, respectively. Maximum wall thickness was 3.4 ±0.6 mm, and PWV was 32% ±4%. Women appeared to have smaller wall area,but after correcting for their smaller artery size, had significantly higher PWV than men (P = 0.03). Older age was associatedwith larger wall area (P = 0.04 for trend) with similar PWVs. However, there were no statistically significant associations between standard risk factors,Framingham global risk, or metabolic syndrome status, therapy for cholesterol or hypertension, coronary or aortic calcium score, and the aortic wall burden. Aortic calcificationwas associated with coronary calcification. Conclusions Asymptomatic elderly in this cohort had a greater descending thoracic aortic wall volume that correlated with age, andwomen had a significantly increased PWV compared to men. In these survivors, the atherosclerotic aortic wall burden was not significantly associated with traditional risk factors or with coronary or aortic calcium scores or coronary calcium progression. Results suggest that age, or as yet unidentified risk factor(s), may be responsible for the increase in atherosclerosis. | Michael A. Chen Miwa Kawakubo Patrick M. Colletti Dongxiang Xu Laurie LaBree Dustin Robert Detrano Stanley P Azen Nathan D. Wong Xue-Qiao Zhao | 2013 | Journal of Geriatric Cardiology2013，10，2： | 6 |
| 4 | 云南农村自然人群冠状动脉钙化与脉压差的关系显示文摘目的:在了解云南农村自然人群冠状动脉钙化及冠状动脉钙化积分(CACS)的分布情况的基础上,进一步探讨冠状动脉钙化及CACS与脉压差的关系。方法:对云南农村自然人群进行随机分层整群抽样,采用16排螺旋计算机断层摄影术(CT)对212名受试者进行冠状动脉扫描,评估冠状动脉钙化程度,并应用Agatston积分法计算冠状动脉钙化积分,按性别、年龄、钙化积分等分组,比较各组间脉压差,探讨冠状动脉钙化及CACS与脉压差相关性。结果:51~60岁组的平均脉压差为(44.67±13.87)mmHg(1mmHg=0.133kPa),61~71岁年龄组平均脉压差为(50.00±17.44)mmHg,差异有统计学意义(P=0.015),且发现脉压差与年龄呈正相关(rs=0.202,P=0.003)。按CACS分组,CACS≥100组的平均脉压差[(55.22±18.79)mmHg]大于CACS〈I组[(46.87±15.46)mmHg]和1≤CACS〈100组[(45.20±15.89)mmHg],差异有统计学意义(P〈0.05)。CACS≥100组的脉压差增大的患者比例(47.1%)同样大于CACS〈1组(17.3%)和1≤CACS〈100组(15.2%),差异有统计学意义(P〈0.05)。在冠状动脉钙化阳性受试者中采用Spearman秩相关分析脉压差与CACS的相关性,结果显示脉压差与CACS呈正相关(相关系数rs=0.282),相关性有统计学意义(P=0.047),且在考虑年龄、胆固醇等混杂因素后仍存在正相关关系(回归系数B=0.887)。结论:云南省农村自然人群的冠心病危险因素脉压差与CACS有关,在冠状动脉钙化者中CACS随脉压差的增大而增大。 | 王议 吴新华 杨瑛 陈章荣 欧阳天昭 匡时权 董瑜 李利华 吕滨 曹慧丽 Robert Detrano | 2014 | 中国循环杂志2014，29，6： | 5 |
| 5 | Metabolic syndrome and coronary artery calcification: a community-based natural population study显示文摘 | CAO Hui-li CHEN Xiong-biao LU Jin-guo HOU Zhi-hui TANG Xiang GAO Yang YU Fang-fang JIANG Shi-liang ZHAO Lian-cheng LI Ying Matthew J Budoff Robert Detrano LU Bin | 2013 | Chinese Medical Journal2013，，24： | 4 |
| 6 | 云南农村自然人群冠状动脉钙化情况的调查研究显示文摘目的观察云南农村自然人群冠状动脉钙化及冠状动脉钙化积分情况。方法对云南农村自然人群进行单纯随机抽样,采用16排螺旋CT对174例研究对象进行冠状动脉扫描,计算冠状动脉钙化,并应用Agatston积分法计算钙化积分,观察冠状动脉钙化及钙化积分的分布特征,按性别、年龄、种族进行分组,比较组间钙化率及钙化积分的差别。结果 174例入选研究对象中39例发现钙化(阳性率22.4%)及钙化积分≥1。51~60岁组、61~71岁组钙化阳性率分别为15.5%、34.4%,钙化积分分别为11.2±52.4、38.0±82.0。钙化阳性率及钙化积分在不同年龄组间有显著性差异(P<0.05),而在性别和种族之间无显著性差异。冠状动脉钙化阳性率为前降支>回旋支=右冠状动脉>左主干。结论云南农村51~71岁自然人群中冠状动脉钙化及钙化积分存在年龄间的差异。钙化发生率最高在前降支,其次为回旋支和右冠状动脉。 | 刘爱波 吴新华 欧阳天昭 曹慧丽 Robert Detrano 陈章荣 匡时权 杨瑛 董瑜 李利华 | 2013 | 中国动脉硬化杂志2013，21，6： | 4 |
