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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | Multimodal imaging in acute retinal ischemia: spectral domain OCT, OCT-angiography and fundus autofluorescence显示文摘AIM: To describe retinal findings of various imaging modalities in acute retinal ischemia. METHODS: Fluorescein angiography(FA), spectral domain optical coherence tomography(SD-OCT), OCTangiography(OCT-A) and fundus autofluorescence(FAF) images of 13 patients(mean age 64y, range 28-86y) with acute retinal ischemia were evaluated. Six suffered from branch arterial occlusion, 2 had a central retinal artery occlusion, 2 had a combined arteriovenous occlusions, 1 patient had a retrobulbar arterial compression by an orbital haemangioma and 2 patients showed an ocular ischemic syndrome.RESULTS: All patients showed increased reflectivity and thickening of the ischemic retinal tissue. In 10 out of 13 patients SD-OCT revealed an additional highly reflective band located within or above the outer plexiform layer. Morphological characteristics were a decreasing intensity with distance from the fovea, partially segmental occurrence and manifestation limited in time. OCT-A showed a loss of flow signal in the superficial and deep capillary plexus at the affected areas. Reduced flow signal was detected underneath the regions with retinal edema. FAF showed areas of altered signal intensity at the posterior pole. The regions of decreased FAF signal corresponded to peri-venous regions. CONCLUSION: Multimodal imaging modalities in retinal ischemia yield characteristic findings and valuable diagnostic information. Conventional OCT identifies hyperreflectivity and thickening and a mid-retinal hyperreflective band is frequently observed. OCT-A examination reveals demarcation of the ischemic retinal area on the vascular level. FAF shows decreased fluorescence signal in areas of retinal edema often corresponding to peri-venous regions. | Nikolaus Feucht Daniel Zapp Lukas Reznicek Chris P.Lohmann Mathias Maier Christian S.Mayer | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 3 |
| 3 | Elastomeric lenses with tunable astigmatism显示文摘Microlenses fabricated using flexible elastomers can be tuned in focal length by application of controlled strain.By varying the strain azimuthally,the lenses may be deformed asymmetrically such that aberrations may be controlled.This approach is used to tune the astigmatism of the tunable lenses,and it is shown that the generated wavefront may be accurately controlled.The lens presented here has an initial focal length of 32.6 mm and a tuning range of 12.3 mm for approximately 10%applied strain.The range of directly tunable Zernike polynomials representing astigmatism is about 3 mm,while the secondary lens errors,which cannot be tuned directly,vary only by about 0.2 mm. | Peter Liebetraut Sebastian Petsch Jens Liebeskind Hans Zappe | 2013 | Light(Science & Applications)2013，2，1： | 3 |
| 4 | Four sesquiterpenes from the insecticidal plant Celastrus angulatus 显示文摘 | Liu J K Becker H Zapp J | 1995 | Phytochemistry1995，40，3： | 1 |
| 5 | In vivo confocal microscopy of corneal small fiber damage in diabetes melhtus 显示文摘 | Messmer EM Schmid-Tannwald C Zapp D | 2010 | Graefes Arch Clin Exp Ophthalmol2010，248，9： | 1 |
| 6 | Rethinking what motivates employees and candidates 显示文摘 | ZAPPE J | 2010 | Journal of Corporate Recruiting Lead- ership2010，，11： | 1 |
| 7 | 查看详情显示文摘 | Aljasem K Werber A Seifert A Zappe H | | 0，，： | 1 |
| 8 | Synthesis- driven structure revision of' plagiochin E', a highly bioacfive bisbibenzyl显示文摘 | SPEICHER A GROH M ZAPP J | 2009 | Synlett2009，，11： | 1 |
| 9 | In vivo confocal microscopy of normal conjunctiva and conjunctivitls显示文摘 | Messmer E M Mackert M J Zapp DM | 2006 | Cornea2006，25，： | 1 |
| 10 | Analysis of Impacts Recorded with an Instrumented Sphere显示文摘 | KLUG BA TENNES BR ZAPP H R | 1989 | Transaction of the ASAE1989，32，3： | 1 |
| 11 | Advanced Instrumented Sphere of Impact Measurements显示文摘 | ZAPP H R EHLERT S H BROWN G K | 1990 | Transaction of the ASAE1990，33，3： | 1 |
| 12 | Just-in-Time Teaching Exercises to Engage Students in an Introductory-Level Dinosaur Course显示文摘 | Laura A. Guertin Sarah E. Zappe Heeyoung Kim | 2007 | Journal of Science Education and Technology2007，，6： | 1 |
| 13 | HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA显示文摘 | Zapp ML Green MR | 1991 | Cell1991，67，3： | 1 |
| 14 | High temperature 10 bar pressure sensor based on 3C-SIC/SOI for turbine control applica- tions 显示文摘 | Zappe S Franklin J Obermeier E | 2000 | Silicon Carbide and Related Materials2000，353，3： | 1 |
| 15 | Sequence-specific RNA binding by theHIV-1 Rev protein显示文摘 | Green MR | 1989 | Nature1989，342，6250： | 1 |
| 16 | Solving time/cost trade-off problem with discounted cash flows using generalized benders decomposition显示文摘 | Erenguc SS Tufekci S Zappe CJ | 1993 | Naval Research Logistics1993，40，1： | 1 |
| 17 | The influence of moderate hypercapnia on neural activity in the anesthetized nonhuman primate 显示文摘 | Zappe AC Uludag K Oeltermann A | 2008 | Cereb Cortex2008，18，11： | 1 |
| 18 | Worldwide innovations in the development of carbon capture technologies and the utilization of CO2 显示文摘 | Markewitz P Kuckshinrichs W Leitner W Linssen J Zapp P Bongartz R Schreiber A Miiller TE | 2012 | Energy Environ Sci2012，5，6： | 1 |
| 19 | Optically active bisbibenzyls from Bazzania trilobata: isolation and stereochemical analysis by chromatographic, chiroptical, and computational methods 显示文摘 | Scher JM Zapp J Becker H | 2004 | Tetrahedron2004，60，44： | 1 |
| 20 | The effect of labeling parameters on perfusion-based fMRI in nonhuman primates显示文摘 | Zappe AC Pfeuffer J Merkle H | 2008 | J Cereb Blood Flow Metab2008，28，3： | 1 |
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