|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pollen indication to source plants in the eastern desert of China显示文摘In order to investigate the indication of major pollen types to source plants, 39 surface pollen samples are collected from 39 plant communities. The results show that diversity of pollen assemblages presents in different commu-nities. Chenopodiaceae pollen percentages are highest in Kalidium communities and Ceratoides communities (higher than 45%, average is 63.4%), but high Ephedra pollen per-centages (higher than 3.3%, average is 16.5%)in Ceratoides communities make it distinguished from Kalidium communi-ties. Artemisia pollen percentages (more than 50%) are much higher than Chenopodiaceae (less than 35%) in Artemisia Communities. Nitraria pollen percentages (higher than 2%, average is 13.6%) are highest in Nitraria communities com-pared with those in other community patterns. Tamariceae pollen percentages (higher than 2%, average is 8.6%) are highest both in Tetraena and Reaumuria communities com-pared with those in other community patterns. But in Reau-muria communities, Artemisia pollen percentages are higher than Chenopodiaceae with some other pollen types such as Gramineae, Compositae, Leguminosae; on the contrary, in Tetraena communities, Artemisia pollen percentages are less than Chenopodiaceae with few other pollen types. Calli-gonum pollen only appears in Calligonum communities (higher than 2%,average is 5%). The results of cluster analysis (CLA) and detrended correspondence analysis (DCA) show that the pollen indication to source plants can be reflected by association indices (A), over-representation in-dices (O), under-representation indices (U), R-value, the av-erage pollen percentages where parent plants are absent (Xa) and the average pollen percentages where parent plants are present (Xp). Zygophyllum, Calligonum, Tetraena, Tribulus and Tamariceae can indicate source plants very well, owing to high A scores. Artemisia, Chenopodiaceae and Gramineae have high R-values, and Nitraria, Cruciferae and sedum have high O scores, so they are over-represented types, but the higher Xp and the lower Xa values make that these pollen types can also indicate source plants moderately. Allium, Leguminosae, Roseceae, Pedicularis and Compositae have low A scores (less than 0.5), high O and/or U scores, so they cannot indicate source plants clearly. Some other pollen types, such as Pinus, Picea, Betula, Quercus, Ulmus, Ephedra, Elaegnaceae, Ranunculaceae, Caryophyllaceae, Polygona-ceae, Saxifragaceae, only appear in pollen assemblages, so their indication cannot be decided. Just like the pollen per-centage ratios of Artemisia and Chenopodiaceae (A/C), the ratios of Ephedra and Artemisia (E/A), Nitraria and Ephedra (N/E) can also indicate the aridity of environment. In typical desert communities, A/C ratios are less than 0.5, E/A ratios are more than 0.1, and N/E ratios are less than 1. In steppe desert, A/C ratios are 0.5―2, E/A ratios are less than 0.1, and N/E ratios are more than 1. | LI Yuecong XU Qinghai ZHAO Yinclkui YANG Xiaolan XIAO Jule CHEN Hui Lü Xinmiao | 2005 | Chinese Science Bulletin2005，50，15： | 17 |
| 2 | Chinese herbal medicine for subacute thyroiditis:a systematic review of randomized controlled trials显示文摘OBJECTIVE:To evaluate the effectiveness and safety of Chinese herbal medicine(CHM) in the treatmentofsubacutethyroiditis.METHODS: Randomized controlled trials found in PubMed, Cochrane Library, and three Chinese databases were selected. RevMan 5.2 software was used to analyze the data with relative risk or mean difference, expressed with 95% of confidence interval. The quality of trials was assessed and gradedthe quality of evidence with GRADE profiler software.RESULTS: Twenty one studies were included. CHM was superior to Western Medicine(include prednisone and NSAIDs) in abating fever, relieving thyroid pain, recovering blood sedimentation, improving thyroid function, and preventing hypothyroidism(P<0.05), while no statistical differences were found in eliminating goiter and reducing relapse rate.CHM plusWestern Medicine were superior toWestern Medicine in abating fever, relieving thyroid pain, eliminating goiter, and reducing relapse rate,while no statistical differences(P>0.05) were found in recovering blood sedimentation and improving thyroid function. The incidence of adverse reactions in treatment group was lower than that in control group(relative risk was 0.12 and 95% confidence interval was 0.03-0.51). The methodological quality of trials is generally poor with a high risk of bias.CONCLUSION: CHM(particularly CHM combined withWestern Medicine) used to treat subacute thyroiditis may improve clinical symptoms and signs,reduce relapse rate, and alleviate the side effects of hormones. Due to poor methodological quality of included trials, further more high-quality studies are warranted to confirm the effectiveness and safety of CHM. | Hui Luo Meng Lü Xiaohua Pei Zhongyuan Xia | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 16 |
