|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 3 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 4 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 5 | Prom market games to real-world markets显示文摘 | Jefferies P Hart M Hui P M | 2001 | The European Physical Journal B2001，20，4： | 1 |
| 6 | P6 aeupoint injec- tion reduce postoperative nausea and vomiting显示文摘 | Shyr M H Hsu J C Wu Y W Hui Y L Tan P P | 1990 | Ma Tsui Hsueh Tsa Chi Anaesthesiol Sinica1990，28，6： | 1 |
| 7 | Cross Entropy Method for Networks Estimation显示文摘 | Hui K P Bean N Kraetzl M | 2005 | Annals of Operations Research2005，134，： | 1 |
| 8 | Two-dimensional traffic flow problems in inhomogeneous lattices显示文摘 | Gu G Q Chung K H Hui P M | 1995 | Physica A1995，217，34： | 1 |
| 9 | Comparison of Affirm VPIII and Papanicolaou tests in the detection of infectious vagi- nitis 显示文摘 | Levi AW Harigopal M Hui P | 2011 | Am J Clin Pathol2011，135，3： | 1 |
| 10 | Comparison of affirm VPⅢ and Papanicolaou tests in the detection of infectious vaginitis显示文摘 | Levi AW Harigopal M Hui P | 2011 | Am J Clin Pathol2011，135，3： | 1 |
| 11 | Proteomic analysis of strawberry leaves infected with Colletotrichum fragariae显示文摘 | Fang X P Chen W Y Xin Y Hengmu Z Chengqi Y Hong Y Hui L Wenfei X Shuzhen W Guizhen Z Hongbo L Liang J Huasheng M Songlin R | 2012 | Journal of proteomics2012，75，： | 1 |
| 12 | Effective-Medium for Weakly Nonlinear Composites显示文摘 | Bergman D J Hui P M | 1988 | Phys Rev B1988，38，10： | 1 |
| 13 | The distribution and scaling of fluctuations for Hang Seng index in Hong Kong stock market显示文摘 | Wang B H Hui P M | 2001 | European Physical Journal B2001，20，4： | 1 |
| 14 | Cellular automaton models of traffic flow along a highway containing a junction显示文摘 | BENJAMIN S C JOHNSON N F HUI P M | 1996 | J phys A1996，29，： | 1 |
| 15 | Two-dimensional traffic flow problems with faulty traffic lights显示文摘 | Chung K H Hui P M Gu G Q | 1995 | Physical Review E1995，51，1： | 1 |
| 16 | Analytic approach to co-evolving dynamics in complex networks: dissatisfied adaptive snow- drift game 显示文摘 | Gr ser O Xu C Hui P M | 2011 | New J Phys2011，13，08： | 1 |
| 17 | Disconnected connected network transitions and phase separation driven by co-evolving dy namics 显示文摘 | Gr ser O Xu C Hui P M | 2009 | Europhys Lett2009，87，38： | 1 |
| 18 | Cellular au tomaton models of tra//ic flow along a highway con taining a junction显示文摘 | Benjamin S C Johnson N F Hui P M | 1996 | Physica A1996，29，31： | 1 |
| 19 | Nanosized bioceramic particles could function as efficient gene delivery vehicles with target specificity for the spleen显示文摘 | TAN K CHEANG P HO I A W LAM P Y P HUI K M | 2007 | Gene Therapy2007，14，： | 1 |
| 20 | Cooperation in N-person evolutionary snowdrift game in scale-free Barabasi-Albert networks 显示文摘 | Lee K H Chan Chun-Him Hui P M | 2008 | Physica A2008，387，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员