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| 1 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 2 | Pm21 from Haynaldia villosa Encodes a CC-NBS- LRR Protein Conferring Powdery Mildew Resistance in Wheat显示文摘 | Liping Xing Ping Hu Jiaqian Liu Kamil Witek Shuang Zhou Jiefei Xu Weihao Zhou Li Gao Zhenpu Huang Ruiqi Zhang Xiue Wang Peidu Chen Haiyan Wang Jonathan D.G. Jones Miroslava Karafiatova Jan Vrana Jan Baros Jaroslav Dolezel Yuanchun Tian Yufeng Wu Aizhong Cao | 2018 | Molecular Plant2018，11，6： | 16 |
| 3 | Friction of low-dimensional nanomaterial systems显示文摘When material dimensions are reduced to the nanoscale,exceptional physical mechanics properties can be obtained that differ significantly from the corresponding bulk materials.Here we review the physical mechanics of the friction of low‐dimensional nanomaterials,including zero‐dimensional nanoparticles,one‐dimensional multiwalled nanotubes and nanowires,and two‐dimensional nanomaterials-such as graphene,hexagonal boron nitride(h‐BN),and transition‐metal dichalcogenides-as well as topological insulators.Nanoparticles between solid surfaces can serve as rolling and sliding lubrication,while the interlayer friction of multiwalled nanotubes can be ultralow or significantly high and sensitive to interwall spacing and chirality matching,as well as the tube materials.The interwall friction can be several orders of magnitude higher in binary polarized h‐BN tubes than in carbon nanotubes mainly because of wall buckling.Furthermore,current extensive studies on two‐dimensional nanomaterials are comprehensively reviewed herein.In contrast to their bulk materials that serve as traditional dry lubricants(e.g.,graphite,bulk h‐BN,and MoS_(2)),large‐area high‐quality monolayered two‐dimensional nanomaterials can serve as single‐atom‐thick coatings that minimize friction and wear.In addition,by appropriately tuning the surface properties,these materials have shown great promise for creating energy‐efficient self‐powered electro‐opto‐magneto‐mechanical nanosystems.State‐of‐the‐art experimental and theoretical methods to characterize friction in nanomaterials are also introduced. | Wanlin GUO Jun YIN Hu QIU Yufeng GUO Hongrong WU Minmin XUE | 2014 | Friction2014，2，3： | 15 |
| 4 | Nat Microbiol:已结首次构建出小鼠肠道微生物组数据库显示文摘小鼠模型通常被广泛用于药理学和医学研究。我们都知道小鼠肠道中的微生物群落通常会对研究结果产生明显的影响,然而目前研究者们并没有获取到关于小鼠肠道中栖息细菌群落的详细信息。近日刊登在国际杂志Nature Microbiology上的一篇研究报告中。德国慕尼黑理工大学的研究者通过研究首次收集到了小鼠肠道中的多种细菌群落。同时研究者还对其进行了分裂、特性分析。最后得到了100种细菌,其中还包括15种迄今为止未知的细菌群落。 | Lu, Qiulun Yao, Yufeng Hu, Zhenkun Hu, Changqing Song, Qixue Ye, Jian Xu, Chengqi Wang, Annabel Z. Chen, Qiuyun Wang, Qing Kenneth | 2016 | 现代生物医学进展2016，16，32： | 13 |
| 5 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 6 | Separation of ionic liquids from dilute aqueous solutions using the method based on CO_2 hydrates显示文摘Ionic liquids (ILs) have been regarded as the potential novel solvents for improved analytical-and process-scale separation methods. The development of methods for the recovery of ILs from aqueous solutions to escape contamination and recycle samples will ultimately govern the viability of ILs in the future industrial applications. Therefore, in this paper a new method for separation of ILs from their dilute aqueous solutions and simultaneously purification of water was proposed on the basis of the CO2 hydrate formation. For illustration, the dilute aqueous solutions with concentrations of ILs ranging from 2×10-3 mol% to 2×10-1mol% were concentrated.The results show that the separation efficiency is very impressive and that the new method is applicable to aqueous solutions of both hydrophobic and hydrophilic ILs.Compared to the literature separation method based on the supercritical CO2,the new method is applicable to lower concentrations,and more importantly, its operation condition is mild. | Xiaoming Peng Yufeng Hu Yansheng Liu Chuanwei Jin Huaijing Lin | 2010 | Journal of Natural Gas Chemistry2010，19，1： | 9 |
