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| 1 | Isolation and characterization of marine-derived actinomycetes with cytotoxic activity from the Red Sea coast显示文摘Objective: To isolate and evaluate the cytotoxic activity of different actinomycetes species isolated from the Red Sea coast in Sharm el-Sheikh, Egypt.Methods: Forty actinomycetes strains were isolated from different sediments and seawater samples collected from the Red Sea coast in Egypt. Actinomycetes were recognized by morphological and microscopic examinations. Cell viability and cytotoxicity induced by the crude extracts on breast cancer cell lines MDA-MB-231 were assessed using methylene blue assay. The strains with promising cytotoxic activity were identified by sequencing and amplifying the 16 S r RNA genes. The antibacterial activities of the crude extracts were performed using Kirby–Bauer disc diffusion method.Results: The results indicated that five ethyl acetate extracts exhibited cytotoxicity towards breast cancer cell lines MDA-MB-231. The highest cytotoxic activity was found for the ethyl acetate extracts of EGY2 and EGY39. The isolate EGY3 was identified as a new Streptomyces species, while the actinomycete EGY22 was found to be a member of the genus Nocardiopsis sp. The crude extract of the isolate EGY8 showed slightly high antimicrobial activity against different test microorganisms.Conclusions: The results of the present study reveal that marine sediments of the Red Sea are a potent source of novel species of actinomycetes. The isolates may be useful in discovery of novel bioactive compounds and an important step in the development of microbial natural product research. | Mohamed Saleh Abdelfattah Mohammed Ismail Youssef Elmallah Usama Wahid Hawas Lamia Taha Abou El-Kassema Mennat Allah Gamal Eid | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，8： | 3 |
| 2 | 药物涂层球囊治疗急性冠脉综合征的系统评价显示文摘目的:系统评价急性冠脉综合征患者应用药物涂层球囊的疗效和安全性。方法:计算机检索Pubmed、Cochrane图书馆、EMbase、中国知网、万方数据库和中国生物医学数据库,由2名研究员独立按照纳入排除标准进行文献筛选和资料提取。结果:纳入DEB-AMI、Besic KM等、PEBSI共3项随机对照研究,其药物涂层球囊联合裸金属支架治疗的靶病变血运重建率分别为23.9%、19.5%、1.8%,主要不良心脏事件率分别为23.9%、24.4%、3.6%。此外纳入PAPPA、Ho HH等、Mahmood Zuhdi AS等、Nanolute共4篇队列研究,单纯药物涂层球囊治疗的靶病变血运重建率分别为3%、0、1.2%、5.2%。结论:药物涂层球囊可作为急性冠脉综合征的有效治疗方案,但其最佳治疗方案尚需更多大样本随机研究数据支持。 | 庞思 陈忠 朱孔博 何砚如 Gondo Esther Kema Hawa 章晓国 童嘉毅 马根山 陈立娟 | 2018 | 东南大学学报(医学版)2018，37，1： | 3 |
| 3 | Self-reported risk of stroke and factors associated with underestimation of stroke risk among older adults with atrial fibrillation: the SAGE-AF study显示文摘Background Though engaging patients with atrial fibrillation(AF) in understanding their stroke risk is encouraged by guidelines, little is known regarding AF patients' perceived stroke risk or its relationship with oral anticoagulation(OAC) use. We aim to identify factors associated with underestimation of stroke risk among older patients with AF and relate this to OAC use. Methods Data are from the ongoing SAGE(Systematic Assessment of Geriatric Elements)-AF study, which included older patients(> 65 years) with non-valvular AF and a CHA2 DS2-VASc score of ≥ 2. Participants reported their perceived risk of having a stroke without OAC. We compared the perceived risk to CHA2 DS2-VASc predicted stroke risk and classified participants as 'over' or 'under' estimators, and identified factors associated with underestimation