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| 1 | Metabolic and hepatic effects of liraglutide,obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis(NASH) in obese mouse models of biopsy-confirmedNASH.METHODS Male wild-type C57 BL/6 J mice(DIO-NASH) and Lep^(ob/ob)(ob/ob-NASH) mice were fed a diet high in trans-fat(40%), fructose(20%) and cholesterol(2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver biopsy for confirmation and stratification of liver steatosis and fibrosis, using the nonalcoholic fatty liver disease activity score(NAS) and fibrosis staging system. The mice were kept on the diet and received vehicle, liraglutide(0.2 mg/kg, SC, BID), obeticholic acid(OCA, 30 mg/kg PO, QD), or elafibranor(30 mg/kg PO, QD) for eight weeks. Within-subject comparisons were performed on changes in steatosis, inflammation, ballooning degeneration, and fibrosis scores. In addition, compound effects were evaluated by quantitative liver histology, including percent fractional area of liver fat, galectin-3, and collagen 1 a1.RESULTS Liraglutide and elafibranor, but not OCA, reduced body weight in both models. Liraglutide improved steatosis scores in DIO-NASH mice only. Elafibranor and OCA reduced histopathological scores of hepatic steatosis and inflammation in both models, but only elafibranor reduced fibrosis severity. Liraglutide and OCA reduced total liver fat, collagen 1 a1, and galectin-3 content, driven by significant reductions in liver weight. The individual drug effects on NASH histological endpoints were supported by global gene expression(RNA sequencing) and liver lipid biochemistry.CONCLUSION DIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of DIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical drug development for NASH. | Kirstine S Tolbol Maria NB Kristiansen Henrik H Hansen Sanne S Veidal Kristoffer TG Rigbolt Matthew P Gillum Jacob Jelsing Niels Vrang Michael Feigh | 2018 | World Journal of Gastroenterology2018，24，2： | 5 |
| 2 | The structure ofcoping among older adults living with HIV/AIDS and de-pressive symptoms 显示文摘 | Hansen NB Harrison B Fambro S | 2013 | Journal of Health Psychology2013，18，2： | 1 |
| 3 | Carvedilol or propranolol in portal hypertension? A randomized comparison显示文摘 | Lise Hobolth S?ren M?ller Henning Gr?nb?k Klaus Roelsgaard Flemming Bendtsen Erik Feldager Hansen | 2012 | Scandinavian Journal of Gastroenterology2012，，4： | 1 |
| 4 | Detection of enterotoxic Bacillus cereus and Bacillus thuringiensis strains by PCR analysis显示文摘 | Hansen BM Hendriksen NB | 2001 | Appl Environmental Microbiol2001，67，1： | 1 |
| 5 | Mitochondrial DNA integrity is not dependent on DNA Polymerase-beta activity显示文摘 | Hansen AB Griner NB Anderson JP | 2006 | DNA Repair2006，5，1： | 1 |
| 6 | Validity of Doppler measurements of anterior cerebral artery blood flow velocity : correlation with brain blood flow in piglets 显示文摘 | Hansen NB Stonestreet BS Rosenkrantz TS | 1983 | Pediatrics1983，72，4： | 1 |
| 7 | Peptide Receptor Radionuclide Therapy with Y-DOTATOC and 177Lu-DOTATOC in Advanced Neuroendocrine Tumors: Results from a Danish Cohort Treated in Switzerland显示文摘 | Pfeifer Andreas Klaus Gregersen Tine Gr?nb?k Henning Hansen Carsten Paln?s Müller-brand Jan Herskind Bruun Karin Krogh Klaus Kj?r Andreas Knigge Ulrich | 2011 | EN2011，，3： | 1 |
| 8 | 2型糖尿病患者夜间高血压的治疗显示文摘一些针对不同人群的研究提示:夜间血压是一个较白天血压更强的心血管事件预测因子,针对夜间高血压的治疗策略已经成为关注的焦点。该研究旨在探讨改变降压药服用时间对2型糖尿病患者降压疗效的影响。该研究是一个开放交叉研究,包括2型糖尿病合并夜间高血压[夜间收缩压〉120mm Hg(1mm Hg=0.133kPa)]患者41例。患者随机分为早晨或夜间服用降压药8周,1次/d,然后改变服药时间治疗8周。 | 赵狄 练桂丽 Rossen NB Knudsen ST Fleischer J Hvas AM EbbehØj E Poulsen PL Hansen KW | 2014 | 中华高血压杂志2014，22，11： | 1 |
| 9 | The impact of receiving an HIV diagnosis and cognitive processing on psychological distress and post- traumatic growth显示文摘 | Nightingale VR Sher TG Hansen NB | 2010 | J Trauma Stress2010，23，4： | 1 |
| 10 | The structure of coping among older adults living with HIV/AIDS and depressive symptoms 显示文摘 | Hansen NB Harrison B Fambro S | 2013 | J Health Psychol2013，18，2： | 1 |
