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| 1 | miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer显示文摘 | Sanhong Liu Zifeng Wang Zukai Liu Shuo Shi Zhaoran Zhang Jiawei Zhang Haifan Lin | 2018 | Journal of Molecular Cell Biology2018，10，4： | 16 |
| 2 | piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism显示文摘piRNAs,小非编码的 RNA 的一个类把蛋白质与 PIWI 联系了,在 germline 开发, transposon silencing,和 epigenetic 规定有宽广函数。在多样的有机体,从重复序列导出的 piRNAs 的一个子集经由在二 PIWI 蛋白质之间的相互影响被生产。这机制,称为的 “ ping-pong”周期,在初发的老鼠睾丸的 PIWI 蛋白质之中操作;然而,它在出生后的睾丸的参与留下逃犯。这里,我们证明成年阴囊的 piRNAs 是乒乓球机制的生产独立人士。我们在与 MILI 和 MIWI 联系的成年、出生后的发展中的睾丸识别了并且描绘 piRNAs 的大人口,在这些睾丸可检测的唯一的 PIWI 蛋白质。在为在他们的 piRNAs 之中的乒乓球机制的 MILI 和 MIWI 或顺序特征之间的相互作用都没在成年睾丸被检测。联系 MILI 、联系 MIWI 的 piRNAs 的多数在一样的 loci 以内从一样的 DNA 海滨发源。piRNAs 的两张人口为 5 ′ 被偏导;Uracil 然而并非为第 10 核苷酸位置,和显示上的腺嘌没有补充。而且在 Miwi 异种,联系 MILI 的 piRNAs 不是 downregulated,但是相反 upregulated。这些结果显示成年阴囊的 piRNAs 是主要,如果不只,由主要处理机制生产了而不是乒乓球机制。在这条主要小径,联系 MILI 、联系 MIWI 的 piRNAs 的生物的续生说可以为一样的先锋竞争;生产的 piRNAs 的类型趋于被可得到的先锋非有选择地在房间规定;并且在处理了成 piRNAs 以前,有 introns 的先锋趋于被拼接。 | Ergin Beyret Na Liu Haifan Lin | 2012 | Cell Research2012，22，10： | 7 |
| 3 | PIWI proteins and their interactors in piRNA biogenesis,germline development and gene expression显示文摘PIWI-interacting RNAs(piRNAs) are a complex class of small non-coding RNAs that are mostly 24–32nucleotides in length and composed of at least hundreds of thousands of species that speciically interact with the PIWI protein subfamily of the ARGONAUTE family. Recent studies revealed that PIWI proteins interact with a number of proteins, especially the TUDOR-domain-containing proteins, to regulate piRNA biogenesis and regulatory function. Current research also provides evidence that PIWI proteins and pi RNAs are not only crucial for transposon silencing in the germline, but also mediate novel mechanisms of epigenetic programming, DNA rearrangements, m RNA turnover, and translational control both in the germline and in the soma. hese new discoveries begin to reveal an exciting new dimension of gene regulation in the cell. | Hsueh-Yen Ku Haifan Lin | 2014 | National Science Review2014，1，2： | 6 |
| 4 | miwi , a Murine Homolog of piwi , Encodes a Cytoplasmic Protein Essential for Spermatogenesis显示文摘 | Wei Deng Haifan Lin | 2002 | Developmental Cell2002，，6： | 2 |
| 5 | The Biogenesis and Function of PIWI Proteins and piRNAs: Progress and Prospect显示文摘 | Travis Thomson Haifan Lin | 2009 | Annual Review of Cell and Developmental Biology2009，，： | 1 |
| 6 | Piwi Is a Key Regulator of Both Somatic and Germline Stem Cells in the Drosophila Testis显示文摘 | Jacob Gonzalez Hongying Qi Na Liu Haifan Lin | 2015 | Cell Reports2015，，1： | 1 |
| 7 | The Biogenesis and Function of PIWI Proteins and piRNAs: Progress and Prospect显示文摘 | Travis Thomson Haifan Lin | 2009 | Annual Review of Cell and Developmental Biology2009，，： | 1 |
| 8 | Flutter and Buffeting-based Selection for Long-span Bridges 显示文摘 | GU Ming X1ANG Haifan LIN Zhixin | 1999 | Journal of Wind Engineering and Industrial Aerodynamics1999，80，： | 1 |
| 9 | MicroRNAs:key regulators of stem cells显示文摘 | Vamsi K Gangaraju Haifan Lin | 2009 | Mol Cell Biol2009，2，10： | 1 |
| 10 | Miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis显示文摘 | DENG Wei LIN Haifan | 2002 | Dev Cell2002，2，6： | 1 |
| 11 | The ever-expanding RNA world显示文摘RNA is perhaps the most mystical molecule in life.As a single molecule endowed with both informational and catalytic capacities,it was proposed by Alexander Rich 52 years ago to be the irst molecule that self-replicated at the origin of life,to be taken over by DNA only later.Although this‘RNA world’(vividly phrased by Walter Gilbert in 1986)remains an enticing yet unproven hypothesis,the crucial roles of messenger RNAs(m RNAs),transfer RNAs(t RNAs),and ribosomal RNAs(r RNAs)in transcribing and translating genetic information into | Haifan Lin | 2014 | National Science Review2014，1，2： | 0 |
| 12 | Insights into plant salt stress signaling and tolerance显示文摘Soil salinization is an essential environmental stressor,threatening agricultural yield and ecological security worldwide.Saline soils accumulate excessive soluble salts which are detrimental to most plants by limiting plant growth and productivity.It is of great necessity for plants to efficiently deal with the adverse effects caused by salt stress for survival and successful reproduction.Multiple determinants of salt tolerance have been identified in plants,and the cellular and physiological mechanisms of plant salt response and adaption have been intensely characterized.Plants respond to salt stress signals and rapidly initiate signaling pathways to re-establish cellular homeostasis with adjusted growth and cellular metabolism.This review summarizes the advances in salt stress perception,signaling,and response in plants.A better under-standing of plant salt resistance will contribute to improving crop performance under saline conditions using multiple engineering approaches.The rhizosphere microbiome-mediated plant salt tolerance as well as chemical priming for enhanced plant salt resistance are also discussed in this review. | Huapeng Zhou Haifan Shi Yongqing Yang Xixian Feng Xi Chen Fei Xiao Honghui Lin Yan Guo | 2024 | Journal of Genetics and Genomics2024，51，1： | 0 |
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