| 7 | Genomic Analyses Yield Markers for Identifying Agronomically Important Genes in Potato显示文摘野土豆种类有实质的 phenotypic 和生理的差异。这里,我们基于茄属节 Petota 的 201 就职的 genomic 分析报导对野、栽培的土豆种类的一个全面评价。我们定序这 201 就职的染色体并且识别了 6 ? 487 ? 从在 clade 的 167 就职的 006 高质量的单个核苷酸多型性(SNP ) 4 茄属节 Petota,包括 146 野并且有宽广地理分布的 21 栽培双土豆就职。染色体宽的基因变化分析比栽培土豆,和在农学地重要的疾病抵抗的高得多的基因差异,基因在野土豆被观察的证明野土豆的差异高。由关于已知的量的特点 loci (QTL ) 利用信息,而且,我们在选择下面识别了 609 基因,包括那些在 tubers 与痛苦的损失相关,那些在 tuberization 包含了,土豆的二个主要驯养的特点。种系发生的分析在 clade 揭示了所有种类的一个纵贯的部门 4,不是就那些在 S.? brevicaule 建筑群,和进一步支持的 S。是的 candolleanum 栽培土豆和在南部的秘鲁的栽培土豆的 monophyletic 起源的祖先。另外,我们分析了 S. 的染色体 ? candolleanum 并且鉴别 529 基因在栽培土豆输了。一起,在这研究产生的分子的标记为为土豆繁殖有用的农学地重要的基因的鉴定提供一个珍贵资源。 | Yangping Li Christophe Colleoni Junjie Zhang Qiqi Liang Yufeng Hu Holly Ruess Reinhard Simon Yinghong Liu Hanmei Liu Guowu Yu Eric Schmitt Ghloe Ponitzki Guangjian Liu Huanhuan Huang Feilong Zhan Lin Chen Yubi Huang David Spooner Binquan Huang | 2018 | Molecular Plant2018，11，3： | 8 |
| 8 | Transcription factor ZmNAC126 plays an important role in transcriptional regulation of maize starch synthesis-related genes显示文摘Maize(Zea mays L.)is one of the most important food crops in the world,and starch is the main component of its endosperm.Transcriptional regulation plays a vital role in starch biosynthesis.However,it is not well understood in maize.We report the identification of the transcription factor ZmNAC126 and its role in regulation of starch synthesis in maize.Transcriptional expression of ZmNAC126 was higher in maize endosperm and kernels than in roots or stems.ZmNAC126 shared a similar expression pattern with starch synthesis genes during seed development,and its expression pattern was also consistent with the accumulation of starch.ZmNAC126 is a typical transcription factor with a transactivation domain between positions 201 and 227 of the amino acid sequence,is located in the nucleus,and binds to CACG repeats in vitro.Yeast one-hybrid assay revealed that ZmNAC126 bound the promoters of ZmGBSSI,ZmSSIIa,ZmSSIV,ZmISA1,and ZmISA2.Transient overexpression of ZmNAC126 in maize endosperm increased the activities of promoters pZmSh2,pZmBt2,pZmGBSSI,pZmSSIIIa,and pZmBT1 but inhibited the activities of pZmISA1 and pZmISA2.ZmNAC126 thus acts in starch synthesis by transcriptionally regulating targeted starch synthesis-related genes in maize kernels. | Qianlin Xiao Yayun Wang Hui Li Chunxia Zhang Bin Wei Yongbin Wang Huanhuan Huang Yangping Li Guowu Yu Hanmei Liu Junjie Zhang Yinghong Liu Yufeng Hu Yubi Huang | 2021 | The Crop Journal2021，9，1： | 5 |
| 9 | Effect of 1-butyl-3-methylimidazolium tetrafluoroborate on the formation rate of CO_2 hydrate显示文摘The effect of the addition of 1-butyl-3-methylimidazolium tetrafluoroborate ([C4mim][BF4]) on the formation rates of CO2 hydrates was investigate. The isothermal and isobaric methods were used to measure the formation rates of CO2 hydrates. As compared to those of pure water, the data of phase equilibrium changed greatly. The effects of pressure, temperature, and the concentration of [C4mim][BF4] aqueous solution on the formation rates of CO2 hydrates were investigated. With a constant concentration of [C4mim][BF4], the rate of gas consumption was enhanced with the lowering of experimental temperature. However, a decrease in pressure exerted an opposite effect on the rate of gas consumption. Moreover, the addition of [C4mim][BF4] raised the equilibrium pressure of hydrate formation at the same temperature. | Qi Chen Yong Yu Peng Zeng Wei Yang Qianqing Liang Xiaoming Peng Yansheng Liu Yufeng Hu | 2008 | Journal of Natural Gas Chemistry2008，17，3： | 5 |
| 10 | Notes on 2-parameter quantum groupsⅠ显示文摘A simpler definition for a class of 2-parameter quantum groups associated to semisimple Lie algebras is given in terms of Euler form.Their positive parts turn out to be 2-cocycle deformations of each other under some conditions.An operator realization of the positive part is given. | HU NaiHong PEI YuFeng Department of Mathematics,East China Normal University,Shanghai 200062,China | 2008 | Science China Mathematics2008，51，6： | 5 |
