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| 1 | Interaction of hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of tupaia CD81显示文摘AIM: To further analyze the interaction of tupaia CD81 with hepatitis C virus (HCV) envelope protein E2. METHODS: A tupaia CD81 large extracellular loop (CD81 LEL), which binds to HCV E2 protein, was cloned and expressed as a GST-fusion protein, and interaction of HCV E2 protein with a tupaia CD81 LEL was evaluated by enzyme-linked immunosorbent assay (EIA). RESULTS: Although tupaia and human CD81 LEL differed in 6 amino acid changes, tupaia CD81 LEL was strongly recognized by anti-CD81 antibodies against human CD81 LEL conformation-dependent epitopes. Investigating LEL CD81-E2 interactions by EIA, we demonstrated that binding of tupaia CD81 LEL GST fusion protein to recombinant HCV E2 protein was markedly reduced compared to binding of human CD81 LEL GST fusion protein to recombinant HCV E2 protein. CONCLUSION: These data suggest that the structural differences in-between the tupaia and human CD81 may alter the interaction of the large extracellular loop with HCV envelope glycoprotein E2. These findings may be important for the understanding of the mechanisms of binding and entry of HCV to PTHs. | Zhan-Fei Tian Hong Shen Xi-Hua Fu Yi-Chun Chen Hubert E Blum Thomas F Baumert Xi-Ping Zhao | 2009 | World Journal of Gastroenterology2009，15，2： | 16 |
| 2 | Cerebral processing of auditory stimuli in patients with irritable bowel syndrome显示文摘瞄准:用大脑决定功能的磁性的回声成像(fMRI ) 非内脏的刺激的服的处理是否在急躁的肠症候群(IBS ) 被改变病人与健康题目相比。围绕针的内脏躯体集中机制,并且识别心理因素的可能的影响,我们使用了听觉的刺激刺激在他们的感情的质量不同。方法:在 8 个 IBS 病人和 8 控制, fMRI 大小用不同感情的质量(钟声,讨厌的偷看(2000 Hz ) ,中立的词,和感情的词的愉快的声音) 的 4 听觉的刺激的一个块图案被执行。坡度回响 T2 * 加权的顺序被用于功能的扫描。统计地图用一般线性模型被构造。结果:到感情的听觉的刺激,,相对控制的 IBS 病人在感情的处理区域的一个更大的变化与更强壮的释放反应了反应模式,在控制不同,没在令人烦恼或愉快的声音之间区分。到中立听觉的刺激,由对比,仅仅 IBS 病人与大重要激活反应了。结论:到在感情的处理刺激的区域的听觉的刺激的改变的服的反应模式建议在 IBS 的改变的感觉处理不能为内脏的感觉是特定的,但是可能在感情的敏感和感情方面的反应反映概括变化,可能与经常在 IBS 病人发现的心理 comorbidity 联系了。 | Viola Andresen Alexander Poellinger Chedwa Tsrouya Dominik Bach Albrecht Stroh Annette Foerschler Petra Georgiewa Marco Schmidtmann Ivo R van der Voort Peter Kobelt Claus Zimmer Bertram Wiedenmann Burghard F Klapp Hubert Monnikes | 2006 | World Journal of Gastroenterology2006，12，11： | 8 |
| 3 | Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells显示文摘AIM: To present an approach for selectively killing retrovirus-infected cells that combines the toxicity of Pseudomonas exotoxin (PE) and the presence of reverse transcriptase (RT) in infected cells. METHODS: PE antisense toxin RNA has palindromic stem loops at its 5' and 3' ends enabling self-primed generation of cDNA in the presence of RT. The RT activity expressed in retrovirus-infected cells converts 'antisense-toxin-RNA' into a lethal toxin gene exclusively in these cells. RESULTS: Using cotransfection studies with PE-expressing RNAs and β-gal expressing reporter plasmids, we show that, in HepG2 and HepG2.2.15 hepatoma cells as well as in duck hepatitis B virus (DHBV) infected cells, HBV or DHBV-polymerase reverse transcribe a lethal cDNA copy of an antisense toxin RNA, which is composed of sequences complementary to a PE gene and eukaryotic transcription and translation signals. CONCLUSION: This finding may have important implications as a novel therapeutic strategy aimed at the elimination of HBV infection. | Peter Hafkemeyer Ulrich Brinkmann Elizabeth Brinkmann Ira Pastan Hubert E Blum Thomas F Baumert | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 4 | Differential control of T regulatory cell proliferation and suppressive activity by mature plasmacytoid versus conventional spleen dendritic cells 显示文摘 | Ouabed A Hubert F X Chabannes D | 2008 | J Im- munol2008，180，9： | 1 |
