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1Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts显示文摘Bone is a dynamic tissue that is constantly renewed by the coordinated action of two cell types, i.e., the bone-resorbing osteoclasts and the bone-forming osteoblasts. However, in some circumstances, bone regeneration exceeds bone self repair capacities. This is notably often the case after bone fractures, osteolytic bone tumor surgery, or osteonecrosis. In this regard,bone tissue engineering with autologous or allogenic mesenchymal stem cells(MSCs) is been widely developed. MSCs can be isolated from bone marrow or other tissues such as adipose tissue or umbilical cord, and can be implanted in bone defects with or without prior amplification and stimulation. However, the outcome of most pre-clinical studies remains relatively disappointing. A better understanding of the successive steps and molecular mechanisms involved in MSC-osteoblastic differentiation appears to be crucial to optimize MSC-bone therapy. In this review, we first present the important growth factors that stimulate osteoblastogenesis. Then we review the main transcription factors that modulate osteoblast differentiation, and the microRNAs(miRs)that inhibit their expression. Finally, we also discuss articles dealing with the use of these factors and miRs in the development of new bone MSC therapy strategies. We particularly focus on the studies using human MSCs, since significant differences exist between osteoblast differentiation mechanisms in humans and mice for instance.Maya Fakhry René Buchet David Magne Eva Hamade Bassam Badran 2013World Journal of Stem Cells2013,5,4:32
2Effect of Deformation Temperature on Microstructure and Mechanical Properties of AZ31 Mg Alloy Processed by Differential-Speed Rolling显示文摘A differential-speed rolling(DSR) was applied to AZ31 magnesium alloy sample at different rolling temperatures of 473,523,573,and 623 K with 1-pass and 2-pass operations.The microstructural evolution and mechanical properties of the deformed samples were investigated.The rolling temperature was found to be an important parameter affecting the microstructural development.After DSR at 473 K,the microstructure was more homogeneous than that obtained after deformation by equal-speed rolling(ESR).The fully recrystallized microstructures were generated after DSR at 573 and 623 K.As to mechanical properties,the yield strength(YS) and ultimate tensile strength(UTS) decreased monotonously with increasing rolling temperature.In contrast,the elongation of the DSR-deformed samples was improved as the rolling temperature increased.The strain hardening exponent(n) calculated by Hollomon equation increased with increasing the rolling temperature,which would explain an increase in the uniform elongation.Mosab Kaseem Bong Kwon Chung Hae Woong Yang Kotiba Hamad Young Gun Ko 2015Journal of Materials Science & Technology2015,31,5:19
3低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系显示文摘低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L Fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) 2020中华高血压杂志2020,28,7:7
4牛支原体诱导宿主免疫应答的研究进展显示文摘牛支原体(Mycoplasma bovis)是一种重要的兽医病原体,牛支原体感染给当前世界养牛业造成了重大的经济损失。本文从天然免疫、体液免疫和细胞免疫三个方面,对宿主感染牛支原体后的免疫应答特点进行了概括和讨论,可帮助我们更好地了解牛支原体与宿主的相互作用,也为合理地设计和研发有效的牛支原体感染防控技术提供参考。季文恒 陈胜利 郝华芳 颜新敏 吴娅琴 翟肖辉 Hussam Askar Hamad 马丽娜 储岳峰 2020中国兽医科学2020,50,4:6
5The AO/ASIF proximal femoral nail antirotation (PFNA): A new design for the treatment of unstable proximal femoral fractures显示文摘Praveen Mereddy Sri Kamath Muthukrishnan Ramakrishnan Hamad Malik Nigel Donnachie 2008Injury2008,,4:6
6肉用犊牛源产气荚膜梭菌的分离鉴定与药敏试验显示文摘为了确定宜春市肉牛犊牛腹泻的发病原因,试验采用牛腹泻五联病原体快速诊断试剂盒初步检验9头腹泻犊牛的粪便样品,对试剂盒检测为阳性的样品进行细菌的分离、纯化、生化鉴定和药敏试验。结果表明:使用牛腹泻五联病原体快速诊断试剂盒检测到有7份产气荚膜梭菌为阳性,2份大肠杆菌为阳性;细菌分离培养、生化鉴定结果符合产气荚膜梭菌的特性;青霉素、呋喃唑酮、多西环素和苯唑西林等药物能够明显抑制分离菌的生长。说明产气荚膜梭菌感染是引起犊牛腹泻的主要原因。张伟锋 郑文亚 丁松林 伍钢 Hamad ALI HAMAD 彭侃霖 刘犇 2019黑龙江畜牧兽医2019,0,14:6
7赣西地区山羊肠道寄生虫感染情况调查显示文摘为了分析赣西地区山羊肠道寄生虫病的发生规律,试验采集宜春市和萍乡市养殖场肉用山羊粪便,随机抽取羊粪312份,通过饱和蔗糖溶液漂浮法、甲醛-乙酸乙酯-改良抗酸染色法、卢戈氏碘液染色法及显微镜观察技术进行寄生虫的分离鉴定。结果表明:检查的312份粪样,寄生虫的总体及混合感染率分别为87.18%和30.77%,其中绦虫、隐孢子虫、吸虫的感染率较低,分别为4.17%、17.95%和20.51%,线虫及球虫的感染率较高,分别为57.05%和68.27%,没有检出寄生虫的仅40份。检查到的寄生虫种类有肝片吸虫、类圆线虫、前后盘吸虫、网尾线虫、莫尼茨绦虫、毛首线虫、艾美耳球虫、矛形歧腔吸虫,其中艾美耳球虫、类圆线虫和网尾线虫检出率较高。说明应加强对球虫和线虫这两种优势虫种的驱虫和防治工作。康劲文 郑文亚 吴青青 温宇婷 袁斌 Hamad Ali Hamad Habiba Mkombe Pandu 刘犇 2018黑龙江畜牧兽医2018,0,20:6
