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| 1 | Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound显示文摘AIM: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis(AE).METHODS: Clinical data and ultrasonography(US) findings of 185 patients(100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme.RESULTS: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm(54.1%); pseudocystic(13.5%); ossification(13.0%); hemangioma-like(8.1%); and metastasis-like(6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern.CONCLUSION: The sonomorphological classification proposed in the present study facilitates the diagnosis,interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies. | Wolfgang Kratzer Beate Gruener Tanja EM Kaltenbach Sarina Ansari-Bitzenberger Peter Kern Michael Fuchs Richard A Mason Thomas FE Barth Mark M Haenle Andreas Hillenbrand Suemeyra Oeztuerk Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 2 | Proposal of a computed tomography classification for hepatic alveolar echinococcosis显示文摘AIM: To establish a computed tomography(CT)-morphological classification for hepatic alveolar echinococcosis was the aim of the study. METHODS: The CT morphology of hepatic lesions in 228 patients with confirmed alveolar echinococcosis(AE) drawn from the Echinococcus Databank of the University Hospital of Ulm was reviewed retrospectively. For this reason, CT datasets of combined positron emission tomography(PET)-CT examinations were evaluated. The diagnosis of AE was made in patientswith unequivocal seropositivity; positive histological findings following diagnostic puncture or partial resection of the liver; and/or findings typical for AE at either ultrasonography, CT, magnetic resonance imaging or PET-CT. The CT-morphological findings were grouped into the new classification scheme.RESULTS: Within the classification a lesion was dedicated to one out of five 'primary morphologies' as well as to one out of six 'patterns of calcification'. 'primary morphology' and 'pattern of calcification' are primarily focussed on separately from each other and combined, whereas the 'primary morphology' V is not further characterized by a 'pattern of calcification'. Based on the five primary morphologies, further descriptive sub-criteria were appended to types Ⅰ-Ⅲ. An analysis of the calcification pattern in relation to the primary morphology revealed the exclusive association of the central calcification with type Ⅳ primary morphology. Similarly, certain calcification patterns exhibited a clear predominance for other primary morphologies, which underscores the delimitation of the individual primary morphological types from each other. These relationships in terms of calcification patterns extend into the primary morphological sub-criteria, demonstrating the clear subordination of those criteria.CONCLUSION: The proposed CT-morphological classification(EMUC-CT) is intended to facilitate the recognition and interpretation of lesions in hepatic alveolar echinococcosis. This could help to interpret different clinical courses better and shall assist in the context of scientific studies to improve the comparability of CT findings. | Tilmann Graeter Wolfgang Kratzer Suemeyra Oeztuerk Mark Martin Haenle Richard Andrew Mason Andreas Hillenbrand Thomas Kull Thomas F Barth Peter Kern Beate Gruener | 2016 | World Journal of Gastroenterology2016，22，13： | 10 |
| 3 | Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study显示文摘AIM:To determine the long-term hepatobiliary complications of alveolar echinococcosis(AE) and treatment options using interventional methods.METHODS:Included in the study were 35 patients with AE enrolled in the Echinococcus Multilocularis Data Bank of the University Hospital of Ulm.Patients underwent endoscopic intervention for treatment of hepatobiliary complications between 1979 and 2012.Patients' epidemiologic data, clinical symptoms, and indications for the intervention, the type of intervention and any additional procedures, hepatic laboratory parameters(pre- and post-intervention), medication and surgical treatment(pre- and post-intervention), as well as complications associated with the intervention and patients‘ subsequent clinical courses were analyzed.In order to compare patients with AE with and without history of intervention, data from an additional 322 patients with AE who had not experienced hepatobiliary complications and had not undergone endoscopic intervention were retrieved and analyzed.RESULTS:Included in the study were 22 male and 13 female patients whose average age at first diagnosis was 48.1 years and 52.7 years at the time of intervention.The average time elapsed between first diagnosis and onset of hepatobiliary complications was 3.7 years.The most common symptoms were jaundice, abdominal pains, and weight loss.Thenumber of interventions per patient ranged from one to ten.Endoscopic retrograde