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| 1 | Magnetic resonance imaging and multi-detector computed tomography assessment of extracellular compartment in ischemic and non-ischemic myocardial pathologies显示文摘Myocardial pathologies are major causes of morbidity and mortality worldwide. Early detection of loss of cellular integrity and expansion in extracellular volume(ECV) in myocardium is critical to initiate effective treatment. The three compartments in healthy myocardium are: intravascular(approximately 10% of tissue volume), interstitium(approximately 15%) and intracellular(approximately 75%). Myocardial cells, fibroblasts and vascular endothelial/smooth muscle cells represent intracellular compartment and the main proteins in the interstitium are types Ⅰ/Ⅲ collagens. Microscopic studies have shown that expansion of ECV is an important feature of diffuse physiologic fibrosis(e.g., aging and obesity) and pathologic fibrosis [heart failure, aortic valve disease, hypertrophic cardiomyopathy, myocarditis, dilated cardiomyopathy, amyloidosis, congenital heart disease, aortic stenosis, restrictive cardiomyopathy(hypereosinophilic and idiopathic types), arrythmogenic right ventricular dysplasia and hypertension]. This review addresses recent advances in measuring of ECV in ischemic and non-ischemic myocardial pathologies. Magnetic resonance imaging(MRI) has the ability to characterize tissue proton relaxation times(T1, T2, and T2*). Proton relaxation times reflect the physical and chemical environments of water protons in myocardium. Delayed contrast enhanced-MRI(DE-MRI) and multi-detector computed tomography(DE-MDCT) demonstrated hyper-enhanced infarct, hypo-enhanced microvascular obstruction zone and moderately enhanced peri-infarct zone, but are limited for visualizing diffuse fibrosis and patchy microinfarct despite the increase in ECV. ECV can be measured on equilibrium contrast enhanced MRI/MDCT and MRI longitudinal relaxation time mapping. Equilibrium contrast enhanced MRI/MDCT and MRI T1 mapping is currently used, but at a lower scale, as an alternative to invasive sub-endomyocardial biopsies to eliminate the need for anesthesia, coronary catheterization and possibility of tissue sampling error. Similar to delayed contrast enhancement, equilibrium contrast enhanced MRI/MDCT and T1 mapping is completely noninvasive and may play a specialized role in diagnosis of subclinical and other myocardial pathologies. DE-MRI and when T1-mapping demonstrated sub-epicardium, sub-endocardial and patchy mid-myocardial enhancement in myocarditis, Behcet's disease and sarcoidosis, respectively. Furthermore, recent studies showed that the combined technique of cine, T2-weighted and DE-MRI technique has high diagnostic accuracy for detecting myocarditis. When the tomographic techniques are coupled with myocardial perfusion and left ventricular function they can provide valuable information on the progression of myocardial pathologies and effectiveness of new therapies. | Maythem Saeed Steven W Hetts Robert Jablonowski Mark W Wilson | 2014 | World Journal of Cardiology2014，6，11： | 4 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | ACE inhibition attenuates radiation-induced cardiopulmonary damage显示文摘 | Sonja J. van der Veen Ghazaleh Ghobadi Rudolf A. de Boer Hette Faber Megan V. Cannon Peter W. Nagle Sytze Brandenburg Johannes A. Langendijk Peter van Luijk Robert P. Coppes | 2014 | Radiotherapy and Oncology2014，，： | 2 |
| 4 | Sonoclot analysis显示文摘 | Hett DA Walker D Pilkington SN | 1995 | Br J Anaesth1995，75，6： | 1 |
| 5 | Two Roads to Positive Regard: Implicit and Explicit Self-Evaluation and Culture显示文摘 | John J. Hetts Michiko Sakuma Brett W. Pelham | 1999 | Journal of Experimental Social Psychology1999，，6： | 1 |
| 6 | Age structure models of balsam fir and eastem hemlock 显示文摘 | Hett J M Loucks O L | 1976 | Journal of Ecology1976，64，： | 1 |
| 7 | Modem meningioma imaging techniques 显示文摘 | Saloner D Uzelac A Hetts S | 2010 | J Neurooncol2010，99，3： | 1 |
| 8 | Hypotheses refinement under topological communication constraints显示文摘 | Gauvain Bourgne Gael Hette Nicolas Maudet | 2007 | International Conference on Autonomous Agents2007，6，2： | 1 |
| 9 | Proteomic approaches to biomarker discovery in prostate and bladder cancers显示文摘 | Pertricoin EF Ardekani AM Hett BA | 2001 | Pro2001，10，： | 1 |
| 10 | Sonoclot analysis显示文摘 | HETT D A WALKER D PILKINGTON S N | 1995 | British J Anaesthesia1995，75，： | 1 |
| 11 | Age structure models of balsam fir and eastern hemlock显示文摘 | Hett J M Loucks O L | | 0，，03： | 1 |
| 12 | Modern meningioma imaging techniques显示文摘 | Saloner D Uzelac A Hetts S | 2010 | J Neurooncol2010，99，3： | 1 |
| 13 | Characterization of Sox9 in European Atlantic sturgeon(Acipenser sturio)显示文摘 | Hett A K Pitra C Jenneckens I | | 0，，02： | 1 |
| 14 | MR imaging of patially thrombosed cerebral aneurysms:characteristics and evolution显示文摘 | Martin AJ Hetts SW Dillon WP | 2011 | AJNR2011，32，2： | 1 |
| 15 | Spinal dural arteriove- nous fistulae: clinical features and long-term results显示文摘 | Narvid J Hetts SW Larsen D | 2008 | Neu- rosurgery2008，62，1： | 1 |
| 16 | To die or not to die:an overview of apoptosis and its role in disease显示文摘 | Hetts SW | | 0，，04： | 1 |
| 17 | Case 110: Nonossifying Fibroma 显示文摘 | Steven W Hetts SDH Russell W | 2007 | Radiology2007，243，： | 1 |
| 18 | To die or not todie:An overview of a poptosis and its role in disease 显示文摘 | | 1998 | JAMA,1998;279(4):3001998，279，4： | 1 |
| 19 | Association between lumbar epidural injection and development of acute para- paresis in patients with spinal dural arteriovenous fistulas 显示文摘 | Hetts SW Narvid J Singh T | 2007 | AJNR Am J Neuroradiol2007，28，3： | 1 |
| 20 | Spinal dural arteriovenous fistulas and intrathecal venous drainage:correlation between digital subtraction angiography,magnetic resonance imaging,and clinical findings:clinical article显示文摘 | Hetts SW Moftakhar P English JD | 2012 | J Neurosurg Spine2012，16，5： | 1 |
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