| 3 | Comparison of tamsulosin with extracorporeal shock wave lithotripsy in treating distal ureteral stones显示文摘背景 Tamsulosin ,一个 alpha-1 受体对手,被表明了在支持远侧的 ureteral 石头经过并且在减少与学习试图在我们把 314 个病人分到三个范畴的不同 sizes.Methods 在远侧的 ureteral 石头的逐出率上与 nifedipine 和 extracerporeal 冲击波 lithotripsy ( ESWL )比较评估 tamsulosin 的效果的石头 expulsion.This 联系的疼痛有效:,有 4.0-5.9 公里的最大的直径的石头;, 6.0-7.9mm ,并且, 8.0-9.9 mm. | ZHANG Meng-yuan DING Sen-tai Lü Jia-ju LUE Yan-he ZHANG Hui XIA Qing-hua | 2009 | Chinese Medical Journal2009，，7： | 10 |
| 4 | Cytokine production during the inhibition of acute vascular rejection in a concordant hamster-to-rat cardiac xenotransplantation model显示文摘当前的学习的目的是调查 interleukin (IL ) 的角色的背景 -2, 干扰素(IFN ) ,在一致 hamster-to-rat 的 IL-4 和 IL-10 心脏的 xenotransplantation 模型。方法 A hamster-to-rat 心脏的移植作为金色的叙利亚的仓鼠心的接受者用 SD 老鼠被执行。60 只 SD 老鼠的一个总数被划分成四个组并且如下对待:控制组(n=15 ) ;脾切除术组(n=15 ) ;CsA 组(n=15 ) ;CsA + 脾切除术组(n=15 ) 。IL-2, IFN- , IL-4 和 IL-10 的层次被酶测量连接 immunosorbent 试金(ELISA ) 。Sera 在每个组在不同时间点被收获:白天 1,和 3 象日子一样,异种皮移植停止在控制组和 CsA 组跳动;白天 1, 3, 7, 14 和 30 在脾切除术组和 CsA+splenectomy 组。P-selectin 和细胞间的粘附 molecule-1 (ICAM-1 ) 的表示被异种皮移植的 immunohistochemical 分析在心脏的 xenotransplantation 以后检验。IL-2 和 IFN- 的结果浆液层次是 upregulated 在未经治疗(白天 3 ) 并且与 CsA + 脾切除术相比的对待脾切除术的动物(白天 7 ) 对待动物(白天 7 ) 。IL-10 是在跟随脾切除术 + CsA 的长期的幸存接受者的 upregulated。既不 P-selectin 也不 ICAM-1 表示在长期的幸存异种皮移植被检测。结论浆液 IL-2 和 IFN- 被提高跟随尖锐脉管的拒绝。浆液 IL-10 在跟随一致心脏的 xenotransplantation 的长期的幸存老鼠被相关到免疫力的抑制和保护的效果。 | ZHANG Xiao-gang Lü Yi WANG Bo LI Hui YU Liang LIU Chang WU Zheng LIU Xue-min | 2007 | Chinese Medical Journal2007，，2： | 10 |
| 5 | Analysis of carbon isotope in phytoliths from C3 and C4 plants and modern soils显示文摘The analysis of carbon isotope in phytoliths from modern plants and surface soils in China shows that the values of carbon isotope are consistent with those from C3 and C4 plants, and the processes of photosynthesis of the original plants can be clearly identified by carbon isotope in phytoliths. The value of carbon isotope varied from -23.8‰ to -28‰, with the maximum distributed in the latitude zone from 34°N to 40°N in North China and East China areas, and the minimum in the Northeast China and South China regions. The values of carbon of phytoliths tend to increase from low to high and then reduce to low value again as the latitude increases. In the same latitude zone, the carbon isotope in phytoliths from grassland soil under the trees is obviously lower than that from grassland soil without any trees with the difference of 1‰ - 2‰. | LÜ Houyuan WANG Yongji WANG Guo'an YANG Hui LI Zhen | 2000 | Chinese Science Bulletin2000，45，19： | 9 |
| 6 | Optomechanically induced transparency in a spinning resonator显示文摘We study optomechanically induced transparency in a spinning microresonator. We find that in the presence of rotation-induced Sagnac frequency shift, both the transmission rate and the group delay of the signal are strongly affected, leading to a Fano-like spectrum of transparency. In particular, tuning the rotary speed leads to the emergence of nonreciprocal optical sidebands. This indicates a promising new way to control hybrid light–sound devices with spinning resonators. | HAO Lü YAJING JIANG YU-ZHU WANG HUI JING | 2017 | Photonics Research2017，5，4： | 8 |
| 7 | Partial sequencing of 5' non-coding region of 7 HGV strains isolated from different areas of China显示文摘 | WANG Xing-Tai ZHUANG Hui SONG Hai-Bo Ll He-Min ZHANG Hua-Yuan and YU Yang(National Institute for the Control of bormceutical and BiologicalPriducts, Beijing 100050, China)(Department of Microbiology, Beijing Medical University, Beijing100083, China)(L | 1999 | World Journal of Gastroenterology1999，5，5： | 7 |