| 11 | Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity显示文摘 | Hansen AB Griner NB Anderson JP | 2006 | DNA Repair2006，5，1： | 1 |
| 12 | The Impact of receiv- ing an HIV diagnosis and cognitive processing on psycholog- ical distress and posttraumatic growth 显示文摘 | Nightingale VR Sher TG Hansen NB | 2010 | Journal of Trau- matic Stress2010，23，4： | 1 |
| 13 | A short-term group treatment model for gay male survivors of childhood sexual abuse living with HIV/AIDS 显示文摘 | MASTEN J KOCHMAN A HANSEN NB | 2007 | Int J Group Psychother2007，57，4： | 1 |
| 14 | Detection of enterotoxic Bacillus cereus and Bacillus thuringiensis strains by PCR analysis显示文摘 | Hansen BM Hendriksen NB | 2001 | Appl Environ Microb2001，67，1： | 1 |
| 15 | The impact of receiving an HIV diagnosis and cognitive processing on psychological distress and posttraumatic growth显示文摘 | Nightingale VR Sher TG Hansen NB | 2010 | J Trauma Stress2010，23，4： | 1 |
| 16 | Magnetic Dynamics of Small Alpha- Fe2O3 and NiO Particles Studied by Neutron Scattering显示文摘 | LEFMANN K BODKER F HANSEN MF VAZQUEZ H CHRISTENSEN NB LINDGARD PA CLAUSEN KN MORUP S | 1999 | European Physical Journal D1999，9，： | 1 |
| 17 | Thrombolytic therapy of acute myocardial infarction alters collagen metabolism显示文摘 | Hansen SS Jensen LT | 1994 | Cardiology1994，85，： | 1 |
| 18 | The structure of cop- ing among older adults living with HIV/AIDS and depressive symptoms显示文摘 | Hansen NB Harrison B Fambro S | 2013 | J Health Psychol2013，18，2： | 1 |
| 19 | Adherence to an- tiretroviral medication in older adults living with HIV/AIDS :a comparison of alternative models显示文摘 | Johnson CJ Heekman TG Hansen NB | 2009 | AIDS Care2009，21，5： | 1 |
| 20 | IPM Strategies and Their Dilemmas Including an Introduction to www. eurowheat.org显示文摘Information about disease management in winter wheat(Triticum aestiva)in eight European countries was collated and analysed by scientists and extension workers within the European Network for the Durable Exploitation of Crop Protection Strategies(ENDURE).This included information about specif ic disease thresholds,decision support systems,host varieties,disease prevalence and pathogen virulence.Major differences in disease prevalence and economic importance were observed.Septoria tritici blotch(Mycosphaerella graminicola)was recognized as the most yield reducing disease in countries with intensive wheat production,but also rust diseases(Puccinia striiformis and Puccinia triticina),powdery mildew(Blumeria graminis)and Fusarium head blight(Fusarium spp.)were seen as serious disease problems.Examples of current integrated pest management(IPM)strategies in different countries have been reported.Disease management and fungicide use patterns showed major differences,with an average input equivalent to 2.3 full dose rates(TFI)in the UK and a TFI of 0.6 in Denmark.These differences are most likely due to a combination of different cropping systems,climatic differences,disease prevalence,and socio-economic factors.The web based information platform www.eurowheat.org was used for dissemination of information and results including information on control thresholds,cultural practices which can infl uence disease attack,fungicide eff icacy,fungicide resistance,and pathogen virulence,which are all elements supporting IPM for disease control in wheat.The platform is open to all users.The target groups of EuroWheat information are researchers,advisors,breeders,and similar partners dealing with disease management in wheat. | Lise Nistrup Jφrgensen Mogens Stφvring Hovmφller Jens Grφnbk Hansen Poul Lassen Bill Clark Rosemary Bayles Bernd Rodemann Kerstin Flath Margot Jahn Tomas Goral Jerzy Czembor J Philip Cheyron Claude Maumene Claude De Pope Rita Ban Ghita Cordsen Nielsen Gunilla Berg | 2014 | Journal of Integrative Agriculture2014，13，2： | 1 |
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