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| 1 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 2 | Construct hepatic analog by cell-matrix controlled assembly technology显示文摘A mixture of hepatic cells and chito- san/gelatin solution was deposited to construct a hepatic analog by way of layer-by-layer deposition technique using a home-made devise. The size and cell concentration of the analogs can be controlled freely. Approximately 90% of the hepatic cells re- mained viable under 0.2 Mpa extrusion pressure. Cultured in vitro 8 weeks before animal test, hepatic cells in structure maintained their phenotype and kept proliferating, and albumin and other secretion of the cells increased. Cords and hepaton-like structures were observed after culture for 20 d. These results indicate that hepatic cells could be assembled di- rectly into a 3D viable structure and expanded to form a hepatic organoid. This accomplishment is consid- ered to be an interesting means for the fabrication of liver replacements. | LIU Haixia YAN Yongnian WANG Xiaohong CHENG Jie LIN Feng XIONG Zhuo Wu Rendong | 2006 | Chinese Science Bulletin2006，51，15： | 7 |
| 3 | 2017 Chinese expert consensus on the clinical application ofserum marker for thyroid cancer显示文摘In recent years, the clinical incidence of thyroid cancer has been increasing year by year, and its risk assessment and clinical management methods have also been accordingly modified and constantly improved. There are great differences between the clinical diagnostic and therapeutic modes and disease management of thyroid cancer employed by various medical institutions in China, particularly with regard to the clinical application of serum marker of thyroid cancer. To this end, the China Anti-Cancer Association Thyroid Cancer Specialized Committee Chinese Association of Thyroid Oncology organized this compilation of ExpertConsensus on Clinical Application of Serum Marker of Thyroid Cancer to help and impel relevant clinical institutions and professionals to standardize clinical diagnosis, treatment, and long-term management of thyroid cancer, and to properly utilize the serum marker for scientific auxiliary clinical diagnosis and assessment of thyroid cancer before and after operation. | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Wei Cui Li Gao Zairong Gao Lin Guo Zhuming Guo Tao Huang Xiaoming Huang Yansong Lin Qinjiang Liu Xin Ni Jianwu Qin Li Ren Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Bin Zhang DaiweiZhao Ying Zheng Jingqiang Zhu Xiangqian Zheng 无 | 2018 | Cancer Biology & Medicine2018，15，4： | 3 |
| 4 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 5 | IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma显示文摘 | Jiankun Liu Yuzhong Duan Xiaoming Cheng Xi Chen Wei Xie Haixia Long Zhihua Lin Bo Zhu | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 2 |
| 6 | Gua Lou Gui Zhi decoction suppresses LPS-induced activation of the TLR4/NF-κBpathway in BV-2 murine microglial cells显示文摘 | Haixia Hu Zuanfang Li Xiaoqin Zhu Ruhui Lin Jiumao Lin Jun Peng Jing Tao Lidian Chen | 2013 | International Journal of Molecular Medicine2013，，6： | 2 |
| 7 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hkkxxn6xnkwnw6xw0.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 8 | Association of therapeutic occasion, gross motor function grading and developmental level with gross motor functional recovery in children with cerebral palsy显示文摘BACKGROUND: The abnormal posture and motor pattern have not stabilized in children with cerebral palsy at early period, thus timely treatment can establish normal postural reflex and motor pattern, and prevent complications of muscle contracture, ankylosis, skeletal deformity, etc. The clinical factors affecting the rehabilitative efficacy of gross motor function in children with cerebral palsy should be observed. OBJECTIVE: To observe the effects of therapeutic occasion, grading of gross motor function and developmental level on the rehabilitative efficacy in children with cerebral palsy. DESIGN: A case-controlled analysis. SETTING: Qilu Children's Hospital of Shandong University. PARTICIPANTS: Totally 138 children with cerebral palsy, who were hospitalized for 12 months in the Rehabilitation Center of Qilu Children's Hospital, Shandong University, were selected from April 2004 to September 2006, and all the children were diagnosed to be accorded with the standard set by the national seminar on cerebral palsy in 2004. There were 97 males and 41 females, including 55 cases of 0-2 years old, 47 cases of 2-4 