| 11 | Tensile, creep behavior and microstructure evolution of an as-cast Ni-based K417G polycrystalline superalloy显示文摘The Ni-based K417 G superalloy is extensively applied as aeroengine components for its low cost and good mid-temperature(600–900?C) properties. Since used in as-cast state, the comprehensive understanding on its mechanical properties and microstructure evolution is necessary. In the present research,the tensile, creep behavior and microstructure evolution of the as-cast K417 G superalloy under different conditions were investigated. The results exhibit that tensile cracks tend to initiate at MC carbide and γ/γ' eutectic structure and then propagate along grain boundary. As the temperature for tensile tests increases from 21?C to 700?C, the yield strength and ultimate tensile strength of K417 G superalloy decreases slightly, while the elongation to failure decreases greatly because of the intermediate temperature embrittlement. When the temperature rises to 900?C, the yield strength and ultimate tensile strength would decrease significantly. The creep deformation mechanism varies under different testing conditions. At 760?C/645 MPa, the creep cracks initiate at MC carbides and γ/γ' eutectic structures,and propagate transgranularly. While at 900?C/315 MPa and 950?C/235 MPa, the creep cracks initiate at grain boundary and propagate intergranularly. As the creep condition changes from 760?C/645 MPa to 900?C/315 MPa and 950?C/235 MPa, the ? phase starts to raft, which reduces the creep deformation resistance and increases the steady-state deformation rate. | Beining Du Ziyang Hu Liyuan Sheng Chuanyong Cui Jinxia Yang Yufeng Zheng Xiaofeng Sun | 2018 | Journal of Materials Science & Technology2018，34，10： | 4 |
| 12 | H_(3)PMo_(12)O_(40)-catalyzed coupling of diarylmethanols with epoxides/diols/aldehydes toward polyaryl-substituted aldehydes显示文摘A versatile heteropoly acid(H_(3)PMo_(12)O_(40))-catalyzed coupling of diarylmethanols with epoxides was established for the synthesis of polyaryl-substituted aldehydes.Furthermore,the catalytic system was also suitable for the reaction of diarylmethanols and diols/aldehydes.The application of such an earthabundant,readily accessible,and nontoxic catalyst provides a green approach for the construction of polyaryl-substituted aldehydes. | Guoping Yang Yufeng Liu Ke Li Wei Liu Bing Yu Changwen Hu | 2020 | Chinese Chemical Letters2020，31，12： | 4 |
| 13 | Surface plasmonic effect and scattering effect of Au nanorods on the performance of polymer bulk heterojunction solar cells显示文摘The surface plasmonic effect and scattering effect of gold nanorods(AuNRs) on the performance of bulk heterojunction photovoltaic devices based on the blend of polythiophene and fullerene are investigated.AuNRs enhance the excitation since the plasmonic effect increases the electric field,mainly in the area near the interface between the active layer and AuNRs.The results show that the incident photo-to-electron conversion efficiency(IPCE) obviously increases for the device with a layer of gold nanorods,resulting from the plasmonic effect of AuNRs in the range of 500-670 nm and the scattering effect in the range of 370-410 nm.The power conversion efficiency(PCE) is increased by 7.6% due to the near field effect of the localized surface plasmons(LSP) of AuNRs and the scattering effect.The short circuit current density is also increased by 9.1% owing to the introduction of AuNRs.However,AuNRs can cause a little deterioration in open circuit voltage. | FANG Yi HOU YanBing LOU ZhiDong TENG Feng TANG AiWei HU YuFeng | 2013 | Science China(Technological Sciences)2013，56，8： | 4 |
| 14 | Monte-Carlo simulation of pinhole collimator of a small field of view gamma camera for small animal imaging显示文摘Needs in scintimammography applications,especially for small animal cardiac imaging,lead to develop a small field of view,high spatial resolution gamma camera with a pinhole collimator.However the ideal pinhole collimator must keep a compromise between spatial resolution and sensitivity.In order to design a pinhole collimator with an optimized sensitivity and spatial resolution,the spatial resolution and the geometric sensitivity response as a function of the source to collimator distance has been obtained by means of Monte-Carlo simulation for a small field of view gamma camera with a pinhole collimator of various-hole diameters.The results show that the camera with pinhole of 1 mm,1.5 mm and 2 mm diameter has respectively spatial resolution of 1.5 mm,2.25 mm and 3 mm and geometric sensitivity of 0.016%,0.022%and 0.036%,while the source to collimator distance is 3 cm.We chose the pinhole collimator with hole diameter size of 1.2 mm for our the gamma camera designed based on the trade-off between sensitivity and resolution. | ZHU Jie MA Wenyan ZHU Yufeng MA Hongguang WU Yuelei HU Huasi ZHANG Boping HUO Yonggang LIU Silu JIAN Bin WANG Zhaomin | 2009 | Nuclear Science and Techniques2009，20，1： | 4 |