8市场乏力,如何突出重围——抗生素之市场销售及研发分析显示文摘抗生素市场正日趋成熟,过去5年的年平均增长率仅为4%。在现有市场机制以及制药工业以追求利益最大化的前提下,如何通过新药开发来突出重围成为各企业战略部署的重要考量。Bashar Hamad 石永进 2010中国处方药2010,9,10:5
9Unexpected alliance between syndecan-1 and innatelike T cells to protect host from autoimmune effects of interleukin-17显示文摘Innate-like T cells, namely natural killer T(NKT) and γδ T cells, play critical roles in linking innate and adaptive immune responses through rapid production of cytokines. Prominent among these cytokines is interleukin-17(IL-17), which is a potent proinflammatory cytokine that plays a critical role in host defense against fungi and extracellular bacteria. However, excessive IL-17-production promotes autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. IL-17 has also been implicated in regulating body fat, which is highly relevant given rises in obesity and type 2 diabetes. NKT cells, γδ T cells and mucosal-associated invariant T cells(MAIT) are the major sources of IL-17 involved in protection of mucosal surfaces from opportunistic infections and causing autoimmunity when become dysregulated. Given the pathogenic effects of IL-17, efforts have been directed towards understanding mechanisms that guard against IL-17 overproduction. One novel potent mechanism is mediated by the heparan sulfate proteoglycan, syndecan-1(sdc1), which is selectively expressed by IL-17-producing subsets of NKT and γδ T cells. This unexpected role for sdc1 is uncovered by analysis of NKT and γδ T cells in sdc1-deficient mice. In this mini-review, we discuss selective expression of sdc1 by these innate T cells and consequences of its absence on IL-17 homeostasis and pathological implications.Anil Kumar Jaiswal Mohanraj Sadasivam Abdel Rahim A Hamad 2018World Journal of Diabetes2018,9,12:5
10Liver transplantation for hepatitis B virus: Decreasing indication and changing trends显示文摘AIM: To evaluate the indication and outcome of hepatitis B virus(HBV)-related liver transplantation(LT) in the era of newer antiviral agents.METHODS: We collected data on all patients who underwent transplantation at King Faisal Specialist Hospital and Research Center.These data included demographic,perioperative and long-term postoperative follow-up data including viral serological markers,HBV DNA,and repeated liver imaging.Between January 1990 and January 2012,133 patients(106 males and 27 females) underwent LT for HBV-related cirrhosis at our center.All patients were followed up frequently during the first year following transplantation,according to our standard protocol; follow-up visits occurred every 3-6 mo thereafter.Breakthrough infection was definedas re-emergence of HBV-DNA or hepatitis B surface antigen(HBs Ag) while on treatment.Five patients transplanted prior to 1992 did not receive immediate posttransplant anti-HBV prophylaxis; all other patients were treated with HBIG and at least one nucleos(t)ide analog.RESULTS: One hundred and thirty-three patients underwent LT for HBV and were followed for a median of 82 mo(range: 1-274).The rates of post-LT survival and HBV recurrence during the follow-up period were 89% and 11%,respectively.The following factors were associated with disease recurrence: younger age(44.3 ± 16.2 years vs 51.4 ± 9.9 years,P = 0.02),positive pretransplant hepatitis B e antigen(HBe Ag)(60% vs 14%,P < 0.0001),detectable pretransplant HBV DNA(60% vs 27%,P = 0.03),positive posttransplant HBs Ag(80% vs 4%,P < 0.0001) and positive posttransplant HBe Ag(27% vs 1%,P < 0.0001).Forty-four(33%) patients had hepatocellular carcinoma(HCC).In the first(pre-2007) group,HBV was the second leading indication for LT after hepatitis C virus infection.A total of 64 transplants were performed,including 46(72%) for decompensated HBV cirrhosis,12(19%) for decompensated cirrhosis complicated by HCC and 6(10%) for compensated cirrhosis complicated by HCC.In the second group,nonalcoholic steatohepatitis surpassed HBV as the second leading indication for LT.A total of 69 HBV related transplants were performed,including 43(62%) for decompensated HBV cirrhosis,7(10%) for decompensated cirrhosis complicated by HCC and 19(27.5%) for compensated cirrhosis complicated by HCC.There was a significant(P = 0.007) increase in the number of transplants for compensated cirrhosis complicated by HCC.CONCLUSION: The use of potent anti-HBV agents has led to a changing trend in the indications for LT.HBV is currently the third leading indication for LT in this hyperendemic area.Waleed Al-hamoudi Hussien Elsiesy Abdulrahman Bendahmash Nasser Al-masri Safiyya Ali Naglaa Allam Mohammed Al Sofayan Hamad Al Bahili Mohammed Al Sebayel Dieter Broering Sammy Saab Faisal Abaalkhail 2015World Journal of Gastroenterology2015,21,26:4
