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| 1 | Probe based confocal laser endomicroscopy of the pancreatobiliary system显示文摘AIM:To review applications of confocal laser endomicroscopy(CLE) in pancreatobiliary lesions and studies that assessed training and interpretation of images. METHODS: A computerized literature search was performed using OVID MEDLINE, EMBASE, Cochrane library, and the ISI Web of Knowledge from 1980 to October 2014. We also searched abstracts from major meetings that included the Digestive Disease Week, Canadian Digestive Disease Week and the United European Gastroenterology Week using a combination of controlled vocabulary and text words related to p CLE, confocal, endomicroscopy, probe-based confocal laser endomicroscopy, and bile duct to identify reports of trials. In addition, recursive searches and crossreferencing was performed, and manual searches of articles identified after the initial search was also completed. We included fully published articles and those in abstract form. Given the relatively recent introduction of CLE we included randomized trials and cohort studies.R E S U LT S : In the evaluation of indeterminate pancreatobiliary strictures CLE with ERCP compared to ERCP alone can increase the detection of cancerous strictures with a sensitivity of(98% vs 45%) andhas a negative predictive value(97% vs 69%), but decreased the specificity(67% vs 100%) and the positive predictive value(71% vs 100%) when compared to index pathology. Modifications in the classification systems in indeterminate biliary strictures have increased the specificity of p CLE from 67% to 73%. In pancreatic cystic lesions there is a need to develop similar systems to interpret and characterize lesions based on CLE images obtained. The presence of superficial vascular network predicts serous cystadenomas accurately. Also training in acquiring and interpretation of images is feasible in those without any prior knowledge in CLE in a relatively simple manner and computer-aided diagnosis software is a promising innovation. CONCLUSION: The role of p CLE in the evaluation of pancreatobiliary disorders might be better suited for those with an intermediate and low probability. | Majid A Almadi Helmut Neumann | 2015 | World Journal of Gastroenterology2015，21，44： | 6 |
| 2 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery显示文摘 | Mary C Corretti Todd J Anderson Emelia J Benjamin David Celermajer Francois Charbonneau Mark A Creager John Deanfield Helmut Drexler Marie Gerhard-Herman David Herrington Patrick Vallance Joseph Vita Robert Vogel | 2002 | Journal of the American College of Cardiology2002，，： | 2 |
| 3 | Social Origins of Civil Society: Explaining the Nonprofit Sector Cross- Nationally显示文摘 | SALAMON L M HELMUT K A | 1998 | Voluntas1998，9，3： | 1 |
| 4 | Influence of the variable-speed wind generators in transient stability margin of the conven tional generators integrated in electrical grids显示文摘 | Nunes Marcus V A Lopes J A Pecas Zurn Hans Helmut | 2004 | IEEE Trans on Energy Conversion2004，19，4： | 1 |
| 5 | Development of a conjunctive use model to evaluate alternative management options for surface and groundwater resources显示文摘 | Sarwar A Helmut E | | 0，，8： | 1 |
| 6 | Cost-effectiveness of controlling Salmonella in the pork chain显示文摘 | Monique A Vander Gaag Helmut W | 2004 | Food Control2004，，15： | 1 |
| 7 | Cloning and sequence analysis of cDNAs for interferon and virus-induced human Mx proteins reveal that they contain putative guanine nucleotidebinding sites : Functional study of the corresponding gene promoter显示文摘 | Horisberger M A Mcmaster G K Helmut Zeller | 1990 | Virol1990，64，3： | 1 |
| 8 | The path of sulfur during the bio-oxidation of pyrite by Thiobacillus Ferrooxidation显示文摘 | Rojas-Chapana J A Michael Giersig Helmut Tributsch | 1996 | Fuel1996，75，8： | 1 |
| 9 | Fixed broadband wire less access: state of the art, challenges, and future di rections 显示文摘 | Helmut Bo1cskei Paulraj A J | 2001 | IEEE Commun Mag2001，6，90： | 1 |
| 10 | Hysteretic models that incorporate strength and stiffness deterioration 显示文摘 | Luis F Ibarra Ricardo A Medina Helmut Krawinkler | 2005 | Earthquake Engineering and Structural Dynamics2005，34，12： | 1 |
| 11 | New Multidentate Potential Ionophors of Ether Amide Type显示文摘 | WHEI O L JOS A A F HELMUT G A | 1985 | Monatshefte Fur Chemic1985，116，： | 1 |
| 12 | Supercritical water oxidation: state of the art显示文摘 | Helmut S Johannes A | 1999 | Chem Eng Technol1999，22，11： | 1 |
| 13 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery显示文摘 | Mary C Corretti Todd J Anderson Emelia J Benjamin David Celermajer Francois Charbonneau Mark A Creager John Deanfield Helmut Drexler Marie Gerhard-Herman David Herrington Patrick Vallance Joseph Vita Robert Vogel | 2002 | Journal of the American College of Cardiology2002，，2： | 1 |
| 14 | Heparanase expression in primary and metastatic pancreatic cancer显示文摘 | KOLIOPANOS A HELMUT F KLEEFF J | 2001 | Cancer Res2001，61，： | 1 |
| 15 | Health effects of endocrine-disrupting chemicals on wildlife,with special reference to the European situation显示文摘 | Erik D Helmut A G | 2000 | Cribical Review in Toxicology2000，30，1： | 1 |
| 16 | The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking显示文摘 | Shotland Yoram Krgmer Helmut Groisman Eduardo A | 2003 | Molecular Microbiology2003，49，6： | 1 |
| 17 | Investigations on polymeric and monomeric intramolecularly hydrogen-bridged UV absorbers of the benzotriazole and triazine class 显示文摘 | Ju I rgen Keck Horst E A Kramer Helmut Port | 1996 | J Phys Chem1996，100，14： | 1 |
| 18 | Neurally selected embryonic stem cells induce tumor formation after long-term survival following engraftment into the subretinal space显示文摘 | Stefan A Helmut K Irina S Klaus A Ulrich S | 2004 | Invest Ophthalmol Vis Sci2004，45，12： | 1 |
| 19 | Preparation of barium titanates from oxalates显示文摘 | STOCKENHUBER Michael MAYER Helmut Lercher Johannes A | 1993 | J Am Ceram Soc1993，76，5： | 1 |
| 20 | Patient - reported outcomes to as- sess the efficacy of extended - release guaifenesin for the treatment of acute respiratory tract infection symptoms显示文摘 | Helmut A Margaret V Gall S | 2013 | Respir Res2013，13，： | 1 |
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