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| 1 | 根据循环乙型肝炎病毒载量预测肝硬化的危险性显示文摘肝硬化是慢性乙型肝炎肝脏炎症和由肝脏炎症引起的肝纤维化的结果。1991~1992年,对3582例未曾接受治疗下预的中国台湾籍乙型肝炎病毒感染者被纳入一项基于人群的前瞻性队列研究。研究起点为血清HBVDNA阳性和超声诊断肝硬化阴性。结果在平均11年的随访期内,3582例病人共随访40038人年,其中365例病人被诊断为肝硬化。 | Iloeje UH Yang HI Su J 陆伟(摘译) 张占卿(审校) | 2006 | 世界感染杂志2006，6，4： | 202 |
| 2 | 土工格栅加筋土挡土墙设计参数的弹塑性有限元研究显示文摘土工格栅加筋土挡土墙在水利、交通及城建等领域的应用越来越广泛。在模拟日本PWRI原型实验墙的基础上 ,应用弹塑性有限元法研究该种结构的各项设计参数 ,包括土的性质、加筋长度、加筋层间隔以及土体与面板的相互作用特性等。为了能够准确的描述加筋土挡土墙结构的性状 ,应用先进的弹塑性模型模拟墙体各个组成部分 ,其中土体用可以描述土体压力相关特性的广义塑性模型模拟 ,土工格栅应用弹塑性边界面模型模拟 ,而土与结构的相互作用应用可模拟滑移、脱开以及闭合的有厚度薄层滑移单元模拟。通过有限元分析 。 | 刘华北 Ling HI | 2004 | 岩土工程学报2004，26，5： | 55 |
| 3 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 4 | The Effect of Chinese Tea on Occurrence of Esophageal Tumor Induced by N-Nitrosomethylbenzylamine in Rats显示文摘Five groups of rats (40 rats per group) were given five different varieties of Chinese tea (1 g/50 ml) and another two groups of rats (a positive control and a negative control) were given tap water as drinking water. Except for the negative control group, all the animals were intubated with A’-nitrosomethyibenzylamine (NMBzA, 5 mg/kg body wt/week). Half of the animals in each group were sacrificed after 6 weeks and the remaining animals at the end of 12 weeks. The incidences of esophageal mucosa lesions (16-59%) at the end of6 weeks were significantly lower in the tea-treated rats than in the positive control group (100%). The incidences of esophageal tumor at the end of 12 weeks (42-67%) were also significantly lower in the tea-treated groups than in the positive control group (90%). The same phenomenon was found with respect to the size and number of tumors in each tumor-bearing animal. The relative anticarcinogenic effects of the five varieties of Chinese tea were different. The Fujian oolong tea and jasmine tea exhibited the strongest effects. The results suggest that Chinese tea can effectively inhibit the carcinogenesis Caused by an N-nitroso compound. 1990 Academic Press.Inc. | HI AND XU YONG Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, China | 1990 | Biomedical and Environmental Sciences1990，3，1： | 11 |
| 5 | 部分断面掘进机液压系统的可靠性研究显示文摘针对部分断面掘进机液压系统可靠性低、故障较多等问题,根据可靠性基本理论,建立该液压系统的可靠性逻辑框图和可靠度计算模型,结合实例对某型掘进机的液压系统进行可靠度计算和可靠性分析,利用MATLAB进行仿真,获得了各液压子系统的可靠度仿真曲线,并给出提高系统可靠度的措施。 | D Trung Hiêu 李晓豁 唐仁鹏 池青帝 胡延涛 | 2012 | 武汉科技大学学报2012，35，1： | 10 |
| 6 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 7 | The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation显示文摘Among various immunoregulatory molecules,the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy.Antibodies targeting two B7 family co-inhibitory receptors,CTLA-4 and PD-1,have elicited long-term clinical outcomes in previously refractory cancer types and are considered a breakthrough in cancer therapy.Despite the success,the relatively low response rate(20–30%)warrants efforts to identify and overcome additional immune-suppressive pathways.Among the expanding list of T cell inhibitory regulators,V domain immunoglobulin suppressor of T cell activation(VISTA)is a unique B7 family checkpoint that regulates a broad spectrum of immune responses.Here,we summarize recent advances that highlight the structure,expression,and multi-faceted immunomodulatory mechanisms of VISTA in the context of autoimmunity,inflammation,and anti-tumor immunity. | Wenwen Xu TạMinh Hiếu Subramaniam Malarkannan Li Wang | 2018 | Cellular & Molecular Immunology2018，15，5： | 8 |
| 8 | Exploring the deep biosphere显示文摘Over the past two decades, scientific drilling into sediments and rocks in the ocean and the continent has revealed the presence of physiologically and phylogenetically complex microbial life in the deep subsurface. Microorganisms, most of which have no cultured or known relatives in the surface biosphere, have been discovered in sediments and rock at depth as deep as 1 km below the seafloor and more than 3 km deep in the continent. The deep biosphere probably represents the most voluminous part of the global biosphere and may constitute as much as 50% of the Earth’s biomass. In this article, we review the current knowledge of and most recent advances in studying the deep biosphere and suggest directions in future research. | FANG JiaSong1,2 & ZHANG Li3 1 State Key Laboratory of Marine Geology, Tongji University, Shanghai 200092, China 2 College of Natural and Computational Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA 3 State Key Laboratory of Geological Processes and Mineral Resources, Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China | 2011 | Science China Earth Sciences2011，54，2： | 6 |
