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| 1 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 2 | Coexistence of osteoporosis (OP) and coronary artery disease (CAD) in the elderly: it is not just a by-chance event显示文摘 | Yesil Y Ulger Z Halil M | 2012 | Arch Gerontol Geriatr2012，54，3： | 1 |
| 3 | A Comparative Analysis ofMachine Learning Systems for Measuring the Impact of Knowl-edge Management Practices 显示文摘 | Dursun D Halil Z Cemil K | 2013 | Decision Support Systems2013，54，2： | 1 |
| 4 | The effect of alkali concentration and solid/liquid ratio on the hydrothermal synthesis of zeolite NaA from natural kaolinite显示文摘 | Mahir Alkan ?i?dem Hopa Zürriye Yilmaz Halil Güler | 2005 | Microporous and Mesoporous Materials2005，，1： | 1 |
| 5 | Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects显示文摘 | Yavuz B B Yavuz B Sener Dede D Cankurtaran M Halil M Ulger Z Nazli N Kabakci G Aytemir K Tokgozoglu L Oto A Ariogul S | 2008 | Gerontology2008，，3： | 1 |
| 6 | Coexistence of osteoporosis(OP) and coronary artery disease(CAD)in the elderly: it is not just a by chance event 显示文摘 | Yesil Y Ulger Z Halil M | 2012 | Ardh Gerontol and Geriatr2012，54，3： | 1 |
| 7 | No alteration in thePFA- 100 in Vitro bleeding time induced by the Ginkgo bil baspeciai extract, EGB761, in elerly patients with mild cognitive impairment显示文摘 | Halil M Cankurtaran M Yavu z BB | 2005 | lood Coagul Fibinolysis2005，16，5： | 1 |
| 8 | How to assess high erythrocyte sedimentation rate (ESR) in elderly? 显示文摘 | Cankttrtaran M Ulger Z Halil M | 2010 | Arch Gerontol Geriatr2010，50，3： | 1 |
| 9 | Allopurinol Ameliorates Thioacetamide-Induced Acute Liver Failure by Regulating Cellular Redox-Sensitive Transcription Factors in Rats显示文摘 | Ulvi Demirel Mehmet Yaln?z Cem Aygün Cemal Orhan Mehmet Tuzcu Kaz?m Sahin ?brahim Hanifi ?zercan ?brahim Halil Bah?ecio?lu | 2012 | Inflammation2012，，4： | 1 |
| 10 | Malnutrition in Turkish Nursing Homes: a Correlate of Short Term Mortality 显示文摘 | Ulger Z Halil M Cankurtaran M | 2013 | Nutr Health Aging2013，17，4： | 1 |
| 11 | Coexistence of osteoporosis ( OP ) and coronary artery disease ( CAD ) in the elderly: it is not just a by chance event显示文摘 | Yesil Y Ulger Z Halil M | 2012 | Arch Gerontol Geriatr2012，54，3： | 1 |
| 12 | Coexistence of osteoporo- sis OP andcoronary artery disease CAD in the elderly it is not just a by chance event显示文摘 | Yesil Y Ulger Z Halil M | 2012 | Arch Gerontol and Geriatr2012，54，3： | 1 |
| 13 | Coexistence of osteoporosis OP and coronary artery disease CAD in the elderly it is not just a by chance event显示文摘 | Yesil Y Ulger Z Halil M | | 0，，03： | 1 |
| 14 | Coexistence of osteoporosis (OP)and coronary artery disease (CAD) in the elderly:it is not just a by chance event显示文摘 | Yesil Y Ulger Z Halil M | 2012 | Arch Gerontol and Geriatr2012，54，3： | 1 |
| 15 | Risk Factors for Hepatocellular Carcinoma in Turkey显示文摘 | ?zden Uzunalimo?lu Cihan Yurdaydin Hülya ?etinkaya Hakan Bozkaya Tülin ?ahin Salih ?olako?lu Ethem Tankurt Mustafa Sario?lu Seren ?zenirler Hikmet Akkiz Nurdan T?zün Halil De?ertekin Atilla ?kten | 2001 | Digestive Diseases and Sciences2001，，5： | 1 |
| 16 | Coexistence of osteoporosis (OP) and coronary artery disease(CAD) in the elderly: it is not just a by chance event显示文摘 | Yesil Y Ulger Z Halil M | 2012 | Archives of gerontology and geriatrics2012，54，3： | 1 |
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