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| 1 | A prospective trial of volumetric intensity-modulated arc therapy vs conventional intensity modulated radiation therapy in advanced head and neck cancer显示文摘AIM: To prospectively compare volumetric intensitymodulated arc therapy(VMAT) and conventional intensity-modulated radiation therapy(IMRT) in coverage of planning target volumes and avoidance of multiple organs at risk(OARs) in patients undergoing definitive chemoradiotherapy for advanced(stage Ⅲ or Ⅳ)squamous cell cancer of the head and neck. METHODS: Computed tomography scans of 20 patients with advanced tumors of the larynx, naso-, oroand hypopharynx were prospectively planned using IMRT(7 field) and VMAT using two arcs. Calculated doses to planning target volume(PTV) and OAR were compared between IMRT and VMAT plans. Dose-volume histograms(DVH) were utilized to obtain calculated doses to PTV and OAR, including parotids, cochlea,spinal cord, brainstem, anterior tongue, pituitary and brachial plexus. DVH's for all structures were compared between IMRT and VMAT plans. In addition the planswere compared for dose conformity and homogeneity. The final treatment plan was chosen by the treating radiation oncologist. RESULTS: VMAT was chosen as the ultimate plan in 18 of 20 patients(90%) because the plans were thought to be otherwise clinically equivalent. The IMRT plan was chosen in 2 of 20 patients because the VMAT plan produced concentric irradiation of the cord which was not overcome even with an avoidance structure. For all patients, VMAT plans had a lower number of average monitor units on average(MU = 542.85) than IMRT plans(MU = 1612.58)(P < 0.001). Using the conformity index(CI), defined as the 95% isodose volume divided by the PTV, the IMRT plan was more conformal with a lower conformity index(CI = 1.61) than the VMAT plan(CI = 2.00)(P = 0.003). Dose homogeneity, as measured by average standard deviation of dose distribution over the PTV, was not different with VMAT(1.45 Gy) or IMRT(1.73 Gy)(P = 0.069). There were no differences in sparing organs at risk.CONCLUSION: In this prospective study, VMAT plans were chosen over IMRT 90% of the time. Compared to IMRT, VMAT plans used only one third of the MUs, had shorter treatment times, and similar sparing of OAR. Overall, VMAT provided similar dose homogeneity but less conformity in PTV irradiation compared to IMRT. This difference in conformity was not clinically significant. | Simon D Fung-Kee-Fung Rachel Hackett Lee Hales Graham Warren Anurag K Singh | 2012 | World Journal of Clinical Oncology2012，3，4： | 2 |
| 2 | Further assessment of Meyer and Allen'S(1991)three-component model of organizational commitment显示文摘 | HACKETT R D BYCIO P HAUSDORF P A | 1994 | Journal of Applied Psychology1994，，79： | 1 |
| 3 | The single,ancient origin of chromist plastids显示文摘 | Yoon H S Hackett J D Pinto G | | 0，，： | 1 |
| 4 | Leader-member Exchange As A Mediator of the Relationship be- tween Transformational Leadership and Followers' Performance and Organizational Citizenship Behavior显示文摘 | WANG H LAW K S HACKETT R D WANG D CHEN Z X | 2005 | The Academy of Man- agement Journal2005，48，3： | 1 |
| 5 | Vasoreactivity of the culprit lesion in unstable angina显示文摘 | Hackett D Davies G | 1994 | Circulation1994，90，1： | 1 |
| 6 | Venlafaxine versus placebo in the preventative treament of recurrent major depression显示文摘 | Montgomery SA Entsuah R Hackett D | 2004 | J Clin Psychiatry2004，65，： | 1 |
| 7 | Telomere dysfunction increases mutation rate and genomic instability 显示文摘 | Hackett J A Feldser D M Greider C W | 2001 | Cell2001，106，3： | 1 |
| 8 | Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis显示文摘 | HAN C ROBINSON D W HACKETT M V | 2006 | J Rheumatol2006，33，11： | 1 |
| 9 | Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1显示文摘 | Hackett TL Warner SM Stefanowicz D | 2009 | Am J Respir Crit Care Med2009，180，2： | 1 |
| 10 | Social adjustment in generalised anxiety disorder: a long-term placebo- controlled study of venlafaxine extended release显示文摘 | Boyer P Mahe V Hackett D | 2004 | Eur Psychiatry2004，19，5： | 1 |
| 11 | Safety and tolerance profile of venlafaxine 显示文摘 | Danjou P Hackett D | 1995 | Int Clin Psychopharmacol1995，10，2： | 1 |
| 12 | Leader-member Echange as a Mediator of the Relationship Between Transformational Leadership and Followers' Performance and Organizational Citizenship Behavior显示文摘 | Law K S Hackett R D Wang D Chen Z | 2005 | Academy of Management Journal2005，，3： | 1 |
| 13 | Linkage analy sis in teraploid potato and association of makers with quanti rive resistance to late blight (Phytophthora infestans) 显示文摘 | Mayer R C Milbourne D Hackett C A | 1998 | Molecular Genetics and Genomics1998，59，2： | 1 |
| 14 | Identification of a spe- cific isoform of tomato lipoxygenase (TomloxC) involved in the generation of fatty acid - derived flavor compounds 显示文摘 | Chen G Hackett R Walker D | 2004 | Plant Physiology2004，136，1： | 1 |
| 15 | Individual-level cultural values as moderatos of perceived organizational support- employee outcome relationships in China: Comparing the effects of power distance and traditionality显示文摘 | Farh J L Hackett R D Liang J | 2007 | Academy of Management Journal2007，50，3： | 1 |
| 16 | Theineidenee, importance, and prophylaxis of acute mou-ntain sickness显示文摘 | Hackett P H Rennie D | 1976 | Lancet1976，2，7996： | 1 |
| 17 | The incidence, impor- tance, and prophylaxis of acute mountain sickness 显示文摘 | Hackett P H Rennin D Levine H D | 1976 | Lancet1976，，2： | 1 |
| 18 | Vasoreactivity of culprit lesion in u nstable angina 显示文摘 | Bogaty P Hackett D Davies G | 1994 | Circulation1994，90，： | 1 |
| 19 | Individual-level cul- tural values as moderators of perceived organizational support-employee outcome relationships in China: Comparing the effects of power distance and tradition- ality显示文摘 | Farh J L Hackett R D Liang J | 2007 | Academy of Management Journal2007，50，3： | 1 |
| 20 | Individual-Level Cultural Values as Moderators of Perceived Organizational Support- Employee Outcome Relationships in China: Comparing the Effects of Power Distance and Traditionality 显示文摘 | FARH J L HACKETT R D LIANG J | 2007 | Academy of Management Journal2007，50，3： | 1 |
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