11Clinical outcomes of transepithelial photorefractive keratectomy versus femtosecond laser assisted keratomileusis for correction of high myopia in South Egyptian population显示文摘AIM: To evaluate the safety and efficacy of transepithelial photorefractive keratectomy(t-PRK) with adjuvant mitomycin C(MMC) versus femtosecond laser assisted keratomileusis(Femto-LASIK) in correction of high myopia.METHODS: Prospective randomized comparative study including 156 eyes of 156 patients with high myopia and a spherical equivalent refraction(SER) <-6.00 D. They were divided randomly into two groups: Group A included 72 eyes treated with t-PRK with adjuvant MMC and Group B included 84 eyes treated with Femto-LASIK. Visual acuity, SER, corneal topography, pachymetry and keratometry were assessed for 12 mo postoperatively.RESULTS: The preoperative mean SER was-8.86±1.81 and-9.25±1.70 D in t-PRK MMC group and Femto-LASIK respectively(P=0.99) which improved to-0.65±0.43 D and-0.69±0.50 D at 12 mo follow up. Mean SER remained stable during the 12 mo of follow-up, with no statistically significant difference between the two groups(P=0.64). In t-PRK MMC group, only six eyes needed retreatment after six months of follow up. And two eyes showed haze(one reversible haze grade 2, while the other had dense irreversible haze grade 4).CONCLUSION: t-PRK MMC provides safe and satisfactory visual outcomes and acceptable risk as Femto-LASIK in patients with high myopia.Amr Mounir Engy Mohamed Mostafa Hatem Ammar Osama Ali Mohammed Alahmady Hamad Alsmman Mahmoud Mohamed Farouk Mohamed Gamal Elghobaier 2020International Journal of Ophthalmology(English edition)2020,13,1:4
12The Emergency Department Crash Cart: A systematic review and suggested contents显示文摘BACKGROUND: As the field of Emergency Medicine grows worldwide, the importance of an Emergency Department Crash Cart(EDCC) has long been recognized. Yet, there is paucity of relevant peer-reviewed literature specifically discussing EDCCs or proposing detailed features for an EDCC suitable for both adult and pediatric patients. METHODS: The authors performed a systematic review of EDCC-specific literature indexed in Pubmed and Embase on December 20, 2016. In addition, the authors reviewed the 2015 American Heart Association(AHA) guidelines for cardiopulmonary resuscitation and emergency cardiovascular care, the 2015 European Resuscitation Council(ERC) guidelines for resuscitation, and the 2013 American College of Surgeons(ACS) Advanced Trauma Life Support(ATLS) 9 th edition.RESULTS: There were a total of 277 results, with 192 unique results and 85 duplicates. After careful review by two independent reviewers, all but four references were excluded. None of the four included articles described comprehensive contents of equipment and medications for both the adult and pediatric populations. This article describes in detail the final four articles specific to EDCC, and proposes a set of suggested contents for the EDCC. CONCLUSION: Our systematic review shows the striking paucity of such a high impact indispensable item in the ED. We hope that our EDCC content suggestions help enhance the level of response of EDs in the resuscitation of adult and pediatric populations, and encourage the implementation of and adherence to the latest evidence-based resuscitation guidelines.Gabrielle A.Jacquet Bachar Hamade Karim A.Diab Rasha Sawaya Gilbert Abou Dagher Eveline Hitti Jamil D.Bayram 2018World Journal of Emergency Medicine2018,9,2:4
13Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Has the Time Come for Cardiologists to Be Hepatologists?显示文摘Mohamed H. Ahmed Salma Barakat Ahmed O. Almobarak Mahir A. Hamad 2012Journal of Obesity2012,,:3
14Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment显示文摘Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages.Adebola Matthew Giwa Rizwan Ahmed Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad 2020World Journal of Diabetes2020,11,1:2
