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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | The preparation of nano-sized H ZSM-5 zeolite and its application in the aromatization of methanol 显示文摘 | NI Y M SUN A M WU X L HAl G L HU J L LI T LI G X | 2011 | Microporous and Mesoporous Materials2011，143，2： | 1 |
| 3 | On the comparative allocation of biomass, energy and nutrient in plants显示文摘 | Abrahamson W G Hal C | 1982 | Ecology1982，63，4： | 1 |
| 4 | Experimental determi- nation of stray capacitances in high frequency transform- ers 显示文摘 | Hal Y L Zhu J G Hui S Y R | 2003 | IEEE Transactions on Power Electronics2003，18，5： | 1 |
| 5 | Cytokinininduced photomorphogenesis in dark-grown Arabidopsis:a proteomic analysis显示文摘 | Lochmanová G Zdráhal Z Konecná H Koukalova S Malbeck J Soucek P Válková M Kiran N.S Brzobohaty B | | 0，，： | 1 |
| 6 | The role of early fol low up com put ed t omography imaging in t he management of t raumat ic brain inju ry patient s wit hint racranial hemorrhage显示文摘 | Smith JS Chang EF Ros ent hal G | | 0，，01： | 1 |
| 7 | The etiopathogenesis of Parkinson disease and suggestions for future research显示文摘 | Litvan I Hal iday G Hal ett M | | 0，，04： | 1 |
| 8 | Key Competences in Europe:interpretation,policy formulation and implementation显示文摘 | Halász G Michel A | | 0，，03： | 1 |
| 9 | Cyber Physical Socio Ecology显示文摘 | SHI X Q HAl Z G | 2011 | Concurrency and Computation-Practice & Experi- ence2011，23，9： | 1 |
| 10 | Supply chain scheduling:Batching anddelivery显示文摘 | Hal N G Potts C N | 2003 | Opresion Research2003，，51： | 1 |
| 11 | Mean platelet volume and D-dimer in patients with suspected deep venous thrombosis显示文摘 | Arzu Canan S?dd?ka Sezgin Hal?c?o?lu Safiye Gürel | 2012 | Journal of Thrombosis and Thrombolysis2012，，2： | 1 |
| 12 | Safety of conjugatedlinoleic acid in overweight or obese human volunteers 显示文摘 | BERVEN G BYE A HALS O | 2000 | Eur J Lipid Sci Technol2000，102，： | 1 |
| 13 | On the right (left) invertible completions for operator matrices显示文摘 | Hal G Chen A | 2010 | Integr Equ Oper Th2010，67，1： | 1 |
| 14 | Metal cluster catalysis: A kinetic and mechanistic study of the carbonylation of methanol to give methyl formate as catalyzed by [Et4N](2)[Fe-3(CO)(9)E] (E = S, Be, Te)显示文摘 | I Y G Jimenez J W van Hal K H Whitmire | | 0，，09： | 1 |
| 15 | The preparation of terminally unsaturated perfluoro olefins by the decomposition of the salts of perfluoro acids 显示文摘 | HALS L J REID T S SMITH G H | 1951 | J Am Chem Soc1951，73，8： | 1 |
| 16 | Factors influencing the production of hardened glaucous carnation plantlets in vitro显示文摘 | Meira Z I V Meir G Hal evy A H | 1983 | Plant Cell Tissue and Organ Culture1983，2，1： | 1 |
| 17 | Growth hormone-releasing hormone antagonist MZ-4 71 inhibits in vivo proliferation of caki- Ⅰ renal adeno carainoma显示文摘 | Jungwirth A Sehally A V Pinski J Groot K Armatis P Hal mos G | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 18 | Privatized-Ad- ministration of the national laboratories: Developments in the government-owned, contractor-operated approach 显示文摘 | Rainey Hal G Bozeman Barry Kingsley Gordon | 2004 | Public Per- formance & Management Review2004，，8： | 1 |
| 19 | Reward Preferences among Public and Private Managers: In Search of the Service Ethic显示文摘 | Rainey Hal G | 1982 | American Review of Public Administration1982，16，4： | 1 |
| 20 | Broadly protective mono- clonal antibodies against H3 influenza viruses following se- quential immunization with different hemagglutinins显示文摘 | WANG T T TAN G S HAl R et ol | 2010 | PLoS Pathogen2010，6，10： | 1 |
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