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| 1 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 2 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 3 | Power management unit chip design for automobile active-matrix organic light-emitting diode display module显示文摘A power management unit (PMU) chip supplying dual panel supply voltage, which has a low electro-magnetic interference (EMI) characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip’s 0.25 μm high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done. | KIM J H PARK J H KIM J H CAO T V LEE T Y BAN H J YANG K KIM H G HA P B KIM Y H | 2009 | Journal of Central South University2009，16，4： | 4 |
| 4 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 5 | Nucleotide excision repair gene XPD polymorphisms and genetic predisposition to melanoma显示文摘 | Tomescu D Kavanagh G Ha T | 2001 | Carcinogenesis2001，22，3： | 1 |
| 6 | Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer显示文摘 | Duffy JP Eibl G Reber HA | 2003 | Mol Cancer2003，2，1： | 1 |
| 7 | Association of low serum concentra- tion of bi/irubin with increased risk of coronary artery disease 显示文摘 | Schwerther HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 8 | Synthesis of biologically active steroid derivativesby the utility of Lawesson's reagent显示文摘 | MOHAMED N R ELMEGEED G A ABD-ELMALEK HA | 2005 | Steroids2005，70，3： | 1 |
| 9 | Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF re- ceptors, distribution of VEGF protein and possible in vivo regulato- ry mechanisms显示文摘 | Plate KH Breier G Weich HA | 1994 | IntJ Cancer1994，59，4： | 1 |
| 10 | An open study to assess the safety and tolerability of meloxicam 15rng in subjects with rheumatic disease and mild renal impairment显示文摘 | Bevis PJR Bird HA Lapham G | 1996 | Br J Rheumatol1996，35，1： | 1 |
| 11 | Association of cow serumconcertration of bilirubin with increased risk of coronary artery disease显示文摘 | Schwertner HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，： | 1 |
| 12 | Association of low serum concentration of bilirubin with in disease risk of coronary artery disease 显示文摘 | Schwerther HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 13 | Optimal Shared-Savings Contracts in Supply Chains: Linear Contracts and Double Moral Hazard显示文摘 | CORBETT C J DECROIX G A HA A Y | 2005 | European Journal of Operational Research2005，163，3： | 1 |
| 14 | Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity显示文摘 | Erken HA Erken G Colak R | 2013 | High Alt Med Biol2013，14，4： | 1 |
| 15 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease 显示文摘 | Schwertner HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 16 | Screening elderly patients in an outpatient ophthalmology clinic for dementia, depression, and functional impairment 显示文摘 | LEE AG BEAVER HA JOGERST G | 2003 | Ophthalmology2003，110，4： | 1 |
| 17 | Role of CD24 protein in predicting metastatic potential of uterine cervical squamous cell carcinoma in patients treated with radiotherapy 显示文摘 | Kwon GY Ha H Ahn G | 2007 | Int J Radial Oncol Biol Phys2007，69，4： | 1 |
| 18 | Phase Ⅱ trial of docetaxel in advanced anthraxcycline-resistant or anthraxcenedione-resistant breast cancer 显示文摘 | Ravdin PM Burris HA Ⅲ Cook G | 1995 | J Clin Oncol1995，13，12： | 1 |
| 19 | Soil microbial population numbers and enzyme activities in relation to altitude and forest degradation显示文摘 | J HA D K SHARMA G D MISHRA R R | 1992 | Soil Bio Biochem1992，24，8： | 1 |
| 20 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Jackson WG Tolan G | 1994 | Clin Chem1994，40，： | 1 |
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