| 9 | ACADEMIC EXPL ORATION Is It Possible to Stody the Pharmacokinetics of Chemical Componentof Herbal Recipe?显示文摘ACADEMICEXPLORATIONIsItPossibletoStodythePharmacokineticsofChemicalComponentofHerbalRecipe?HuangXi(黄熙);JiangYong-pei(姜永培)andW... | $$$$Huang Xi(黄熙) Jiang Yong-pei(姜永培) and Wen Ai-dong (文爱东)(The Hijing Hospital, The Fourth Military Medical University, Hi’an 710032)Zang Yi-ming (臧益民) and Niu Guo-bao (牛国保)(Department of Physiology, The fourth Military Medical University, | 1995 | Chinese Journal of Integrative Medicine1995，1，4： | 3 |
| 10 | Growth of Large-size Crystal of PbWO4 by Vertical Bridgman Method with Multi-crucibles显示文摘 | Yang P Liao J Shen B Shao P Hi H Yin Z | 2002 | Journal of Crystal Growth2002，236，： | 2 |
| 11 | p27 as a target for cancer therapeutics 显示文摘 | Blain SW Scher HI Cordon-Cardo C | 2003 | Cancer Cell2003，3，2： | 2 |
| 12 | Circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis显示文摘AIM: To examine the association between circulating 25-hydroxyvitamin D [25(OH)D] levels and colorectal adenoma in a case-control study and a meta-analysis. METHODS: We conducted a matched case-control study(112 cases and 112 matched controls) and combined 15 studies, including our study, in a metaanalysis. The study-specific odds ratios(ORs) and 95% confidence intervals(CIs) were pooled using a randomeffects model. In total, 5454 colorectal adenomas and 6656 controls were included in the meta-analysis. RESULTS: In a meta-analysis including 14 previous studies and our study, we observed a significant inverse association between circulating 25(OH)D levels and colorectal adenoma(OR = 0.68; 95%CI: 0.54-0.82) when comparing the highest category with the lowest category. Stratification by adenoma location(proximal or distal adenoma) showed similar estimates. When we stratified by study region, the ORs(95%CIs) were 0.70(0.52-0.88) in the US and 0.66(0.34-0.97) in Asia. CONCLUSION: These data suggest an inverse association between circulating 25(OH) Dlevels and colorectal adenoma in both Western and Asian populations. | Yoon Ji Choi Young Ha Kim Chang Ho Cho Sung Hi Kim Jung Eun Lee | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 13 | Detection of middle cerebral artery emboli during carotid cndarterectomy using transcranial Doppler ultrasonography显示文摘 | Spencer MP Thomus HI Nicholls SC | 1993 | Stroke1993，24，： | 2 |
| 14 | Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level显示文摘 | Chen CJ Yang HI Su J | | 0，，： | 2 |
| 15 | Rb-Sr isotope dating of silicalite from the Dajiangping massive sulfide ore deposit,Guangdong Province显示文摘THE Dajiangping pyrite ore deposit located in the Yunfu County of Guangdong Province is asuper-large pyrite ore deposit. Its age has not been defined so far because of the absence of fos-sil. This note is to use Rb-Sr isotope dating of silicalite to constrain the age of the ore depositand place special emphasis on its geological significance. | Wang, HI Li, HY Wang, YX Wang, HH | 1997 | Chinese Science Bulletin1997，42，23： | 2 |
| 16 | Antithrombotic therapy in patients with mechanical and biological heart valves 显示文摘 | Stein PD Alpert JS Bussey HI | 2001 | Chest2001，119，1： | 2 |
| 17 | Preparation, Characterization of Superacid SO_4^(2-)/ZrO_2-SiO_2 and Its Activity on Catalytic Synthesis of Methyl p-Nitrobenzoate显示文摘Solid superacid SO42-/Zr O2-SiO2 was prepared by dip-impregnation method, and its catalytic activity was tested with esterification of p-nitrobenzoic acid and methanol. The optimum conditions were also found, that is, the molar ratio between silica and zirconia was 10:1, the calcination temperature was 550 ℃ and the soaked consistency of H2SO4 was 1.0 mol?L-1. Under the conditions that the ratio of methanol to acid(m L/g) was 12:1, the amount of catalyst was 0.5 g, the reaction time was 5 h and the stirring speed was 800 r?min-1, the yield of methyl p-nitrobenzoate could reach up to 90.5%. Then the characterizations of cataslyst, including the acidity and types of acidic centers, specific surface area and surface structure was respectively examined by Hammett indicator, in-situ pyridine IR, BET method, FT-IR(KBr), transmission electron microscope(TEM), and X-ray diffraction(XRD). The results showed that the catalyst SO42-/Zr O2-SiO2 was superacid with high specific surface area due to Ho<-12.70. It contained acidic sites of Lewis and BrΦnsted, and its surface structure changed after esterification. The zirconia crystal was mainly tetragonal and silica crystal was not found. | 王刚 TAO Liya HOU Xin CAO Hi DONG Cheng NIE Wo XU Jun 张立庆 | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，5： | 2 |
| 18 | Telomerase as a diagnostic and therapeutic tar-get for cancer显示文摘 | Doyle LA Hi smith WE | 2002 | Expert Rev Anticancer Ther2002，2，2： | 1 |
| 19 | Gastrin-histamine sequence in the regulation of gastric acid secretion显示文摘 | Waldum HI Sandvik AK Brenna E | 1991 | Gut1991，32，6： | 1 |
| 20 | Comparison of psychologic and cognitive functions after general or regional anesthesia 显示文摘 | Ghoneim M M Hi nrichs JV O'Hara MW | 1988 | Anesthesiology1988，69，4： | 1 |
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