| 8 | High-pressure granulite from Western Kunlun,northwestern China:Its metamorphic evolution,zircon SHRIMP U-Pb ages and tectonic implication显示文摘High-pressure mafic granulites occurring as lenticular bodies within garnet-amphibolites in Kangxiwar Fault have been first reported in this paper. The P-T conditions of two metamorphic stages were ob-tained using calibrated geothermal barometers and ThermoCalc Program. The peak metamorphic con-dition of these high-pressure granulites is about 760―820℃,1.0―1.2 GPa and the retrograde meta-morphic condition is about 620―720℃,0.7―0.8 GPa. The petrological studies show that they have a near-isobaric cooling P-T path which suggests that the Western Kunlun underwent initial crustal thickening,subsequent exhumation and cooling. The SHRIMP zircon U-Pb dating gives two groups of ages for high-pressure granulites. One is 177±6 Ma which is obtained from the rim of the zircon. We consider this age should be the metamorphic age. And the other is 456±30 Ma which is obtained from the core of the zircon and should be the protolith age. The formation of these high-pressure granulites in western Kunlun is closely correlated with the evolution of the Paleo-Tethys and has important im-plications for the research on Tethys and Paleo-Asian tectonic zone. | QU JunFeng ZHANG LiFei AI YongLiang L Zeng WANG JianPing ZHOU Hui WANG ShiYan | 2007 | Science China Earth Sciences2007，50，7： | 7 |
| 9 | The magnetic properties of Serbian loess and its environmental significance显示文摘This paper reports a loess-paleosol sequence located in the Danube River basin,Serbia,which formed at least since the latest part of the early Pleistocene,and before the paleomagnetic B/M boundary.Various magnetic parameters of the Serbian V-L1-V-S4 loess-paleosol sequence have been measured and analyzed in the Titel Loess Plateau.These parameters show a very similar magnetic behavior compared with that of the Chinese loess.There is a general positive relationship between magnetic susceptibility() and pedogenesis.The main contributors to are the magnetic grains of SP(superparamagnetic) and SD(single domain) magnetic domains,while MD(multi domain) contributes only a small percentage.The difference in between loess and paleosol mainly is caused by pedogenesis.The very fine magnetic minerals increase gradually with increasing soil development(from loess to soil),and they lead to higher.The thermomagnetic curves show thatmagnetic minerals in the loess layers are magnetite and maghemite,both providing a major contribution to.In contrast the paleosol layers mainly are composed of magnetite,with almost no or a very small amount of maghemite,as implied by a reversible thermomagnetic behavior.This indicates that pedogenic conditions during V-S3 and V-S4 strong soil development have resulted in maghemite that is no longer stable,and has been resolved or converted to other stable phase minerals.This likely indicates that soil moisture during V-S3 and V-S4 development exceeded a critical condition of maghemite stability. | LIU XiuMing LIU Zhi Lü Bin MARKOVI S B CHEN JiaSheng GUO Hui MA MingMing ZHAO GuoYong FENG Hua | 2013 | Chinese Science Bulletin2013，58，3： | 7 |
| 10 | Archaeological records of Dadiwan in the past 60 ka and the origin of millet agriculture显示文摘This paper reports the recent excavation of Unit Dadiwan06 at the Dadiwan site in Qin’an County, Gansu.A 65 ka chronological framework is established for Dadiwan06 on the basis of absolute dating (AMS 14C and OSL), stratigraphy, climate change events and archaeology.Artifact distributions reveal patterns of human behavioral variation and adaptation over the past 60 ka, from primitive hunting and gathering to advanced hunting and gathering, to primitive Neolithic agriculture, and finally to advanced Neolithic agriculture. | ZHANG DongJu CHEN FaHu BETTINGER R L BARTON L JI DuXue MORGAN C WANG Hui CHENG XiaoZhong DONG GuangHui GUILDERSON T P ZHAO Hui | 2010 | Chinese Science Bulletin2010，55，16： | 6 |
| 11 | Determination of critical slip surface of fractured rock slopes based on fracture orientation data显示文摘The critical slip surface of a fractured rock slope tends to extend along the fractures.Thus,fracture orientation plays a critical role in determining the critical slip surface.Based on fracture orientation data,this paper examines the critical slip surfaces of fractured rock slopes.Given that the surface of a fractured rock slope extends along the fracture surfaces,or the wedges,with each composed of two arbitrary fractures,the critical slip surface is determined via stochastic dynamics.In addition,a fracture frequency method is proposed as a means of analyzing the critical slip surface.According to this method,the critical slip surface slips in whichever direction has the lowest fracture frequency.Based on the stochastic dynamics method and the fracture frequency method,the critical slip surface of the slope is finally determined,that is,the critical slip surface takes the form of a plane passing the slope toe with a dip of 120° and a dip angle of 45°. | ZHANG Wen CHEN JianPing ZHANG Wu L Yan MA YuFei XIONG Hui | 2013 | Science China(Technological Sciences)2013，56，5： | 5 |
