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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | New use of a three-dimensional pelet culture system for human intervertebral disc cels:initial characterization and potential use for tissue engineering显示文摘 | Lee JY Hal R Pelinkovic D | | 0，，1976： | 1 |
| 3 | Cloning and expression of the chicken interferon gamma gene显示文摘 | Dig by M R Lowent hal J W | 1995 | Interferon Cytoline Res1995，15，11： | 1 |
| 4 | Recommender system显示文摘 | Resnick P Hal R V | 1997 | Commu- nications of the A CM1997，40，3： | 1 |
| 5 | Laboratory scale investigations ofalgal toxin removal by water treatment显示文摘 | Hal T Hart J Croll R | 2000 | Water EnvironmentalManagement2000，14，1： | 1 |
| 6 | The rice bHLH pro- tein OslRO2 is an essential regulator of the genes involved in Fe uptake under Fe-defeient conditions显示文摘 | Ogo Y hal R N Nakanishi H | 2007 | Plant J2007，51，： | 1 |
| 7 | Pattern recognition receptorsfor respiratory syneytial virus infection design of vaccines显示文摘 | Zeng R Cui Y Hal Y | 2012 | Virus Res2012，167，2： | 1 |
| 8 | The Art of Standards Wars 显示文摘 | Carl Shapiro Hal R Varian | 1999 | California Management Review1999，1999，： | 1 |
| 9 | Wear of railway contact wires against current collector materials显示文摘 | Da Hal He Rafael R | 1998 | Wear1998，，215： | 1 |
| 10 | Experimental determi- nation of stray capacitances in high frequency transform- ers 显示文摘 | Hal Y L Zhu J G Hui S Y R | 2003 | IEEE Transactions on Power Electronics2003，18，5： | 1 |
| 11 | Verbal and Nonverbal Communication of Deception 显示文摘 | Zukerman M De Paulo B M Rosent hal R | 1981 | Advances in Experimental Social Psychology1981，，14： | 1 |
| 12 | Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group Ⅱ metabotropic glutamate receptor agonist (2R, 4R)-4-aminopyrrolidine-2,4-dicarboxylate显示文摘 | Foibergrova'J Druga R Ota'hal J | 2005 | Experi Neurol2005，192，2： | 1 |
| 13 | Interactions in the uptake of amino acids,ammonium and nitrate ions in the Arctic salt - marshgrass, Puccinellia phryganodes显示文摘 | Henry HAL Jefferies R L | 2003 | Plant Cell Environment2003，26，： | 1 |
| 14 | Monitoring Agents With Other Agents显示文摘 | VARIAN HAL R | 1990 | Journal of Institutional and Theoretical Economics1990，，146： | 1 |
| 15 | Biological hydrogen production,fundamentals and limiting processes显示文摘 | Hal enbeck P C Benemann J R | | 0，，： | 1 |
| 16 | 1-n-Butyl-3-methylimidazolium () octylsulfate-an even 'greener' ionic liquid显示文摘 | WASSERSCHEID P HAL R V BOSMANN A | 2002 | Green Chem2002，4，： | 1 |
| 17 | Role-based access control models显示文摘 | Edwoard J Coyne Hal L Feinstein | 1996 | IEEE Computer1996，29，2： | 1 |
| 18 | The Effects in Humans of Rapid Loss of Body Mass on a Boxingrelated Task显示文摘 | Smith M S Dyson R Hal E T | 2000 | Eur J Appl Physiol2000，83，1： | 1 |
| 19 | Effect of orally administered epidermal growth factors on intestine recovery of neonatal pigs infected with rotavirus显示文摘 | Zijlstra R T odle J Hal W F | 1994 | Journal of Pediatric Gastroenterology and Nutrition1994，19，： | 1 |
| 20 | Interaction of Dr adhesion with collagen type IV is a critical step in Escherichia coli renal persistence 显示文摘 | Selvarangan R Goluszko P Sing hal J | 2004 | Infect Immun2004，72，8： | 1 |
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