15Climate change impact and adaptation on wheat yield, water use and water use efficiency at North Nile Delta显示文摘Investigation of climate change impacts on food security has become a global hot spot.Even so,efforts to mitigate these issues in arid regions have been insufficient.Thus,in this paper,further research is discussed based on data obtained from various crop and climate models.Two DSSATcrop models(CMs)(CERESWheat and N-Wheat)were calibrated with two wheat cultivars(Gemiza9 and Misr1).A baseline simulation(1981-2010)was compared with different scenarios of simulations using three Global Climate Models(GCMs)for the 2030s,2050s and 2080s.Probable impacts of climate change were assessed using the GCMs and CMs under the high emission Representative Concentration Pathway(RCP8.5).Results predicted decreased wheat grain yields by a mean of 8.7%,11.4%and 13.2%in the 2030s,2050s and 2080s,respectively,relative to the baseline yield.Negative impacts of climatic change are probable,despite some uncertainties within the GCMs(i.e.,2.1%,5.0%and 8.0%)and CMs(i.e.,2.2%,6.0%and 9.2%).Changing the planting date with a scenario of plus or minus 5 or 10 days from the common practice was assessed as a potentially effective adaptation option,which may partially offset the negative impacts of climate change.Delaying the sowing date by 10 days(from 20 November to 30 November)proved the optimum scenario and decreased further reduction in wheat yields resulting from climate change to 5.2%,6.8%and 8.5%in the 2030s,2050s and 2080s,respectively,compared with the 20 November scenario.The planting 5-days earlier scenario showed a decreased impact on climate change adaptation.However,the 10-days early planting scenario increased yield reduction under projected climate change.The cultivar Misr1 was more resistant to rising temperature than Gemiza9.Despite the negative impacts of projected climate change on wheat production,water use efficiency would slightly increase.The ensemble of multi-model estimated impacts and adaptation uncertainties of climate change can assist decision-makers in planning climate adaptation strategies.Marwa Gamal Mohamed Ali Mahmoud Mohamed Ibrahim Ahmed El Baroudy Michael Fullen El-Said Hamad Omar Zheli Ding Ahmed Mohammed Saad Kheir 2020Frontiers of Earth Science2020,14,3:2
16Theoretical work on magnetocaloric effect in La_(0.75)Ca_(0.25)MnO_(3)显示文摘In this work,a phenomenological model is applied to describe the magnetocaloric effect for the La_(0.75)Ca_(0.25)MnO_(3)system near a second-order phase transition from a ferromagnetic to a paramagnetic state.Based on this model,it can predict the values of the magnetocaloric properties from calculation of magnetization as a function of temperature under different external magnetic fields.The magnetic entropy change reaches a peak of about 5.39 J/(kg·K)at 257 K upon 4 T applied field variation.TheΔSM distribution is much more uniform than that of gadolinium,which is desirable for an Ericson-cycle magnetic refrigerator.Mahmoud Aly HAMAD 2012Journal of Advanced Ceramics2012,1,4:2
17Magnetocaloric effect in La_(0.7)Sr_(0.3)MnO_(3)/Ta_(2)O_(5) composites显示文摘The magnetocaloric effect (MCE) achieved for La_(0.7)Sr_(0.3)MnO_(3)/Ta_(2)O_(5) composites has been investigated. The maximum value of magnetic entropy change of La_(0.7)Sr_(0.3)MnO_(3) composites is found to decrease slightly with the further increasing of Ta_(2)O_(5) concentration. It is shown that La_(0.7)Sr_(0.3)MnO_(3)/Ta_(2)O_(5) composites exhibit much more uniform magnetic entropy change than that of gadolinium. Moreover, the results indicate that the temperature range between 100 K and 400 K can be covered using the La_(0.7)Sr_(0.3)MnO_(3)/Ta_(2)O_(5) composites. Therefore, MCE makes the composites promising for room-temperature magnetic cooling applications.Mahmoud Aly HAMAD 2013Journal of Advanced Ceramics2013,2,3:2
