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| 1 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 2 | B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy显示文摘 | Vijay K Kuchroo Mercy Prabhu Das Julia A Brown Ann M Ranger Scott S Zamvil Raymond A Sobel Howard L Weiner Nasrin Nabavi Laurie H Glimcher | 1995 | Cell1995，，5： | 2 |
| 3 | 显示文摘 | Wierman K W Platt C L Howard J K | 2004 | J Magn Magn Mater2004，278，： | 1 |
| 4 | Intercellular adhesion molecule - 1 mediates murine colon adenocarcinoma invasion显示文摘 | Howard K Lo KK Ao L | 2014 | J Surg Res2014，187，1： | 1 |
| 5 | Whole body inverse dynamics over a complete gait cycle based only on measured kinematics显示文摘 | Ren L Jones R K Howard D | 2008 | Journal of Biomechanics2008，41，12： | 1 |
| 6 | Subcritical solvent extraction of procyanidins from dried red grape pomace 显示文摘 | MONRAD J K HOWARD L R KING J W | 2010 | Journal of Agricultural and Food Chemistry2010，58，7： | 1 |
| 7 | Predictive modeling of human walking over a complete gait cycle 显示文摘 | Ren L Jones R K Howard D | 2007 | Journal of Biomechanics2007，40，7： | 1 |
| 8 | Quality in diced on ions stored in film packages显示文摘 | Howard L R Yoo K S Pike L M | 1994 | Food Sci1994，59，： | 1 |
| 9 | How do floating aquatic weeds affect wet- land conservation and development? How can these effects be mini- mized? 显示文摘 | Howard G W K Harley L S | 1998 | Wetlands Ecology and Management1998，5，： | 1 |
| 10 | Blueberry fruit response to postharvest application of ultraviolet radiation显示文摘 | PERKINS-VEAZIE P COLLINS J K HOWARD L | 2008 | Postharvest Biol Technol2008，47，： | 1 |
| 11 | Percutaneous absorption: a single-lager model 显示文摘 | KIYOSHI K MALGORIATS S HOWARD L | 1993 | J Pharm Sci1993，82，5： | 1 |
| 12 | How do floating aquatic weeds affect wetland conservation and development? How can these effects be minimized? 显示文摘 | Howard G W Harley K L S | 1998 | Wetland Ecology and Management1998，5，： | 1 |
| 13 | Corn as a production system for human and animal vaccines显示文摘 | Streatfield S J Lane J R Brooks C A Barker D K Poage M L Mayor J M Lamphear B J Drees C F Jilka J M Hood E E and Howard J A | 2003 | Vaccine2003，21，： | 1 |
| 14 | The effects of tamoxifen on endometrial insulin-like growth factor-1 expression显示文摘 | Gray K Howard L | 1998 | Obstet Gynecol1998，91，1： | 1 |
| 15 | Validation of a solid-phase microextraction method for headspace analysis of wine aroma components 显示文摘 | HOWARD K L MIKE J H RIESEN R | 2005 | American Journal of Enology and Viticulture2005，56，1： | 1 |
| 16 | Impact of stoichiometry on L10 ordering in FePt and FePtCu thin films 显示文摘 | Wierman K W Platt C L Howard J K | 2004 | J Magn Magn Mater2004，278，： | 1 |
| 17 | Fast-trackpaediatric cardiac surgery : the feasibility and benefits of aprotocol for uncomplicated cases 显示文摘 | HOWARD F BROWN K L GARSIDE V | 2010 | Eur J CardiothoracSurg2010，37，1： | 1 |
| 18 | Blueberry fruit response to postharvest application of ultraviolet radiation显示文摘 | Perkins-Veazie P COLLINS J K HOWARD L | 2008 | Postharvest Biology and Technology2008，47，： | 1 |
| 19 | Blueberry fruit response to postharvest application of ultraviolet radiation显示文摘 | PERKINS-VEAZIE P COLLINS J K HOWARD L | 2008 | Postharvest Biology and Technology2008，47，3： | 1 |
| 20 | Validation of a solid- phase microextraction method for headspace analysis of wine aroma components显示文摘 | Howard K L Mike J H Riesen R | 2005 | American Journal of Enology and Viticulture2005，56，1： | 1 |
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