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| 1 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 2 | The role of RASSF1A hypermethylation in cancer 显示文摘 | Hesson LB Cooper WN Latif F | 2007 | Dis Markers2007，23，12： | 1 |
| 3 | RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family显示文摘 | Eckfeld K Hesson L Vos MD | 2004 | Cancer Res2004，64，23： | 1 |
| 4 | RASSF2 associates with and stabilizes the proapoptotic kinase MST2 显示文摘 | Cooper W N Hesson L B Matallanas D | 2009 | Oncogene2009，28，33： | 1 |
| 5 | Effect of alti- tude training on serum creatine kinase activity and serum eorti- sol concentration in triathletes 显示文摘 | WILBER R L DRAKE S D HESSON J L | 2000 | Eur J Appl Physio2000，81，： | 1 |
| 6 | In Vivo Gene Transfer to the Mouse Nasal Cavity Mucosa Using a Stable Cationic Lipid Emulsion显示文摘 | Tae Woo Kim Hesson Chung Ick Chan Kwon Ha Chin Sung Seo Young Jeong | 2000 | Molecules and Cells2000，，2： | 1 |
| 7 | Structure of the hepa-titis C virus RNA helicase domain显示文摘 | Yao N Hesson T Cable M | 1997 | Nat Struct Biol1997，4，： | 1 |
| 8 | The role of RASSF1A hypermethylation in cancer显示文摘 | HESSON LB COOPER WN LATIF F | 2007 | Dis Markers2007，23，12： | 1 |
| 9 | The role of RASSF1A methylation in cancer显示文摘 | Hesson LB Cooper WN Latif F | 2007 | Dis Markers2007，23，12： | 1 |
| 10 | CpG island promoter hy- permethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations显示文摘 | Hesson LB Wilson R Morton D | 2005 | Oncogene2005，24，24： | 1 |
| 11 | RASSF2 associates with and stabilizes the proapoptotic kinase MST2显示文摘 | Wendy N Cooper Luke B Hesson David Matallanas | 2009 | Oncogene2009，20，： | 1 |
| 12 | The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias显示文摘 | Hesson LB Dunwell TL Cooper WN | 2009 | Mol Cancer2009，8，1： | 1 |
| 13 | The role ofRASSF1A methylation in cancer显示文摘 | Hesson LB Cooper WN Latif F | 2007 | Dis Markers2007，23，12： | 1 |
| 14 | Frequent epigenetic inactivation of the slit2 gene in gliomas显示文摘 | Dallol A Krex D Hesson L | 2003 | Oncogene2003，22，： | 1 |
| 15 | Effect of altitude training on serum ereatine kinase activity and serum cortisol concentration in triathletes 显示文摘 | Wilbler RL Drake SD Hesson JL | 2000 | Eur J Appl Physiol2000，81，1： | 1 |
| 16 | Frequent epigenetic in activation of the SLIF2 gene in gliomas显示文摘 | Dallol A Krex D Hesson L | 2003 | Oncogene2003，22，29： | 1 |
| 17 | RASSF2 associates with and stabilizes the proapoptotic ki- nase MST2 显示文摘 | COOPER W N HESSON L B MATALLANAS D | 2009 | Oncogene2009，28，33： | 1 |
| 18 | NOREl A, ahomologue of RASSF]A tumour suppressor geneis inactivated in human cancers显示文摘 | Hesson L Dallol A Minna JD | 2003 | Oncogene2003，22，6： | 1 |
| 19 | Effect of altitude training on serum creatine kinase activity and serum cortisol concentration in triathletes显示文摘 | Wilber R L Drabe S D Hesson J L | 2000 | European Journal Applied Physiology2000，81，： | 1 |
| 20 | Association of a miRNA-137 Polymorphism with Schizophrenia in a Southern Chinese Han Population显示文摘 | Guoda Ma Jingwen Yin Jiawu Fu Xudong Luo Haihong Zhou Hua Tao Lili Cui You Li Zhixiong Lin Bin Zhao Zheng Li Juda Lin Keshen Li Luke Hesson | 2014 | BioMed Research International2014，，： | 1 |
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