| 15 | Application of wavelet transform in structural health monitoring显示文摘Structural health monitoring(SHM)is a process of implementing a damage detection strategy in existing structures to evaluate their condition to ensure safety.The changes in the material,geometric and/or structural properties affect structural responses,which can be captured and analyzed for condition assessment.Various vibration-based damage detection algorithms have been developed in the past few decades.Among them,wavelet transform(WT)gained popularity as an efficient method of signal processing to build a framework to identify modal properties and detect damage in structures.This article presents the state-of-the-art implementation of various WT tools in SHM with a focus on civil structures.The unique features and limitations of WT,and a comparison of WT and other signal processing methods,are further discussed.The comprehensive literature review in this study will help interested researchers to investigate the use of WT in SHM to meet their specific needs. | Yashodhya Kankanamge Yufeng Hu Xiaoyun Shao | 2020 | Earthquake Engineering and Engineering Vibration2020，19，2： | 4 |
| 16 | Metabolic and Phylogenetic Profile of Bacterial Community in Guishan Coastal Water(Pearl River Estuary), South China Sea显示文摘Characteristics of a microbial community are important as they indicate the status of aquatic ecosystems. In the present study, the metabolic and phylogenetic profile of the bacterioplankton community in Guishan coastal water(Pearl River Estuary), South China Sea, at 12 sites(S1–S12) were explored by community-level physiological profiling(CLPP) with BIOLOG Eco-plate and denaturing gradient gel electrophoresis(DGGE). Our results showed that the core mariculture area(S6, S7 and S8) and the sites associating with human activity and sewage discharge(S11 and S12) had higher microbial metabolic capability and bacterial community diversity than others(S1–5, S9–10). Especially, the diversity index of S11 and S12 calculated from both CLPP and DGGE data(H >3.2) was higher than that of others as sewage discharge may increase water nitrogen and phosphorus nutrient. The bacterial community structure of S6, S8, S11 and S12 was greatly influenced by total phosphorous, salinity and total nitrogen. Based on DGGE fingerprinting, proteobacteria, especially γ- and α-proteobacteria, were found dominant at all sites. In conclusion, the aquaculture area and wharf had high microbial metabolic capability. The structure and composition of bacterial community were closely related to the level of phosphorus, salinity and nitrogen. | HU Xiaojuan LIU Qing LI Zhuojia HE Zhili GONG Yingxue CAO Yucheng YANG Yufeng | 2014 | Journal of Ocean University of China2014，13，5： | 4 |
| 17 | An ultrasound simulation method for carotid arteries with a wall structure of three membranes显示文摘Ultrasound simulation for carotid arteries is helpful to the performance assessments of vessel wall detection and signal processing methods by using ultrasound techniques.An ultrasound simulation method of carotid artery wall with a three-membrane structure is proposed in present study.According to the ultrasound speckle distributions varying with the shapes and densities of scatterer distributions,as well as the statistic results of the clinical images,the parameters of distributions,densities and intensities of scatterers for different kinds of tissues in the carotid artery phantoms are determined.Each region is acoustically characterized using FIELD II software to produce the radio frequency echo signals,from which ultrasound images are derived.The results based on 30 simulations show that the echo distributions of the intimae,mediae,adventitias and blood are consistent with the clinical ones.Moreover,compared with the results from the central frequency of 8 MHz,the mean measurements for thicknesses of the intima,media and adventitia membranes,as well as the lumen diameter from the simulation images based on 12 MHz are the same as the preset ones,and the maximum relative errors are the 4.01%,1.25%,0.04%and 0.15%,respectively.The simulation under this condition is more realistic. | HU Xiao ZHANG Yufeng GAO Lian CAI Guanghui JIA Zhiguo ZHANG Kexin DENG Li | 2015 | Chinese Journal of Acoustics2015，34，3： | 3 |