| 12 | A New Somphospondylan Sauropod (Dinosauria, Titanosauriformes) from the Late Cretaceous of Ganzhou, Jiangxi Province of Southern China显示文摘A new somphospondylan sauropod (Dinosauria, Titanosauriformes): Gannansaurus sinensis gen. et sp. nov. from the Late Cretaceous Nanxiong Formation of Ganzhou Basin, Jiangxi Province of southern China is erected based on one nearly complete dorsal vertebra and a mid-caudal vertebra. It is characterized by two centroprezygapophyseal lamina fossae; large, square-shaped concavity formed by centroprezygapophyseal lamina and dorsal margin of the centrum; large infraparapophyseal fossa; three openings present within the large lateral concavity, which occupy 65% length of the centrum; the posterior centroparapophyseal lamina (PCPL) and the anterior centroparapophyseal lamina (ACPL) weakly developed; the posterior centrodiapophyseal lamina (PCDL) separated by an infradiapophyseal fossa into two branches dorsally; parapophyseal and diapophyseal laminae cross to form 'K' configuration. It shares some characters with the Early Cretaceous form-Euhelopus, indicating that it is more closely related to Euhelopus rather than to other titanosauriform sauropods. This means Gannansaurus may have a close phylogenetic relationship with Euhelopus. | Lü Junchang YI Laiping ZHONG Hui WEI Xuefang | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 5 |
| 13 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 14 | Biliary papillomatosis: analysis of 18 cases显示文摘 | JIANG Li YAN Lü-nan JIANG Li-sheng LI Fu-yu YE Hui LI Ning CHENG Nan-sheng ZHOU Yong | 2008 | Chinese Medical Journal2008，，24： | 4 |
| 15 | Hybrid uncertainties-based analysis and optimization design of powertrain mounting systems显示文摘In this study,a hybrid uncertainties-based analysis and optimization method is presented for the designs of the powertrain mounting system(PMS)involving mixed uncertainties.In the presented method,the PMS parameters with sufficient data are treated as random variables,while those with limited information are defined as interval variables.Then,an uncertainty-based analysis method called as hybrid interval-random perturbation-central difference method(HIRP-CDM),is proposed to compute the hybrid interval-random outputs of the inherent characteristics of the PMS in concerned directions.In addition,the hybrid interval-random-Monte Carlo method(HIR-MCM)is developed to verify the computational accuracy of HIRP-CDM.Next,an optimization model mixed uncertainties is built up for the PMS design based on HIRP-CDM,in which the hybrid intervalrandom outputs of the concerned inherent characteristics are adopted to construct the design objective and constrains.The complex optimization problem can be effectively settled by means of HIRP-CDM.The effectiveness of the presented method is verified by a numerical example. | CAI BoHao SHANGGUAN Wen-Bin LÜHui BO Tao | 2020 | Science China(Technological Sciences)2020，63，5： | 4 |
| 16 | Delivering DNA into Plant Cell by Gene Carriers of ZnS Nanoparticles显示文摘The development of nanotechnology provides a new method for genetic engineering.However,the nanoparticles as gene carriers have been mainly used in the mammalian cells so far.We observed that ZnS nanoparticles modified with positively charged poly-L-lysine(PLL) successfully delivered GUS-encoding plasmid DNA into tobacco cells by means of ultrasound-assisted method.Polymerase chain reaction(PCR) detection,Southern blot analysis and GUS histochemical staining were carried out for the regenerated plants.The stable genetic modified plants mediated by ZnS nanoparticles can be obtained.This article demonstrates the great potential of nanoparticles as gene carrier in plant transformation and proves a novel approach for plant genetic decoration. | FU Yu-qin LI Lu-hua WANG Pi-wu QU Jing FU Yong-ping WANG Hui SUN Jing-ran LÜ Chang-li | 2012 | Chemical Research in Chinese Universities2012，28，4： | 4 |
