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| 1 | Endovascular treatment of nonvariceal acute arterial upper gastrointestinal bleeding显示文摘Transcatheter arterial embolization as treatment of upper nonvariceal gastrointestinal bleeding is increasingly being used after failed primary endoscopic treatment.The results after embolization have become better and surgery still has a high mortality.Embolization is a safe and effective procedure,but its use is has been limited because of relatively high rates of rebleeding and high mortality,both of which are associated with gastrointestinal bleeding and non-gastrointestinal related mortality causes.Transcatheter arterial embolization is a valuable minimal invasive method in the treatment of early rebleeding and does not involve a high risk of treatment associated complications.A multidisciplinary approach is necessary in the treatment of these patients and should comprise gastroenterologists,interventional radiologists,anaesthesiologists,and surgeons to achieve the best possible results. | Poul Erik Andersen Stevo Duvnjak | 2010 | World Journal of Radiology2010，2，7： | 11 |
| 2 | Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite显示文摘 | Nenad Ignjatovic Zorica Aj dukovic Jelena Rajkovic Stevo Najman Dragan Mihailovic Dragan Uskokovic | 2015 | Journal of Bionic Engineering2015，12，4： | 3 |
| 3 | Vascularization and osteogenesis in ectopically implanted bone tissue-engineered constructs with endothelial and osteogenic differentiated adipose-derived stem cells显示文摘BACKGROUND A major problem in the healing of bone defects is insufficient or absent blood supply within the defect.To overcome this challenging problem,a plethora of approaches within bone tissue engineering have been developed recently.Bearing in mind that the interplay of various diffusible factors released by endothelial cells(ECs)and osteoblasts(OBs)have a pivotal role in bone growth and regeneration and that adjacent ECs and OBs also communicate directly through gap junctions,we set the focus on the simultaneous application of these cell types together with platelet-rich plasma(PRP)as a growth factor reservoir within ectopic bone tissue engineering constructs.AIM To vascularize and examine osteogenesis in bone tissue engineering constructs enriched with PRP and adipose-derived stem cells(ASCs)induced into ECs and OBs.METHODS ASCs isolated from adipose tissue,induced in vitro into ECs,OBs or just expanded were used for implant construction as followed:BPEO,endothelial and osteogenic differentiated ASCs with PRP and bone mineral matrix;BPUI,uninduced ASCs with PRP and bone mineral matrix;BC(control),only bone mineral matrix.At 1,2,4 and 8 wk after subcutaneous implantation in mice,implants were extracted and endothelial-related and bone-related gene expression were analyzed,while histological analyses were performed after 2 and 8 wk.RESULTS The percentage of vascularization was significantly higher in BC compared to BPUI and BPEO constructs 2 and 8 wk after implantation.BC had the lowest endothelial-related gene expression,weaker osteocalcin immunoexpression and Spp1 expression compared to BPUI and BPEO.Endothelial-related gene expression and osteocalcin immunoexpression were higher in BPUI compared to BC and BPEO.BPEO had a higher percentage of vascularization compared to BPUI and the highest CD31 immunoexpression among examined constructs.Except Vwf,endothelial-related gene expression in BPEO had a later onset and was upregulated and well-balanced during in vivo incubation that induced late onset of Spp1 expression and pronounced osteocalcin immunoexpression at 2 and 8 wk.Tissue regression was noticed in BPEO constructs after 8 wk.CONCLUSION Ectopically implanted BPEO constructs had a favorable impact on vascularization and osteogenesis,but tissue regression imposed the need for discovering a more optimal EC/OB ratio prior to considerations for clinical applications. | Jelena G Najdanović Vladimir J Cvetković Sanja T Stojanović MarijaĐVukelić-Nikolić Jelena MŽivković Stevo J Najman | 2021 | World Journal of Stem Cells2021，13，1： | 3 |
| 4 | Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components--Guidance of the inflammatory response as basis for osteochondral regeneration显示文摘The aim of the present study was the in vitro and in vivo analysis of a bi-layered 3D-printed scaffold combining a PLA layer and a biphasic PLA/bioglass G5 layer for regeneration of osteochondral defects in vivo Focus of the in vitro analysis was on the(molecular)weight loss and the morphological and mechanical variations after immersion in SBF.The in vivo study focused on analysis of the tissue reactions and differences in the implant bed vascularization using an established subcutaneous implantation model in CD-1 mice and established histological and histomorphometrical methods.Both scaffold parts kept their structural integrity,while changes in morphology were observed,especially for the PLA/G5 scaffold.Mechanical properties decreased with progressive degradation,while the PLA/G5 scaffolds presented higher compressive modulus than PLA scaffolds.The tissue reaction to PLA included low numbers of BMGCs and minimal vascularization of its implant beds,while the addition of G5 lead to higher numbers of BMGCs and a higher implant bed vascularization.Analysis revealed that the use of a bi-layered scaffold shows the ability to observe distinct in vivo response despite the physical proximity of PLA and PLA/G5 layers.Altogether,the results showed that the addition of G5 enables to reduce scaffold weight loss and to increase mechanical strength.Furthermore,the addition of G5 lead to a higher vascularization of the implant bed required as basis for bone tissue regeneration mediated by higher numbers of BMGCs,while within the PLA parts a significantly lower vascularization was found optimally for chondral regeneration.Thus,this data show that the analyzed bi-layered scaffold may serve as an ideal basis for the regeneration of osteochondral tissue defects.Additionally,the results show that it might be able to reduce the number of experimental animals required as it may be possible to analyze the tissue response to more than one implant in one experimental animal. | Mike Barbeck Tiziano Serra Patrick Booms Sanja Stojanovic Stevo Najman Elisabeth Engel Robert Sader Charles James Kirkpatrick Melba Navarro Shahram Ghanaati | 2017 | Bioactive Materials2017，2，4： | 3 |