of risk using multiple logistic regression. Results The average CHA2 DS2-VASc score of 915 participants(average age: 75 years, 47% female, 86% white) was 4.3 ± 1.6, 43% of participants had discordant predicted and self-reported stroke risks. Among the 376 participants at highest risk(CHA2 DS2-VASc score ≥ 5), 46% of participants underestimated their risk. Older participants(≥ 85 years) were more likely and OAC treated patients less likely to underestimate their risk of developing a future stroke than respective comparison groups. Conclusions A significant proportion of study participants misperceived their stroke risk, mostly by overestimating. Almost half of participants at high risk of stroke underestimated their risk, with older patients more likely to do so. Patients on OAC were less likely to underestimate their risk, suggesting that successful efforts to educate patients about their stroke risk may influence treatment choices. | Jordy Mehawej Jane Saczynski Jerry H.Gurwitz Hawa O.Abu Benita A.Bamgbade Wei-Jia WANG Tenes Paul Katherine Trymbulak Connor Saleeba Zi-Yue WANG Catarina I.Kiefe Robert J.Goldberg David D.Mc Manus | 2020 | Journal of Geriatric Cardiology2020，17，8： | 2 |
| 4 | 内镜下胰管支架置入术用于缓解胰腺癌患者的疼痛:系统综述与meta分析显示文摘背景:腹痛是一种致人衰弱的症状,大约80%的胰腺癌患者都会出现腹痛。胰管减压虽然未被广泛采纳,但有报道该方法能缓解腹痛症状。本研究旨在评估内镜下胰管减压对于缓解胰腺癌患者餐后梗阻型腹痛的作用、效果及安全性。方法:该系统综述的文献检索时间截至2020年10月7日。由两位研究者独立地筛选文献、提取数据,并对文献质量进行评估。结果:12篇文献共计192例有腹痛症状且尝试胰管减压的胰腺癌患者纳入研究。其中,167例患者成功完成胰管减压(平均年龄62.5岁,58.7%为男性)。159(95.2%)例患者采用塑料支架。所有被纳入的研究均报道了胰管支架置入术后患者疼痛部分或完全缓解,缓解率为93%(95%CI:79%-100%)。平均的疼痛缓解期为94˘16天。内镜逆行性胰胆管造影(ERCP)相关的不良反应包括括约肌切开术后出血(1.8%)、ERCP后胰腺炎(0.6%)和胰管出血(0.6%)。2例行内镜超声引导的胰管减压患者未报道任何不良反应。在成功置入支架的167例患者中,支架移位和支架阻塞的发生率分别为3.6%和3.0%。未报道不良反应相关的死亡病例。文献质量评估提示,绝大部分文献质量较低或难以评价。结论:初步分析结果表明,对于部分经选择的胰腺癌病例,内镜下胰管引流可能是缓解梗阻型疼痛一种安全有效的方法。但该侵入性方法的作用尚需随机对照研究来进一步明确。 | Pradeep K.Siddappa Fadi Hawa Larry J.Prokop MHassan Murad Barham K.Abu Dayyeh Vinay Chandrasekhara Mark D.Topazian Fateh Bazerbachi | 2021 | Gastroenterology Report2021，9，2： | 2 |
| 5 | Adult-onset autoim- mune diabetes in Europe is prevalent with a broad clinical phenotype:Action LADA 7 显示文摘 | Hawa MI Kolb H Schloot N | 2013 | Diabetes Care2013，36，4： | 1 |
| 6 | Immrne reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type I diabetes mellitus显示文摘 | Lohmann T hawa M Leslie RD | 2000 | Lancet2000，365，： | 1 |
| 7 | Antioxidant and Antiproliferative Activity of Diospyros lotus L. Extract and Isolated Compounds显示文摘 | Monica Rosa Loizzo Ataa Said Rosa Tundis Usama W. Hawas Khaled Rashed Federica Menichini Natale Giuseppe Frega Francesco Menichini | 2009 | Plant Foods for Human Nutrition2009，，4： | 1 |
| 8 | Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon 显示文摘 | Hawa MI Picardi A Costanza F | 2006 | Clin Immunol2006，118，23： | 1 |
| 9 | Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality 显示文摘 | Hawa M I Fava D Medici F | 2000 | Diabetes Care2000，23，2： | 1 |
| 10 | Lack of effect of vitamin D administration during pregnancy and early life on diabetes incidence in the non-obese diabetic mouse显示文摘 | HAWA M I VALORANI M G BUCKLEY L R | 2004 | Horm Metab Res2004，36，9： | 1 |