years and 36 cases of 4-6 years. Informed contents were obtained from relatives of all the children. METHODS: ① Comprehensive rehabilitation treatment: Vojta method was to induce the children to turn over the body and crawl by stimulating reflective turn over and crawling on belly. Bobath method including trainings of head control, turning over body, keeping sitting position, keeping balance, crawling, keeping standing position, and walking, etc.; The children were massaged by using the maneuvers of push, press, rub, pull, wave, etc. according to the sites and types of palsy. Acupuncture was performed mainly at bilateral motor areas, the needle was retained for 1 hour per time, 6 days continuously every week, and followed by a 1-day interval. ② Prognosis assessment: The gross motor functional grading of the children with cerebral palsy at admission was assessed using the Chinese version of gross motor function classification system (GMFCS). The gross motor functions of the children with cerebral palsy were assessed before rehabilitation treatment and 12 months after rehabilitation treatment by using gross motor function measure (GMFM). The improved GMFM total score was calculated. Developmental quotient was evaluated using Gesell developmental schedules (GDS) after 12-month rehabilitation treatment. Univariate analysis of variance was performed using the improved GMFM total score with age, GMFCS grade and developmental level (developmental quotient). MAIN OUTCOME MEASURES: Effects of age started to accept rehabilitation treatment, GMFCS grade and developmental level on the recovery of gross motor function in children with cerebral palsy. RESULTS: All the 138 children with cerebral palsy were involved in the analysis of results. The improved GMFM total scores were significantly different among the children with cerebral palsy of different ages started to accept treatment, GMFCS grades and developmental levels (F=13.464, 37.283, 30.814, P < 0.01). The younger the children started to accept treatment, the lower the their GMFCS grades and the higher their developmental levels, then the higher their improved GMFM total scores. CONCLUSION: The recovery of gross motor function is better in younger children started to accepted treatment with cerebral palsy with lower GMFCS grades and higher developmental levels. | Hongying Li Huafeng Yu Lin Sang Haixia Ma | 2007 | Neural Regeneration Research2007，2，9： | 2 |
| 9 | Reverse Apolipoprotein A-I Mimetic Peptide R-D4F Inhibits Neointimal Formation Following Carotid Artery Ligation in Mice显示文摘 | Lin Du Xinkai Qu Haixia Zhen Rujun Li Jun Wang Mingxing Chen Pei Zhao Zhengang Zhang Kaizheng Gong | 2013 | The American Journal of Pathology2013，，： | 1 |
| 10 | Comparisons of corneal biomechanical and tomographic parameters among thin normal cornea,forme fruste keratoconus,and mild keratoconus显示文摘Background:To compare the dynamic corneal response(DCR)and tomographic parameters of thin normal cornea(TNC)with thinnest corneal thickness(TCT)(≤500μm),forme fruste keratoconus(FFKC)and mild keratoconus(MKC)had their central corneal thickness(CCT)matched by Scheimpflug imaging(Pentacam)and corneal visualization Scheimpflug technology(Corvis ST).Methods:CCT were matched in 50 eyes with FFKC,50 eyes with MKC,and 53 TNC eyes with TCT≤500μm.The differences in DCR and tomographic parameters among the three groups were compared.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic significance of these parameters.Back propagation(BP)neural network was used to establish the keratoconus diagnosis model.Results:Fifty CCT-matched FFKC eyes,50 MKC eyes and 50 TNC eyes were included.The age and biomechanically corrected intraocular pressure(bIOP)did not differ significantly among the three groups(all P>0.05).The index of height asymmetry(IHA)and height decentration(IHD)differed significantly among the three groups(all P<0.05).IHD also had sufficient strength(area under the ROC curves(AUC)>0.80)to differentiate FFKC and MKC from TNC eyes.Partial DCR parameters showed significant differences between the MKC and TNC groups,and the deflection amplitude of the first applanation(A1DA)showed a good potential to differentiate(AUC>0.70)FFKC and MKC from TNC eyes.Diagnosis model by BP neural network showed an accurate diagnostic efficiency of about 91%.Conclusions:The majority of the tomographic and DCR parameters differed among the three groups.The IHD and partial DCR parameters assessed by Corvis ST distinguished FFKC and MKC from TNC when controlled for CCT. | Lei Tian Di Zhang Lili Guo Xiao Qin Hui Zhang Haixia Zhang Ying Jie Lin Li | 2021 | Eye and Vision2021，8，1： | 1 |