| 7 | Active Serum Vitamin D Levels Are Inversely Correlated With Coronary Calcification显示文摘 | Karol E. Watson Marla L. Abrolat Lonzetta L. Malone Jeffrey M. Hoeg Terry Doherty Robert Detrano Linda L. Demer | 1997 | Circulation1997，，6： | 2 |
| 8 | Coronary artery calci-fication compared with carotid intima-media thicknessin the prediction of cardiovascular disease incidence:the Multi-Ethnic Study of Atherosclerosis (MESA)显示文摘 | Folsom A R Kronmal R A Detrano R C O'Leary DH Bild D E Bluemke D A | 2008 | Arch Intern Med2008，168，： | 1 |
| 9 | Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterialsites显示文摘 | Karim R Hodis HN Detrano R | | 0，，07： | 1 |
| 10 | Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence:the Multi-Ethnic Study of Atherosclerosis (MESA) 显示文摘 | Folsom A R Kronmal R A Detrano R C | 2008 | Arch Intern Med2008，168，12： | 1 |
| 11 | The diagnosis accuracy of the exercise electrocardiogra:a analysis of 22 years of research 显示文摘 | Detrano R Frocilicher V | 1989 | Prog Cardiarase Dic1989，32，： | 1 |
| 12 | Computer probability estimates of angiographic coronary artery disease:transportability and comparison with cardiologists estimates显示文摘 | Detrano R Bobbio M Olson H | 1992 | Comput Biomed Res1992，25，5： | 1 |
| 13 | Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)显示文摘 | Bild D E Detrano R Peterson D | 2005 | Circulation2005，111，10： | 1 |
| 14 | Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis(MESA)显示文摘 | Bild DE Detrano R Peterson D | 2005 | Circulation2005，111，10： | 1 |
| 15 | The diagnostic accuracy of the accuracy of the exercise electrocardiogram: a meta analysis of 22 years of research 显示文摘 | Gianrossi R Froelicher V | 1989 | Prog Cardiovasc Dis1989，32，3： | 1 |
| 16 | Prognostic significance of coronary calcific deposits in asymptomatic high-risk subjects显示文摘 | Detrano RC Wong ND Doherty TM | 1997 | Am J Med1997，102，4： | 1 |
| 17 | Incidence and Predictors of Hypertension Among Rural Chinese Adults : Results From Liaoning Province ]显示文摘 | Sun Z Q Zheng L Q Detrano R | 2010 | Annals of Family Medicine2010，8，： | 1 |
| 18 | Coronary artery calcification:pathophysiology,epidemiology,imaging methods,and clinical implications 显示文摘 | Wexler L Brundage B Detrano R | 1996 | Circulation1996，94，5： | 1 |
| 19 | The diangnostic accuracy of the exercise electrocardiogram: a meta-analysis of 22 years of research显示文摘 | Detrano R Frodlicher V | 1998 | Prog Cardiovasc Dis1998，32，3： | 1 |
| 20 | Combined use of computed tomography coronary calcium scores and C - reactive protein levels in predicting cardiovascular events in nondiabetic individuals 显示文摘 | Detrano R Xiang M | 2002 | Circulation2002，106，16： | 1 |
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