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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | Negative Inteference in Cardiac Troponin Ⅰ Immunoassays by Circulating Troponin Autoantibodies 显示文摘 | Susann E Heidi H | 2005 | Clinical Chemistry2005，51，： | 1 |
| 4 | Phenolic compounds and expression of 4CL genes in Silver Birch clones and Pt4CLI a Lines 显示文摘 | Suvi S Terhi H Heidi T | 2014 | PLOS ONE2014，9，12： | 1 |
| 5 | TOPLESS mediates auxin-de- pendent transcriptional repression during Arabidopsis embry- ogenesis显示文摘 | HEIDI S MIKE H JEFF A L | 2008 | Science2008，319，5868： | 1 |
| 6 | On industrial knowl- edge bases, commercial opportunities and global innova- tion network linkages显示文摘 | Sverre J H Heidi W A Brend E | 2014 | Research Policy2014，43，： | 1 |
| 7 | PPAR-α agonist actions in the liver of obese insulin-resistant monkeys: reduction in hepatic lipoprotein lipase activity, triglyceride content and TNF-αexpression显示文摘 | HEIDI K O RUBY I B CAMILLE H | 2006 | The Journal of the Federation of American Sociaties for Experimental Biology2006，20，3： | 1 |
| 8 | Erythrocyte G protein as a novel target for malarial chemotherapy显示文摘 | Sean CM Travis H Heidi EH | 2006 | PLoS Med2006，3，12： | 1 |
| 9 | Sclerosing lymphangitis of the pe, nis显示文摘 | Ted R Heidi H | 2003 | J Am Aead Dermatol2003，49，5： | 1 |
| 10 | Improved postprandial glycemic control with biphasic insulin aspart relative to biphasic insulin lispro and biphasic human insulin in patient with type 2 diabetes 显示文摘 | Kjeld H Michele C Heidi S | 2002 | Diabetes Care2002，25，： | 1 |
| 11 | Sclerosing lymphangitis of the penis显示文摘 | Ted R Heidi H | 2003 | J Am Acad Dermatol2003，49，5： | 1 |
| 12 | Accumulating Mutations in Series of Haplotypes at the KITand MITF Loci Are Major Determinants of White Markings in Franches-Montagnes Horses 显示文摘 | Haase B Heidi S H Matthew M B | 2013 | Plos One2013，8，75： | 1 |
| 13 | Biosynthesis of phloridzin in apple 显示文摘 | Christian G Heidi H Jasmin K | 2009 | Plant Science2009，176，： | 1 |
| 14 | A comparison between EEG-recording and scoring by QUISI version 1.0 and standard PSG with visual scoring显示文摘 | Ingrid Ehlert Heidi Danker-Hopfe Liselotte H?ller P. Rickenbach R. Baumgart-Schmitt Professor Dr. W. M. Herrmann | 1998 | Somnologie - Schlafforschung und Schlafmedizin1998，，3： | 1 |
| 15 | Coating doxycycline on titanium-based implants: Two in vivo studies显示文摘Regardless of the substantial progress in designing titanium-based dental implants and aseptic techniques,infection remains as the most common complication after implantation surgeries.Although,having a weakened immune system or systematic diseases is not seen as contraindicated for dental implants anymore,controlling the immune system is required to avoid surgical site infections after implantation.These patients have to control the surgical site infections by taking a high daily dose of oral antibiotics after dental implantation.The antibiotics oral administration has many side effects such as gastrointestinal symptoms,skin rashes and thrush.Coating antibiotics on the biomaterials surface could be a promising solution to reduce these disadvantages through locally releasing antibiotics in a controlled manner.The aim of this study was to investigate the effects of doxycycline coating layer on titanium-zirconium alloy surfaces in vitro and in vivo.In our previous studies,we demonstrated the chemical presence of doxycycline layer in vitro.In this study,we examined its physical presence using field emission scanning electron microscope and confocal microscope.We also analyzed its controlled released manner using Nano-Drop UV Vis spectrometer.After in vitro characterization of the coating layer,we evaluated its effects on the implant osseointegration in dogs and rabbits.The histological and histomorphometrical results exhibited no significant difference between doxycycline coated and uncoated groups regarding the implants osseointegration and biocompatibility for dental applications.Therefore,coating a doxycycline layer on TiZr implants could be favorable for reducing or removing the antibiotics oral administration after the implantation surgery. | Maryam Rahmati Ståle Petter Lyngstadaas Janne E.Reseland Ingrid Andersbakken Heidi Straume Haugland Mónica López-Peña Antonio Gonzalez Cantalapiedra Fernando Maria Guzon Muñoz Håvard Jostein Haugen | 2020 | Bioactive Materials2020，5，4： | 1 |
| 16 | Determination of source contributions of NMHCs in Helsinki (601N, 251E) using chemical mass balance and the Unmix multivariate receptor models显示文摘 | Heidi H Hannele H Tuomas L | 2003 | Atmospheric Environment2003，37，： | 1 |
| 17 | On industrial knowledge bases, commercial opportunities and global innovation network linkages显示文摘 | Sverre J H Heidi W A Bernd E | 2014 | Research Policy2014，，43： | 1 |
| 18 | Cost effectiveness and patient satisfaction and vacuum formed retainers显示文摘 | Lisa H Heidi R Alison W | 2007 | Eur J Orthod2007，29，4： | 1 |
| 19 | Evaluation of the impact of annealing on gelatinisation at intermediate water content of wheat and potato starches:A differential scanning calorimetry and small angle X-ray scattering study显示文摘 | Heidi J Nicolay M Michel H J | 1998 | Carbohydrate Research1998，306，： | 1 |
| 20 | Phloridzin: biosynthesis, distribution and physiological relevance in plants显示文摘 | Christian G Heidi H Karl S | 2010 | Phytochemistry2010，，71： | 1 |
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