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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | Elastomeric lenses with tunable astigmatism显示文摘Microlenses fabricated using flexible elastomers can be tuned in focal length by application of controlled strain.By varying the strain azimuthally,the lenses may be deformed asymmetrically such that aberrations may be controlled.This approach is used to tune the astigmatism of the tunable lenses,and it is shown that the generated wavefront may be accurately controlled.The lens presented here has an initial focal length of 32.6 mm and a tuning range of 12.3 mm for approximately 10%applied strain.The range of directly tunable Zernike polynomials representing astigmatism is about 3 mm,while the secondary lens errors,which cannot be tuned directly,vary only by about 0.2 mm. | Peter Liebetraut Sebastian Petsch Jens Liebeskind Hans Zappe | 2013 | Light(Science & Applications)2013，2，1： | 3 |
| 3 | Tunable microfluidic microlenses 显示文摘 | WerberA Hans Zappe | 2005 | Applied Optics2005，44，16： | 1 |
| 4 | Variable optofluidic slit aperture显示文摘The shape of liquid interfaces can be precisely controlled using electrowetting,an actuation mechanism which has been widely used for tunable optofluidic micro-optical components such as lenses or irises.We have expanded the considerable flexibility inherent in electrowetting actuation to realize a variable optofluidic slit,a tunable and reconfigurable two-dimensional aperture with no mechanically moving parts.This optofluidic slit is formed by precisely controlled movement of the liquid interfaces of two highly opaque ink droplets.The 1.5mmlong slit aperture,with controllably variable discrete widths down to 45 mm,may be scanned across a length of 1.5mmwith switching times between adjacent slit positions of less than 120 ms.In addition,for a fixed slit aperture position,the width may be tuned to a minimum of 3 mmwith high uniformity and linearity over the entire slit length.This compact,purely fluidic device offers an electrically controlled aperture tuning range not achievable with extant mechanical alternatives of a similar size. | Stefan Schuhladen Kaustubh Banerjee Moritz Stürmer Philipp Müller Ulrike Wallrabe Hans Zappe | 2016 | Light(Science & Applications)2016，5，1： | 1 |
| 5 | Usefulness of Heart Rate to Predict Cardiac Events in Treated Patients With High-Risk Systemic Hypertension显示文摘 | Stevo Julius Paolo Palatini Sverre E. Kjeldsen Alberto Zanchetti Michael A. Weber Gordon T. McInnes Hans R. Brunner Giuseppe Mancia M. Anthony Schork Tsushung A. Hua Bjoern Holzhauer Dion Zappe Silja Majahalme Kenneth Jamerson Nevres Koylan | 2012 | The American Journal of Cardiology2012，，5： | 1 |
| 6 | Wafer-scale fabricated thermo-pneumatically tunable microlenses显示文摘We have developed a self-contained,liquid tunable microlens based on polyacrylate membranes integrated with compact on-chip thermo-pneumatic actuation fabricated using full-wafer processing.Silicone oil is used as the optical liquid,which is pushed or pulled into the lens cavity via an extended microfluidic channel structure without any pumps,valves or other mechanical means.The heat load generated by the thermal actuator is physically isolated from the lens chamber.The back focal length may be tuned from infinity to 4 mm with a maximum power consumption of 300 mW.The principal application is fine tuning of the back focal length,for which tuning time constants as small as 100 ms are suitable. | Wei Zhang Hans Zappe Andreas Seifert | 2014 | Light(Science & Applications)2014，3，1： | 1 |
| 7 | An imaging spectrometer employing tunable hyperchromatic microlenses显示文摘We present the design,fabrication and characterization of hydraulically-tunable hyperchromatic lenses for two-dimensional(2D)spectrally-resolved spectral imaging.These hyperchromatic lenses,consisting of a positive diffractive lens and a tunable concave lens,are designed to have a large longitudinal chromatic dispersion and the images of different wavelengths from each other.2D objects of different wavelengths can consequently be imaged using the tunability of the lens system.Two hyperchromatic lens concepts are demonstrated and their spectral characteristics as well as their functionality in spectral imaging applications are shown. | Phuong-Ha Cu-Nguyen Adrian Grewe Patrik Feßer Andreas Seifert Stefan Sinzinger Hans Zappe | 2015 | Light(Science & Applications)2015，4，1： | 1 |
| 8 | Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae)显示文摘 | Dirk Umlauf Josef Zapp Hans Becker Klaus Peter Adam | 2004 | Phytochemistry2004，，17： | 1 |
| 9 | Cascading optofluidic phase modulators for performance enhancement in refractive adaptive optics显示文摘We discuss the implementation and performance of an adaptive optics(AO)system that uses two cascaded deformable phase plates(DPPs),which are transparent optofluidic phase modulators,mimicking the common woofer/tweeter-type astronomical AO systems.One of the DPPs has 25 electrodes forming a keystone pattern best suited for the correction of low-order and radially symmetric modes;the second device has 37 hexagonally packed electrodes better suited for high-order correction.We also present simulation results and experimental validation for a new open-loop control strategy enabling simultaneous control of both DPPs,which ensures optimum correction for both large-amplitude low-order,and complex combinations of low-and high-order aberrations.The resulting system can reproduce Zernike modes up to the sixth radial order with stroke and fidelity up to twice better than what is attainable with either of the DPPs individually.The performance of the new AO configuration is also verified in a custom-developed fluorescence microscope with sensorless aberration correction. | Pouya Rajaeipour Kaustubh Banerjee Alex Dorn Hans Zappe Caglar Ataman | 2020 | Advanced Photonics2020，2，6： | 0 |
| 10 | The engineered eyeball, a tunable imaging system using soft-matter micro-optics显示文摘We demonstrate a tunable imaging system based on the functionality of the mammalian eye using soft-matter micro-optical components.Inspired by the structure of the eye,as well as by the means through which nature tunes its optical behavior,we show that the technologies of microsystems engineering and micro-optics may be used to realize a technical imaging system whose biomimetic functionality is entirely distinct from that of conventional optics.The engineered eyeball integrates a deformable elastomeric refractive structure whose shape is mechanically controlled through application of strain using liquid crystal elastomer(LCE)actuators;two forms of tunable iris,one based on optofluidics and the other on LCEs with embedded heaters;a fixed lens arrangement;and a commercial imaging sensor chip.The complete microsystem,optimized to yield optical characteristics close to those of the human eye,represents the first fully functional,soft-matter-based tunable single-aperture eye-like imager. | Sebastian Petsch Stefan Schuhladen Lucas Dreesen Hans Zappe | 2016 | Light(Science & Applications)2016，5，1： | 0 |
| 11 | 热驱动微光学(英文)显示文摘通过实例研究和近期报道的文献,论述了热驱动微光学的研究进展。驱动器主要通过应用在液体和液气界面的压力来调控光学微流体,包括微镜片和薄膜微透镜,热驱动器利用芯片上的温度变化产生所需要的压力差,从而对微透镜进行调控。同时还讨论了用于微光学结构的各种设备、结构、液体和膜材料,并提供了典型操作特性。 | 张维 ZAPPE Hans | 2014 | 中国光学2014，7，2： | 0 |
| 12 | Novel components for tunable micro-optics显示文摘We will present some technologies and devices employed for the fabrication of tunable micro-optics. Tunable liquid lenses and lens arrays as well as polymer membrane-based microlenses and scanning mirrors are of both academic and industrial interest in this area. | HANS Zappe | 2008 | Optoelectronics Letters2008，4，2： | 0 |
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