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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Breast le- sions: evaluation with US strain imaging-clinical experience of multiple observers 显示文摘 | Regner DM Hesley GK Hangiandreou N J | 2006 | Radiology2006，238，2： | 1 |
| 3 | Direct enzyme21inked immu 2noassay for urinary deoxypyrinoline as a specificmarker forme- asur2ing bone resorption显示文摘 | Robins SP Woitge H Hesley R | 1994 | J Bone Miner Res1994，9，10： | 1 |
| 4 | Safety and immunogenicity of a bivalent Haemophilus influenzae type b/hepatitis B vaccine in healthy infants Hib-HB Vaccine Study Group显示文摘 | West DJ Hesley TM Jonas LC | | 0，，06： | 1 |
| 5 | Large sample of neph- rogenic systemic fibrosis cases from a single institu- tion显示文摘 | Lee CU Wood CM Hesley GK | 2009 | Arch Dermatol2009，145，10： | 1 |
| 6 | Mr-imaging of the breast with rotating delivery of excitation off resonance-clinical-experience with pathological correlation显示文摘 | Harms SE Flamig DP Hesley KL | | 0，，02： | 1 |
| 7 | MR (~-uided focused ul- trasoundfor the treatment of uterine fibroids显示文摘 | Hesley GK Gorny KR Woodrum DA | 2013 | Cardiovasc ln- tervent Radiol2013，36，1： | 1 |
| 8 | High-content high-throughput assays for characterizing the viability and morphology of human i PSC-derived neuronal cultures显示文摘 | Sirenko O Hesley J Rusyn I Cromwell EF | 2014 | Assay Drug Dev Technol2014，12，910： | 1 |
| 9 | Frequency and severity of adverse effects of iodinated and gadolinium contrast materials:retrospective review of 456,930 doses显示文摘 | Hunt CH Hartman RP Hesley GK | 2009 | AJR2009，193，： | 1 |
| 10 | Breast lesions: evaluation with US strain imaging-clinal experience of multiple observers显示文摘 | Regner DM Hesley GK Hangiandreou N J | 2006 | Radiology2006，238，2： | 1 |
| 11 | Breast lesions:evaluation with US strain imagingclinical experience of multiple observers显示文摘 | Regner DM Hesley GK Hangiandreou NJ | 2006 | Radiology2006，238，2： | 1 |
| 12 | High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells显示文摘 | Sirenko O Hesley J Rusyn I Cromwell EF | 2014 | Assay Drug Dev Technol2014，12，1： | 1 |
| 13 | Intraaortic balloon counterpulsation with and without reperfusion for myocardial infarction shock显示文摘 | De wwd MA Notske RV Hesley GR | 1980 | Circulation1980，61，： | 1 |
| 14 | MR imaging of the breast with rotating delvery of excitation off resonance:clinical experience with path ologic correlation显示文摘 | Flamig DP Hesley KL | 1993 | Radiology1993，187，2： | 1 |
| 15 | Frequency and severity of adverse effects of iodinated and gadolinium contrast materials: retrospective review of 456,930 doses显示文摘 | Hunt CH Hartman RP Hesley GK | 2009 | Am J Roentgenol2009，193，4： | 1 |
| 16 | Direct enzyme -linked immunoassay for urinary deoxypyridinoline as a specific marker for measuring bone resorption 显示文摘 | Robins SP Woitge H Hesley R | 1994 | J Bone Miner ires1994，9，10： | 1 |
| 17 | Incidence of bleeding after 15,181 percutaneous biopsies and the role of aspirin显示文摘 | Atwell TD Smith RL Hesley GK | 2010 | AJR2010，194，： | 1 |
| 18 | Comparing fo- cused ultrasound and uterine artery embolization for uterine fi- broids-rationale and design of the Fibroid Interventions : reducing symptoms today and tomorrow (FIRSTT) trial 显示文摘 | Bouwsma EV Hesley GK Woodrum DA | 2011 | Fertil Steril2011，96，3： | 1 |
| 19 | A two-dose hepatitis B vaccine regimen: proof of priming and memory responses in young adults显示文摘 | Luis S. Marsano David J. West Ivan Chan Teresa M. Hesley Jenny Cox Vernon Hackworth Richard N. Greenberg | 1998 | Vaccine1998，，6： | 1 |
| 20 | Breast lesions:evaluation with US strain imaging-clinical experience of multiple observers显示文摘 | Regner DM Hesley GK Hangiajdreou NJ | | 0，，02： | 1 |
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