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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，： | 2 |
| 3 | Venous thromboembolic disease: an obeervational study in medical- surgical intensive care unit patients显示文摘 | Cook D Atria J Weaver B | 2000 | J Crit Care2000，15，： | 2 |
| 4 | 向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。 | Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos | 2016 | Cell Research2016，26，5： | 2 |
| 5 | Corticosteroid treatment for sepsis:a critical appraisal and meta -analysis of the literature显示文摘 | Cronin L Cook D J Carlet J | 1995 | Crit Care Med1995，23，： | 2 |
| 6 | DEA models for supply chain efficiency evaluation显示文摘 | Liang L Feng Y Cook W D Zhu J | 2006 | Annals of Operations Research2006，145，1： | 1 |
| 7 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 8 | Prevention of ventilator associated pneumonia:Current practice in Canadian intensive care units显示文摘 | Heyland D K Cook D J Dodek P M | 2002 | J Crit Care2002，17，3： | 1 |
| 9 | Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis显示文摘 | Haake V Cook D Riechmann J L | 2002 | Plant Physiology2002，130，： | 1 |
| 10 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 11 | Multiple organ dysfunction score:a reliable description of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 12 | Test of the RCS method for preserving low-frequency variability in long tree-ring chronologies显示文摘 | Esper J Cook E D Schweingruber F H | 2003 | Tree-Ring Research2003，59，2： | 1 |
| 13 | Multiple organ dysfunction:baseline and serial component scores显示文摘 | Cook R Cook D Tilley J | 2001 | Crit Care Med2001，29，： | 1 |
| 14 | Nutritional value of dietary nucleic acids to trout显示文摘 | Tacon A G J Cooke D J | 1980 | Nutr Rep Int1980，22，： | 1 |
| 15 | Methodology for antithrombotic and thrombolytic therapy guideline develop- ment: American College of Chest Physicians evidence-based clinical practice guidelines (8th ed) 显示文摘 | Schtinemann H J Cook D Guyatt G | 2008 | Chest2008，133，： | 1 |
| 16 | An official ATS statement:grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations 显示文摘 | Schfinemann H J Jaeschke R Cook D J | 2006 | Am J Respir Crit Care Med2006，174，5： | 1 |
| 17 | Expanded polystyrene beads as lightweight aggregate forconcrete显示文摘 | Cook D J | | 0，，04： | 1 |
| 18 | Grades of Recommendation for Antithrombotic Agents显示文摘 | Guyatt GH Cook D J Jaeschke R | 2008 | Chest2008，133，： | 1 |
| 19 | Nonhuman primate models of stroke for translational neuroprotection research显示文摘 | Cook D J Tymianski M | 2012 | Neurotherapeuties2012，9，2： | 1 |
| 20 | Systematic reviews: synthesis of best evidence for clinical decisions 显示文摘 | COOK D J MULROW C D HAYNES R B | 1997 | Aim Intern Med1997，126，5： | 1 |
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