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| 1 | Alterations of endogenous metabolites in urine of rats exposed to decabromodiphenyl ether using metabonomic approaches显示文摘There is large usage of polybrominated diphenyl ethers(PBDEs) especially for decabromodiphenyl ether(BDE-209, Deca-BDE) in controlling the risks of fire. The toxicological effects of PBDEs are worth being concerned about. Female SD rats were daily gavaged with BDE-209 ether at the dose of 100 mg/kg for 20 days. Histological observation was performed for the screening of the target organs for BDE-209 exposure. The distribution and metabolism of PBDEs in the exposed main organs were evidenced by HRGC-HRMS. Alterations of the endogenous metabolite concentrations in urine were investigated using metabonomic approaches based on1H NMR spectrum. Histopathological changes including serious edema in kidney, hepatocellular spotty necrosis and perivasculitis in liver indicated that BDE-209 caused potential influences on endogenous metabolism in the exposed liver and the kidney. BDE-209 was found to be highly accumulated in lipid, ovary, kidney and liver after 20 days' exposure. Occurrence of other lower brominated PBDEs in the rats demonstrated that reductive debromination process happened in vivo. Hydroxylated and methoxylated–BDEs, as metabolism products, were also detected in the rat tissues. A total of 12 different endogenous metabolites showed obvious alterations in urine from the exposed rats, indicating the disturbance of the corresponding internal biochemical processes induced by BDE-209 exposure. These findings in vivo suggested the potential health risk might be of concern due to the toxicological effects of BDE-209 as a ubiquitous compound in the environment. | Weijin Yang Jianjie Fu Thanh Wang Hanxia Liu Yawei Wang Qunfang Zhou Guibin Jiang | 2014 | Journal of Environmental Sciences2014，26，4： | 3 |
| 2 | Quantitative structure–activity relationship for prediction of the toxicity of polybrominated diphenyl ether (PBDE) congeners显示文摘 | Yawei Wang Chunyan Zhao Weiping Ma Hanxia Liu Thanh Wang Guibin Jiang | 2005 | Chemosphere2005，，4： | 1 |
| 3 | Emerging organic contamination in China显示文摘 | Guibin JIANG Qinghua ZHANG Yawei WANG Hanxia LIU Chunyang LIUO Rui GUO | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 1 |
| 4 | E-waste recycling induced polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorinated dibenzo- p -dioxins and dibenzo-furans pollution in the ambient environment显示文摘 | Hanxia Liu Qunfang Zhou Yawei Wang Qinghua Zhang Zongwei Cai Guibin Jiang | 2007 | Environment International2007，，1： | 1 |
| 5 | A GH3-like gene, CcGH3, isolated from Capsicum chinense L. fruit is regulated by auxin and ethylene*显示文摘 | Kede Liu Byoung-Cheorl Kang Hui Jiang Shanna L. Moore Hanxia Li Christopher B. Watkins Tim L. Setter Molly M. Jahn | 2005 | Plant Molecular Biology2005，，4： | 1 |
| 6 | E-waste recycling induced polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and dibenzo-furans pollution in the ambient environment显示文摘 | LIU Hanxia ZHOU Qunfang WANG Yawei | 2008 | Environ Intern2008，34，1： | 1 |
| 7 | Polybrominated diphenyl ethers and organochlorine pesticides in sewage sludge of wastewater treatment plants in China显示文摘 | Yawei Wang Qinghua Zhang Jianxia Lv An Li Hanxia Liu Guogang Li Guibin Jiang | 2007 | Chemosphere2007，，9： | 1 |
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