cholangiopancreatography(ERCP)was most frequently performed in combination with stent placement(82.9%),followed by percutaneous transhepatic cholangiodrainage(31.4%)and ERCP without stent placement(22.9%).In 14.3%of cases,magnetic resonance cholangiopancreatography was performed.A total of eight patients received a biliary stent.A comparison of biochemical hepatic function parameters at first diagnosis between patients who had or had not undergone intervention revealed that these were significantly elevated in six patients who had undergone intervention.Complications(cholangitis,pancreatitis)occurred in six patients during and in 12patients following the intervention.The average survival following onset of hepatobiliary complications was 8.8years.CONCLUSION:Hepatobiliary complications occur in about 10%of patients.A significant increase in hepatic transaminase concentrations facilitates the diagnosis.Interventional methods represent viable management options. | Tilmann Graeter Franziska Ehing Suemeyra Oeztuerk Richard Andrew Mason Mark Martin Haenle Wolfgang Kratzer Thomas Seufferlein Beate Gruener | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 4 | Parameters affecting different acoustic radiation force impulse applications in the diagnosis of fibrotic liver changes显示文摘AIM: To analyze the virtual touch tissue quantification(VTTQ) and virtual touch imaging quantification(VTIQ) techniques, and identify possible factors that may influence VTTQ and VTIQ measurements.METHODS: One hundred and eighty-six(104 women/82 men) of 323 subjects met the inclusion criteria(age > 18 years, no history of chronic or gastrointestinal disease, body-mass index(BMI) < 30 kg/m2, a fasting period of at least three hours, no history of hepatotoxic pharmaceuticals, alcohol consumption < 24 g/d in men and < 12 g/d in women, and normal findings upon ultrasound examination of the abdomen). Measurements were taken at depths of 50 mm with VTTQ, 15 mm and 25 mm with VTIQ in the right hepatic lobe, and at 15 mm with only VTIQ in the left hepatic lobe. The examiner acquired six measurements per position, thereby giving 24 measurements in total.RESULTS: The 95% confidence intervals of mean were1.23-1.29 m/s for VTTQ and 1.29-1.37 m/s, 1.17-1.23 m/s, and 1.48-1.57 m/s for VTIQ in a depth of 15 mm and 25 mm in the right hepatic lobe and 15 mm in the left hepatic lobe. Only superficial measurements in the right hepatic lobe with the VTIQ method exhibited an effect of age on shear wave velocity. Measurements acquired using the 6C1 probe with the VTTQ method showed no dependence on BMI. By comparison, BMI influenced measurements taken with the VTIQ method using the 9L4 probe in the superficial and deep areas of the right hepatic lobe, as well as in the left hepatic lobe(P = 0.0160, P = 0.0019, P = 0.0173, respectively). Gender influenced measurements at depths of 50 mm with VTTQ and 25 mm with VTIQ in the right hepatic lobe(P = 0.0001, P = 0.0269). Significant differences were found between measurements with the 6C1(VTTQ) and 9L4 probes(VTIQ)(P = 0.0067), between superficial and deep measurements(P < 0.0001), and between the right and left lobes of the liver(P < 0.0001). CONCLUSION: Measurements in the right lobe and deep regions are preferable. Gender differences must be considered. BMI must be considered when assessing VTIQ technology. | Sabrina Galgenmueller Heike Jaeger Wolfgang Kratzer Stefan A Schmidt Suemeyra Oeztuerk Mark M Haenle Richard A Mason Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 5 | Prevalence of cholelithiasis in patients with chronic inflammatory bowel disease显示文摘AIM: To investigate the effect of chronic inflammatory bowel disease (CIBD) specific risk factors for cholecystolithiasis,as duration and involvement pattern of the disease and prior surgery in patients with Crohn's disease (CD) and ulcerative colitis (UC).METHODS: A total of 222 patients with CD (135 females,87 males; average age, 35.8±11.8 years; range 17-81 years)and 88 patients with UC (39 females, 49 males; average age, 37.2±13.6 years; range 16-81 years) underwent clinical and ultrasound examinations. Besides age, sex and degree of obesity, patients' CIBD specific parameters, including duration and extent of disease and prior operations were documented and evaluated statistically using logistic regression.RESULTS: The overall prevalence of gallbladder stone disease in patients with CD was 13% (n = 30). Only age could be shown to be an independent risk factor (P = 0.014).Compared to a collective representative for the general population in the same geographic region, the prevalence of cholecystolithiasis was higher in all corresponding age groups. Patients with UC showed an overall prevalence of gallbladder stone disease of only 4.6%.CONCLUSION:Only age but not disease-specific factors such as duration and extent of disease, and prior surgery are independent risk factors for the development of cholecystolithiasis in patients with CIBD. | Wolfgang Kratzer Mark M Haenle Richard A Mason Christian von Tirpitz Volker Kaechele | 2005 | World Journal of Gastroenterology2005，11，39： | 3 |