| 11 | Hearing loss and cognitive decline among older adults with atrial fibrillation:the SAGE-AF study显示文摘Objective To examine the association between hearing loss and cognitive function cross-sectionally and prospectively among older adults with atrial fibrillation(AF).Methods Patients with AF≥65-year-old(n=1244)in the SAGE(Systematic Assessment of Geriatric Elements)-AF study were recruited from five internal medicine or cardiology clinics in Massachusetts and Georgia.Hearing was assessed by a structured questionnaire at baseline.Cognitive function was assessed by Montreal Cognitive Assessment(MoCA)at baseline and one year.Cognitive impairment was defined as score≤23 on the MoCA.The associations between hearing loss and cognitive function were examined by multivariable adjusted logistic regression.Results Participants with hearing loss(n=451,36%)were older,more likely to be male,and have depressive symptoms than patients without hearing loss.At baseline,528(42%)participants were cognitively impaired.Individuals with hearing loss were significantly more likely to have cognitive impairment at baseline[adjusted odds ratio(OR)=1.37,95%confidence interval(CI):1.05–1.81].Among the 662 participants who did not have cognitive impairment at baseline and attended the one-year follow-up visit,106(16%)developed incident cognitive impairment.Individuals with,versus those without,hearing loss were significantly more likely to develop incident cognitive impairment at one year(adjusted OR=1.68,95%CI:1.07–2.64).Conclusions Hearing loss is a prevalent but under-recognized factor associated with cognitive impairment in patients with AF.Assessment for hearing loss may be indicated among these patients to identify individuals at high-risk for adverse outcomes. | Wei-Jia WANG Darleen Lessard Hawa Abu David D.McManus Tanya Mailhot Jerry H.Gurwitz Robert J.Goldberg Jane Saczynski | 2020 | Journal of Geriatric Cardiology2020，17，4： | 1 |
| 12 | A threshold-based real-time inci- dent detection system for urban traffic networks 显示文摘 | AHMED F HAWAS Y E | 2012 | Proce- dia-Social and Behavioral Sciences2012，48，： | 1 |
| 13 | Principles of Autoantibodies as Disease-specific Markers 显示文摘 | Hawa M Beyan M Leslie RD | 2004 | Autoimmunity2004，37，： | 1 |
| 14 | Apportionment of sources of fine and coarse particles in four major Australian cities by positive matrix factorization显示文摘 | Chan Y C Cohen D D Hawas O | 2008 | Atmospheric Envi- ronment2008，42，2： | 1 |
| 15 | Progress in bioethanol process- ing显示文摘 | Mustafa B Hawa B Cahide O | 2008 | Progress in Energy and Combustion Science2008，34，5： | 1 |
| 16 | Zopicloneand zaleplon vs benzodiazepines in the treatm ent of insomnia:Canadian consensus statement显示文摘 | Montplaisir J Hawa R Moller H | 2003 | Hum Psychopharmacol2003，18，1： | 1 |
| 17 | Evaluating and enhancing the operational performance of public bus systems using GIS-based data envelopment analysis显示文摘 | HAWAS Y E KHAN M B BASU N | 2012 | Journal of Public Transportation2012，15，2： | 1 |
| 18 | Immune reactivity to glutamic aciddecarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus显示文摘 | Lohmann T Hawa M Leslie RD | 2000 | Lancet2000，356，9223： | 1 |
| 19 | The potential of the coelomic fluid in sea cucumber as anantioxidant 显示文摘 | Hawa I Zulaikah M Iamaludin M | 1999 | Mal J Nutr1999，23，5： | 1 |
| 20 | Heterogeneity of Type I dia- betes:analysis of monozygotic twins in Great Britain and the U- nited States显示文摘 | Redondo M J Yu L Hawa M | 2001 | Diabetologia2001，44，3： | 1 |
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