| 18 | Ordered two-dimensional porous Co3O4 nanosheets as electrocatalysts for rechargeable Li-O2 batteries显示文摘Lithium-oxygen batteries have attracted considerable interest in the past a few years, because they have higher theoretical specific energy than Li-ion batteries. However, the available en ergy den sities of the Li-O2 batteries are much less than expected. It is particularly urgent to find catalyst with high activity. Herein, a series of Co3O4 with differe nt morphologies (ordered two-dimensio nal porous nano sheets, flowerlike and cuboidlike) were successfully prepared through facile hydrothermal and calcinatio n methods. Ordered two-dime nsional Co3O4 nano sheets show the best cycling stability. Detailed experimental results reveal that the superiority of the unique two-dimensional uniform porous structures is vital for Li-O2 batteries cathode catalysts. Due to the ordered structures with high surface areas and active sites, the catalysts indicate a high specific discharge capacity of about 10,417 mAh/g at a current density of 200 mA/g, and steadily cycle for more than 50 times with a limited capacity of 1,000 mAh/g. | Yu Zhang Mingzhen Hu Mengwei Yuan Genban Sun Yufeng Li Kebin Zhou Chen Chen Caiyun Nan Yadong Li | 2019 | Nano Research2019，12，2： | 3 |
| 19 | Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection:A randomized clinical trial显示文摘Importance:Recurrent respiratory tract infection(RRTI)is common in children.Inappropriate RRTI treatment will lead to asthma and other diseases,thereby seriously affecting the growth and physical health of children.Immune function modulation can prevent and alleviate childhood RRTI.Yupingfeng(YPF),a patented traditional Chinese medicine(TCM),has immunomodulatory effects and is widely used in China to treat children with RRTI.Objective:To evaluate the safety and efficacy of YPF monotherapy in treating children with RRTI.Methods:This multicenter,randomized,double-blind,double-simulation,noninferiority clinical trial was conducted from January 2015 to August 2017,with an 8-week treatment period and 52-week follow-up after the drug withdrawal.Children aged 2–6 years with RRTI meeting the inclusion and exclusion criteria were enrolled in 13 hospitals in China and divided randomly into three groups(2:2:1 ratio)to receive YPF,pidotimod,or placebo.The primary outcome was the proportion of RRTI returning to normal standard level during the follow-up.The secondary outcomes were reduction in the number of RRTI recurrences,effect on clinical symptoms(in accord with TCM practice),effect per symptom,and safety.The trial was registered at the Chinese Clinical Trials Registry(www.chictr.org.cn)under the unique identifier ChiCTR-IPR-15006847.Results:Three hundred and fifty-one children were enrolled and randomly assigned to 3 groups;124,125,and 61 children in the YPF,pidotimod,and placebo groups,respectively,had completed the trial.During the follow-up,the proportion of RRTI returning to normal standard level was 73.13%,67.15%,and 38.81%with YPF,pidotimod,and placebo,respectively(P<0.0001).The proportion of cases who returned to normal standard level in the YPF group was 34.32%higher than that in the placebo group.The safety profile did not significantly differ among the groups.Interpretation:YPF granules were noninferior to the active control drug pidotimod oral solution for the treatment of RRTI in children,and were superior to placebo,with a high safety profile. | Baoping Xu Xinmin Li Siyuan Hu Yixiao Bao Fengmei Chen Zhimin Chen Yonggang Du Enmei Liu Yufeng Liu Qinghui Mou Baoling Su Bo Wang Jianwen Xu Guiping Xu Qiaozhi Yang Liwei Gao Xiaohui Liu Lei Li Rong Ma Kunling Shen | 2022 | Pediatric Investigation2022，6，2： | 3 |
| 20 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
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