| 5 | Endovascular treatment of aortoiliac aneurysms: From intentional occlusion of the internal iliac artery to branch iliac stent graft显示文摘Approximately 20%-40% of patients with abdominal aortic aneurysms can have unilateral or bilateral iliac artery aneurysms and/or ectasia. This influences and compromises the distal sealing zone during endovascular aneurysm repair. There are a few endovascular techniques that are used to treat these types of aneurysms, including intentional occlusion/over-stenting of the internal iliac artery on one or both sides, the 'bell-bottom' technique, and the more recent method of using an iliac branch stent graft. In some cases, other options include the 'snorkel and sandwich' technique and hybrid interventions. Pelvic ischemia, represented as buttock claudication, has been reported in 16%-55% of cases; this is followed by impotence, which has been described in 10%-17% of cases following internal iliac artery occlusion. The bellbottom technique can be used for a common iliac artery up to 24 mm in diameter given that the largest diameter of the stent graft is 28 mm. There is a paucity of data and evidence regarding the 'snorkel and sandwich' technique, which can be used in a few clinical scenarios. The hybrid intervention is comprised of a surgical operation, and is not purely endovascular. The newest branch stent graft technology enables preservation of the anterograde flow of important side branches. Technical success with the newest technique ranges from 85%-96.3%, and in some small series, technical success is 100%. Buttock claudication was reported in up to 4% of patients treated with a branch stent graft at 5-year follow-up. Mid- and short-term follow-up results showed branch patency of up to 88% during the 5-6-year period. Furthermore, branch graft occlusion is a potential complication, and it has been described to occur in 1.2%-11% of cases. Iliac branch stent graft placement represents a further development in endovascular medicine, and it has a high technical success rate without serious complications. | Stevo Duvnjak | 2016 | World Journal of Radiology2016，8，3： | 2 |
| 6 | Stroke is More Common than Myocardial Infarction in Hypertension: Analysis based on 11 Major Randomized Intervention Trials显示文摘 | Sverre E. Kjeldsen Stevo Julius Thomas Hedner Lennart Hansson | 2001 | Blood Pressure2001，，4： | 2 |
| 7 | Global stability and asymptotics of some classes of rational differece equations 显示文摘 | Stevo Stevic | 2006 | J Math Anal Appl2006，316，： | 1 |
| 8 | Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial显示文摘 | Stevo Julius Sverre E Kjeldsen Michael Weber Hans R Brunner Steffan Ekman Lennart Hansson Tsushung Hua John Laragh Gordon T McInnes Lada Mitchell Francis Plat Anthony Schork Beverly Smith Alberto Zanchetti | 2004 | The Lancet2004，，9426： | 1 |
| 9 | On the difference equationα+xn-x/xn显示文摘 | Stevo Stevic | 2008 | Computers and Mathematics with Applications2008，56，： | 1 |
| 10 | The physiological determinants and risk correlations of elevated heart rate显示文摘 | Paolo Palatini Stevo Julius | 1999 | American Journal of Hypertension1999，，1： | 1 |
| 11 | Weighted Composition Operators from Zygmund Spaces into Bloch Spaces显示文摘 | Li Songxiao Stevo Stevic | 2008 | Applied Mathematics and Computation2008，206，： | 1 |
| 12 | Effects of intensive blood-显示文摘 | Lennart Hansson Alberto Zancbetti S George Carruthers B jom Dahlof Dag Elmfeldt Stevo Julius | 1998 | Lancet1998，351，13： | 1 |
| 13 | Asymptotic behavior of second-order dynamic equations 显示文摘 | Bohner Martin Stevic Stevo | 2007 | Applied Mathematics and Compu- tation2007，188，： | 1 |
| 14 | Feasibility of treating prehypertension with an angiotensin-receptor blocker显示文摘 | Stevo J Shawna DN Brent ME | 2006 | N Engl J Med2006，351，： | 1 |
| 15 | Asymptotic behavior of second-order dynamic equations 显示文摘 | Bohner Martin Stcvi8 Stevo | 2007 | Applied Mathematics and Com- putation2007，188，： | 1 |
| 16 | Products of composition and integral type operators from H∞ to the Bloch space显示文摘 | Songxiao Li Stevo Stevic | 2008 | Complex Variables and Elliptic Equations2008，，5： | 1 |
| 17 | Autonomic imbalance, hypertension, and cardiovascular risk显示文摘 | Robert D Brook Stevo Julius | 2000 | American Journal of Hypertension2000，，6： | 1 |
| 18 | Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial显示文摘 | Stevo Julius Sverre E Kjeldsen Michael Weber Hans R Brunner Steffan Ekman Lennart Hansson Tsushung Hua John Laragh Gordon T McInnes Lada Mitchell Francis Plat Anthony Schork Beverly Smith Alberto Zanchetti | 2004 | 2004 (9426)2004，，9426： | 1 |
| 19 | Global asymptotic stability of second order rational difference equation显示文摘 | Lin-Xia Hu Wan-Tong Li Stevo Stevic | | 0，，08： | 1 |
| 20 | Usefulness of Heart Rate to Predict Cardiac Events in Treated Patients With High-Risk Systemic Hypertension显示文摘 | Stevo Julius Paolo Palatini Sverre E. Kjeldsen Alberto Zanchetti Michael A. Weber Gordon T. McInnes Hans R. Brunner Giuseppe Mancia M. Anthony Schork Tsushung A. Hua Bjoern Holzhauer Dion Zappe Silja Majahalme Kenneth Jamerson Nevres Koylan | 2012 | The American Journal of Cardiology2012，，5： | 1 |
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