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| 1 | Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. | Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf | 2012 | World Journal of Gastroenterology2012，18，6： | 16 |
| 2 | Discrimination of sepsis and systemic inflammatory response ayndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a,and interleukin- 6显示文摘 | Selberg Oliver Hecker Hartmut Martin Michael | 2000 | Crit Care Med2000，28，8： | 1 |
| 3 | Intracoronary Bone Marrow Cell Transfer After Myocardial Infarction: Eighteen Months’ Follow-Up Data From the Randomized, Controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) Trial显示文摘 | Gerd P. Meyer Kai C. Wollert Joachim Lotz Jan Steffens Peter Lippolt Stephanie Fichtner Hartmut Hecker Arnd Schaefer Lubomir Arseniev Bernd Hertenstein Arnold Ganser Helmut Drexler | 2006 | Circulation2006，，10： | 1 |
| 4 | Novel NKX2-5 mutations in diseased heart tis- sues of patients with cardiac malformations 显示文摘 | Reamon-Buettner Stella Marie Hecker Hartmut Spanel-Borowski Katharina | 2004 | The American Journal of Pathology2004，164，6： | 1 |
| 5 | Neuropsychological characterization of hepatic encephalopathy显示文摘 | Karin Weissenborn Jochen C Ennen Hans Schomerus Norbert Rückert Hartmut Hecker | 2001 | Journal of Hepatology2001，，5： | 1 |
| 6 | Dose-Dependent Effect of Aspirin on Carotid Atherosclerosis显示文摘 | Carsten Ranke Hartmut Hecker Andreas Creutzig | | 0，，： | 1 |
| 7 | Intracoronary Bone Marrow Cell Transfer After Myocardial Infarction: Eighteen Months’ Follow-Up Data From the Randomized, Controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) Trial显示文摘 | Gerd P. Meyer Kai C. Wollert Joachim Lotz Jan Steffens Peter Lippolt Stephanie Fichtner Hartmut Hecker Arnd Schaefer Lubomir Arseniev Bernd Hertenstein Arnold Ganser Helmut Drexler | 2006 | Circulation2006，，10： | 1 |
| 8 | Hepatitis C virus infection affects the brain—evidence from psychometric studies and magnetic resonance spectroscopy显示文摘 | Karin Weissenborn Jochen Krause Martin Bokemeyer Hartmut Hecker Andreas Schüler Jochen C. Ennen Bj?rn Ahl Michael P. Manns Klaus W. B?ker | 2004 | Journal of Hepatology2004，，5： | 1 |
| 9 | 冠状动脉旁路移植术前对环氧化酶-1抑制性的评估:血小板聚集率与患者自测的对比研究显示文摘背景抗血小板治疗导致的血小板功能减退可产生围手术期出血,数项对手术前5日内摄入阿司匹林的影响研究结果不一,有的认为摄入阿司匹林会增加围手术期输血量,而有的认为并无显著影响。本项研究的目的在于对比患者自身报告服药情况与血小板功能测定两种方法评估阿司匹林摄入对围手术期输血需求的影响。方法在一项前瞻性研究中,对100例行冠状动脉旁路移植术的患者,术前5日阿司匹林的摄入进行标准化问卷调查。另外,使用Multiplate血小板功能分析仪测定花生四烯酸介导的全血血小板聚集率。结果23例手术前5日内服用阿司匹林的患者中有11例血小板聚集功能异常,77例手术前未服用阿司匹林的患者中有9例血小板功能异常。服用与未服用阿司匹林的患者相比,手术后24小时内胸管引流量及红细胞输注量无显著差别。手术前血小板聚集功能异常的患者(〈51U)所需的血小板输注量(1.1U)显著高于血小板聚集功能正常的患者(0.3U,P=0.001)。结论本研究结果显示全血花生四烯酸诱导血小板聚集率对于血小板相关的凝血功能异常及血小板输注量的预测优于患者自身报告阿司匹林的摄入情况。 | Niels Rahe-Meyer, MD, PhD Michael Winterhalter, M4 Julia Hartmann Albert Pattison Hartmut Hecker Andreas Calatzis, MD Cristina Solomon, MD 曹晖(译) | 2011 | 麻醉与镇痛2011，7，3： | 0 |
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