| 17 | Simulation and projection of climate change using CMIP6 Muti-models in the Belt and Road Region显示文摘Climate condition over a region is mostly determined by the changes in precipitation,temperature and evaporation as the key climate variables.The countries belong to the Belt and Road region are subjected to face strong changes in future climate.In this paper,we used five global climate models from the latest Sixth Phase of Coupled Model Intercomparison Project(CMIP6)to evaluate future climate changes under seven combined scenarios of the Shared Socioeconomic Pathways and the Representative Concentration Pathways(SSP1-1.9,SSP1-2.6,SSP2-4.5,SSP3-7.0,SSP4-3.4,SSP4-6.0 and SSP5-8.5)across the Belt and Road region.This study focuses on undertaking a climate change assessment in terms of future changes in precipitation,air temperature and actual evaporation for the three distinct periods as near-term period(2021−2040),mid-term period(2041−2060)and long-term period(2081−2100).To discern spatial structure,Köppen−Geiger Climate Classification method has been used in this study.In relative terms,the results indicate an evidence of increasing tendency in all the studied variables,where significant changes are anticipated mostly in the long-term period.In addition to,though it is projected to increase under all the SSP-RCP scenarios,greater increases will be happened under higher emission scenarios(SSP5-8.5 and SSP3-7.0).For temperature,robust increases in annual mean temperature is found to be 5.2°C under SSP3-7.0,and highest 7.0°C under SSP5-8.5 scenario relative to present day.The northern part especially Cold and Polar region will be even more warmer(+6.1°C)in the long-term(2081−2100)period under SSP5-8.5.Similarly,at the end of the twenty-first century,annual mean precipitation is inclined to increase largely with a rate of 2.1%and 2.8%per decade under SSP3-7.0 and SSP5-8.5 respectively.Spatial distribution demonstrates that the largest precipitation increases are to be pronounced in the Polar and Arid regions.Precipitation is projected to increase with response to increasing warming most of the regions.Finally,the actual evaporation is projected to increase significantly with rate of 20.3%under SSP3-7.0 and greatest 27.0%for SSP5-8.5 by the end of the century.It is important to note that the changes in evaporation respond to global mean temperature rise consistently in terms of similar spatial pattern for all the scenarios where stronger increase found in the Cold and Polar regions.The increase in precipitation is overruled by enhanced evaporation over the region.However,this study reveals that the CMIP6 models can simulate temperature better than precipitation over the Belt and Road region.Findings of this study could be the reliable basis for initiating policies against further climate induced impacts in the regional scale. | YanRan Lü Tong Jiang YanJun Wang BuDa Su JinLong Huang Hui Tao | 2020 | Research in Cold and Arid Regions2020，12，6： | 4 |
| 18 | Quantitative assessment of gas washing of oils in the Tazhong area of the Tarim Basin,Northwest China显示文摘Gas washing has been known in the Tazhong area of the Tarim Basin,but its quantitative assessment has not yet been reported.Here the influence of gas washing fractionation in the area was discussed based on the gas chromatogram data of 68 oils and the results of the mixing experiments of a black oil and a condensate.The results show that the intensity of gas washing fractionation decreased generally from northern to southern part and vertically from deep reservoirs to shallow reservoirs.The gas washing fractionation was mainly controlled by fault systems in this area,with the increase of n-alkane mass depletion positively correlated to the number and scale of faults.Gas washing fractionation appears to have affected the hydrocarbon property,and as a result the diversity of the crude oils is markedly controlled by gas washing.In addition,the occurrence of waxy oil in this area may be resulted from multiple factors including gas washing,mixed filling and migration fractionation. | YANG ChuPeng GENG AnSong LIAO ZeWen SUN YongGe ZHANG LüHui | 2009 | Science China Earth Sciences2009，52，1： | 4 |
| 19 | Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds. | Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun | 2015 | Bone Research2015，3，3： | 4 |
| 20 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员