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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 3 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 4 | Imidazole Alkaloids from Lepidium meyenii显示文摘 | Cui B Zheng BL He K | 2003 | Journal of Natural Products2003，66，8： | 1 |
| 5 | Efect of a lipidic extract from Lepidium meyenii on sexual behaviorin mice and rats显示文摘 | He K Kim CH | 2000 | Urology2000，55，4： | 1 |
| 6 | Defective functions of circulating CD4+CD25+ and CD4+CD25-T cells in patients with chronic ordinary urticaria显示文摘 | Chen WC Chiang BL Liu HE | | 0，，02： | 1 |
| 7 | Evidence that rodents are a reservoir of hepatitis E virus for humans in Nepal 显示文摘 | He J Innis BL Shrestha MP | 2002 | J Clin Microbiol2002，40，12： | 1 |
| 8 | Evidence that rodents are areservoir of hepatitis E virus for humans in nepal显示文摘 | He J Innis BL Shrestha MP | 2002 | Journal ofclinical microbiology2002，40，12： | 1 |
| 9 | Low Ki-67 proliferation index is an indicator of poor prognosis in gastric cancer显示文摘 | Lee HE Kim MA Lee BL | | 0，，03： | 1 |
| 10 | B-type natriuretic peptide attenu- ates cardiac hypertrophy via the transforming growth factor-ssl/ smad7 pathway in vivo and in vitro显示文摘 | He JG Chen YL Chen BL | 2010 | Clin Exp Pharmacol Physi- ol2010，37，3： | 1 |
| 11 | Research into Articles on influence of key factors on curative effect of acupoint application for treatment of winter diseases in summa显示文摘 | Fang YG Liu BY Liu WH Peng J He LY Zi MJ Wen BL | | 0，，： | 1 |
| 12 | Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia显示文摘 | He BL Shi X Man CH | 2014 | Blood2014，123，16： | 1 |
| 13 | Cisplatin ototoxicity in ratcochlear organotypic cultures 显示文摘 | Ding D He J Allman BL | 2011 | Hear Res2011，282，12： | 1 |
| 14 | Reliable typing of MERS-CoV variants with a small genome fragment 显示文摘 | Smits SL Raj VS Pas SD Reusken CB Mohran K Farag EA A1-Romaihi HE A1Hajri MM Haagmans BL Koopmans MP | 2015 | J Clin Virol2015，64，： | 1 |
| 15 | B type natriuretic peptide at- tenuates cardiac hypertrophy via the transforming growth factorss1/smad7 pathway in vivo and in vitro显示文摘 | He J G Chen YL Chen BL | 2010 | Clin Exp PharmacolPhysiol2010，37，3： | 1 |
| 16 | Defective functions of circulating CD4 + CD25 + and CD4 + CD25- T cells in pa- tients with chronic ordinary urticaria 显示文摘 | Chen WC Chiang BL Liu HE | 2008 | J Dermatol Sci2008，51，2： | 1 |
| 17 | Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons显示文摘 | Toledo-Aral JJ Moss BL He ZJ | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 18 | Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats 显示文摘 | Zleng BL He K Kim CH el al | 2000 | Urology2000，55，4： | 1 |
| 19 | Imidazole alkaloids from Lepidium meyenii显示文摘 | Cui B Zheng BL He K | 2003 | J Nat Prod2003，66，8： | 1 |
| 20 | Directed evolution of a novel adeno-associated virus(AAV)vector that crosses the seizurecompromised blood-brain barrier(BBB)显示文摘 | Gray SJ Blake BL Criswell HE | 2010 | Mol Ther2010，18，3： | 1 |
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