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| 1 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 2 | PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15显示文摘Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer patients.Recently,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse models.Herein,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer patients.Single-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)TILs.Furthermore,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)TILs.Transcriptionally and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 expression.Notably,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)TILs.Taken together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies. | Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee Ji Won Han Seong Jin Choi Seongju Jeong Minwoo Jeon Hyunglae Kim Jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-Cheol Shin | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 3 | Development and validation of a prognostic nomogram model for Chinese patients with primary small cell carcinoma of the esophagus显示文摘BACKGROUND Primary small cell carcinoma of the esophagus(PSCE)is a highly invasive malignant tumor with a poor prognosis compared with esophageal squamous cell carcinoma.Due to the limited samples size and the short follow-up time,there are few reports on elucidating the prognosis of PSCE,especially on the establishment and validation of a survival prediction nomogram model covering general information,pathological factors and specific biological proteins of PSCE patients.AIM To establish an effective nomogram to predict the overall survival(OS)probability for PSCE patients in China.METHODS The nomogram was based on a retrospective study of 256 PSCE patients.Univariate analysis and multivariate Cox proportional hazards regression analysis were used to examine the prognostic factors associated with PSCE,and establish the model for predicting 1-,3-,and 5-year OS based on the Akaike information criterion.Discrimination and validation were assessed by the concordance index(C-index)and calibration curve and decision curve analysis(DCA).Histology type,age,tumor invasion depth,lymph node invasion,detectable metastasis,chromogranin A,and neuronal cell adhesion molecule 56 were integrated into the model.RESULTS The C-index was prognostically superior to the 7th tumor node metastasis(TNM)staging in the primary cohort[0.659(95%CI:0.607-0.712)vs 0.591(95%CI:0.517-0.666),P=0.033]and in the validation cohort[0.700(95%CI:0.622-0.778)vs 0.605(95%CI:0.490-0.721),P=0.041].Good calibration curves were observed for the prediction probabilities of 1-,3-,and 5-year OS in both cohorts.DCA analysis showed that our nomogram model had a higher overall net benefit compared to the 7th TNM staging.CONCLUSION Our nomogram can be used to predict the survival probability of PSCE patients,which can help clinicians to make individualized survival predictions. | Dong-Yun Zhang Gai-Rong Huang Jian-Wei Ku Xue-Ke Zhao Xin Song Rui-Hua Xu Wen-Li Han Fu-You Zhou Ran Wang Meng-Xia Wei Li-Dong Wang | 2021 | World Journal of Clinical Cases2021，9，30： | 2 |
| 4 | Intensive glycemic control and macrovascular events in type 2 diabetes mellitus: a meta-analysis of randomized controlled trials显示文摘在那里的背景不是在类型 2 糖尿病的集中的葡萄糖控制是否能在这些病人减少 macrovascular 事件的发生的协议。我们执行了包括控制的 MEDLINE, EMBASE,和 Cochrane 在使随机化的控制 trials.Methods 数据库比较集中的葡萄糖控制或常规葡萄糖控制的元分析试用收款机, Cochrane 图书馆,和科学引证索引被寻找发现相关试用。结果措施是主要 macrovascular events.Results 的发生包含 28 的六试用 065 个病人被包括。分析建议有在有集中的葡萄糖治疗对控制的病人的主要 macrovascular 事件的显然减少的发生(RR 0.92;95% Cl 0.87, 0.98;P=0.005 ) 。然而,在类型 2 糖尿病的集中的 glycemia 控制策略没与常规 glycemia 控制策略相比从任何原因在死亡的发生上显示出重要影响,集中 14.7% ,控制 12.0%(RR 0.95;95% Cl 0.80, 1.12;P=0.55 ) ,以及在心血管的死亡的发生上,集中 3.7% ,控制 3.6%(RR 1.10, 95% Cl 0.79, 1.53;P=0.57 ) 到正常的 glycemia 的 .Conclusions 控制(或近正常的层次) 在类型 2,糖尿病看起来在减少主要 macrovascular 事件的发生有效,但是没有也的重要差别从任何原因或从在二 glycemia 控制策略之间的心血管的死亡的死亡。 | WU Hong KU Mao-jin ZOU Da-jin HAN Qiao-jun HU Xue | 2010 | Chinese Medical Journal2010，，20： | 2 |
| 5 | Anti-HIV lignans from Justicia procumbens显示文摘Twenty-one lignans including three new ones(1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1 D and 2 D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate(13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L^-1 and a selective index(SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A(3) and diphyllin(8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95(SI > 6.2) and 0.38 μmol·L^-1(SI = 5.3), respectively. | XU Xin-Ya WANG Dong-Ying KU Chuen-Fai ZHAO Yang CHENG Han LIU Kang-Lun RONG Li-Jun ZHANG Hong-Jie | 2019 | Chinese Journal of Natural Medicines2019，17，12： | 2 |