| 6 | A novel antibacterial titania coating: Metal ion toxicity and in vitro surface colonization显示文摘 | F. Heidenau W. Mittelmeier R. Detsch M. Haenle F. Stenzel G. Ziegler H. Gollwitzer | 2005 | Journal of Materials Science: Materials in Medicine2005，，10： | 2 |
| 7 | Ultrasonographically delected gallbladder polyps: A reason for concern? A seven-year follow-up study 显示文摘 | Kratzer W Haenle MM Voegtle A | 2008 | BMC Gastroenterol2008，8，： | 1 |
| 8 | Pregnancy is not a risk factor for gallstone disease: Results of a randomly selected population sample显示文摘AIM: To investigate the prevalence, risk factors, and selection of the study population for cholecystolithiasis in an urban population in Germany, in relation to our own findings and to the results in the international literature.METHODS: A total of 2 147 persons (1 111 females,age 42.8±12.7 years; 1 036 males, age 42.3±13.1 years)participating in an investigation on the prevalence of Echinococcus multilocularis were studied for risk factors and prevalence of gallbladder stone disease.Risk factors were assessed by means of a standardized interview and calculation of body mass index (BMI). A diagnostic ultrasound examination of the gallbladder was performed. Data were analyzed by multiple logistic regression, using the SAS statistical software package.RESULTS: Gallbladder stones were detected in 171study participants (8.0%, n = 2 147). Risk factors for the development of gallbladder stone disease included age, sex, BMI, and positive family history. In a separate analysis of female study participants, pregnancy (yes/no)and number of pregnancies did not exert any influence.CONCLUSION: Findings of the present study confirm that age, female sex, BMI, and positive family history are risk factors for the development of gallbladder stone disease. Pregnancy and the number of pregnancies,however, could not be shown to be risk factors. There seem to be no differences in the respective prevalence for gallbladder stone disease in urban and rural populations. | Thomas Walcher Mark Martin Haenle Martina Kron Birgit Hay Richard Andrew Mason Alexa Friederike Alice von Schmiesing Armin Imhof Wolfgang Koenig Peter Kern Bernhard Otto Boehm Wolfgang Kratzer | 2005 | World Journal of Gastroenterology2005，11，43： | 1 |
| 9 | Comparison of contrast-enhanced power Doppler ultrasound (Levovist) and computed tomography in alveolar echinococcosis显示文摘 | W. Kratzer S. Reuter K. Hirschbuehl A. R. Ehrhardt R. A. Mason M. M. Haenle P. Kern A. Gabelmann | 2005 | Abdominal Imaging2005，，3： | 1 |
| 10 | Overweight,physical activity,tobacco and alcohol consumption in a cross-sectional random sample of German adults显示文摘 | Haenle MM Brockmann SO Kron M | 2006 | BMC Public Health2006，6，： | 1 |
| 11 | Ultrasonographically detected gallbladder polyps:A reason for concern? A seven-year follow-up study 显示文摘 | Kratzer W Haenle MM Voegtle A | 2008 | BMC Gastroenterol2008，8，： | 1 |
| 12 | A model of implant-associated infection in the tibial metaphysis of rats显示文摘 | Haenle M Zietz C Lindner T | 2013 | ScientificWorld Journal2013，，48： | 1 |
| 13 | An extended spectrum bactericidal titanium dioxide(TiO2)coating for metallic implants:in vitro effectiveness against MRSA and mechanical properties显示文摘 | Haenle M Fritsche A Zietz C | 2011 | J Mater Sci Mater Med2011，22，2： | 1 |
| 14 | Overweight,physical activity,to- bacco and alcohol consumption in a cross-sectional random sample of German adults显示文摘 | haenle MM Brockmann SO Kron M | 2006 | BMC Public Health2006，，6： | 1 |
| 15 | Treatment of acetabular defects during re-ision total hip arthroplasty preliminary clinical and radiological out- come using hone substitute materials 显示文摘 | Haenle M Schltiter S Ellenrieder M | 2013 | Hip Int2013，23，1： | 1 |
| 16 | Overweight,physical activity,tobacco and alcohol consumption in a crosssectional random sample of German adults显示文摘 | Haenle MM Brockmann SO Kron M | 2006 | BMC Public Health2006，6，： | 1 |
| 17 | Assessment of cup po- sition from plain radiographs:impact of pelvic tilting 显示文摘 | Haenle M Heitner A Mittelmeier W | 2007 | Surg Ra- diol Anat2007，29，1： | 1 |
| 18 | Vitamin C supplement use May protect against gallstones:an observational study on a randomly selected population显示文摘 | Walcher T Haenle MM Kron M | 2009 | BMC Gastroenterol2009，9，： | 1 |
| 19 | Overweight, physi- cal activity, tobacco and alcohol consumption in a cross-sectional random sample of German adults显示文摘 | Haenle MM Brockmann SO Kron M | 2006 | BMC Public Health2006，6，： | 1 |
| 20 | Assessment of cup posi- tion from plain radiographs: Impact of pelvic tilting 显示文摘 | Haenle M Heitner A Mittelmeier W | 2007 | Surg Radiol Anat2007，1，： | 1 |
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