18Application of AHP and a mathematical index to estimate livability in tourist districts:The case of Al Qasba in Sharjah显示文摘Urban planners must ensure that urban public spaces are enjoyable to use to create a lively city that expresses their culture and traditions and welcomes social diversity.This study aims to develop a theoretical index for assessing the livability levels in tourist districts.Therefore,a survey-based study accompanied by a literature review is used to derive criteria for livability.In addition to using the analytic hierarchy process to develop an importa ncebased hierarchy of criteria,mathematical analysis is applied to derive the livability index.Furthermore,one of Sharjah's well-known public spaces,Al Qasba Tourist District,is assessed as a case study.This study discussed the main concepts and factors of livability in urban public spaces to examine the livable extent of Qasba and the significanee of criteria.Results show that the current livability level in Al Qasba is less than 50%,confirming its urgent need for further urban improvement.This study explores the livability assessment criteria and their influencing parameters.Using the suggested conceptual livability in dexen ables decision makers to assess the livability level,analyze the in fluencing factors,and suggest solutions to improve the overall livability levels of open public spaces.Emad Mushtaha Imad Alsyouf Luai Al Labadl Rawan Hamad Noor Khatib Maitha Al Mutawa 2020Frontiers of Architectural Research2020,9,4:2
19Enteric duplication cyst as a leading point for ileoileal intussusception in an adult:A rare cause of complete small intestinal obstruction显示文摘Duplication of alimentary tract(DAT) presenting as an ileoileal intussusception is a very rare clinical entity.Herein,a case of an ileoileal intussusception due to DAT is presented.A 32-year-old woman was hospitalized due to diffuse,intermittent abdominal pain,vomiting and constipation for 3 d associated with abdominal distention.Plain abdominal X-ray revealed dilated small bowel.Abdominal computed tomography showed grossly dilated small bowel with 'sausage' and 'doughnut' signs of small bowel intussusception.She underwent laparotomy,with findings of ileoileal intussusception due to a cystic lesion adjacent to the mesenteric side.Resection of the cystic lesion along with the affected segment of intestine,with an end to end anastomosis was performed.The histopathology was consistent with enteric duplication cyst.This case highlights the DAT,although,an uncommon cause of adult ileoileal intussusception should be considered in the differential diagnosis of intussusception in adults,particularly when the leading point is a cystic lesion.Hamad Hadi Al-Qahtani 2016World Journal of Gastrointestinal Surgery2016,8,6:2
20Assessment of the Off-season Rainfall of January to February 2020 and Its Socio Economic Implications in Tanzania: A Case Study of the Northern Coast of Tanzania显示文摘This article examines the off season rainfall in northern coast Tanzania(NCT)including Zanzibar which occurred in January and February 2020(JF).Like the JF rainfalls of 2001,2004,2010,2016 and 2018,the JF(2020)rainfall was more unique in damages including loss of lives,properties and infrastructures.The study used the NCEP/NCAR reanalysis data to examine the cause of uniqueness of JF rainfall in 2001,2004,2010,2016,2018 and 2020 over NCT and Zanzibar.These datasets include monthly mean u,v wind at 850,700,500,and 200 mb;SSTs,mean sea level pressure(MSLP)anomalies,Dipole Mode Index(DMI),and monthly rainfall from NCT and Zanzibar stations.Datasets were processed and calculated into long term,seasonal,and monthly averages,indeed,Precipitation Index(PI)was calculated.Correlation analysis between the rainfall(December to January),SST,DMI and 850 mb wind vectors;and long-term percentage contribution of investigated parameters was calculated.Results revealed significant positive and negative correlations between JF rainfall,SSTs and DMI.Moreover,JFs of 2004 and 2016 had higher rainfalls of 443 mm with percentage contribution of up to 406%,while January and February,2020 had the highest of 269.1 and 101.1mm in Zanzibar and 295 and 146.1 mm over and NCT areas,with highest January long-term rainfall contribution of 356%in Zanzibar and 526%over NCT.The DJF(2019/20)had the highest rainfall record of 649.5 mm in Zanzibar contributing up to 286%,while JF 2000 rainfall had a good spatial and temporal distribution over most NCT areas.JF,2020 rainfall had impacts of more than 20 people died in Lindi and several infrastructures including Kiyegeya Bridge in Morogoro were damaged.Conclusively,more research works on understanding the dynamics of wet and dry JF seasons should be conducted.Kombo Hamad Kai Sarah E Osima Agnes Laurence Kijazi Mohammed Khamis Ngwali Asya Omar Hamad 2021Journal of Atmospheric Science Research2021,4,2:2
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