| 6 | The effects of resistance training onmuscle and body fat mass and muscle strength in type 2 diabeticwomen显示文摘 | Kwon HR Han KA Ku YH | 2010 | Korean Diabetes J2010，34，2： | 1 |
| 7 | Sulforaphane inhibits endothelialprotein C receptor shedding in vitro and in vivo显示文摘 | Ku SK Han MS Bae JS | 2014 | Vas-cul Pharmacol2014，63，1： | 1 |
| 8 | Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival显示文摘 | KANG SS HAN KS KU BM | 2010 | Cancer Res2010，70，3： | 1 |
| 9 | Resistance exercise did not alterintramuscular adipose tissue but reduced retinol-binding protein-4 concentration in individuals with type 2 diabetes mellitus显示文摘 | Ku YH Han KA Ahn H | 2010 | J lnt Med Res2010，38，： | 1 |
| 10 | Recent advances in amino acid and energy nutrition of prolific sows显示文摘 | Boyd RD Touchette KJ Castro GC Johnston ME Lee KU Han IK | | 0，，： | 1 |
| 11 | Arterial wall adaptation under elevated longitudinal stretch in organ culture 显示文摘 | HAN HC KU DN VITO RP | 2003 | Ann Bi- orned Eng2003，31，40： | 1 |
| 12 | Effects of recombinant adenovirusmediated uncoupling protein 2 over-expression on endothelial function and apoptosis显示文摘 | Lee KU Lee IK Han J | 2005 | Cite Res2005，96，11： | 1 |
| 13 | Bioelectrocatalytic detection of glycated hemoglobin (HbA 1c ) based on the competitive binding of target and signaling glycoproteins to a boronate-modified surface显示文摘 | Seung Yeon Song Yong Duk Han Yoo Min Park Chi Yong Jeong Yong Ju Yang Moo Sub Kim Yunhee Ku Hyun C. Yoon | 2012 | Biosensors and Bioelectronics2012，，1： | 1 |
| 14 | Arterial wall adaptation under elevated longitudinal stretch in organ culture显示文摘 | Han H C Ku D N Vito R P | 2003 | Ann Biomed Eng2003，31，4： | 1 |
| 15 | Clinical results and poatic factors in radiotherapy for unreacetable hepatocellular carcinoma a retro- spective study of 158 patients显示文摘 | Stung J Park HC Han Ku | 2003 | Int J Radial Oncol Biol Phys2003，55，2： | 1 |
| 16 | Effects of recombinant adenovirusmediated uncoupling protein 2 overexpression on endothelial function and apoptosis显示文摘 | Lee KU Lee IK Han J | 2005 | Circ Res2005，96，11： | 1 |
| 17 | Changes of opening angle in hypertensive and hypotensive arteries in 3-day organ culture 显示文摘 | Han H C Maxim S Ku D N | 2006 | J Biomeeh2006，39，13： | 1 |
| 18 | Quantitative prediction of improvement in cardiac function after revascularization with MR imaging and modeling:initial results显示文摘 | Han HC Ku DN | 2001 | Radiology2001，221，2： | 1 |
| 19 | Caffeine-mediated in-hibition of calcium release channel inositol 1,4, 5-tri-sphosphate receptor subtype 3 blocks glioblastoma in-vasion and extends survival 显示文摘 | Kang SS Han KS Ku BM | 2010 | Cancer Res2010，70，3： | 1 |
| 20 | Surface plasmon excitation in semitransparent inverted polymer photovoltaic devices and their applications as label-free optical sensors显示文摘Herein,we report on surface plasmon(SP)-sensitive semitransparent inverted polymer photovoltaic(PV)devices that are based on multilayered material systems consisting of poly(3-hexylthiophene):fullerene-derivative bulk-heterojunction PV layers and thin gold or silver anodes.We demonstrate that these PV devices allow the simultaneous generation of both electrical power and SPs on their anodes for photoexcitation just above the optical absorption edge of the PV layers,resulting not only in attenuated total reflection,but also in attenuated photocurrent generation(APG)under the SP resonance(SPR)condition.Moreover,we also confirm that the biomolecular interaction of biotin–streptavidin on the PV devices can be precisely detected via apparent SPR angle shifts in the APG spectra,even without the need for complex attenuated total reflection configurations.We highlight our view that APG measurements made using these PV devices show great potential for the development of future generations of compact and highly sensitive SPR-based optical sensors. | Byoungchoo Park Soo Hong Yun Chan Youn Cho Young Chan Kim Jung Chul Shin Hong Goo Jeon Yoon Ho Huh Inchan Hwang Ku Youn Baik Young In Lee Han Sup Uhm Guang Sup Cho Eun Ha Choi | 2014 | Light(Science & Applications)2014，3，1： | 1 |
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