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1根据循环乙型肝炎病毒载量预测肝硬化的危险性显示文摘肝硬化是慢性乙型肝炎肝脏炎症和由肝脏炎症引起的肝纤维化的结果。1991~1992年,对3582例未曾接受治疗下预的中国台湾籍乙型肝炎病毒感染者被纳入一项基于人群的前瞻性队列研究。研究起点为血清HBVDNA阳性和超声诊断肝硬化阴性。结果在平均11年的随访期内,3582例病人共随访40038人年,其中365例病人被诊断为肝硬化。Iloeje UH Yang HI Su J 陆伟(摘译) 张占卿(审校) 2006世界感染杂志2006,6,4:202
2慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 2017中华高血压杂志2017,25,11:12
3RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone.Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M 2013中国神经肿瘤杂志2013,11,1:8
4Growth of Large-size Crystal of PbWO4 by Vertical Bridgman Method with Multi-crucibles显示文摘Yang P Liao J Shen B Shao P Hi H Yin Z 2002Journal of Crystal Growth2002,236,:2
5Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level显示文摘Chen CJ Yang HI Su J 0,,:2
6Incidence and determinants of spontaneous hepatitis B surface antigen seroclearance: a community- based foltow-up study 显示文摘Liu J Yang HI Lee MH 2010Gastroenterology2010,139,:1
7Expression of LAG-3 by tumor infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8 + T-cell function in Hodgkin lymphoma patients 显示文摘GANI)HI MK LAMBLEY E DURAISWAMY J 2006Blood2006,108,7:1
8Positive effects of -amyrin on pentobarbital-indueed sleep in mice via GABAergic neurotransmitter system显示文摘Jeon S J Park HI Gao Q 2015Behav Brain Res2015,291,:1
9Side launch excitation of selected modes in graded-index optical fibers 显示文摘Szczepanek P S Berthold HI J W 1978Applied Optics1978,17,20:1
10Lichen planus is as- sociated with human herpesvirus type 7 replication and infiltration of plasmacytoid dendritic cells 显示文摘De Vries HI van Marie J Teunissen MB 2006Br J Dermatol2006,154,2:1
11An admissions OSCE : the multiple mini-interview 显示文摘Eva KW Rosenfeld J Reiter HI 2004Med Edu2004,38,:1
12Acitretin in psoriasis: an overview of adverse effects显示文摘Katz HI Waalen J Leach EE 1999J Am Acad Dermatol1999,41,32:1
13Enhanced Activity of Bismuth-Compounded TiO2 Nanoparticles for Photocatalytieally Degrading Rhodamine B Solution显示文摘Wang J Jing L Q Xne E P et hi 2008Journal of Hazardous Materials2008,,160:1
14Risk of hepatocellular carcinoma aceross a bilological gradient of serum hepatitis B virus DNA level显示文摘Chen CJ Yang HI Su J 2006JAMA2006,295,1:1
15Dosimetric consideration for cathter-based and gamma emitters in the therapy of neointimal hyperplasia in human coronary arteries显示文摘Amols HI Zaider M Weinberger J 1996Int J Radiat Oncol Biol Phys1996,36,:1
16The susceptibility of cerebral endothelial cells to astroglial induction of blood-brain barrier enzymes depends on their proliferative state显示文摘Meyer J Rauh J Galla HI 1991J Neurochem1991,57,6:1
17Visual circle scale (VOS)-a patient-friendly scale to measure pain compared to VAS and Likert scale显示文摘Huber JF Hi islet J Zumstein MD 2007Z Orthop Unfall2007,145,6:1
18An official ATS state- ment: grading the quality of evidence and strength of recommenda- tions in ATS guidelines and recommendations显示文摘Sehttnemann HI Jaesehke R Cook D J 2006Am J Res~ir Crit i Care Mad2006,174,5:1
19Ostegenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis显示文摘Roach HI Aigner T Erenpeisa J 1995J Cell Biol1995,131,3:1
20Challenges in the transvaginal management of abnormal uterine bleeding secondary to cesarean section scar defect显示文摘Wang C J Huang HI Chao A 2011Eur J Obstet Gynecol Reprod Biol2011,154,2:1
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