| 5 | An insertion/deletion polymorphism in the angiotensin Ⅰ converting enzyme gene accounting for half the variance of serum enzyme levels显示文摘 | Rigat B Hubert C Alhen-Gelas F | 1990 | J Clin Invest1990，86，4： | 1 |
| 6 | Predictive value of viral load and other markers for progression to clinical AIDS after CD4+ cell count falls below 200/micro L显示文摘 | Carre N Boufassa F Hubert JB | 1998 | Int J Epidemion1998，27，5： | 1 |
| 7 | An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels显示文摘 | RIGAT B HUBERT C ALHENC G F | 1990 | J Clin Invest1990，86，4： | 1 |
| 8 | An insertion/deletion polymorphism in the angiotensin Ⅰ-converting enzyme gene accounting for half the variance of serum enzyme levels 显示文摘 | RIGAT B HUBERT C ALHENC-GELAS F | 1990 | J Clin Invest1990，86，4： | 1 |
| 9 | An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels显示文摘 | Rigat B Hubert C Alhenc-Gelas F | 1990 | J Clin Invest1990，86，4： | 1 |
| 10 | Chalcopyrite thin film solar cells by electrodeposition 显示文摘 | LINCOT D GUILLEMOLESA J F TAUNIER S GUIMARD D SICX-KURDI J CHAUMONT A ROUSSEL O RAMDANI O HUBERT C FAUVARQUE J P BODEREAU N PARISSI L PANHELEUX P FANOUILLERE P NAGHAVI N GRAND P P BENFARAH M MOGENSEN P KERREC O | 2004 | Solar Energy2004，77，： | 1 |
| 11 | Half-wavelength power transmission lines显示文摘 | Hubert F J Gent M R | 1965 | IEEE Trans on Power Apparatus and Systems1965，84，10： | 1 |
| 12 | High interaction alginate - hyaluronate associations by hyaluronate deacetylation for the preparation of effident biomaterials显示文摘 | Oerther S Maurin A Payan E Hubert P I.apicque F Presle N etal | | 0，，： | 1 |
| 13 | An insertion/deleton polymorphism in the angiotensin Ⅰ-converting enzyme gene accounting for half the variance of serum enzyme levels显示文摘 | RIGAT B HUBERT C ALHENC-GELAS F | 1990 | J Clin Invest1990，86，4： | 1 |
| 14 | An insertion/deletion polymorphism in the angiotensin Ⅰ converting enzyme gene accounting for haft the variance of serum enzyme levels显示文摘 | Rigat B Hubert C Alhenc-Gelas F | 1990 | J Clin Invest1990，86，： | 1 |
| 15 | Half-wavelength power transmission lines显示文摘 | Hubert F J Gent M R | 1965 | IEEE Trans on Power Apparatus and Systems1965，84，10： | 1 |
| 16 | An insertion/deletion polymorphism in the angiotensin I - coverting enzyme gene accounting for half the variance of serum negyme levels 显示文摘 | Rigat B Hubert C Alhenc - Gelas F | 1990 | J Clin Invest1990，86，4： | 1 |
| 17 | Half-wavelength power transmission lines显示文摘 | Hubert F J Gent M R | 1965 | IEEE Trans on Power Apparatus and Systems1965，84，10： | 1 |
| 18 | An insertion / deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels 显示文摘 | Rigat B Hubert C Alhenc-Gelas F | 1990 | J Clin Invest1990，86，4： | 1 |
| 19 | An insertion/deletion poly- morphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels显示文摘 | Rigat B Hubert C Alhenc-Gelas F | 1990 | J Clin Invest1990，86，4： | 1 |
| 20 | Evaluation of the emergency dispersion model at the Deutscher Wetterdienst using ETEX data 显示文摘 | Hubert G Barbara F Ingo J | 1998 | Atmospheric Environment1998，32，24： | 1 |
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