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| 1 | Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most frequent causes of cancer-related death.Sorafenib,a multitarget angiogenesis inhibitor,is an approved frontline treatment for advanced HCC in Western countries,although a complete response(CR)to treatment is infrequently reported.Capecitabine,an oral fluoropyrimidine,has been shown to be effect in both treatment-naïve patients and those previously treated with sorafenib.To date,how-ever,only one case of sustained CR to metronomic capecitabine has been reported.Case presentation:We describe three cases of advanced HCC treated with metronomic capecitabine where a CR was obtained.In the first case,capecitabine was administered as first line therapy;in the second case,capecitabine was used after intolerance to sorafenib;while in the third case,capecitabine was administered after sorafenib failure.Conclusion:Capecitabine is a potentially important treatment option for patients with advanced HCC and may even represent a cure in certain cases. | Giovanni Brandi Michela Venturi Stefania De Lorenzo Francesca Garuti Giorgio Frega Andrea Palloni Ingrid Garajovà Francesca Abbati Gioconda Saccoccio Rita Golfieri Maria Abbondanza Pantaleo Maria Aurelia Barbera | 2018 | Cancer Communications2018，38，1： | 2 |
| 2 | Young women, cervical intraepithelial neoplasia and Human papillomavirus: risk factors for persistence and recurrence显示文摘 | Frega A Stentella P Deloris A | 2003 | Cancer Letters2003，196，2： | 1 |
| 3 | Vaginal intraepi- thelial neoplasia: a therapeutical dilemma显示文摘 | Frega A Sopracordevole F Assorgi C | 2013 | Anticancer Res2013，33，1： | 1 |
| 4 | Prediction of persistent vaginal intraepithelial neoplasia in previously hysterectomized women by high-risk HPV DNA detection 显示文摘 | Frega A French D Piazze J | 2007 | Cancer Lett2007，249，2： | 1 |
| 5 | Pregnancy outcome after loop electrosurgical excision procedure for cervical intra-epithelial neoplasia 显示文摘 | Frega A Sesti F De Sanctis L | 2013 | Int J Gynecol Obstet2013，122，2： | 1 |
| 6 | Antioxidant and Antiproliferative Activity of Diospyros lotus L. Extract and Isolated Compounds显示文摘 | Monica Rosa Loizzo Ataa Said Rosa Tundis Usama W. Hawas Khaled Rashed Federica Menichini Natale Giuseppe Frega Francesco Menichini | 2009 | Plant Foods for Human Nutrition2009，，4： | 1 |
| 7 | Evaluation of E6andE7mRNA expression in HPV DNA positive breast cancer显示文摘 | Frega A Lorenzon L Bononi M | 2012 | Eur J Gynaecol Oncol2012，33，2： | 1 |
| 8 | Vaginal intraepithelial neoplasia : A therapeutical dilemma 显示文摘 | Frega A Sopracordevole F Assorgi C | 2013 | Anticancer Res2013，33，1： | 1 |
| 9 | Young women, cervical intraepithelial neoplasia and human papillomavirus: risk factors for persistence and recurrence 显示文摘 | Frega A Stentella P De Ioris A | 2003 | Cancer Lett2003，196，： | 1 |
| 10 | The re-infection rate of high -risk HPV and the recurrence rate of vulvar intra -epithelial neoplasia (VIN) usual type after surgical treatment显示文摘 | Frega A Sopracordevole F Scirpa P | 2011 | Med Sci Monit2011，17，9： | 1 |
| 11 | Vaginal intraepithe- lial neoplasia: a therapeutical dilemma 显示文摘 | Frega A Sopracordevole F Assorgi C | 2013 | Anticancer Res2013，33，1： | 1 |
| 12 | Young women,cervical intraepithelial neoplasia and human papilloma virus: risk factors for persistence and recurrence显示文摘 | Frega A Stentella P De lofts A | 2003 | Cancer Letters2003，196，： | 1 |
| 13 | Imiquimod 5% cream versus cold knife excision for treatment of V1N 2/3: a five-year follow-up 显示文摘 | Frega A Sesti F Sopracordevole F | 2013 | Eur Rev Med Pharmacol Sci2013，17，7： | 1 |
| 14 | Prediction of persistent vaginal intraepithelial neoplasia in previously hysterectomized women by high-risk HPV DNA detection显示文摘 | Frega A French D Piazze J | 2007 | Cancer Lett2007，249，7： | 1 |
| 15 | Young women,cervical intraepithelial neoplasia and human papillomavirus:risk factors for per- sistence and recurrence显示文摘 | Frega A Stente|la P De Ioris A | 2003 | Cancer Letters2003，196，2： | 1 |
| 16 | Young women,cervical intraepithelial neoplasia and human papillomavirus:risk factors for persistence and recurrence显示文摘 | Frega A Stentella P De Ioris A | 2003 | Cancer Letters2003，196，2： | 1 |
| 17 | Non-small cell lung cancer in a very young woman:a case report and critical review of the literature显示文摘 | Polo V Zago G Frega S | 2015 | Am J Case Rep2015，3，16： | 1 |
| 18 | Prediction of persistent vaginal intraepithelial neoplasis in previously hystereetomized women by highrisk HPV DNA deteetion显示文摘 | Frega A French D Piazze J | 2007 | Catleer Lett2007，249，2： | 1 |
| 19 | Fertility-spar- ing treatment of endometrial cancer precursors among young women: a reproductive point of view显示文摘 | Ricciardi E Maniglio P Frega A | 2012 | Eur Rev Med Pharmacol Sci2012，16，14： | 1 |
| 20 | Yaung women,cervical intraepithelial neoplasia and human papillomavirus:risk factors for persistence and recurrence显示文摘 | Frega A Stentella P DeIoris A | 2003 | Cancer Letters2003，196，2： | 1 |
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