| 11 | Energy balance and partition in Inner Mongolia steppe ecosystems with different land use types显示文摘 | Shiping Chen Jiquan Chen Guanghui Lin Wenli Zhang Haixia Miao Long Wei Jianhui Huang Xingguo Han | 2009 | Agricultural and Forest Meteorology2009，，11： | 1 |
| 12 | 显示文摘 | Qiu Haixia Yu Jiugao Lin Tong | 2003 | Chemistry2003，，9： | 1 |
| 13 | P-(skew) sysmmetric common solutions to a pair of quaternion matrix equations显示文摘 | WANG Q W CHANG Haixia LIN Chunyan | 2008 | Appl Math Comput2008，195，： | 1 |
| 14 | QSAR study onACE inhibitors by using OSC-PLS algorithm显示文摘 | LONG Haixia WANG Yuanqiang LIN Yong | 2010 | Journal of the ChineseChemical Society2010，57，3： | 1 |
| 15 | Biophysical regulations of NEE light response in a steppe and a cropland in Inner Mongolia显示文摘Aims Ecosystem carbon models often require accurate net ecosystem exchange of CO_(2)(NEE)light-response parameters,which can be derived from the Michaelis–Menten equation.These parameters include maximum net ecosystem exchange(NEE_(max)),apparent quantum use efficiency(a)and daytime ecosystem respiration rate(R_(e)).However,little is known about the effects of land conversion between steppe and cropland on these parameters,especially in semi-arid regions.To understand how these parameters vary in responses to biotic and abiotic factors under land conversions,seasonal variation of light-response parameters were evaluated for a steppe and a cropland of Inner Mongolia,China,during three consecutive years(2006–08)with different precipitation amounts.Methods NEE was measured over a steppe and a cropland in Duolun,Inner Mongolia,China,using the eddy covariance technique,and NEE light-response parameters(NEE_(max),α and R_(e))were derived using the Michaelis–Menten model.Biophysical regulations of these parameters were evaluated using a stepwise regression analysis.Important Findings The maximum absolute values of NEE_(max) occurred in the meteorological regimes of 15℃ | Ping Zhang Shiping Chen Wenli Zhang Haixia Miao Jiquan Chen Xingguo Han Guanghui Lin | 2012 | Journal of Plant Ecology2012，5，2： | 1 |
| 16 | IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma显示文摘 | Jiankun Liu Yuzhong Duan Xiaoming Cheng Xi Chen Wei Xie Haixia Long Zhihua Lin Bo Zhu | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 1 |
| 17 | MdWRKY11 improves copper tolerance by directly promoting the expression of the copper transporter gene MdHMA5显示文摘Overuse of fungicides and fertilizers has resulted in copper(Cu)contamination of soils and toxic levels of Cu in apple fruits.To breed Cu-resistant apple(Malus domestica)cultivars,the underlying molecular mechanisms and key genes involved in Cu resistance must be identified.Here,we show that MdWRKY11 increases Cu tolerance by directly promoting the transcription of MdHMA5.MdHMA5 is a Cu transporter that may function in the storage of excess Cu in root cell walls and stems for Cu tolerance in apple.The transcription factor MdWRKY11 is highly induced by excess Cu.MdWRKY11 overexpression in transgenic apple enhanced Cu tolerance and decreased Cu accumulation.Apple calli transformed with an MdWRKY11-RNAi construct exhibited the opposite phenotype.Both an in vivo chromatin immunoprecipitation assay and an in vitro electrophoretic mobility shift assay indicated that MdWRKY11 binds to the promoter of MdHMA5.Furthermore,MdWRKY11 promoted MdHMA5 expression in transgenic apple plants,as revealed by quantitative PCR.Moreover,inhibition of MdWRKY11 expression by RNA interference led to a significant decrease in MdHMA5 transcription.Thus,MdWRKY11 directly regulates MdHMA5 transcription.Our work resulted in the identification of a novel MdWRKY11-MdHMA5 pathway that mediates Cu resistance in apple. | Kun Shi Xuan Liu Yunpeng Zhu Yixue Bai Dongqian Shan Xiaodong Zheng Lin Wang Haixia Zhang Chanyu Wang Tianci Yan Fangfang Zhou Zehui Hu Yanzhao Sun Yan Guo Jin Kong | 2020 | Horticulture Research2020，7，1： | 1 |
| 18 | Granularity Research based on Pan-weighted Field of Pansystems显示文摘 | Li Haixia Lin He Wu Aiping Li Yongli Wang Jiajia | 2008 | Kybernetes2008，37，910： | 1 |
| 19 | Early protective effect of total hypoxic preconditioning on rats against systemic injury from hemorrhagic shock and resuscitation显示文摘 | Zeyan Duan Lei Zhang Jin Liu Xujin Xiang Haixia Lin | 2012 | Journal of Surgical Research2012，，： | 1 |
| 20 | 显示文摘 | Qiu Haixia Yu Jiugao Lin Tong | 2003 | Chemistry2003，，9： | 1 |
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